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Select item 109275161.

Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment

Jingyi Ma, Khatoun Al Moussawi, Hantao Lou, Hok Fung Chan, Yihua Wang, Joseph Chadwick, Chansavath Phetsouphanh, Elizabeth A. Slee, Shan Zhong, Thomas M. Leissing, Andrew Roth, Xiao Qin, Shuo Chen, Jie Yin, Indrika Ratnayaka, Yang Hu, Pakavarin Louphrasitthiphol, Lewis Taylor, Paulo J. G. Bettencourt, Mary Muers, David R. Greaves, Helen McShane, Robert Goldin, Elizabeth J. Soilleux, Mathew L. Coleman, Peter J. Ratcliffe, Xin Lu

Proc Natl Acad Sci U S A. 2024 Mar 5; 121(10): e2309957121. Published online 2024 Feb 29. doi: 10.1073/pnas.2309957121

PMCID:: PMC10927516

Article PDF–4.9M

Select item 108420262.

Essential role of Mg²⁺ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes

Neha Gupta, Cristina Soriano-Úbeda, Paula Stein, Virginia Savy, Brian N. Papas, Goli Ardestani, Ingrid Carvacho, Dominique Alfandari, Carmen J. Williams, Rafael A. Fissore

Cell Rep. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113232. Published online 2023 Oct 11. doi: 10.1016/j.celrep.2023.113232

PMCID:: PMC10842026

Article PDF–3.0M

Select item 92768113.

Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics

Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe

Cell Death Dis. 2022 Jul; 13(7): 600. Published online 2022 Jul 12. doi: 10.1038/s41419-022-05052-9

PMCID:: PMC9276811

Article PDF–1.8M

Select item 89880084.

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju

J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787

PMCID:: PMC8988008

Article PDF–6.1M

Select item 88360185.

The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism

Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monné Rodríguez, Julia Günter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz

Int J Mol Sci. 2022 Feb; 23(3): 1536. Published online 2022 Jan 28. doi: 10.3390/ijms23031536

PMCID:: PMC8836018

Article PDF–3.1M

Select item 86333476.

FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling

Zuo-lin Li, Bin Wang, Lin-li Lv, Tao-tao Tang, Yi Wen, Jing-yuan Cao, Xiao-xiao Zhu, Song-tao Feng, Steven D. Crowley, Bi-cheng Liu

Acta Pharmacol Sin. 2021 Dec; 42(12): 2106–2119. Published online 2021 Mar 3. doi: 10.1038/s41401-021-00617-4

PMCID:: PMC8633347

Article PDF–8.2M

Select item 83338717.

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao

Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931

PMCID:: PMC8333871

Article PDF–1.4M

Select item 78099128.

miR-212 promotes renal interstitial fibrosis by inhibiting hypoxia-inducible factor 1-α inhibitor

Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Yue-Ting Li

Mol Med Rep. 2021 Mar; 23(3): 189. Published online 2021 Jan 6. doi: 10.3892/mmr.2021.11828

PMCID:: PMC7809912

Article PDF–9.2M

Select item 66862699.

MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells

Nuo Yin, Longzhang Zhu, Liang Ding, Junjie Yuan, Li Du, Mingmang Pan, Feng Xue, Haijun Xiao

Cell Mol Biol Lett. 2019; 24: 51. Published online 2019 Aug 8. doi: 10.1186/s11658-019-0177-6

PMCID:: PMC6686269

Article PDF–3.9M

Select item 588798710.

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

Jingwei Sim, Andrew S. Cowburn, Asis Palazon, Basetti Madhu, Petros A. Tyrakis, David Macías, David M. Bargiela, Sandra Pietsch, Michael Gralla, Colin E. Evans, Thaksaon Kittipassorn, Yu C.J. Chey, Cristina M. Branco, Helene Rundqvist, Daniel J. Peet, Randall S. Johnson

Cell Metab. 2018 Apr 3; 27(4): 898–913.e7. doi: 10.1016/j.cmet.2018.02.020

PMCID:: PMC5887987

Article PDF–4.0M

Select item 425849711.

