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Select item 109755041.

Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes

Hiroyuki Mori, Sydney K. Peterson, Rachel C. Simmermon, Katherine A. Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina M. Uranga, Jessica N. Maung, Warren T. Yacawych, Kenneth T. Lewis, Rebecca L. Schill, Taryn Hetrick, Ryo Seino, Ken Inoki, Joshua J. Coon, Ormond A. MacDougald

Mol Metab. 2024 May; 83: 101916. Published online 2024 Mar 14. doi: 10.1016/j.molmet.2024.101916

PMCID:: PMC10975504

Article PDF–5.9M

Select item 109402942.

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2

Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya

Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6

PMCID:: PMC10940294

Article PDF–6.0M

Select item 108666623.

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis

Jackelyn R. Raymundo, Hui Zhang, Giovanni Smaldone, Wenjuan Zhu, Kathleen E. Daly, Benjamin J. Glennon, Giovanni Pecoraro, Marco Salvatore, William A. Devine, Cecilia W. Lo, Luigi Vitagliano, Alexander G. Marneros

J Clin Invest. 2024 Feb 15; 134(4): e174138. Published online 2023 Dec 19. doi: 10.1172/JCI174138

PMCID:: PMC10866662

Article PDF–143M

Select item 108665654.

Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites

Susana Cavallero, Mehrdad Roustaei, Sandro Satta, Jae Min Cho, Henry Phan, Kyung In Baek, Ana M. Blázquez-Medela, Sheila Gonzalez-Ramos, Khoa Vu, Seul-Ki Park, Tomohiro Yokota, Jennifer Sumner, Julia J. Mack, Curt D. Sigmund, Srinivasa T. Reddy, Rongsong Li, Tzung K. Hsiai

Sci Adv. 2024 Feb 16; 10(7): eadj7481. Published online 2024 Feb 14. doi: 10.1126/sciadv.adj7481

PMCID:: PMC10866565

Article PDF–3.3M

Select item 108232785.

SCD1 inhibition enhances the effector functions of CD8⁺ T cells via ACAT1‐dependent reduction of esterified cholesterol

Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana, Tomonori Yaguchi, Yutaka Kawakami, Shuichi Hirai

Cancer Sci. 2024 Jan; 115(1): 48–58. Published online 2023 Oct 25. doi: 10.1111/cas.15999

PMCID:: PMC10823278

Article PDF–1.4M

Select item 105916726.

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury

Natalia A. Veniaminova, Yunlong Y. Jia, Adrien M. Hartigan, Thomas J. Huyge, Shih-Ying Tsai, Marina Grachtchouk, Seitaro Nakagawa, Andrzej A. Dlugosz, Scott X. Atwood, Sunny Y. Wong

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Sep 26; 42(9): 113121. Published online 2023 Sep 19. doi: 10.1016/j.celrep.2023.113121

PMCID:: PMC10591672

Article PDF–3.4M

Select item 100060947.

Lrig1-expressing epidermal progenitors require SCD1 to maintain the dermal papilla niche

Sophia Beng Hui Lim, Shang Wei, Andy Hee-Meng Tan, Maurice A. M. van Steensel, Xinhong Lim

Sci Rep. 2023; 13: 4027. Published online 2023 Mar 10. doi: 10.1038/s41598-023-30411-7

Correction in:: Sci Rep. 2023; 13: 5689.

PMCID:: PMC10006094

Article PDF–2.6M

Select item 98960588.

SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes

Yueqing Xue, Liangyu Lin, Qing Li, Keli Liu, Mingyuan Hu, Jiayin Ye, Jianchang Cao, Jingjie Zhai, Fanjun Zheng, Yu Wang, Tao Zhang, Liming Du, Cheng Gao, Guan Wang, Xuefeng Wang, Jun Qin, Xinhua Liao, Xiangyin Kong, Lydia Sorokin, Yufang Shi, Ying Wang

Adv Sci (Weinh) 2023 Feb; 10(4): 2201949. Published online 2022 Dec 11. doi: 10.1002/advs.202201949

PMCID:: PMC9896058

Article PDF–6.1M

Select item 98012199.

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych, Agnieszka Dobrzyn

Mol Metab. 2023 Jan; 67: 101659. Published online 2022 Dec 15. doi: 10.1016/j.molmet.2022.101659

PMCID:: PMC9801219

Article PDF–3.9M

Select item 948236010.

Effects of CRISPR/Cas9-mediated stearoyl-Coenzyme A desaturase 1 knockout on mouse embryo development and lipid synthesis

Huibin Tian, Huimin Niu, Jun Luo, Weiwei Yao, Wenchang Gao, Yang Wen, Min Cheng, Anmin Lei, Jinlian Hua

PeerJ. 2022; 10: e13945. Published online 2022 Sep 14. doi: 10.7717/peerj.13945

PMCID:: PMC9482360

Article PDF–3.7M

Select item 938646411.

