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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102184972.

The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson’s Disease-Associated Neurodegeneration

Xin Wang, Xi Chen, Guangdong Liu, Huaibin Cai, Weidong Le

Int J Mol Sci. 2023 May; 24(10): 8614. Published online 2023 May 11. doi: 10.3390/ijms24108614

PMCID:: PMC10218497

Abstract Article PDF–868K

Select item 99606503.

Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson’s Model

Jessica IChi Lai, Alessandra Porcu, Benedetto Romoli, Maria Keisler, Fredric P. Manfredsson, Susan B. Powell, Davide Dulcis

Int J Mol Sci. 2023 Feb; 24(4): 4204. Published online 2023 Feb 20. doi: 10.3390/ijms24044204

PMCID:: PMC9960650

Abstract Article PDF–12M

Select item 98628084.

Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor Associated with Human Brain Aging via H3K79 Hypermethylation

Hendrikus J. Van Heesbeen, Lars Von Oerthel, Paul M. De Vries, Cindy M. R. J. Wagemans, Marten P. Smidt

Int J Mol Sci. 2023 Jan; 24(2): 1387. Published online 2023 Jan 10. doi: 10.3390/ijms24021387

PMCID:: PMC9862808

Abstract Article PDF–6.0M

Select item 97972085.

Function of Excitatory Periaqueductal Gray Synapses in the Ventral Tegmental Area following Inflammatory Injury

Claire Elena Manning, Michael Fritz, Julie Ann Kauer

eNeuro. 2022 Nov-Dec; 9(6): ENEURO.0324-22.2022. Prepublished online 2022 Dec 7. Published online 2022 Dec 19. doi: 10.1523/ENEURO.0324-22.2022

PMCID:: PMC9797208

Abstract Article PDF–2.1M

Select item 95632476.

Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia

Sean Austin O. Lim, Rong Xia, Yunmin Ding, Lisa Won, William J. Ray, Stephen A. Hitchcock, Daniel S. McGehee, Un Jung Kang

Neurobiol Dis. Author manuscript; available in PMC 2022 Oct 14.

Published in final edited form as: Neurobiol Dis. 2015 Apr; 76: 67–76. Published online 2015 Feb 4. doi: 10.1016/j.nbd.2015.01.003

PMCID:: PMC9563247

Abstract Article PDF–637K

Select item 94256277.

A Pitx3-deficient developmental mouse model for fine motor, olfactory, and gastrointestinal symptoms of Parkinson’s disease

Bin Song, Jacob W. Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S. Schweitzer, Kwang-Soo Kim

Neurobiol Dis. Author manuscript; available in PMC 2022 Aug 30.

Published in final edited form as: Neurobiol Dis. 2022 Aug; 170: 105777. Published online 2022 May 27. doi: 10.1016/j.nbd.2022.105777

PMCID:: PMC9425627

Abstract Article PDF–1.6M

Select item 92829308.

Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson’s disease model

Peibo Xu, Hui He, Qinqin Gao, Yingying Zhou, Ziyan Wu, Xiao Zhang, Linyu Sun, Gang Hu, Qian Guan, Zhiwen You, Xinyue Zhang, Wenping Zheng, Man Xiong, Yuejun Chen

J Clin Invest. 2022 Jul 15; 132(14): e156768. Published online 2022 Jul 15. doi: 10.1172/JCI156768

PMCID:: PMC9282930

Abstract Article PDF–19M

Select item 86580409.

Nkx2.9 Contributes to Mid-Hindbrain Patterning by Regulation of mdDA Neuronal Cell-Fate and Repression of a Hindbrain-Specific Cell-Fate

Willemieke M. Kouwenhoven, Lars von Oerthel, Maria Gruppilo, Jianmin Tian, Cindy M. R. J. Wagemans, Imke G. J. Houwers, Joseph Locker, Simone Mesman, Marten P. Smidt

Int J Mol Sci. 2021 Dec; 22(23): 12663. Published online 2021 Nov 23. doi: 10.3390/ijms222312663

PMCID:: PMC8658040

Abstract Article PDF–7.2M

Select item 835396210.

