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Items: 1 to 20 of 280

1.
IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
Shivam Rai, Yang Zhang, Elodie Grockowiak, Quentin Kimmerlin, Nils Hansen, Cedric B. Stoll, Marc Usart, Damien Luque Paz, Hui Hao-Shen, Yexuan Zhu, Julien Roux, Michael S. Bader, Stefan Dirnhofer, Christopher J. Farady, Timm Schroeder, Simón Méndez-Ferrer, Radek C. Skoda
Blood Adv. 2024 Mar 12; 8(5): 1234–1249. Published online 2024 Jan 13. doi: 10.1182/bloodadvances.2023011338
PMCID:
PMC10912850
AbstractArticlePDF–6.0M
2.
Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms
Kristin Holl, Nicolas Chatain, Susanne Krapp, Julian Baumeister, Tiago Maié, Sarah Schmitz, Anja Scheufen, Nathalie Brock, Steffen Koschmieder, Daniel Moreno-Andrés
Sci Rep. 2024; 14: 2810. Published online 2024 Feb 2. doi: 10.1038/s41598-024-53240-8
PMCID:
PMC10837458
AbstractArticlePDF–3.9M
3.
Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway
Yirou Lei, Jiaying He, Fang Hu, Hao Zhu, Jing Gu, Lijuan Tang, Man Luo
BMC Pulm Med. 2023; 23: 385. Published online 2023 Oct 12. doi: 10.1186/s12890-023-02656-5
PMCID:
PMC10568888
AbstractArticlePDF–3.1M
4.
Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms
Elodie Grockowiak, Claudia Korn, Justyna Rak, Veronika Lysenko, Adrien Hallou, Francesca M. Panvini, Matthew Williams, Claire Fielding, Zijian Fang, Eman Khatib-Massalha, Andrés García-García, Juan Li, Reema A. Khorshed, Sara González-Antón, E. Joanna Baxter, Anjali Kusumbe, Bridget S. Wilkins, Anna Green, Benjamin D. Simons, Claire N. Harrison, Anthony R. Green, Cristina Lo Celso, Alexandre P. A. Theocharides, Simón Méndez-Ferrer
Nat Cancer. 2023; 4(8): 1193–1209. Published online 2023 Aug 7. doi: 10.1038/s43018-023-00607-x
PMCID:
PMC10447237
AbstractArticlePDF–18M
5.
Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis
Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan
Int J Nanomedicine. 2023; 18: 3727–3744. Published online 2023 Jul 7. doi: 10.2147/IJN.S413692
PMCID:
PMC10335290
AbstractArticlePDF–11M
6.
miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
Wei Dong, Jin Chen, Yadong Wang, Junfei Weng, Xingxiang Du, Xu Fang, Wenyu Liu, Tao Long, Jiaxiang You, Wensheng Wang, Xiaoping Peng
Mol Cell Biochem. 2023 May 31 : 1–12. doi: 10.1007/s11010-023-04754-8 [Epub ahead of print]
Correction in:
Mol Cell Biochem. 2023 Jul 11
PMCID:
PMC10230473
AbstractArticlePDF–4.3M
7.
ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms
Zhongxun Shi, Jinqin Liu, Yingying Zhao, Lin Yang, Yanan Cai, Peihong Zhang, Zefeng Xu, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Junying Wu, Xin Yan, Zexing Li, Wenjun Zhang, Yiru Yan, Huijun Huang, Gang Huang, Bing Li, Xudong Wu, Zhijian Xiao
Haematologica. 2023 May 1; 108(5): 1359–1373. Published online 2022 Aug 25. doi: 10.3324/haematol.2021.280320
PMCID:
PMC10153516
AbstractArticlePDF–5.4M
8.
M2型巨噬细胞来源的外泌体lncRNA NR_028113.1通过激活JAK2/STAT3通路促进巨噬细胞的极化
张 梦莹, 李 志, 裴 纬亚, 李 雪琴, 杨 辉, 朱 小龙, 吕 坤
Nan Fang Yi Ke Da Xue Xue Bao. 2023 Mar 20; 43(3): 393–399. Chinese. doi: 10.12122/j.issn.1673-4254.2023.03.08
PMCID:
PMC10122731
AbstractArticlePDF–2.0M
9.
The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells
Anne Marie Staehle, Jan Caspar Peeken, Georg Vladimirov, Mirjam Elisabeth Hoeness, Sarolta Bojtine Kovacs, Nikolaos Karantzelis, Albert Gruender, Christoph Koellerer, Jonas Samuel Jutzi, Heike Luise Pahl, Hans Felix Staehle
Leukemia. 2023; 37(4): 919–923. Published online 2023 Jan 28. doi: 10.1038/s41375-023-01826-y
PMCID:
PMC10079541
AbstractArticlePDF–1.6M
10.
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation
Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Blood. 2022 Jun 23; 139(25): 3630–3646. Published online 2022 Apr 18. doi: 10.1182/blood.2021014465
PMCID:
PMC9728578
AbstractArticle
11.
JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
Rida Al-Rifai, Marie Vandestienne, Jean-Rémi Lavillegrand, Tristan Mirault, Julie Cornebise, Johanne Poisson, Ludivine Laurans, Bruno Esposito, Chloé James, Olivier Mansier, Pierre Hirsch, Fabrizia Favale, Rayan Braik, Camille Knosp, Jose Vilar, Giuseppe Rizzo, Alma Zernecke, Antoine-Emmanuel Saliba, Alain Tedgui, Maxime Lacroix, Lionel Arrive, Ziad Mallat, Soraya Taleb, Marc Diedisheim, Clément Cochain, Pierre-Emmanuel Rautou, Hafid Ait-Oufella
Nat Commun. 2022; 13: 6592. Published online 2022 Nov 3. doi: 10.1038/s41467-022-34469-1
Correction in:
Nat Commun. 2022; 13: 7921.
PMCID:
PMC9633755
AbstractArticlePDF–3.8M
12.
Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms
Amanda Fernandes de Oliveira Costa, Leticia Olops Marani, Thiago Mantello Bianco, Adriana Queiroz Arantes, Izabela Aparecida Lopes, Diego Antonio Pereira-Martins, Leonardo Carvalho Palma, Priscila Santos Scheucher, Josiane Lilian dos Santos Schiavinato, Larissa Sarri Binelli, Cleide Araújo Silva, Susumu S. Kobayashi, João Agostinho Machado-Neto, Eduardo Magalhães Rego, Robert Samuel Welner, Lorena Lobo de Figueiredo-Pontes
Front Immunol. 2022; 13: 768592. Published online 2022 Sep 23. doi: 10.3389/fimmu.2022.768592
PMCID:
PMC9539129
AbstractArticlePDF–2.6M
13.
Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm
Mohammed Ferdous-Ur Rahman, Yue Yang, Bao T. Le, Avik Dutta, Julia Posyniak, Patrick Faughnan, Mohammad A. Sayem, Nadine S. Aguilera, Golam Mohi
Nat Commun. 2022; 13: 5347. Published online 2022 Sep 13. doi: 10.1038/s41467-022-32928-3
PMCID:
PMC9470702
AbstractArticlePDF–3.9M
14.
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm
Shivam Rai, Elodie Grockowiak, Nils Hansen, Damien Luque Paz, Cedric B. Stoll, Hui Hao-Shen, Gabriele Mild-Schneider, Stefan Dirnhofer, Christopher J. Farady, Simón Méndez-Ferrer, Radek C. Skoda
Nat Commun. 2022; 13: 5346. Published online 2022 Sep 13. doi: 10.1038/s41467-022-32927-4
PMCID:
PMC9470591
AbstractArticlePDF–2.6M
15.
Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes
Won Kyung Kim, Adam W. Olson, Jiaqi Mi, Jinhui Wang, Dong-Hoon Lee, Vien Le, Alex Hiroto, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Robert Cardiff, Sungyong You, Zijie Sun
Nat Commun. 2022; 13: 4364. Published online 2022 Jul 28. doi: 10.1038/s41467-022-32119-0
PMCID:
PMC9334353
AbstractArticlePDF–13M
16.
Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations
Rebecca J. Austin, Jasmin Straube, Claudia Bruedigam, Gabor Pali, Sebastien Jacquelin, Therese Vu, Joanne Green, Julius Gräsel, Lianne Lansink, Leanne Cooper, Shin-Jye Lee, Nien-Tsu Chen, Chung-Wei Lee, Ashraful Haque, Florian H. Heidel, Richard D’Andrea, Geoff R. Hill, Ann Mullally, Michael D. Milsom, Megan Bywater, Steven W. Lane
Leukemia. Author manuscript; available in PMC 2022 Jun 23.
Published in final edited form as: Leukemia. 2020 Apr; 34(4): 1075–1089. Published online 2019 Nov 15. doi: 10.1038/s41375-019-0638-y
PMCID:
PMC9221569
AbstractArticlePDF–2.4M
17.
TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche
Juo-Chin Yao, Karolyn A. Oetjen, Tianjiao Wang, Haoliang Xu, Grazia Abou-Ezzi, Joseph R. Krambs, Salil Uttarwar, Eric J. Duncavage, Daniel C. Link
J Clin Invest. 2022 Jun 1; 132(11): e154092. Published online 2022 Jun 1. doi: 10.1172/JCI154092
PMCID:
PMC9151699
AbstractArticlePDF–3.1M
18.
EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice
Zili Lei, Wanwan Liu, Ya Nie, Yanhong Yang, Guibin Chen, Li Huang, Huijuan Wu, Yuting Lei, Lei Chen, Qing Hu, Hedong Rong, Siping Yu, Qi Song, Fengxue Tong, Jiao Guo
Front Immunol. 2022; 13: 843378. Published online 2022 Apr 13. doi: 10.3389/fimmu.2022.843378
PMCID:
PMC9043958
AbstractArticlePDF–8.1M
19.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
20.
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation
Sabine Jurado, Anna S Fedl, Markus Jaritz, Daniela Kostanova‐Poliakova, Stephen G Malin, Charles G Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger
EMBO J. 2022 Apr; 41(7): e108397. Published online 2022 Feb 14. doi: 10.15252/embj.2021108397
PMCID:
PMC8982625
AbstractArticlePDF–2.4M

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