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Items: 1 to 20 of 64

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia
Laura M. Meyer, Sebastian E. Koschade, Jonas B. Vischedyk, Marlyn Thoelken, Andrea Gubas, Martin Wegner, Marion Basoglu, Stefan Knapp, Manuel Kaulich, Stefan Eimer, Shabnam Shaid, Christian H. Brandts
Autophagy. 2023; 19(11): 2982–2996. Published online 2023 Jul 13. doi: 10.1080/15548627.2023.2230839
PMCID:
PMC10549194
AbstractArticlePDF–2.3M
3.
Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection
Masaya Fukushi, Ryosuke Ohsawa, Yasushi Okinaka, Daisuke Oikawa, Tohru Kiyono, Masaya Moriwaki, Takashi Irie, Kosuke Oda, Yasuhiro Kamei, Fuminori Tokunaga, Yusuke Sotomaru, Hirofumi Maruyama, Hideshi Kawakami, Takemasa Sakaguchi
PLoS One. 2023; 18(6): e0287545. Published online 2023 Jun 23. doi: 10.1371/journal.pone.0287545
PMCID:
PMC10289332
AbstractArticlePDF–1.3M
4.
Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget’s disease of bone
Xiangxiang Hu, Sing-Wai Wong, Kaixin Liang, Tai-Hsien Wu, Sheng Wang, Lufei Wang, Jie Liu, Mitsuo Yamauchi, Brian L. Foster, Jenny P.-Y. Ting, Baohong Zhao, Henry C. Tseng, Ching-Chang Ko
Sci Adv. 2023 Jan; 9(4): eade6998. Published online 2023 Jan 27. doi: 10.1126/sciadv.ade6998
PMCID:
PMC9882986
AbstractArticlePDF–3.1M
5.
OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy
Yin Xu, Yun Liu, Xi Chen, Qia Xu, Liwei Liu, Hui Liu, Ruowen Guo, Yide Qin
Transl Psychiatry. 2022; 12: 230. Published online 2022 Jun 4. doi: 10.1038/s41398-022-02004-x
PMCID:
PMC9167278
AbstractArticlePDF–3.8M
6.
Optineurin promotes myogenesis during muscle regeneration in mice by autophagic degradation of GSK3β
Xiao Chen Shi, Bo Xia, Jian Feng Zhang, Rui Xin Zhang, Dan Yang Zhang, Huan Liu, Bao Cai Xie, Yong Liang Wang, Jiang Wei Wu
PLoS Biol. 2022 Apr; 20(4): e3001619. Published online 2022 Apr 27. doi: 10.1371/journal.pbio.3001619
PMCID:
PMC9084533
AbstractArticlePDF–5.6M
7.
Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation
Mingying Hou, Zhengbo Shao, Shiqi Zhang, Xinna Liu, Pan Fan, Menglu Jiang, Yutong Zhao, Rong Xiao, Huiping Yuan
Cell Death Dis. 2022 Apr; 13(4): 362. Published online 2022 Apr 18. doi: 10.1038/s41419-022-04836-3
PMCID:
PMC9016082
AbstractArticlePDF–8.1M
8.
Intrinsic antiviral activity of Optineurin prevents hyperproliferation of a primary herpes simplex virus type-2 infection
Chandrashekhar D Patil, Rahul Suryawanshi, Joshua Ames, Raghuram Koganti, Alex Agelidis, Divya Kapoor, Tejabhiram Yadavalli, Lulia Koujah, Henry C Tseng, Deepak Shukla
J Immunol. Author manuscript; available in PMC 2023 Jan 1.
Published in final edited form as: J Immunol. 2022 Jan 1; 208(1): 63–73. Published online 2021 Dec 8. doi: 10.4049/jimmunol.2100472
PMCID:
PMC9015683
AbstractArticlePDF–1.8M
9.
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation
Di Liu, Zhiyao Zhao, Yuanchu She, Lei Zhang, Xiangtian Chen, Ling Ma, Jun Cui
Proc Natl Acad Sci U S A. 2022 Feb 15; 119(7): e2113454119. Published online 2022 Feb 10. doi: 10.1073/pnas.2113454119
PMCID:
PMC8851536
AbstractArticlePDF–1.7M
10.
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling
Jiajia Wang, Jiaying Wang, Wenxiang Hong, Lulu Zhang, Liqian Song, Qi Shi, Yanfei Shao, Guifeng Hao, Chunyan Fang, Yueping Qiu, Lijun Yang, Zhaoxu Yang, Jincheng Wang, Ji Cao, Bo Yang, Qiaojun He, Qinjie Weng
Nat Commun. 2021; 12: 6198. Published online 2021 Oct 27. doi: 10.1038/s41467-021-26477-4
PMCID:
PMC8551263
AbstractArticlePDF–3.0M
11.
Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3
Zheng-Zhao Liu, Chun-Gu Hong, Wen-Bao Hu, Meng-Lu Chen, Ran Duan, Hong-Ming Li, Tao Yue, Jia Cao, Zhen-Xing Wang, Chun-Yuan Chen, Xiong-Ke Hu, Ben Wu, Hao-Ming Liu, Yi-Juan Tan, Jiang-Hua Liu, Zhong-Wei Luo, Yan Zhang, Shan-Shan Rao, Ming-Jie Luo, Hao Yin, Yi-Yi Wang, Kun Xia, Lang Xu, Si-Yuan Tang, Rong-Gui Hu, Hui Xie
Autophagy. 2021; 17(10): 2766–2782. Published online 2020 Nov 4. doi: 10.1080/15548627.2020.1839286
PMCID:
PMC8526045
AbstractArticlePDF–14M
12.
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
Joshua Ames, Tejabhiram Yadavalli, Rahul Suryawanshi, James Hopkins, Alexander Agelidis, Chandrashekhar Patil, Brian Fredericks, Henry Tseng, Tibor Valyi-Nagy, Deepak Shukla
Nat Commun. 2021; 12: 5401. Published online 2021 Sep 13. doi: 10.1038/s41467-021-25642-z
PMCID:
PMC8437952
AbstractArticlePDF–8.7M
13.
Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation
Wan Du, Fang Hua, Xiong Li, Jian Zhang, Shasha Li, Weichao Wang, Jiajia Zhou, Weimin Wang, Peng Liao, Yijian Yan, Gaopeng Li, Shuang Wei, Sara Grove, Linda Vatan, Witold Zgodziński, Marek Majewski, Grzegorz Wallner, Haoyan Chen, Ilona Kryczek, Jing-Yuan Fang, Weiping Zou
Cancer Discov. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Cancer Discov. 2021 Jul; 11(7): 1826–1843. Published online 2021 Feb 24. doi: 10.1158/2159-8290.CD-20-1571
PMCID:
PMC8292167
AbstractArticlePDF–2.7M
14.
Neuroprotective effects of bone marrow Sca-1+ cells against age-related retinal degeneration in OPTN E50K mice
Xinna Liu, Mingying Hou, Shiqi Zhang, Yutong Zhao, Qi Wang, Menglu Jiang, Mengxian Du, Zhengbo Shao, Huiping Yuan
Cell Death Dis. 2021 Jun; 12(6): 613. Published online 2021 Jun 15. doi: 10.1038/s41419-021-03851-0
PMCID:
PMC8203676
AbstractArticlePDF–4.8M
15.
Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response
Peng Xue, Xiangxiang Hu, Emily Chang, Lufei Wang, Minghui Chen, Tai-Hsien Wu, Dong-Joon Lee, Brian L. Foster, Henry C. Tseng, Ching-Chang Ko
Exp Mol Med. 2021 Apr; 53(4): 667–680. Published online 2021 Apr 16. doi: 10.1038/s12276-021-00596-w
PMCID:
PMC8102640
AbstractArticlePDF–2.3M
16.
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Sandra Franco-Iborra, Ainhoa Plaza-Zabala, Marta Montpeyo, David Sebastian, Miquel Vila, Marta Martinez-Vicente
Autophagy. 2021; 17(3): 672–689. Published online 2020 Feb 24. doi: 10.1080/15548627.2020.1728096
PMCID:
PMC8032238
AbstractArticlePDF–6.1M
17.
A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis
Lauren Mifflin, Zhirui Hu, Connor Dufort, Cynthia C. Hession, Alec J. Walker, Kongyan Niu, Hong Zhu, Nan Liu, Jun S. Liu, Joshua Z. Levin, Beth Stevens, Junying Yuan, Chengyu Zou
Proc Natl Acad Sci U S A. 2021 Mar 30; 118(13): e2025102118. Published online 2021 Mar 25. doi: 10.1073/pnas.2025102118
PMCID:
PMC8020785
AbstractArticlePDF–2.0M
18.
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
Shiqi Zhang, Zhengbo Shao, Xinna Liu, Mingying Hou, Fang Cheng, Dawei Lei, Huiping Yuan
Cell Death Discov. 2021; 7: 49. Published online 2021 Mar 15. doi: 10.1038/s41420-021-00432-0
PMCID:
PMC7960725
AbstractArticlePDF–4.0M
19.
iTRAQ-Based Quantitative Proteomics Indicated Nrf2/OPTN-Mediated Mitophagy Inhibits NLRP3 Inflammasome Activation after Intracerebral Hemorrhage
Yijun Cheng, Mingjian Liu, Hao Tang, Bin Chen, Guoyuan Yang, Weiguo Zhao, Yu Cai, Hanbing Shang
Oxid Med Cell Longev. 2021; 2021: 6630281. Published online 2021 Feb 9. doi: 10.1155/2021/6630281
PMCID:
PMC7892225
AbstractArticlePDF–4.4M
20.
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injury
Ying Wang, Jiefu Zhu, Zhiwen Liu, Shaoqun Shu, Ying Fu, Yuxue Liu, Juan Cai, Chengyuan Tang, Yu Liu, Xiaoming Yin, Zheng Dong
Redox Biol. 2021 Jan; 38: 101767. Published online 2020 Oct 23. doi: 10.1016/j.redox.2020.101767
PMCID:
PMC7606859
AbstractArticlePDF–20M

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