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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 100423682.

IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice

Lara R. Mittereder, Jonathan Swoboda, Roberto De Pascalis, Karen L. Elkins

PLoS One. 2023; 18(3): e0283161. Published online 2023 Mar 27. doi: 10.1371/journal.pone.0283161

PMCID:: PMC10042368

Abstract Article PDF–1.1M

Select item 99690903.

IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression

Umesh Bhattarai, Xiaochen He, Rui Xu, Xiaoguang Liu, Lihong Pan, Yuxiang Sun, Jian-Xiong Chen, Yingjie Chen

Front Immunol. 2023; 14: 1105664. Published online 2023 Feb 13. doi: 10.3389/fimmu.2023.1105664

PMCID:: PMC9969090

Abstract Article PDF–13M

Select item 97547664.

cDC1-derived IL-27 regulates small intestinal CD4⁺ T cell homeostasis in mice

Fatemeh Ahmadi, Fredrik Junghus, Christian Ashworth, Amanda Lappalainen, Urs Mörbe, Knut Kotarsky, William W. Agace

J Exp Med. 2023 Mar 6; 220(3): e20221090. Published online 2022 Dec 14. doi: 10.1084/jem.20221090

PMCID:: PMC9754766

Abstract Article PDF–4.8M

Select item 92712185.

Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

Jianwei Wang, Miho Sekai, Takeshi Matsui, Yosuke Fujii, Mitsuru Matsumoto, Osamu Takeuchi, Nagahiro Minato, Yoko Hamazaki

Int Immunol. 2019 Mar; 31(3): 127–139. Published online 2018 Dec 10. doi: 10.1093/intimm/dxy073

PMCID:: PMC9271218

Abstract Article PDF–3.0M

Select item 90097366.

A tumor-specific pro-IL-12 activates preexisting cytotoxic T cells to control established tumors

Diyuan Xue, Benjamin Moon, Jing Liao, Jingya Guo, Zhuangzhi Zou, Yanfei Han, Shuaishuai Cao, Yang Wang, Yang-Xin Fu, Hua Peng

Sci Immunol. Author manuscript; available in PMC 2022 Jul 7.

Published in final edited form as: Sci Immunol. 2022 Jan 7; 7(67): eabi6899. Published online 2022 Jan 7. doi: 10.1126/sciimmunol.abi6899

PMCID:: PMC9009736

Abstract Article PDF–1.4M

Select item 88646357.

Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation

Seth D Merkley, Samuel M Goodfellow, Yan Guo, Zoe E R Wilton, Janie R Byrum, Kurt C Schwalm, Darrell L Dinwiddie, Rama R Gullapalli, Vojo Deretic, Anthony Jimenez Hernandez, Steven B Bradfute, Julie G In, Eliseo F Castillo

J Crohns Colitis. 2022 Feb; 16(2): 259–274. Published online 2021 Aug 10. doi: 10.1093/ecco-jcc/jjab144

PMCID:: PMC8864635

Abstract Article PDF–3.5M

Select item 87592418.

GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation

Kamaljeet Kaur, Holly Bachus, Crystal Lewis, Amber M. Papillion, Alexander F. Rosenberg, André Ballesteros-Tato, Beatriz León

Cell Rep. Author manuscript; available in PMC 2022 Jan 14.

Published in final edited form as: Cell Rep. 2021 Dec 28; 37(13): 110178. doi: 10.1016/j.celrep.2021.110178

PMCID:: PMC8759241

Abstract Article PDF–2.6M

Select item 85696379.

The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo

Allison N. Gerber, Kaveh Abdi, Nevil J. Singh

Cell Rep. Author manuscript; available in PMC 2021 Nov 5.

Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109816. doi: 10.1016/j.celrep.2021.109816

PMCID:: PMC8569637

Abstract Article PDF–1.6M

Select item 852559210.

IL-35 promotes CD4⁺Foxp3⁺ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms

Ying Shao, William Y. Yang, Fatma Saaoud, Charles Drummer, IV, Yu Sun, Keman Xu, Yifan Lu, Huimin Shan, Ethan M. Shevach, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

JCI Insight. 2021 Oct 8; 6(19): e152511. Published online 2021 Oct 8. doi: 10.1172/jci.insight.152511

PMCID:: PMC8525592

Abstract Article PDF–2.6M

Select item 834793611.

A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis

Chun-Hao Hung, Tung-Liang Lee, Anna Yu-Szu Huang, Kang-Chung Yang, Yu-Chiau Shyu, Shau-Ching Wen, Mu-Jie Lu, Shinsheng Yuan, Che-Kun James Shen

Int J Mol Sci. 2021 Aug; 22(15): 8024. Published online 2021 Jul 27. doi: 10.3390/ijms22158024

PMCID:: PMC8347936

Abstract Article PDF–4.4M

Select item 833129812.

