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Items: 1 to 20 of 200

1.
TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis
Chao Fang, Rui Zhong, Shuai Lu, Gang Yu, Zhilin Liu, Chengyuan Yan, Jingyu Gao, Yang Tang, Yingming Wang, Qichun Zhao, Xinzhe Feng
Int J Biol Sci. 2024; 20(6): 1992–2007. Published online 2024 Mar 11. doi: 10.7150/ijbs.91519
PMCID:
PMC11008261
ArticlePDF–9.3M
2.
Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss
Alma S. Popescu, Claire A. Butler, David H. Allendorf, Thomas M. Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M. Pocock, Peter Thornton, Guy C. Brown
Glia. 2023 Apr; 71(4): 974–990. Published online 2022 Dec 8. doi: 10.1002/glia.24318
PMCID:
PMC10952257
ArticlePDF–3.5M
3.
Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages
Yunsheng Liang, Yongfei Hu, Jun Zhang, Haosen Song, Xiaoqian Zhang, Yishan Chen, Yu Peng, Lihua Sun, Yuzhe Sun, Ruzeng Xue, Suyun Ji, Chuanwei Li, Zhili Rong, Bin Yang, Yingping Xu
Theranostics. 2024; 14(5): 2232–2245. Published online 2024 Mar 11. doi: 10.7150/thno.94121
PMCID:
PMC10945340
ArticlePDF–12M
4.
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
Tao Yin, Metin Yesiltepe, Luciano D’Adamio
EMBO Rep. 2024 Mar; 25(3): 1326–1360. Published online 2024 Feb 12. doi: 10.1038/s44319-024-00077-x
PMCID:
PMC10933458
ArticlePDF–6.6M
5.
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits
Nannan Zhang, Qingjie Ji, Yunfeng Chen, Xiwu Wen, Fangzhen Shan
Cell Death Dis. 2024 Mar; 15(3): 193. Published online 2024 Mar 7. doi: 10.1038/s41419-024-06579-9
PMCID:
PMC10920707
ArticlePDF–12M
6.
TREM2 gene induces differentiation of induced pluripotent stem cells into dopaminergic neurons and promotes neuronal repair via TGF‐β activation in 6‐OHDA‐lesioned mouse model of Parkinson's disease
Hanbai Liang, Ping Liu, Zijing Wang, Huan Xiong, Cheng Yin, Dongdong Zhao, Chunhui Wu, Longyi Chen
CNS Neurosci Ther. 2024 Feb; 30(2): e14630. Published online 2024 Feb 13. doi: 10.1111/cns.14630
PMCID:
PMC10862187
ArticlePDF–13M
7.
Study on pyroptosis-related genes Casp8, Gsdmd and Trem2 in mice with cerebral infarction
Shunli Liang, Linsheng Xu, Xilin Xin, Rongbo Zhang, You Wu
PeerJ. 2024; 12: e16818. Published online 2024 Feb 9. doi: 10.7717/peerj.16818
PMCID:
PMC10860548
ArticlePDF–6.5M
8.
Dynamics of host immune responses and a potential function of Trem2hi interstitial macrophages in Pneumocystis pneumonia
Hu-Qin Yang, Han Sun, Kang Li, Ming-Ming Shao, Kan Zhai, Zhao-Hui Tong
Respir Res. 2024; 25: 72. Published online 2024 Feb 5. doi: 10.1186/s12931-024-02709-1
PMCID:
PMC10845524
ArticlePDF–3.0M
9.
Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages
Rui Sun, Chao Lei, Zhishan Xu, Xuemei Gu, Liu Huang, Liang Chen, Yi Tan, Min Peng, Kavitha Yaddanapudi, Leah Siskind, Maiying Kong, Robert Mitchell, Jun Yan, Zhongbin Deng
Nat Commun. 2024; 15: 966. Published online 2024 Feb 1. doi: 10.1038/s41467-024-45084-7
PMCID:
PMC10834982
ArticlePDF–9.3M
10.
Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development
Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C. Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J. Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteoli
Immunity. 2024 Jan 9; 57(1): 86–105.e9. doi: 10.1016/j.immuni.2023.12.002
PMCID:
PMC10783804
Article
11.
Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models
Melanie Das, Wenjie Mao, Yuliya Voskobiynyk, Deanna Necula, Irene Lew, Cathrine Petersen, Allie Zahn, Gui-Qiu Yu, Xinxing Yu, Nicholas Smith, Faten A. Sayed, Li Gan, Jeanne T. Paz, Lennart Mucke
Neurobiol Dis. Author manuscript; available in PMC 2023 Nov 27.
Published in final edited form as: Neurobiol Dis. 2023 Oct 1; 186: 106263. Published online 2023 Aug 15. doi: 10.1016/j.nbd.2023.106263
PMCID:
PMC10681293
ArticlePDF–1.1M
12.
TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice
Xiaoling Xie, Wuju Zhang, Min Xiao, Tiantian Wei, Yingqi Qiu, Jingyang Qiu, Hao Wang, Zeyou Qiu, Sheng Zhang, Yating Pan, Linlin Mao, Yuhua Li, Bin Guo, Wanwen Yang, Yuxing Hu, Shujie Hu, Yan Gong, Jun Yang, Guozhi Xiao, Yue Zhang, Xiaochun Bai
Blood. 2023 Jun 29; 141(26): 3184–3198. Published online 2023 Apr 5. doi: 10.1182/blood.2022018619
PMCID:
PMC10646818
Article
13.
TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum
Dandan Zhu, Min Huang, Pei Shen, Bei Zhang, Guo Chen, Jinling Chen, Lian Duan, Yinong Duan
J Cell Mol Med. 2023 Aug; 27(15): 2261–2269. Published online 2023 Jul 10. doi: 10.1111/jcmm.17842
PMCID:
PMC10399532
ArticlePDF–20M
14.
TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo
Audrey Lee-Gosselin, Nur Jury-Garfe, Yanwen You, Luke Dabin, Disha Soni, Sayan Dutta, Jean-Christophe Rochet, Jungsu Kim, Adrian L. Oblak, Cristian A. Lasagna-Reeves
Cells. 2023 Jun; 12(12): 1597. Published online 2023 Jun 10. doi: 10.3390/cells12121597
PMCID:
PMC10296847
ArticlePDF–5.0M
15.
Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer’s disease
Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Song
J Biol Chem. 2023 May; 299(5): 104688. Published online 2023 Apr 11. doi: 10.1016/j.jbc.2023.104688
PMCID:
PMC10193014
ArticlePDF–1.5M
16.
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma
Rui Sun, Rowland Han, Colin McCornack, Saad Khan, G. Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M. Schoch, Diane D. Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin Luo, Allegra Petti, Timothy M. Miller, Jason D. Ulrich, David M. Holtzman, Albert H. Kim
Sci Adv. 2023 May; 9(19): eade3559. Published online 2023 May 12. doi: 10.1126/sciadv.ade3559
PMCID:
PMC10181199
ArticlePDF–3.4M
17.
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
Borislav Dejanovic, Tiffany Wu, Ming-Chi Tsai, David Graykowski, Vineela D. Gandham, Christopher M. Rose, Corey E. Bakalarski, Hai Ngu, Yuanyuan Wang, Shristi Pandey, Mitchell G. Rezzonico, Brad A. Friedman, Rose Edmonds, Ann De Mazière, Raphael Rakosi-Schmidt, Tarjinder Singh, Judith Klumperman, Oded Foreman, Michael C. Chang, Luke Xie, Morgan Sheng, Jesse E. Hanson
Nat Aging. 2022; 2(9): 837–850. Published online 2022 Sep 20. doi: 10.1038/s43587-022-00281-1
PMCID:
PMC10154216
ArticlePDF–20M
18.
Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer’s disease
Ravi S. Pandey, Kevin P. Kotredes, Michael Sasner, Gareth R. Howell, Gregory W. Carter
BMC Genomics. 2023; 24: 172. Published online 2023 Apr 4. doi: 10.1186/s12864-023-09280-x
PMCID:
PMC10074678
ArticlePDF–3.0M
19.
TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder
Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qin
J Neuroinflammation. 2023; 20: 89. Published online 2023 Apr 3. doi: 10.1186/s12974-023-02772-3
PMCID:
PMC10069075
ArticlePDF–8.7M
20.
TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment
Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing Li
Cell Death Dis. 2023 Mar; 14(3): 219. Published online 2023 Mar 28. doi: 10.1038/s41419-023-05735-x
PMCID:
PMC10050330
ArticlePDF–5.1M

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