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Select item 100791551.

Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection

Wenjuan Dong, Jing Wang, Lei Tian, Jianying Zhang, Erik W. Settles, Chao Qin, Daniel R. Steinken-Kollath, Ashley N. Itogawa, Kimberly R. Celona, Jinhee Yi, Mitchell Bryant, Heather Mead, Sierra A. Jaramillo, Hongjia Lu, Aimin Li, Ross E. Zumwalt, Sanjeet Dadwal, Pinghui Feng, Weiming Yuan, Sean P. J. Whelan, Paul S. Keim, Bridget Marie Barker, Michael A. Caligiuri, Jianhua Yu

Nat Commun. 2023; 14: 1936. Published online 2023 Apr 6. doi: 10.1038/s41467-023-37336-9

PMCID:: PMC10079155

Abstract Article PDF–5.0M

Select item 98660722.

Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction

Katrin Schröer, Montaha Alshawabkeh, Sebastian Schellhorn, Katrin Bronder, Wenli Zhang, Anja Ehrhardt

Viruses. 2023 Jan; 15(1): 55. Published online 2022 Dec 24. doi: 10.3390/v15010055

PMCID:: PMC9866072

Abstract Article PDF–1.6M

Select item 96997873.

Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa

Khaoula Zekri-Nechar, José J. Zamorano-León, Carmen Reche, Manel Giner, Ana López-de-Andrés, Rodrigo Jiménez-García, Antonio J. López-Farré, Carlos Hugo Martínez-Martínez

Dis Markers. 2022; 2022: 1118195. Published online 2022 Nov 18. doi: 10.1155/2022/1118195

PMCID:: PMC9699787

Abstract Article PDF–1.2M

Select item 92900144.

Associations of coagulation factor X and XI with incident acute coronary syndrome and stroke: A nested case‐control study

Huiting Chen, Miaoyan Shen, Rundong Niu, Xuanwen Mu, Qin Jiang, Rong Peng, Yu Yuan, Hao Wang, Qiuhong Wang, Handong Yang, Huan Guo, Meian He, Xiaomin Zhang, Tangchun Wu

J Thromb Haemost. 2021 Nov; 19(11): 2781–2790. Published online 2021 Aug 31. doi: 10.1111/jth.15486

PMCID:: PMC9290014

Abstract Article PDF–984K

Select item 91232945.

Role of LL-37 in thrombotic complications in patients with COVID-19

Zilei Duan, Juan Zhang, Xue Chen, Ming Liu, Hongwen Zhao, Lin Jin, Zhiye Zhang, Ning Luan, Ping Meng, Jing Wang, Zhaoxia Tan, Yaxiong Li, Guohong Deng, Ren Lai

Cell Mol Life Sci. 2022 Jun; 79(6): 309. Published online 2022 May 21. doi: 10.1007/s00018-022-04309-y

PMCID:: PMC9123294

Abstract Article PDF–3.6M

Select item 89424696.

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

Edward R Kastenhuber, Marisa Mercadante, Benjamin Nilsson-Payant, Jared L Johnson, Javier A Jaimes, Frauke Muecksch, Yiska Weisblum, Yaron Bram, Vasuretha Chandar, Gary R Whittaker, Benjamin R tenOever, Robert E Schwartz, Lewis Cantley

eLife. 2022; 11: e77444. Published online 2022 Mar 23. doi: 10.7554/eLife.77444

PMCID:: PMC8942469

Abstract Article PDF–751K

Select item 88087417.

Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples

Erin E. Soule, Haixiang Yu, Lyra Olson, Ibtehaj Naqvi, Shekhar Kumar, Sriram Krishnaswamy, Bruce A. Sullenger

Cell Chem Biol. 2022 Feb 17; 29(2): 215–225.e5. Published online 2022 Feb 2. doi: 10.1016/j.chembiol.2022.01.009

PMCID:: PMC8808741

Abstract Article PDF–2.8M

Select item 87409628.

Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19

Marissa J. M. Traets, Roel H. T. Nijhuis, Servaas A. Morré, Sander Ouburg, Jasper A. Remijn, Bastiaan A. Blok, Bas de Laat, Eefje Jong, Gerarda J. M. Herder, Aernoud T. L. Fiolet, Stephan P. Verweij

PLoS One. 2022; 17(1): e0260897. Published online 2022 Jan 7. doi: 10.1371/journal.pone.0260897

PMCID:: PMC8740962

Abstract Article PDF–1.1M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 765025510.

Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex

Manjunath Goolyam Basavaraj, Sriram Krishnaswamy

J Biol Chem. 2020 Nov 6; 295(45): 15198–15207. Published online 2020 Aug 28. doi: 10.1074/jbc.RA120.015325

PMCID:: PMC7650255

Abstract Article PDF–1.1M

Select item 732765111.

