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Select item 110173701.

Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice

Ming-Hsuan Ou-Yang, Jonathan E. Kurz, Toshihiro Nomura, Jelena Popovic, Tharinda W. Rajapaksha, Hongxin Dong, Anis Contractor, Dane M. Chetkovich, Warren G. Tourtellotte, Robert Vassar

Sci Transl Med. Author manuscript; available in PMC 2024 Apr 15.

Published in final edited form as: Sci Transl Med. 2018 Sep 19; 10(459): eaao5620. doi: 10.1126/scitranslmed.aao5620

PMCID:: PMC11017370

Abstract Article PDF–2.3M

Select item 104766432.

Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice

Annie Y. Yao, Patrick J. Halloran, Yingying Ge, Neeraj Singh, John Zhou, James Galske, Wanxia He, Riqiang Yan, Xiangyou Hu

J Neurosci. 2023 Aug 30; 43(35): 6197–6211. doi: 10.1523/JNEUROSCI.2124-22.2023

PMCID:: PMC10476643

Abstract Article PDF–3.9M

Select item 102359683.

ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation

Gui-Feng Zhou, Jing Tang, Yuan-Lin Ma, Xian Fu, Jun-Yan Liu, Ren-Zhi Yang, Hong-Sheng Zhang, Xiang-Hai Cai, Jing-Wen Wang, Xiao-Yong Xie, Li Song, Biao Luo, Jian Chen, Long Chen, Xiao-Juan Deng, Guo-Jun Chen

Proc Natl Acad Sci U S A. 2023 May 30; 120(22): e2220148120. Published online 2023 May 22. doi: 10.1073/pnas.2220148120

PMCID:: PMC10235968

Abstract Article PDF–6.5M

Select item 101614664.

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan

Mol Neurodegener. 2023; 18: 31. Published online 2023 May 4. doi: 10.1186/s13024-023-00611-w

PMCID:: PMC10161466

Abstract Article PDF–10M

Select item 100262515.

Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation

Marc R Benoit, Mabintou Darboe, Brati Das, Yingying Ge, John Zhou, Annie Yao, Wanxia He, Riqiang Yan, Xiangyou Hu

Hum Mol Genet. 2023 Apr 1; 32(7): 1193–1207. Published online 2022 Nov 12. doi: 10.1093/hmg/ddac282

PMCID:: PMC10026251

Abstract Article PDF–2.1M

Select item 99424146.

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler

Mol Neurodegener. 2023; 18: 13. Published online 2023 Feb 21. doi: 10.1186/s13024-023-00596-6

PMCID:: PMC9942414

Abstract Article PDF–2.3M

Select item 99187367.

Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and aged animals

Rangjuan Cao, Peng Chen, Hongsheng Wang, Hongyang Jing, Hongsheng Zhang, Guanglin Xing, Bin Luo, Jinxiu Pan, Zheng Yu, Wen-Cheng Xiong, Lin Mei

Nat Commun. 2023; 14: 744. Published online 2023 Feb 10. doi: 10.1038/s41467-023-36454-8

PMCID:: PMC9918736

Abstract Article PDF–4.0M

Select item 99054738.

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup

Sci Rep. 2023; 13: 2216. Published online 2023 Feb 7. doi: 10.1038/s41598-023-28846-z

PMCID:: PMC9905473

Abstract Article PDF–3.1M

Select item 97824749.

PS1 Affects the Pathology of Alzheimer’s Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus

Nuomin Li, Yunjie Qiu, Hao Wang, Juan Zhao, Hong Qing

Int J Mol Sci. 2022 Dec; 23(24): 16151. Published online 2022 Dec 18. doi: 10.3390/ijms232416151

PMCID:: PMC9782474

Abstract Article PDF–3.5M

Select item 957665910.

The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes

Ryan Keable, Shangfeng Hu, Grant Pfundstein, Irina Kozlova, Feifei Su, Ximing Du, Hongyuan Yang, Jenny Gunnersen, Melitta Schachner, Iryna Leshchyns’ka, Vladimir Sytnyk

Cell Mol Life Sci. 2022; 79(11): 555. Published online 2022 Oct 17. doi: 10.1007/s00018-022-04575-w

PMCID:: PMC9576659

Abstract Article PDF–18M

Select item 931676611.