FIH-1 Disrupts an LRRK1/EGFR Complex to Positively Regulate Keratinocyte Migration

Han Peng, Nihal Kaplan, Wending Yang, Spiro Getsios, Robert M. Lavker

Am J Pathol. 2014 Dec; 184(12): 3262–3271. doi: 10.1016/j.ajpath.2014.08.014

PMCID:: PMC4258497

Article PDF–1.6M

Select item 420760412.

A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice

Xiaoquan Zhu, Fengchao Wang, Yanyang Zhao, Peng Yang, Jun Chen, Hanzi Sun, Lei Liu, Wenjun Li, Lin Pan, Yanru Guo, Zhaohui Kou, Yu Zhang, Cheng Zhou, Jiang He, Xue Zhang, Jianxin Li, Weitian Han, Jian Li, Guanghui Liu, Shaorong Gao, Ze Yang

PLoS Genet. 2014 Oct; 10(10): e1004589. Published online 2014 Oct 23. doi: 10.1371/journal.pgen.1004589

PMCID:: PMC4207604

Article PDF–3.6M

Select item 383203413.

Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Carsten C. Scholz, Miguel A. S. Cavadas, Murtaza M. Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G. Fallon, Alex Cheong, Eoin P. Cummins, Cormac T. Taylor

Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46): 18490–18495. Published online 2013 Oct 21. doi: 10.1073/pnas.1309718110

PMCID:: PMC3832034

Article PDF–997K

Select item 363226714.

FIH-1/c-Kit Signaling: A Novel Contributor to Corneal Epithelial Glycogen Metabolism

Han Peng, Julia Katsnelson, Wending Yang, Melissa A. Brown, Robert M. Lavker

Invest Ophthalmol Vis Sci. 2013 Apr; 54(4): 2781–2786. Published online 2013 Apr 17. doi: 10.1167/iovs.12-11512

PMCID:: PMC3632267

Article PDF–517K

Select item 357241015.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 343518816.

microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation

Han Peng, Nihal Kaplan, Robert B. Hamanaka, Julia Katsnelson, Hanz Blatt, Wending Yang, Liangliang Hao, Paul J. Bryar, Randall S. Johnson, Spiro Getsios, Navdeep S. Chandel, Robert M. Lavker

Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35): 14030–14034. Published online 2012 Aug 13. doi: 10.1073/pnas.1111292109

PMCID:: PMC3435188

Article PDF–966K

Select item 330877717.

Factor Inhibiting HIF (FIH) Recognizes Distinct Molecular Features within Hypoxia-inducible Factor-α (HIF-α) versus Ankyrin Repeat Substrates

Sarah E. Wilkins, Sarah Karttunen, Rachel J. Hampton-Smith, Iain Murchland, Anne Chapman-Smith, Daniel J. Peet

J Biol Chem. 2012 Mar 16; 287(12): 8769–8781. Published online 2012 Jan 23. doi: 10.1074/jbc.M111.294678

PMCID:: PMC3308777

Article PDF–3.7M

Select item 319081818.

Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation

Rachelle S. Singleton, David C. Trudgian, Roman Fischer, Benedikt M. Kessler, Peter J. Ratcliffe, Matthew E. Cockman

J Biol Chem. 2011 Sep 30; 286(39): 33784–33794. Published online 2011 Jul 30. doi: 10.1074/jbc.M111.262808

PMCID:: PMC3190818

Article PDF–1.4M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 311015120.

A Systems Approach Reveals that the Myogenesis Genome Network Is Regulated by the Transcriptional Repressor RP58

Shigetoshi Yokoyama, Yoshiaki Ito, Hiroe Ueno-Kudoh, Hirohito Shimizu, Kenta Uchibe, Sonia Albini, Kazuhiko Mitsuoka, Shigeru Miyaki, Minako Kiso, Akane Nagai, Tomohiro Hikata, Tadahiro Osada, Noritsugu Fukuda, Satoshi Yamashita, Daisuke Harada, Valeria Mezzano, Masataka Kasai, Pier Lorenzo Puri, Yoshihide Hayashizaki, Haruo Okado, Megumi Hashimoto, Hiroshi Asahara

Dev Cell. Author manuscript; available in PMC 2011 Jun 7.

Published in final edited form as: Dev Cell. 2009 Dec; 17(6): 836–848. doi: 10.1016/j.devcel.2009.10.011

PMCID:: PMC3110151

Article PDF–2.0M

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