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Items: 1 to 20 of 118

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders
Kisho Obi-Nagata, Norimitsu Suzuki, Ryuhei Miyake, Matthew L. MacDonald, Kenneth N. Fish, Katsuya Ozawa, Kenichiro Nagahama, Tsukasa Okimura, Shoji Tanaka, Masanobu Kano, Yugo Fukazawa, Robert A. Sweet, Akiko Hayashi-Takagi
Sci Adv. 2023 Jun; 9(23): eade5973. Published online 2023 Jun 9. doi: 10.1126/sciadv.ade5973
PMCID:
PMC10256173
ArticlePDF–1.8M
3.
Disrupted-in-schizophrenia-1 is required for normal pyramidal cell–interneuron communication and assembly dynamics in the prefrontal cortex
Jonas-Frederic Sauer, Marlene Bartos
eLife. 2022; 11: e79471. Published online 2022 Oct 14. doi: 10.7554/eLife.79471
PMCID:
PMC9566853
ArticlePDF–5.0M
4.
Chronic N-Acetylcysteine Treatment Prevents Amphetamine-Induced Hyperactivity in Heterozygous Disc1 Mutant Mice, a Putative Prodromal Schizophrenia Animal Model
Chuan-Ching Lai, Rathinasamy Baskaran, Chih-Yu Tsao, Li-Heng Tuan, Pei-Fen Siow, Mahalakshmi Palani, Lukas Jyuhn-Hsiarn Lee, Chih-Min Liu, Hai-Gwo Hwu, Li-Jen Lee
Int J Mol Sci. 2022 Aug; 23(16): 9419. Published online 2022 Aug 20. doi: 10.3390/ijms23169419
PMCID:
PMC9408838
ArticlePDF–1.7M
5.
Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit
Hanna Jaaro-Peled, Sunil Kumar, Dalton Hughes, Akiko Sumitomo, Sun-Hong Kim, Sandra Zoubovsky, Yuki Hirota-Tsuyada, Diana Zala, Julie Bruyere, Brittany M. Katz, Beverly Huang, Rafael Flores, III, Soumya Narayan, Zhipeng Hou, Aris N. Economides, Takatoshi Hikida, William C. Wetsel, Karl Deisseroth, Susumu Mori, Nicholas J. Brandon, Motomasa Tanaka, Koko Ishizuka, Miles D. Houslay, Frédéric Saudou, Kafui Dzirasa, Akira Sawa, Toshifumi Tomoda
Mol Psychiatry. Author manuscript; available in PMC 2022 Aug 14.
Published in final edited form as: Mol Psychiatry. 2022 Mar; 27(3): 1805–1815. Published online 2022 Feb 14. doi: 10.1038/s41380-021-01389-3
PMCID:
PMC9272458
ArticlePDF–1.8M
6.
Polysialylation in a DISC1 Mutant Mouse
Yuka Takahashi, Chikara Abe, Masaya Hane, Di Wu, Ken Kitajima, Chihiro Sato
Int J Mol Sci. 2022 May; 23(9): 5207. Published online 2022 May 6. doi: 10.3390/ijms23095207
PMCID:
PMC9102787
ArticlePDF–3.0M
7.
Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction
Lingzhen Song, Xiaxia Xu, Peggy Putthoff, David Fleck, Marc Spehr, Ileana L. Hanganu-Opatz
J Neurosci. 2022 Jan 26; 42(4): 601–618. doi: 10.1523/JNEUROSCI.1203-21.2021
PMCID:
PMC8805616
ArticlePDF–6.0M
8.
Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice
Xiaxia Xu, Lingzhen Song, Rebecca Kringel, Ileana L. Hanganu-Opatz
Nat Commun. 2021; 12: 6810. Published online 2021 Nov 23. doi: 10.1038/s41467-021-27114-w
PMCID:
PMC8611076
ArticlePDF–5.3M
9.
High-sucrose diets contribute to brain angiopathy with impaired glucose uptake and psychosis-related higher brain dysfunctions in mice
Shinobu Hirai, Hideki Miwa, Tomoko Tanaka, Kazuya Toriumi, Yasuto Kunii, Hiroko Shimbo, Takuya Sakamoto, Mizuki Hino, Ryuta Izumi, Atsuko Nagaoka, Hirooki Yabe, Tomoya Nakamachi, Seiji Shioda, Takashi Dan, Toshio Miyata, Yasumasa Nishito, Kazuhiro Suzuki, Mitsuhiro Miyashita, Toshifumi Tomoda, Takatoshi Hikida, Junjiro Horiuchi, Masanari Itokawa, Makoto Arai, Haruo Okado
Sci Adv. 2021 Nov; 7(46): eabl6077. Published online 2021 Nov 10. doi: 10.1126/sciadv.abl6077
PMCID:
PMC8580307
ArticlePDF–1.4M
10.
