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Select item 88732141.

RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair

Yanxuan Xiao, Jingyi Li, Xiaoyu Liao, Yumin He, Tao He, Cuiping Yang, Lu Jiang, So Mi Jeon, Jong-Ho Lee, Yongbin Chen, Rui Liu, Qianming Chen

Bone Res. 2022; 10: 19. Published online 2022 Feb 24. doi: 10.1038/s41413-022-00194-0

PMCID:: PMC8873214

Abstract Article PDF–2.4M

Select item 88644742.

Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development

Shuyi Chen, Huijie Wu, Zhengyang Wang, Mengping Jia, Jieyu Guo, Jiayu Jin, Xiaobo Li, Dan Meng, Ling Lin, Aiwu Ruth He, Ping Zhou, Xiuling Zhi

Cell Mol Gastroenterol Hepatol. 2022; 13(3): 949–973.e7. Published online 2021 Nov 2. doi: 10.1016/j.jcmgh.2021.10.012

PMCID:: PMC8864474

Abstract Article PDF–11M

Select item 85267743.

SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response

Thomas L. Jetton, Patricio Flores-Bringas, John L. Leahy, Dhananjay Gupta

J Biol Chem. 2021 Nov; 297(5): 101250. Published online 2021 Sep 28. doi: 10.1016/j.jbc.2021.101250

PMCID:: PMC8526774

Abstract Article PDF–3.3M

Select item 85106804.

SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF-1α

Maoquan Li, Jinqiu Ning, Jiwei Wang, Qiqian Yan, Ke Zhao, Xiaoshi Jia

Int J Mol Med. 2021 Dec; 48(6): 210. Published online 2021 Oct 6. doi: 10.3892/ijmm.2021.5043

PMCID:: PMC8510680

Abstract Article PDF–2.8M

Select item 83338715.

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao

Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931

PMCID:: PMC8333871

Abstract Article PDF–1.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 60313347.

Inhibition of methyltransferase Setd7 allows the in vitro expansion of myogenic stem cells with improved therapeutic potential

Robert N Judson, Marco Quarta, Menno J Oudhoff, Hesham Soliman, Lin Yi, Chih Kai Chang, Gloria Lou, Ryan Vander Werff, Alissa Cait, Mark Hamer, Justin Blonigan, Patrick Paine, Linda T N Doan, Elena Groppa, WenJun He, Le Su, Regan H Zhang, Peter Xu, Christine Eisner, Marcela Low, Ingrid Barta, Coral-Ann B Lewis, Colby Zaph, Mohammad M Karimi, Thomas A Rando, Fabio M Rossi

Cell Stem Cell. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Cell Stem Cell. 2018 Feb 1; 22(2): 177–190.e7. Published online 2018 Jan 25. doi: 10.1016/j.stem.2017.12.010

PMCID:: PMC6031334

Abstract Article PDF–3.6M

Select item 59337858.

Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis

Ryo Tamura, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Kazuya Maeda, Toshinori Ueno, Takao Masaki

PLoS One. 2018; 13(5): e0196844. Published online 2018 May 3. doi: 10.1371/journal.pone.0196844

PMCID:: PMC5933785

Abstract Article PDF–9.5M

Select item 58158539.

Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

Xuehui Hong, He Huang, Xingfeng Qiu, Zhijie Ding, Xing Feng, Yuekun Zhu, Huiqin Zhuo, Jingjing Hou, Jiabao Zhao, Wangyu Cai, Ruihua Sha, Xinya Hong, Yongxiang Li, Hongjiang Song, Zhiyong Zhang

eLife. 2018; 7: e29511. Published online 2018 Jan 31. doi: 10.7554/eLife.29511

PMCID:: PMC5815853

Abstract Article PDF–6.9M

Select item 510056110.

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells

Natasha K. Tuano, Jun Okabe, Mark Ziemann, Mark E. Cooper, Assam El-Osta

Nucleic Acids Res. 2016 Nov 2; 44(19): 9206–9217. Published online 2016 Jul 20. doi: 10.1093/nar/gkw621

PMCID:: PMC5100561

Abstract Article PDF–2.9M

Select item 501267711.

Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection

Menno J. Oudhoff, Frann Antignano, Alistair L. Chenery, Kyle Burrows, Stephen A. Redpath, Mitchell J. Braam, Georgia Perona-Wright, Colby Zaph

PLoS Pathog. 2016 Sep; 12(9): e1005876. Published online 2016 Sep 6. doi: 10.1371/journal.ppat.1005876

PMCID:: PMC5012677

Abstract Article PDF–3.9M

Select item 492089312.