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang

Alzheimers Res Ther. 2022; 14: 103. Published online 2022 Jul 26. doi: 10.1186/s13195-022-01050-3

PMCID:: PMC9316766

Abstract Article PDF–7.1M

Select item 929953512.

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan

Sci Adv. 2022 Jul; 8(29): eabo3610. Published online 2022 Jul 20. doi: 10.1126/sciadv.abo3610

PMCID:: PMC9299535

Abstract Article PDF–5.5M

Select item 928678513.

BACE1: More than just a β‐secretase

Hannah A. Taylor, Lena Przemylska, Eva M. Clavane, Paul J. Meakin

Obes Rev. 2022 Jul; 23(7): e13430. Published online 2022 Feb 4. doi: 10.1111/obr.13430

PMCID:: PMC9286785

Abstract Article PDF–12M

Select item 912430614.

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

De‐Juan Yuan, Guang Yang, Wei Wu, Qi‐Fa Li, De‐en Xu, Michael Ntim, Chun‐Yan Jiang, Ji‐Chuan Liu, Yue Zhang, Ying‐Zi Wang, Dan‐Dan Zhu, Supratik Kundu, Ai‐Ping Li, Zhi‐Cheng Xiao, Quan‐Hong Ma, Shao Li

Aging Cell. 2022 May; 21(5): e13593. Published online 2022 Mar 30. doi: 10.1111/acel.13593

PMCID:: PMC9124306

Abstract Article PDF–3.3M

Select item 876005015.

BACE1 controls synaptic function through modulating release of synaptic vesicles

Brati Das, Neeraj Singh, Annie Y. Yao, John Zhou, Wanxia He, Xiangyou Hu, Riqiang Yan

Mol Psychiatry. 2021; 26(11): 6394–6410. Published online 2021 Jun 22. doi: 10.1038/s41380-021-01166-2

PMCID:: PMC8760050

Abstract Article PDF–4.3M

Select item 869503816.

MiR-29c-3p May Promote the Progression of Alzheimer's Disease through BACE1

Yanqun Cao, Xiangxiang Tan, Quzhe Lu, Kai Huang, Xiaoer Tang, Zhiming He

J Healthc Eng. 2021; 2021: 2031407. Published online 2021 Dec 15. doi: 10.1155/2021/2031407

PMCID:: PMC8695038

Abstract Article PDF–1.3M

Select item 862480717.

The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system

Johanna Tüshaus, Stephan A. Müller, Joshua Shrouder, Martina Arends, Mikael Simons, Nikolaus Plesnila, Carl P. Blobel, Stefan F. Lichtenthaler

FASEB J. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: FASEB J. 2021 Nov; 35(11): e21962. doi: 10.1096/fj.202100936R

PMCID:: PMC8624807

Abstract Article PDF–1.3M

Select item 861229518.

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings

Selene Lomoio, Rachel Willen, WonHee Kim, Kevin Z. Ho, Edward K. Robinson, Dmitry Prokopenko, Matthew E. Kennedy, Rudolph E. Tanzi, Giuseppina Tesco

Sci Transl Med. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Sci Transl Med. 2020 Nov 18; 12(570): eaba1871. doi: 10.1126/scitranslmed.aba1871

PMCID:: PMC8612295

Abstract Article PDF–4.2M

Select item 841389419.

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

Catarina Perdigão, Mariana A. Barata, Tatiana Burrinha, Cláudia Guimas Almeida

J Biol Chem. 2021 Sep; 297(3): 101056. Published online 2021 Aug 8. doi: 10.1016/j.jbc.2021.101056

PMCID:: PMC8413894

Abstract Article PDF–3.9M

Select item 833906020.

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Stephan Frank, Takashi Saito, Takaomi C. Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti

Cell Death Dis. 2021 Aug; 12(8): 769. Published online 2021 Aug 4. doi: 10.1038/s41419-021-04062-3