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Select item 108615181.

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang, Linli Que, Guoqing Zhu, Li Liu, Qi Chen, Chuanfu Li, Guoqiang Shao, Yuehua Li, Jiantao Li

Cell Death Dis. 2024 Feb; 15(2): 135. Published online 2024 Feb 12. doi: 10.1038/s41419-024-06470-7

PMCID:: PMC10861518

Article PDF–6.3M

Select item 108304832.

HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

Avinash Thakur, Kwangjin Park, Rebecca Cullum, Bettina M. Fuglerud, Mina Khoshnoodi, Sibyl Drissler, Tabea L. Stephan, Jeremy Lotto, Donghwan Kim, Frank J. Gonzalez, Pamela A. Hoodless

Commun Biol. 2024; 7: 144. Published online 2024 Jan 31. doi: 10.1038/s42003-024-05835-0

PMCID:: PMC10830483

Article PDF–13M

Select item 107897423.

ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function

Yue Zhu, Qinqin Wang, Xinyu Xie, Cuihong Ma, Yuemei Qiao, Yu Zhang, Yanjun Wu, Yuan Gao, Jing Jiang, Xin Liu, Jianfeng Chen, Chen Li, Gaoxiang Ge

Cell Death Dis. 2024 Jan; 15(1): 55. Published online 2024 Jan 15. doi: 10.1038/s41419-024-06441-y

PMCID:: PMC10789742

Article PDF–8.7M

Select item 107261354.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek

Front Endocrinol (Lausanne) 2023; 14: 1266527. Published online 2023 Dec 4. doi: 10.3389/fendo.2023.1266527

PMCID:: PMC10726135

Article PDF–7.0M

Select item 106829335.

Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis

Samira Benhamouche-Trouillet, Evan O'Loughlin, Ching-Hui Liu, William Polacheck, Julien Fitamant, Mary McKee, Nabeel El-Bardeesy, Christopher S. Chen, Andrea I. McClatchey

Development. 2018 May 1; 145(9): dev162123. Published online 2018 Apr 30. doi: 10.1242/dev.162123

PMCID:: PMC10682933

Article

Select item 106811206.

Keratin 79 is a PPARA target that is highly expressed by liver damage

Donghwan Kim, Inwook Choi, Sang Keun Ha, Frank J. Gonzalez

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Nov 27.

Published in final edited form as: Biochem Biophys Res Commun. 2023 Apr 2; 650: 132–136. Published online 2023 Jan 30. doi: 10.1016/j.bbrc.2023.01.071

PMCID:: PMC10681120

Article PDF–1.0M

Select item 105980537.

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells

Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer

Mol Metab. 2023 Dec; 78: 101821. Published online 2023 Oct 6. doi: 10.1016/j.molmet.2023.101821

PMCID:: PMC10598053

Article PDF–4.3M

Select item 104705208.

Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations

Cecelia Kelly, Jayanth Jawahar, Lauren Davey, Jeffrey I. Everitt, Joseph A. Galanko, Chelsea Anderson, Jonathan E. Avendano, Jessica R. McCann, R. Balfour Sartor, Raphael H. Valdivia, John F. Rawls

mBio. 2023 Jul-Aug; 14(4): e01504-23. Published online 2023 Aug 1. doi: 10.1128/mbio.01504-23

PMCID:: PMC10470520

Article PDF–5.6M

Select item 103184079.

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Daniel A. Michelson, Chong Zuo, Michael Verzi, Christophe Benoist, Diane Mathis

J Exp Med. 2023 Oct 2; 220(10): e20230461. Published online 2023 Jul 3. doi: 10.1084/jem.20230461

PMCID:: PMC10318407

Article PDF–6.6M

Select item 1023199410.

Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy

Marta Martinez-Calle, Guillaume Courbon, Bridget Hunt-Tobey, Connor Francis, Jadeah Spindler, Xueyan Wang, Luciene M. dos Reis, Carolina S.W. Martins, Isidro B. Salusky, Hartmut Malluche, Thomas L. Nickolas, Rosa M.A. Moyses, Aline Martin, Valentin David

J Clin Invest. 2023 Jun 1; 133(11): e159928. Published online 2023 Jun 1. doi: 10.1172/JCI159928

PMCID:: PMC10231994

Article PDF–13M

Select item 1018208011.

Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice

Swati Ghosh, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol

Sci Rep. 2023; 13: 7752. Published online 2023 May 12. doi: 10.1038/s41598-023-33994-3

Correction in:: Sci Rep. 2023; 13: 11673.

PMCID:: PMC10182080

Article PDF–6.6M

Select item 998443412.

General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions

Susanna Säisä-Borreill, Guillaume Davidson, Thomas Kleiber, Andréa Thevenot, Elisabeth Martin, Stanislas Mondot, Hervé Blottière, Alexandra Helleux, Gabrielle Mengus, Michelina Plateroti, Isabelle Duluc, Irwin Davidson, Jean-Noel Freund

Cell Death Differ. 2023 Mar; 30(3): 839–853. Published online 2023 Jan 13. doi: 10.1038/s41418-022-01109-6

PMCID:: PMC9984434

Article PDF–8.1M

Select item 988872513.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Article PDF–6.9M

Select item 955156714.

KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood

Marie-Albane Minati, Mohamad Assi, Maxime Libert, Sabine Cordi, Frédéric Lemaigre, Patrick Jacquemin

Front Cell Dev Biol. 2022; 10: 995013. Published online 2022 Sep 27. doi: 10.3389/fcell.2022.995013

PMCID:: PMC9551567

Article PDF–5.6M

Select item 942649015.

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

Sage E. Foley, Michael J. Dente, Xuqiu Lei, Benjamin F. Sallis, Ethan B. Loew, Mario Meza-Segura, Katherine A. Fitzgerald, Beth A. McCormick

mBio. 2022 Jul-Aug; 13(4): e01993-22. Published online 2022 Aug 15. doi: 10.1128/mbio.01993-22

PMCID:: PMC9426490

Article PDF–2.3M

Select item 942140016.

Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development

Linh T. Trinh, Anna B. Osipovich, Leesa Sampson, Jonathan Wong, Chris V.E. Wright, Mark A. Magnuson

iScience. 2022 Sep 16; 25(9): 104905. Published online 2022 Aug 11. doi: 10.1016/j.isci.2022.104905

PMCID:: PMC9421400

Article PDF–4.7M

Select item 940468417.

hsa-miR-34a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury Via Targeting HNF4α

Xiaoqiang Zheng, Gang Wang, Jiang Yuan, Nuoya Li, Biaolei Yan, Jinlong Yan, Yanling Sheng

Turk J Gastroenterol. 2022 Jul; 33(7): 596–605. Published online 2022 Jul 1. doi: 10.5152/tjg.2022.21169

PMCID:: PMC9404684

Article PDF–4.1M

Select item 938238918.

Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism

Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Biol Reprod. 2022 Aug; 107(2): 574–589. Published online 2022 Apr 4. doi: 10.1093/biolre/ioac066

PMCID:: PMC9382389

Article PDF–1.7M

Select item 938025419.

HNF4A modulates glucocorticoid action in the liver

A. Louise Hunter, Toryn M. Poolman, Donghwan Kim, Frank J. Gonzalez, David A. Bechtold, Andrew S.I. Loudon, Mudassar Iqbal, David W. Ray

Cell Rep. 2022 Apr 19; 39(3): 110697. Published online 2022 Apr 19. doi: 10.1016/j.celrep.2022.110697

PMCID:: PMC9380254

Article

Select item 935594620.

Mettl3-mediated mRNA m⁶A modification controls postnatal liver development by modulating the transcription factor Hnf4a

Yan Xu, Zhuowei Zhou, Xinmei Kang, Lijie Pan, Chang Liu, Xiaoqi Liang, Jiajie Chu, Shuai Dong, Yanli Li, Qiuli Liu, Yuetong Sun, Shanshan Yu, Qi Zhang

Nat Commun. 2022; 13: 4555. Published online 2022 Aug 5. doi: 10.1038/s41467-022-32169-4