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Select item 105446801.

Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51

Muhammad G. Mousa, Lahari Vuppaladhadiam, Meredith O. Kelly, Terri Pietka, Shelby Ek, Karen C. Shen, Gretchen A. Meyer, Brian N. Finck, Rita T. Brookheart

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Apr 25; 42(4): 112336. Published online 2023 Mar 31. doi: 10.1016/j.celrep.2023.112336

PMCID:: PMC10544680

Abstract Article PDF–1.3M

Select item 99128392.

Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages

Yinglan Cheng, Ichiro Manabe, Sumio Hayakawa, Yusuke Endo, Yumiko Oishi

Front Immunol. 2023; 14: 1009973. Published online 2023 Jan 27. doi: 10.3389/fimmu.2023.1009973

PMCID:: PMC9912839

Abstract Article PDF–8.2M

Select item 96067223.

O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development

Sanjiv Neupane, Steven J. Berardinelli, Daniel C. Cameron, Richard C. Grady, David E. Komatsu, Christopher J. Percival, Megumi Takeuchi, Atsuko Ito, Ta-Wei Liu, Alison V. Nairn, Kelley W. Moremen, Robert S. Haltiwanger, Bernadette C. Holdener

Matrix Biol. Author manuscript; available in PMC 2022 Oct 27.

Published in final edited form as: Matrix Biol. 2022 Mar; 107: 77–96. Published online 2022 Feb 12. doi: 10.1016/j.matbio.2022.02.002

PMCID:: PMC9606722

Abstract Article PDF–6.7M

Select item 83642004.

Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization

Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xi’e Wang, Junyu Xiao, Chih-chen Wang, Lei Wang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2100133118. Published online 2021 Aug 4. doi: 10.1073/pnas.2100133118

PMCID:: PMC8364200

Abstract Article PDF–2.5M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 73280006.

Site-1 protease ablation in the osterix-lineage in mice results in bone marrow neutrophilia and hematopoietic stem cell alterations

Debabrata Patra, Joongho Kim, Qiang Zhang, Eric Tycksen, Linda J. Sandell

Biol Open. 2020 Jun 15; 9(6): bio052993. Published online 2020 Jun 23. doi: 10.1242/bio.052993

PMCID:: PMC7328000

Abstract Article PDF–15M

Select item 64837167.

Site-1 protease–derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability

Fei Wang, Chuanming Xu, Renfei Luo, Kexin Peng, Nirupama Ramkumar, Shiying Xie, Xiaohan Lu, Long Zhao, Chang-Jiang Zuo, Donald E. Kohan, Tianxin Yang

JCI Insight. 2019 Apr 4; 4(7): e124174. Published online 2019 Apr 4. doi: 10.1172/jci.insight.124174

PMCID:: PMC6483716

Abstract Article PDF–4.3M

Select item 58613648.

Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice

Debabrata Patra, Elizabeth DeLassus, Jennifer Mueller, Grazia Abou-Ezzi, Linda J. Sandell

Biol Open. 2018 Feb 15; 7(2): bio032094. Published online 2018 Feb 1. doi: 10.1242/bio.032094

PMCID:: PMC5861364

Abstract Article PDF–28M

Select item 48134609.

Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age

Jeff P. Gorski, Nichole T. Huffman, Julian Vallejo, Leticia Brotto, Sridar V. Chittur, Anne Breggia, Amber Stern, Jian Huang, Chenglin Mo, Nabil G. Seidah, Lynda Bonewald, Marco Brotto

J Biol Chem. 2016 Feb 26; 291(9): 4308–4322. Published online 2015 Dec 30. doi: 10.1074/jbc.M115.686626

PMCID:: PMC4813460

Abstract Article PDF–2.9M

Select item 451400310.

Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control

Sarah Klünder, Jörg Heeren, Sandra Markmann, René Santer, Thomas Braulke, Sandra Pohl

J Lipid Res. 2015 Aug; 56(8): 1625–1632. doi: 10.1194/jlr.M060756

PMCID:: PMC4514003

Abstract Article PDF–908K

Select item 440629811.

MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development

Annita Achilleos, Nichole T. Huffman, Edwidge Marcinkiewicyz, Nabil G. Seidah, Qian Chen, Sarah L. Dallas, Paul A. Trainor, Jeff P. Gorski

Hum Mol Genet. 2015 May 15; 24(10): 2884–2898. Published online 2015 Feb 4. doi: 10.1093/hmg/ddv050

PMCID:: PMC4406298

Abstract Article PDF–1.5M

Select item 414181912.

Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis

Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, Linda J. Sandell

PLoS One. 2014; 9(8): e105674. Published online 2014 Aug 22. doi: 10.1371/journal.pone.0105674

PMCID:: PMC4141819

Abstract Article PDF–21M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 333747814.

Hypopigmentation and Maternal-Zygotic Embryonic Lethality Caused by a Hypomorphic Mbtps1 Mutation in Mice

Sophie Rutschmann, Karine Crozat, Xiaohong Li, Xin Du, Jeffrey C. Hanselman, Alana A. Shigeoka, Katharina Brandl, Daniel L. Popkin, Dianne B. McKay, Yu Xia, Eva Marie Y. Moresco, Bruce Beutler

G3 (Bethesda) 2012 Apr; 2(4): 499–504. Published online 2012 Apr 1. doi: 10.1534/g3.112.002196

PMCID:: PMC3337478

Abstract Article PDF–1.0M

Select item 319072915.

Site-1 Protease Is Essential to Growth Plate Maintenance and Is a Critical Regulator of Chondrocyte Hypertrophic Differentiation in Postnatal Mice

Debabrata Patra, Elizabeth DeLassus, Shinya Hayashi, Linda J. Sandell

J Biol Chem. 2011 Aug 19; 286(33): 29227–29240. Published online 2011 Jun 7. doi: 10.1074/jbc.M110.208686

PMCID:: PMC3190729

Abstract Article PDF–20M

Select item 318949216.

Three-dimensional visualisation of testis cord morphogenesis, a novel tubulogenic mechanism in development

Alexander N. Combes, Emmanuelle Lesieur, Vincent R. Harley, Andrew H. Sinclair, Melissa H. Little, Dagmar Wilhelm, Peter Koopman

Dev Dyn. Author manuscript; available in PMC 2011 Oct 9.

Published in final edited form as: Dev Dyn. 2009 May; 238(5): 1033–1041. doi: 10.1002/dvdy.21925

PMCID:: PMC3189492

Abstract Article PDF–2.5M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311174418.

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

Estelle Rousselet, Jadwiga Marcinkiewicz, Jasna Kriz, Ann Zhou, Mary E. Hatten, Annik Prat, Nabil G. Seidah

J Lipid Res. 2011 Jul; 52(7): 1383–1391. doi: 10.1194/jlr.M014118

PMCID:: PMC3111744

Abstract Article PDF–1.3M

Select item 305814719.

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell specific manner

Daniel L. Popkin, John R. Teijaro, Brian M. Sullivan, Shuzo Urata, Sophie Rutschmann, Juan Carlos de la Torre, Stefan Kunz, Bruce Beutler, Michael Oldstone

Cell Host Microbe. Author manuscript; available in PMC 2012 Mar 17.

Published in final edited form as: Cell Host Microbe. 2011 Mar 17; 9(3): 212–222. doi: 10.1016/j.chom.2011.02.006

PMCID:: PMC3058147

Abstract Article PDF–1.9M

Select item 302347920.

Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization

Jeff P. Gorski, Nichole T. Huffman, Sridar Chittur, Ronald J. Midura, Claudine Black, Julie Oxford, Nabil G. Seidah

J Biol Chem. 2011 Jan 21; 286(3): 1836–1849. Published online 2010 Nov 12. doi: 10.1074/jbc.M110.151647

PMCID:: PMC3023479

Abstract Article PDF–3.4M

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