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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Article PDF–2.2M

Select item 72268122.

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex

Marissa M. Minor, F. Blaine Hollinger, Adrienne L. McNees, Sung Yun Jung, Antrix Jain, Joseph M. Hyser, Karl-Dimiter Bissig, Betty L. Slagle

Cells. 2020 Apr; 9(4): 834. Published online 2020 Mar 30. doi: 10.3390/cells9040834

PMCID:: PMC7226812

Article PDF–2.3M

Select item 55316113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Article PDF–2.7M

Select item 48392944.

A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects

Ming Li, Jingyun Li, Changshuai Wei, Qing Lu, Xinyu Tang, Stephen W. Erickson, Stewart L. Macleod, Charlotte A. Hobbs, the National Birth Defects Prevention Study

Ann Hum Genet. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Ann Hum Genet. 2016 Jan; 80(1): 20–31. Published online 2015 Nov 27. doi: 10.1111/ahg.12139

PMCID:: PMC4839294

Article PDF–341K

Select item 46754515.

Obstructive Heart Defects Associated with Candidate Genes, Maternal Obesity, and Folic Acid Supplementation

Xinyu Tang, Mario A. Cleves, Todd G. Nick, Ming Li, Stewart L. MacLeod, Stephen W. Erickson, Jingyun Li, Gary M. Shaw, Bridget S. Mosley, Charlotte A. Hobbs, the National Birth Defects Prevention Study

Am J Med Genet A. Author manuscript; available in PMC 2016 Jun 1.

Published in final edited form as: Am J Med Genet A. 2015 Jun; 167(6): 1231–1242. Published online 2015 Apr 2. doi: 10.1002/ajmg.a.36867

PMCID:: PMC4675451

Article PDF–1.5M

Select item 46172116.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Article PDF–2.2M

Select item 45162517.

Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes

Radhika S. Ganu, Yasuko Ishida, Markos Koutmos, Sergios-Orestis Kolokotronis, Alfred L. Roca, Timothy A. Garrow, Lawrence B. Schook

PLoS One. 2015; 10(7): e0134084. Published online 2015 Jul 27. doi: 10.1371/journal.pone.0134084

PMCID:: PMC4516251

Article PDF–2.0M

Select item 43214448.

Genome-wide association study of selenium concentrations

Marilyn C. Cornelis, Myriam Fornage, Millennia Foy, Pengcheng Xun, Vadim N. Gladyshev, Steve Morris, Daniel I. Chasman, Frank B. Hu, Eric B. Rimm, Peter Kraft, Joanne M. Jordan, Dariush Mozaffarian, Ka He

Hum Mol Genet. 2015 Mar 1; 24(5): 1469–1477. Published online 2014 Oct 24. doi: 10.1093/hmg/ddu546

PMCID:: PMC4321444

Article PDF–252K

Select item 37735059.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

Simona Principe, E. Ellen Jones, Yunee Kim, Ankit Sinha, Julius O. Nyalwidhe, Jasmin Brooks, O. John Semmes, Dean A. Troyer, Raymond S. Lance, Thomas Kislinger, Richard R. Drake

Proteomics. Author manuscript; available in PMC 2014 May 1.

Published in final edited form as: Proteomics. 2013 May; 13(0): 1667–1671. Published online 2013 Apr 23. doi: 10.1002/pmic.201200561

PMCID:: PMC3773505

Article PDF–630K

Select item 376617810.

Genome-wide association study identifies loci affecting blood copper, selenium and zinc

David M. Evans, Gu Zhu, Veronica Dy, Andrew C. Heath, Pamela A. F. Madden, John P. Kemp, George McMahon, Beate St Pourcain, Nicholas J. Timpson, Jean Golding, Debbie A. Lawlor, Colin Steer, Grant W. Montgomery, Nicholas G. Martin, George Davey Smith, John B. Whitfield

Hum Mol Genet. 2013 Oct 1; 22(19): 3998–4006. Published online 2013 May 29. doi: 10.1093/hmg/ddt239

PMCID:: PMC3766178

Article PDF–714K

Select item 366165511.

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, Sami Alkayyali, Themistocles L. Assimes, Thomas Quertermous, Fahim Abbasi, Jussi Paananen, Hans Häring, Torben Hansen, Oluf Pedersen, Ulf Smith, Markku Laakso, the MAGIC Investigators, the DIAGRAM Consortium, the GENESIS Consortium, the RISC Consortium, Jacqueline M. Dekker, John J. Nolan, Leif Groop, Ele Ferrannini, Klaus-Peter Adam, Walter E. Gall, Timothy M. Frayling, Mark Walker

Diabetes. 2013 Jun; 62(6): 2141–2150. Published online 2013 May 17. doi: 10.2337/db12-0876

PMCID:: PMC3661655

Article PDF–575K

Select item 319082612.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Article PDF–5.7M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 294516814.