Astrocyte DISC1 contributes to cognitive function in a brain region-dependent manner
Alexey V Shevelkin, Chantelle E Terrillion, Yuto Hasegawa, Olga A Mychko, Yan Jouroukhin, Akira Sawa, Atsushi Kamiya, Mikhail V Pletnikov
Hum Mol Genet. 2020 Sep 1; 29(17): 2936–2950. Published online 2020 Aug 17. doi: 10.1093/hmg/ddaa180
PMCID:
PMC8248941
ArticlePDF–2.6M
11.
The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood
Kun Yang, Mari A. Kondo, Hanna Jaaro-Peled, Tyler Cash-Padgett, Shin-ichi Kano, Koko Ishizuka, Jonathan Pevsner, Toshifumi Tomoda, Akira Sawa, Minae Niwa
Schizophr Res. Author manuscript; available in PMC 2021 Apr 16.
Published in final edited form as: Schizophr Res. 2019 Aug; 210: 149–156. Published online 2019 Jun 13. doi: 10.1016/j.schres.2019.05.032
PMCID:
PMC8050833
ArticlePDF–515K
12.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
ArticlePDF–2.0M
13.
Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Sakamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Nat Commun. 2021; 12: 1398. Published online 2021 Mar 3. doi: 10.1038/s41467-021-21713-3
Correction in:
Nat Commun. 2021; 12: 2570.
PMCID:
PMC7930023
ArticlePDF–2.3M
14.
Functional brain defects in a mouse model of a chromosomal t(1;11) translocation that disrupts DISC1 and confers increased risk of psychiatric illness
Marion Bonneau, Shane T. O’ Sullivan, Miguel A. Gonzalez-Lozano, Paul Baxter, Phillippe Gautier, Elena Marchisella, Neil R. Hardingham, Robert A. Chesters, Helen Torrance, David M. Howard, Maurits A. Jansen, Melanie McMillan, Yasmin Singh, Michel Didier, Frank Koopmans, Colin A. Semple, Andrew M. McIntosh, Hansjürgen Volkmer, Maarten Loos, Kevin Fox, Giles E. Hardingham, Anthony C. Vernon, David J. Porteous, August B. Smit, David J. Price, J. Kirsty Millar
Transl Psychiatry. 2021; 11: 135. Published online 2021 Feb 19. doi: 10.1038/s41398-021-01256-3
PMCID:
PMC7895946
ArticlePDF–1.7M
15.
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1
Su Been Lee, Jihyun Park, Yongdo Kwak, Young-Un Park, Truong Thi My Nhung, Bo Kyoung Suh, Youngsik Woo, Yeongjun Suh, Eunbyul Cho, Sehyung Cho, Sang Ki Park
Transl Psychiatry. 2021; 11: 110. Published online 2021 Feb 4. doi: 10.1038/s41398-021-01212-1
PMCID:
PMC7862247
ArticlePDF–1.2M
16.
Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal–Hippocampal Coupling and the Cognitive Performance Throughout Development
Xiaxia Xu, Lingzhen Song, Ileana L Hanganu-Opatz
Cereb Cortex. 2021 Feb; 31(2): 1240–1258. Published online 2020 Oct 10. doi: 10.1093/cercor/bhaa291
PMCID:
PMC7786359
ArticlePDF–2.3M
17.
The DISC1 R264Q variant increases affinity for the dopamine D2 receptor and increases GSK3 activity
Ping Su, Hailong Zhang, Albert H. C. Wong, Fang Liu
Mol Brain. 2020; 13: 87. Published online 2020 Jun 3. doi: 10.1186/s13041-020-00625-1
PMCID:
PMC7271519
ArticlePDF–1.3M
18.
Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
Razia Sultana, Amita Shrestha, Charles C. Lee, Olalekan M. Ogundele
Front Cell Neurosci. 2020; 14: 94. Published online 2020 May 5. doi: 10.3389/fncel.2020.00094
PMCID:
PMC7214624
ArticlePDF–10M
19.
Parvalbumin Interneuron Dysfunction in a Thalamo-Prefrontal Cortical Circuit in Disc1 Locus Impairment Mice
Kristen Delevich, Hanna Jaaro-Peled, Mario Penzo, Akira Sawa, Bo Li
eNeuro. 2020 Mar-Apr; 7(2): ENEURO.0496-19.2020. Prepublished online 2020 Feb 6. Published online 2020 Mar 2. doi: 10.1523/ENEURO.0496-19.2020
PMCID:
PMC7054897
ArticlePDF–8.1M
20.
Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment
Mattia Chini, Jastyn A. Pöpplau, Christoph Lindemann, Laura Carol-Perdiguer, Marilena Hnida, Victoria Oberländer, Xiaxia Xu, Joachim Ahlbeck, Sebastian H. Bitzenhofer, Christoph Mulert, Ileana L. Hanganu-Opatz
Neuron. 2020 Jan 8; 105(1): 60–74.e7. doi: 10.1016/j.neuron.2019.09.042
PMCID:
PMC6953432
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