Rare variants lowering the levels of coagulation factor X are protective against ischemic heart disease

Elvezia Maria Paraboschi, Amit Vikram Khera, Piera Angelica Merlini, Laura Gigante, Flora Peyvandi, Mark Chaffin, Marzia Menegatti, Fabiana Busti, Domenico Girelli, Nicola Martinelli, Oliviero Olivieri, Sekar Kathiresan, Diego Ardissino, Rosanna Asselta, Stefano Duga

Haematologica. 2020 Jul; 105(7): e365–e369. doi: 10.3324/haematol.2019.237750

PMCID:: PMC7327651

Article PDF–1.4M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 700526013.

Production and control of coagulation proteins for factor X activation in human endothelial cells and fibroblasts

Clay T. Cohen, Nancy A. Turner, Joel L. Moake

Sci Rep. 2020; 10: 2005. Published online 2020 Feb 6. doi: 10.1038/s41598-020-59058-4

PMCID:: PMC7005260

Abstract Article PDF–4.5M

Select item 634903214.

Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Ruwan Gunaratne, Shekhar Kumar, James W. Frederiksen, Steven Stayrook, Jens L. Lohrmann, Kay Perry, Kristin M. Bompiani, Charlene V. Chabata, Nabil K. Thalji, Michelle D. Ho, Gowthami Arepally, Rodney M. Camire, Sriram Krishnaswamy, Bruce A. Sullenger

Nat Biotechnol. Author manuscript; available in PMC 2019 Jan 28.

Published in final edited form as: Nat Biotechnol. 2018 Aug; 36(7): 606–613. Published online 2018 Jun 4. doi: 10.1038/nbt.4153

PMCID:: PMC6349032

Abstract Article PDF–983K

Select item 627436915.

Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Wenzhi Wang, Jing Yuan, Xiaoli Fu, Fancui Meng, Shijun Zhang, Weiren Xu, Yongnan Xu, Changjiang Huang

Molecules. 2016 Apr; 21(4): 491. Published online 2016 Apr 14. doi: 10.3390/molecules21040491

PMCID:: PMC6274369

Abstract Article PDF–2.8M

Select item 588003116.

Suppressive Role of Tissue Factor Pathway Inhibitor-α in Platelet-Dependent Fibrin Formation under Flow Is Restricted to Low Procoagulant Strength

Stella Thomassen, Tom G. Mastenbroek, Frauke Swieringa, Kristien Winckers, Marion A.H. Feijge, Roy Schrijver, Judith M.E.M. Cosemans, Susan A. Maroney, Alan E. Mast, Tilman M. Hackeng, Johan W.M. Heemskerk

Thromb Haemost. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Thromb Haemost. 2018 Mar; 118(3): 502–513. Published online 2018 Feb 16. doi: 10.1055/s-0038-1627453

PMCID:: PMC5880031

Abstract Article PDF–1.0M

Select item 582740617.

Activities of Thrombin and Factor Xa Are Essential for Replication of Hepatitis E Virus and Are Possibly Implicated in ORF1 Polyprotein Processing

Gayatri D. Kanade, Kunal D. Pingale, Yogesh A. Karpe

J Virol. 2018 Mar 15; 92(6): e01853-17. Prepublished online 2018 Jan 10. Published online 2018 Feb 26. doi: 10.1128/JVI.01853-17

PMCID:: PMC5827406

Abstract Article PDF–1.2M

Select item 570911718.

Catalytically inactive Gla-domainless factor Xa binds to TFPI and restores ex vivo coagulation in hemophilia plasma

Atanur Ersayin, Aline Thomas, Landry Seyve, Nicole Thielens, Mathieu Castellan, Raphaël Marlu, Benoît Polack, Marie-Claire Dagher

Haematologica. 2017 Dec; 102(12): e483–e485. doi: 10.3324/haematol.2017.174037

PMCID:: PMC5709117

Article PDF–862K

Select item 563001219.

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Yuichi Kamikubo, G. Loredana Mendolicchio, Antonella Zampolli, Patrizia Marchese, Andrea S. Rothmeier, Jennifer Nagrampa Orje, Andrew J. Gale, Sriram Krishnaswamy, András Gruber, Henrik Østergaard, Lars C. Petersen, Wolfram Ruf, Zaverio M. Ruggeri

Blood. 2017 Oct 5; 130(14): 1661–1670. Prepublished online 2017 Jul 20. doi: 10.1182/blood-2017-02-767079

PMCID:: PMC5630012

Abstract Article

Select item 562901520.

Rendering Factor Xa Zymogen-like as a Therapeutic Strategy to Treat Bleeding

Nabil K. Thalji, Rodney M. Camire

Curr Opin Hematol. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Curr Opin Hematol. 2017 Sep; 24(5): 453–459. doi: 10.1097/MOH.0000000000000369

PMCID:: PMC5629015

Abstract Article PDF–326K

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