The conserved Mediator subunit cyclin C (CCNC) is required for brown adipocyte development and lipid accumulation

Ziyi Song, Alus M. Xiaoli, Youlei Li, Gerile Siqin, Tian Wu, Randy Strich, Jeffrey E. Pessin, Fajun Yang

Mol Metab. 2022 Oct; 64: 101548. Published online 2022 Jul 19. doi: 10.1016/j.molmet.2022.101548

PMCID:: PMC9386464

Article PDF–6.6M

Select item 909121712.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss

Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5

PMCID:: PMC9091217

Article PDF–7.2M

Select item 891782313.

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Ruth Choa, Junichiro Tohyama, Shogo Wada, Hu Meng, Jian Hu, Mariko Okumura, Rebecca M. May, Tanner F. Robertson, Ruth-Anne Langan Pai, Arben Nace, Christian Hopkins, Elizabeth A. Jacobsen, Malay Haldar, Garret A. FitzGerald, Edward M. Behrens, Andy J. Minn, Patrick Seale, George Cotsarelis, Brian Kim, John T. Seykora, Mingyao Li, Zoltan Arany, Taku Kambayashi

Science. Author manuscript; available in PMC 2022 Mar 12.

Published in final edited form as: Science. 2021 Jul 30; 373(6554): eabd2893. doi: 10.1126/science.abd2893

PMCID:: PMC8917823

Article PDF–1.8M

Select item 849887714.

A CD10‐OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1

Shubin Yu, Yiwen Lu, An Su, Jianing Chen, Jiang Li, Boxuan Zhou, Xinwei Liu, Qidong Xia, Yihong Li, Jiaqian Li, Min Huang, Yingying Ye, Qiyi Zhao, Sushi Jiang, Xiaoqing Yan, Xiaojuan Wang, Can Di, Jiayao Pan, Shicheng Su

Adv Sci (Weinh) 2021 Oct; 8(19): 2101848. Published online 2021 Aug 7. doi: 10.1002/advs.202101848

PMCID:: PMC8498877

Article PDF–8.0M

Select item 847208715.

Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation

Joshua Abd Alla, Yahya F. Jamous, Ursula Quitterer

Int J Mol Sci. 2021 Sep; 22(18): 9883. Published online 2021 Sep 13. doi: 10.3390/ijms22189883

PMCID:: PMC8472087

Article PDF–11M

Select item 826247716.

Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy

Quentin Raas, Malu-Clair van de Beek, Sonja Forss-Petter, Inge M.E. Dijkstra, Abigail Deschiffart, Briana C. Freshner, Tamara J. Stevenson, Yorrick R.J. Jaspers, Liselotte Nagtzaam, Ronald J.A. Wanders, Michel van Weeghel, Joo-Yeon Engelen-Lee, Marc Engelen, Florian Eichler, Johannes Berger, Joshua L. Bonkowsky, Stephan Kemp

J Clin Invest. 2021 Apr 15; 131(8): e142500. Published online 2021 Apr 15. doi: 10.1172/JCI142500

PMCID:: PMC8262477

Article PDF–3.4M

Select item 809197417.

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Danyang Wan, Nhien Tran, Oksana Gavrilova, Kai Ge

Genes Dev. 2021 May 1; 35(9-10): 713–728. doi: 10.1101/gad.347583.120

PMCID:: PMC8091974

Article PDF–13M

Select item 783906318.

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou, Xingxing Zhu, Chaofan Li, Yanfeng Li, Zhenqing Ye, Virginia Smith Shapiro, John A. Copland, III, Taro Hitosugi, David A. Bernlohr, Jie Sun, Hu Zeng

Cell Rep. Author manuscript; available in PMC 2021 Jan 27.

Published in final edited form as: Cell Rep. 2021 Jan 5; 34(1): 108601. doi: 10.1016/j.celrep.2020.108601

PMCID:: PMC7839063

Article PDF–2.6M

Select item 779608019.

Interplay between Thyroid Hormones and Stearoyl-CoA Desaturase 1 in the Regulation of Lipid Metabolism in the Heart

Adam Olichwier, Volodymyr V. Balatskyi, Marcin Wolosiewicz, James M. Ntambi, Pawel Dobrzyn

Int J Mol Sci. 2021 Jan; 22(1): 109. Published online 2020 Dec 24. doi: 10.3390/ijms22010109

PMCID:: PMC7796080

Article PDF–6.0M

Select item 773379720.

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

Junmei Yi, Jiajun Zhu, Jiao Wu, Craig B. Thompson, Xuejun Jiang

Proc Natl Acad Sci U S A. 2020 Dec 8; 117(49): 31189–31197. Published online 2020 Nov 23. doi: 10.1073/pnas.2017152117

PMCID:: PMC7733797

Article PDF–1.5M

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