Variation at the NFATC2 Locus Increases the Risk of Thiazolidinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study

Swneke D. Bailey, Changchun Xie, Ron Do, Alexandre Montpetit, Rafael Diaz, Viswanathan Mohan, Bernard Keavney, Salim Yusuf, Hertzel C. Gerstein, James C. Engert, Sonia Anand, on behalf of the DREAM investigators

Diabetes Care. 2010 Oct; 33(10): 2250–2253. Published online 2010 Jul 13. doi: 10.2337/dc10-0452

PMCID:: PMC2945168

Article PDF–153K

Select item 290133615.

Maternal Genes and Facial Clefts in Offspring: A Comprehensive Search for Genetic Associations in Two Population-Based Cleft Studies from Scandinavia

Astanand Jugessur, Min Shi, Håkon Kristian Gjessing, Rolv Terje Lie, Allen James Wilcox, Clarice Ring Weinberg, Kaare Christensen, Abee Lowman Boyles, Sandra Daack-Hirsch, Truc Trung Nguyen, Lene Christiansen, Andrew Carl Lidral, Jeffrey Clark Murray

PLoS One. 2010; 5(7): e11493. Published online 2010 Jul 9. doi: 10.1371/journal.pone.0011493

PMCID:: PMC2901336

Article PDF–778K

Select item 281034416.

An Integrative Predictive Model of Coronary Artery Calcification in Arteriosclerosis

Michael McGeachie, Rachel L Badovinac Ramoni, Josyf C. Mychaleckyj, Karen L Furie, Jonathan M. Dreyfuss, Yongmei Liu, David Herrington, Xiuqing Guo, João A. Lima, Wendy Post, Jerome I. Rotter, Stephen Rich, Michèle Sale, Marco F. Ramoni

Circulation. Author manuscript; available in PMC 2010 Dec 15.

Published in final edited form as: Circulation. 2009 Dec 15; 120(24): 2448–2454. doi: 10.1161/CIRCULATIONAHA.109.865501

PMCID:: PMC2810344

Article PDF–448K

Select item 277583217.

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

Philippa J. Talmud, Fotios Drenos, Sonia Shah, Tina Shah, Jutta Palmen, Claudio Verzilli, Tom R. Gaunt, Jacky Pallas, Ruth Lovering, Kawah Li, Juan Pablo Casas, Reecha Sofat, Meena Kumari, Santiago Rodriguez, Toby Johnson, Stephen J. Newhouse, Anna Dominiczak, Nilesh J. Samani, Mark Caulfield, Peter Sever, Alice Stanton, Denis C. Shields, on behalf of the ASCOT investigators, Sandosh Padmanabhan, Olle Melander, Claire Hastie, Christian Delles, on behalf of the NORDIL investigators, Shah Ebrahim, Michael G. Marmot, George Davey Smith, Debbie A. Lawlor, Patricia B. Munroe, for the BRIGHT Consortium, Ian N. Day, Mika Kivimaki, John Whittaker, Steve E. Humphries, Aroon D. Hingorani

Am J Hum Genet. 2009 Nov 13; 85(5): 628–642. doi: 10.1016/j.ajhg.2009.10.014

PMCID:: PMC2775832

Article PDF–2.8M

Select item 270009218.

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

Gary M Shaw, Wei Lu, Huiping Zhu, Wei Yang, Farren BS Briggs, Suzan L Carmichael, Lisa F Barcellos, Edward J Lammer, Richard H Finnell

BMC Med Genet. 2009; 10: 49. Published online 2009 Jun 3. doi: 10.1186/1471-2350-10-49

PMCID:: PMC2700092

Article PDF–1020K

Select item 267765919.

Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study

Abee L. Boyles, Allen J. Wilcox, Jack A. Taylor, Min Shi, Clarice R. Weinberg, Klaus Meyer, Åse Fredriksen, Per Magne Ueland, Anne Marte W. Johansen, Christian A. Drevon, Astanand Jugessur, Truc Nguyen Trung, Håkon K. Gjessing, Stein Emil Vollset, Jeffrey C. Murray, Kaare Christensen, Rolv T. Lie

Genet Epidemiol. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Genet Epidemiol. 2009 Apr; 33(3): 247–255. doi: 10.1002/gepi.20376

PMCID:: PMC2677659

Article PDF–213K

Select item 263705020.

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

Patricia A. Gonzales, Trairak Pisitkun, Jason D. Hoffert, Dmitry Tchapyjnikov, Robert A. Star, Robert Kleta, Nam Sun Wang, Mark A. Knepper

J Am Soc Nephrol. 2009 Feb; 20(2): 363–379. doi: 10.1681/ASN.2008040406

PMCID:: PMC2637050

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