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Select item 108832801.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck

Mol Syst Biol. 2024 Feb; 20(2): 75–97. Published online 2024 Jan 15. doi: 10.1038/s44320-023-00005-6

PMCID:: PMC10883280

Article PDF–3.4M

Select item 107002182.

BCLAF1-induced HIF-1α accumulation under normoxia enhances PD-L1 treatment resistances via BCLAF1-CUL3 complex

Bowen Yao, Ye Lu, Yazhao Li, Yixue Bai, Xinyu Wei, Yuanyuan Yang, Demao Yao

Cancer Immunol Immunother. 2023 Dec; 72(12): 4279–4292. Published online 2023 Oct 31. doi: 10.1007/s00262-023-03563-8

PMCID:: PMC10700218

Article PDF–7.4M

Select item 105646223.

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Roslin J. Adamson, N Connor Payne, Sergio G. Bartual, Ralph Mazitschek, Alex N. Bullock

Free Radic Biol Med. 2023 Aug 1; 204: 215–225. doi: 10.1016/j.freeradbiomed.2023.04.021

PMCID:: PMC10564622

Article PDF–5.7M

Select item 104139334.

Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination

Gaurav Kumar, Shi Fang, Daria Golosova, Ko-Ting Lu, Daniel T Brozoski, Ibrahim Vazirabad, Curt D Sigmund

Function (Oxf) 2023; 4(5): zqad034. Published online 2023 Jul 3. doi: 10.1093/function/zqad034

PMCID:: PMC10413933

Article PDF–1.4M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Article PDF–23M

Select item 101894956.

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Yu-Han H. Hsu, Greta Pintacuda, Ruize Liu, Eugeniu Nacu, April Kim, Kalliopi Tsafou, Natalie Petrossian, William Crotty, Jung Min Suh, Jackson Riseman, Jacqueline M. Martin, Julia C. Biagini, Daya Mena, Joshua K.T. Ching, Edyta Malolepsza, Taibo Li, Tarjinder Singh, Tian Ge, Shawn B. Egri, Benjamin Tanenbaum, Caroline R. Stanclift, Annie M. Apffel, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Steven A. Carr, Monica Schenone, Jake Jaffe, Nadine Fornelos, Hailiang Huang, Kevin C. Eggan, Kasper Lage

iScience. 2023 May 19; 26(5): 106701. Published online 2023 Apr 18. doi: 10.1016/j.isci.2023.106701

PMCID:: PMC10189495

Article PDF–5.3M

Select item 101488477.

Prenatal phthalate exposure and cord blood DNA methylation

Jooah Lee, Jeeyoung Kim, Sabrina Shafi Zinia, Jaehyun Park, Sungho Won, Woo Jin Kim

Sci Rep. 2023; 13: 7046. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33002-8

PMCID:: PMC10148847

Article PDF–1.1M

Select item 100926438.

BAG6 supports stress fiber formation by preventing the ubiquitin-mediated degradation of RhoA

Maho Miyauchi, Reina Matsumura, Hiroyuki Kawahara

Mol Biol Cell. 2023 Apr 1; 34(4): ar34. Published online 2023 Mar 17. doi: 10.1091/mbc.E22-08-0355

PMCID:: PMC10092643

Article PDF–23M

Select item 100198929.

BPOZ-2 is a negative regulator of the NLPR3 inflammasome contributing to SARS-CoV-2-induced hyperinflammation

Jingfei Li, Haotian Lin, Tinghui Fan, Linfei Huang, Xinyong Zhang, Yanhong Tai, Yi Fang, Qihong Li, Ruzhou Zhao, Penghao Wang, Li Zhou, Luming Wan, Yuhua Wu, Hui Zhong, Congwen Wei, Xiaopan Yang

Front Cell Infect Microbiol. 2023; 13: 1134511. Published online 2023 Mar 2. doi: 10.3389/fcimb.2023.1134511

PMCID:: PMC10019892

Article PDF–9.6M

Select item 1001172310.

KLHL12 can form large COPII structures in the absence of CUL3 neddylation

Tamara Moretti, Kyungho Kim, Astha Tuladhar, Jinoh Kim

Mol Biol Cell. 2023 Mar 1; 34(3): br4. Published online 2023 Feb 21. doi: 10.1091/mbc.E22-08-0383

PMCID:: PMC10011723

Article PDF–1.2M

Select item 995044711.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Article PDF–8.4M

Select item 982755112.

XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7

Bao‐qin Liu, Rong‐bei Liu, Wen‐ping Li, Xin‐tao Mao, Yi‐ning Li, Tao Huang, Hao‐li Wang, Hao‐tian Chen, Jiang‐yan Zhong, Bing Yang, Ren‐jie Chai, Qian Cao, Jin Jin, Yi‐yuan Li

EMBO Rep. 2023 Jan; 24(1): e55387. Published online 2022 Nov 17. doi: 10.15252/embr.202255387

PMCID:: PMC9827551

Article PDF–3.3M

Select item 972816413.

Cullin 3/KCTD5 Promotes the Ubiqutination of Rho Guanine Nucleotide Dissociation Inhibitor 1 and Regulates Its Stability

Hee Jun Cho, Ki-Jun Ryu, Kyoung Eun Baek, Jeewon Lim, Taeyoung Kim, Chae Yeong Song, Jiyun Yoo, Hee Gu Lee

J Microbiol Biotechnol. 2020 Oct 28; 30(10): 1488–1494. Published online 2020 Aug 28. doi: 10.4014/jmb.2007.07033

PMCID:: PMC9728164

Article PDF–1.4M

Select item 967184414.

The differentially expressed gene signatures of the Cullin 3-RING ubiquitin ligases in neuroendocrine cancer

Jong-Uk Park, Dong-Kyu Kim, Ji-Ye Kim, Jae-Hyun Jo, Yeong-Mu Kim, Dong-Hyun Jung, Hye-Ji Kim, Seon-Mi Ok, Hyo Je Cho, Sangjune Kim, Christophe E. Redon, Mirit I. Aladjem, Sang-Min Jang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Dec 25.

Published in final edited form as: Biochem Biophys Res Commun. 2022 Dec 25; 636(Pt 2): 71–78. Published online 2022 Nov 8. doi: 10.1016/j.bbrc.2022.10.108

PMCID:: PMC9671844

Article PDF–1.6M

Select item 953517215.

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein

Min Dong, Min Qian, Zhengyi Ruan

J Immunother Cancer. 2022; 10(10): e005270. Published online 2022 Oct 5. doi: 10.1136/jitc-2022-005270

Correction in:: J Immunother Cancer. 2023; 11(12): e005270corr1.

PMCID:: PMC9535172

Article PDF–10M

Select item 952570316.

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Zhuoyao Chen, Rafael M. Ioris, Stacey Richardson, Ava N. Van Ess, Iolanda Vendrell, Benedikt M. Kessler, Francesca M. Buffa, Luca Busino, Steven C. Clifford, Alex N. Bullock, Vincenzo D’Angiolella

Cell Death Differ. 2022 Oct; 29(10): 1955–1969. Published online 2022 Apr 4. doi: 10.1038/s41418-022-00983-4

PMCID:: PMC9525703

Article PDF–4.4M

Select item 947546217.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Article PDF–4.6M

Select item 936000018.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, Tatsuya Sawasaki, Fuminori Tokunaga

Cell Death Dis. 2022 Aug; 13(8): 694. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05145-5

PMCID:: PMC9360000

Article PDF–6.1M

Select item 934879719.

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses

Yalan Wang, Xiaotong Cao, Pei Liu, Weijia Zeng, Rui Peng, Qing Shi, Kai Feng, Pingzhao Zhang, Huiru Sun, Chenji Wang, Hongyan Wang

Sci Adv. 2022 Aug; 8(31): eabm5578. Published online 2022 Aug 3. doi: 10.1126/sciadv.abm5578

PMCID:: PMC9348797

Article PDF–6.7M

Select item 934596020.

ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression

Yizeng Fan, Tao Hou, Weichao Dan, Yasheng Zhu, Bo Liu, Yi Wei, Zixi Wang, Yang Gao, Jin Zeng, Lei Li

Cell Death Differ. 2022 Aug; 29(8): 1611–1624. Published online 2022 Feb 22. doi: 10.1038/s41418-022-00951-y

PMCID:: PMC9345960

Article PDF–5.6M

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