Tau Knockout Exacerbates Degeneration of Parvalbumin-Positive Neurons in Substantia Nigra Pars Reticulata in Parkinson’s Disease-Related α-Synuclein A53T Mice

Luyan Jiao, Meige Zheng, Jinhai Duan, Ting Wu, Zhao Li, Lin Liu, Xianhong Xiang, Xiaolu Tang, Jinyang He, Xingjian Li, Guofeng Zhang, Jinhui Ding, Huaibin Cai, Xian Lin

FASEB J. Author manuscript; available in PMC 2021 Aug 10.

Published in final edited form as: FASEB J. 2020 Sep; 34(9): 12239–12254. Published online 2020 Jul 30. doi: 10.1096/fj.202000017RR

PMCID:: PMC8353962

Abstract Article PDF–3.0M

Select item 764932411.

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling

Parivash Nouri, Sebastian Götz, Benedict Rauser, Martin Irmler, Changgeng Peng, Dietrich Trümbach, Christian Kempny, Carina G. Lechermeier, Agnes Bryniok, Andrea Dlugos, Ellen Euchner, Johannes Beckers, Claude Brodski, Claudia Klümper, Wolfgang Wurst, Nilima Prakash

Front Cell Dev Biol. 2020; 8: 587778. Published online 2020 Oct 26. doi: 10.3389/fcell.2020.587778

PMCID:: PMC7649324

Abstract Article PDF–13M

Select item 724438812.

Periaqueductal gray and rostromedial tegmental inhibitory afferents to ventral tegmental area have distinct synaptic plasticity and opiate sensitivity

St. Robyn Laurent, Valentina Martinez Damonte, Ayumi C. Tsuda, Julie A. Kauer

Neuron. Author manuscript; available in PMC 2021 May 20.

Published in final edited form as: Neuron. 2020 May 20; 106(4): 624–636.e4. Published online 2020 Mar 18. doi: 10.1016/j.neuron.2020.02.029

PMCID:: PMC7244388

Abstract Article PDF–1.6M

Select item 690144113.

Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function

Carolyn G. Sweeney, Patrick J. Kearney, Rita R. Fagan, Lindsey A. Smith, Nicholas C. Bolden, Rubing Zhao-Shea, Iris V. Rivera, Jenya Kolpakova, Jun Xie, Guangping Gao, Andrew R. Tapper, Gilles E. Martin, Haley E. Melikian

Neuropsychopharmacology. 2020 Jan; 45(2): 384–393. Published online 2019 Jul 5. doi: 10.1038/s41386-019-0457-x

PMCID:: PMC6901441

Abstract Article PDF–2.2M

Select item 689275414.

Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification

Sylvie Dumas, Åsa Wallén-Mackenzie

Front Cell Dev Biol. 2019; 7: 307. Published online 2019 Nov 28. doi: 10.3389/fcell.2019.00307

PMCID:: PMC6892754

Abstract Article PDF–7.7M

Select item 687628215.

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia

Sharmilee Vetrivel, Natascia Tiso, Andrea Kügler, Martin Irmler, Marion Horsch, Johannes Beckers, Daniela Hladik, Florian Giesert, Valerie Gailus-Durner, Helmut Fuchs, Sibylle Sabrautzki, Martin Hrabě de Angelis, Jochen Graw

Exp Eye Res. 2019 Nov; 188: 107632. doi: 10.1016/j.exer.2019.03.024

PMCID:: PMC6876282

Abstract Article

Select item 678913916.

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Daniel F. Cardozo Pinto, Hongbin Yang, Iskra Pollak Dorocic, Johannes W. de Jong, Vivian J. Han, James R. Peck, Yichen Zhu, Christine Liu, Kevin T. Beier, Marten P. Smidt, Stephan Lammel

Nat Commun. 2019; 10: 4633. Published online 2019 Oct 11. doi: 10.1038/s41467-019-12392-2

PMCID:: PMC6789139

Abstract Article PDF–6.5M

Select item 674108817.

Location and Size of Dopaminergic and Serotonergic Cell Populations Are Controlled by the Position of the Midbrain–Hindbrain Organizer

Claude Brodski, Daniela M. Vogt Weisenhorn, Massimo Signore, Inge Sillaber, Matthias Oesterheld, Vania Broccoli, Dario Acampora, Antonio Simeone, Wolfgang Wurst

J Neurosci. 2003 May 15; 23(10): 4199–4207. doi: 10.1523/JNEUROSCI.23-10-04199.2003