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

Maximilianos Elkouris, Haroula Kontaki, Athanasios Stavropoulos, Anastasia Antonoglou, Kostas C. Nikolaou, Martina Samiotaki, Eszter Szantai, Dimitra Saviolaki, Peter J. Brown, Paschalis Sideras, George Panayotou, Iannis Talianidis

Cell Rep. 2016 Jun 21; 15(12): 2733–2744. Published online 2016 Jun 9. doi: 10.1016/j.celrep.2016.05.051

PMCID:: PMC4920893

Abstract Article

Select item 450541413.

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell

Kyoko Fujimaki, Takeshi Ogihara, David L. Morris, Hisanobu Oda, Hitoshi Iida, Yoshio Fujitani, Raghavendra G. Mirmira, Carmella Evans-Molina, Hirotaka Watada

J Biol Chem. 2015 Jul 3; 290(27): 16607–16618. Published online 2015 May 20. doi: 10.1074/jbc.M115.661777

PMCID:: PMC4505414

Abstract Article PDF–2.6M

Select item 439227914.

Transcriptional Activity of the Islet β Cell Factor Pdx1 Is Augmented by Lysine Methylation Catalyzed by the Methyltransferase Set7/9

Aarthi V. Maganti, Bernhard Maier, Sarah A. Tersey, Megan L. Sampley, Amber L. Mosley, Sabire Özcan, Boobalan Pachaiyappan, Patrick M. Woster, Chad S. Hunter, Roland Stein, Raghavendra G. Mirmira

J Biol Chem. 2015 Apr 10; 290(15): 9812–9822. Published online 2015 Feb 24. doi: 10.1074/jbc.M114.616219

PMCID:: PMC4392279

Abstract Article PDF–2.6M

Select item 431955915.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 415676216.

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

Dalia Barsyte-Lovejoy, Fengling Li, Menno J. Oudhoff, John H. Tatlock, Aiping Dong, Hong Zeng, Hong Wu, Spencer A. Freeman, Matthieu Schapira, Guillermo A. Senisterra, Ekaterina Kuznetsova, Richard Marcellus, Abdellah Allali-Hassani, Steven Kennedy, Jean-Philippe Lambert, Amber L. Couzens, Ahmed Aman, Anne-Claude Gingras, Rima Al-Awar, Paul V. Fish, Brian S. Gerstenberger, Lee Roberts, Caroline L. Benn, Rachel L. Grimley, Mitchell J. S. Braam, Fabio M. V. Rossi, Marius Sudol, Peter J. Brown, Mark E. Bunnage, Dafydd R. Owen, Colby Zaph, Masoud Vedadi, Cheryl H. Arrowsmith

Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35): 12853–12858. Published online 2014 Aug 18. doi: 10.1073/pnas.1407358111

PMCID:: PMC4156762

Abstract Article PDF–1.1M

Select item 410367317.

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication

Ping Kong, Silvia E. Racedo, Stephania Macchiarulo, Zunju Hu, Courtney Carpenter, Tingwei Guo, Tao Wang, Deyou Zheng, Bernice E. Morrow

Hum Mol Genet. 2014 Aug 15; 23(16): 4215–4231. Published online 2014 Apr 4. doi: 10.1093/hmg/ddu140

PMCID:: PMC4103673

Abstract Article PDF–2.4M

Select item 361932018.

Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Donglai Wang, Jingyi Zhou, Xiangyu Liu, Danyu Lu, Changchun Shen, Yipeng Du, Fu-Zheng Wei, Boyan Song, Xiaopeng Lu, Yu Yu, Lina Wang, Ying Zhao, Haiying Wang, Yang Yang, Yoshimitsu Akiyama, Hongquan Zhang, Wei-Guo Zhu

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5516–5521. Published online 2013 Mar 18. doi: 10.1073/pnas.1216596110

PMCID:: PMC3619320

Abstract Article PDF–916K

Select item 361757419.

Expression and Function of Set7/9 in Pancreatic Islets

Takeshi Ogihara, Nathan L. Vanderford, Bernhard Maier, Roland W. Stein, Raghavendra G. Mirmira

Islets. Author manuscript; available in PMC 2013 Apr 5.

Published in final edited form as: Islets. 2009 Nov; 1(3): 269–272. doi: 10.4161/isl.1.3.9779

PMCID:: PMC3617574

Abstract Article PDF–711K

Select item 330538320.

Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates Wnt5a

Li Chen, Filomena Gabriella Fulcoli, Rosa Ferrentino, Stefania Martucciello, Elizabeth A. Illingworth, Antonio Baldini

PLoS Genet. 2012 Mar; 8(3): e1002571. Published online 2012 Mar 15. doi: 10.1371/journal.pgen.1002571

PMCID:: PMC3305383

Abstract Article PDF–6.5M

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