Silencing IL12p35 Promotes Angiotensin II-Mediated Abdominal Aortic Aneurysm through Activating the STAT4 Pathway

Lanlan Wang, Chengyun Hu, Yongfei Dong, Feibiao Dai, Yongxia Xu, Yumeng Dai, Lijie Shao, Defa Zhu

Mediators Inflamm. 2021; 2021: 9450843. Published online 2021 Jul 27. doi: 10.1155/2021/9450843

PMCID:: PMC8331298

Abstract Article PDF–1.8M

Select item 831088713.

Targeted cytokine delivery: cell therapy to remodel the pre-metastatic niche

Michael A. Morgan, Lucas Lange, Axel Schambach

Signal Transduct Target Ther. 2021; 6: 282. Published online 2021 Jul 25. doi: 10.1038/s41392-021-00694-1

PMCID:: PMC8310887

Article PDF–545K

Select item 810255014.

Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers

Hye-Hyun Ahn, Christine Carrington, Yizong Hu, Heng-wen Liu, Christy Ng, Hwanhee Nam, Andrew Park, Catherine Stace, Will West, Hai-Quan Mao, Martin G. Pomper, Christopher G. Ullman, Il Minn

Sci Rep. 2021; 11: 9733. Published online 2021 May 6. doi: 10.1038/s41598-021-89124-4

PMCID:: PMC8102550

Abstract Article PDF–1.3M

Select item 808555215.

Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis

Hui Zhang, Yuxuan Li, Lin Yuan, Lutian Yao, Jie Yang, Liping Xia, Hui Shen, Jing Lu

Front Endocrinol (Lausanne) 2021; 12: 642676. Published online 2021 Apr 16. doi: 10.3389/fendo.2021.642676

PMCID:: PMC8085552

Abstract Article PDF–4.8M

Select item 734757216.

Th1 responses in vivo require cell-specific provision of OX40L dictated by environmental cues

Dominika W. Gajdasik, Fabrina Gaspal, Emily E. Halford, Remi Fiancette, Emma E. Dutton, Claire Willis, Timo Rückert, Chiara Romagnani, Audrey Gerard, Sarah L. Bevington, Andrew S. MacDonald, Marina Botto, Timothy Vyse, David R. Withers

Nat Commun. 2020; 11: 3421. Published online 2020 Jul 9. doi: 10.1038/s41467-020-17293-3

PMCID:: PMC7347572

Abstract Article PDF–2.6M

Select item 733845117.

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state

Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, Giorgio Trinchieri, Alan Sher

Nat Commun. 2020; 11: 3366. Published online 2020 Jul 6. doi: 10.1038/s41467-020-17136-1

Correction in:: Nat Commun. 2020; 11: 4624.

PMCID:: PMC7338451

Abstract Article PDF–3.5M

Select item 727803918.

Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation

Takuma Misawa, Jeffrey A. SoRelle, Jin Huk Choi, Tao Yue, Kuan-wen Wang, William McAlpine, Jianhui Wang, Aijie Liu, Koichi Tabeta, Emre Turer, Bret Evers, Evan Nair-Gill, Subhajit Poddar, Lijing Su, Feiya Ou, Liyang Yu, Jamie Russell, Sara Ludwig, Xiaoming Zhan, Sara Hildebrand, Xiaohong Li, Miao Tang, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler

Sci Immunol. Author manuscript; available in PMC 2020 Jul 24.

Published in final edited form as: Sci Immunol. 2020 Jan 24; 5(43): eaaz0085. doi: 10.1126/sciimmunol.aaz0085

PMCID:: PMC7278039

Abstract Article PDF–1.7M

Select item 716348019.

Endogenous IL‐12 synthesis is not required to prevent hyperexpression of type 2 cytokine and antibody responses

Julia D. Rempel, Ian P. Lewkowich, Kent T. HayGlass

Eur J Immunol. 2000 Feb; 30(2): 347–355. Published online 2000 Aug 28. doi: 10.1002/1521-4141(200002)30:2<347::AID-IMMU347>3.0.CO;2-H

PMCID:: PMC7163480

Abstract PDF–165K

Select item 702582420.

c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

Caroline Tizian, Annette Lahmann, Oliver Hölsken, Catalina Cosovanu, Michael Kofoed-Branzk, Frederik Heinrich, Mir-Farzin Mashreghi, Andrey Kruglov, Andreas Diefenbach, Christian Neumann

eLife. 2020; 9: e52549. Published online 2020 Feb 10. doi: 10.7554/eLife.52549

Correction in:: eLife. 2020; 9: e56774.

PMCID:: PMC7025824

Abstract Article PDF–3.0M

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