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Select item 108284431.

The P2Y₂ receptor mediates terminal adipocyte differentiation and insulin resistance: Evidence for a dual G-protein coupling mode

Shenqi Qian, Yi Shi, Jared Senfeld, Qianman Peng, Jianzhong Shen

J Biol Chem. 2024 Feb; 300(2): 105589. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105589

PMCID:: PMC10828443

Article PDF–3.6M

Select item 107945482.

P2Y₂-P2X7 receptors cross-talk in primed mesenteric endothelial cells upregulates NF-κB signaling favoring mononuclear cell adhesion in schistosomiasis

Nathália Ferreira Oliveira, Matheus Macedo L. V. Monteiro, Nathália Santos Mainieri, Augusto Shuiti Tamura, Letícia Massimo Pereira, Leticia Diniz Crepaldi, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio, Claudia Lucia Martins Silva

Front Immunol. 2023; 14: 1328897. Published online 2024 Jan 4. doi: 10.3389/fimmu.2023.1328897

PMCID:: PMC10794548

Article PDF–6.1M

Select item 107654953.

Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome

Zahra Kargarpour, Sanja Cicko, Thomas C. Köhler, Andreas Zech, Slagjana Stoshikj, Christina Bal, Andreas Renner, Marco Idzko, Ahmed El-Gazzar

Front Immunol. 2023; 14: 1310098. Published online 2023 Dec 20. doi: 10.3389/fimmu.2023.1310098

PMCID:: PMC10765495

Article PDF–4.5M

Select item 105430844.

Cell-type-specific role of P2Y2 receptor in HDM-driven model of allergic airway inflammation

Dominik Schneble, Ahmed El-Gazzar, Zahra Kargarpour, Markus Kramer, Seda Metekol, Slagjana Stoshikj, Marco Idzko

Front Immunol. 2023; 14: 1209097. Published online 2023 Sep 14. doi: 10.3389/fimmu.2023.1209097

PMCID:: PMC10543084

Article PDF–7.0M

Select item 104944565.

Sex-specific effect of P2Y₂ purinergic receptor on glucose metabolism during acute inflammation

Randi J. Ulbricht, Christian A. Rivas, Hailee Marino, Erin Snyder, Dana James, Jamila Makhloufi, Nathan Johnson, Scott Zimmerman, Jianjie Wang

Front Endocrinol (Lausanne) 2023; 14: 1248139. Published online 2023 Aug 28. doi: 10.3389/fendo.2023.1248139

PMCID:: PMC10494456

Article PDF–1.4M

Select item 104438116.

P2Y₂ receptor decreases blood pressure by inhibiting ENaC

Antonio G. Soares, Jorge Contreras, Elena Mironova, Crystal R. Archer, James D. Stockand, Tarek Mohamed Abd El-Aziz

JCI Insight. 2023 Jul 24; 8(14): e167704. Published online 2023 Jul 24. doi: 10.1172/jci.insight.167704

PMCID:: PMC10443811

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Select item 102913297.

A purinergic mechanism underlying metformin regulation of hyperglycemia

Jared Senfeld, Qianman Peng, Yi Shi, Shenqi Qian, Jianzhong Shen

iScience. 2023 Jun 16; 26(6): 106898. Published online 2023 May 19. doi: 10.1016/j.isci.2023.106898

PMCID:: PMC10291329

Article PDF–4.7M

Select item 86783138.

Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells

Gang Xue, Ningbo Zheng, Jing Fang, Guangxu Jin, Xiaoyin Li, Gianpietro Dotti, Qing Yi, Yong Lu

Cancer Cell. Author manuscript; available in PMC 2022 Dec 13.

Published in final edited form as: Cancer Cell. 2021 Dec 13; 39(12): 1610–1622.e9. Published online 2021 Oct 21. doi: 10.1016/j.ccell.2021.09.011

PMCID:: PMC8678313

Article PDF–2.1M

Select item 84485279.

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare

eLife. 2021; 10: e67777. Published online 2021 Sep 7. doi: 10.7554/eLife.67777

PMCID:: PMC8448527

Article PDF–5.5M

Select item 835959510.

P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC

Mengjie Chen, Haibing Chen, Yonggui Gu, Peng Sun, Jianxiong Sun, Haojun Yu, Hongliang Zheng, Donghui Chen

BMC Musculoskelet Disord. 2021; 22: 680. Published online 2021 Aug 11. doi: 10.1186/s12891-021-04569-y

PMCID:: PMC8359595

Article PDF–7.8M

Select item 819719711.

P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice

Theodomir Dusabimana, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park

Int J Mol Sci. 2021 Jun; 22(11): 5528. Published online 2021 May 24. doi: 10.3390/ijms22115528

PMCID:: PMC8197197

Article PDF–3.3M

Select item 786474812.

Purinergic Signaling Mediates PTH and Fluid Flow-Induced Osteoblast Proliferation

Yanghui Xing, Liang Song, Yingying Zhang, Tengyu Zhang, Jian Li, Chunjing Tao

Biomed Res Int. 2021; 2021: 6674570. Published online 2021 Jan 27. doi: 10.1155/2021/6674570

PMCID:: PMC7864748

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Select item 756818513.

P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response

Theodomir Dusabimana, So Ra Kim, Eun Jung Park, Jihyun Je, Kyuho Jeong, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park

Mol Metab. 2020 Dec; 42: 101089. Published online 2020 Sep 25. doi: 10.1016/j.molmet.2020.101089

PMCID:: PMC7568185

Article PDF–4.1M

Select item 752192214.

Vascular control of the CO₂/H⁺-dependent drive to breathe

Colin M Cleary, Thiago S Moreira, Ana C Takakura, Mark T Nelson, Thomas A Longden, Daniel K Mulkey

eLife. 2020; 9: e59499. Published online 2020 Sep 14. doi: 10.7554/eLife.59499

PMCID:: PMC7521922

Article PDF–1.1M

Select item 737018815.

Signaling Through Purinergic Receptor P2Y₂ Enhances Macrophage IL-1β Production

Gonzalo de la Rosa, Ana I. Gómez, María C. Baños, Pablo Pelegrín

Int J Mol Sci. 2020 Jul; 21(13): 4686. Published online 2020 Jun 30. doi: 10.3390/ijms21134686

PMCID:: PMC7370188

Article PDF–2.5M

Select item 728387416.

P2Y₂ Receptor Promotes High-Fat Diet-Induced Obesity

Yue Zhang, Carolyn M. Ecelbarger, Lisa A. Lesniewski, Christa E. Müller, Bellamkonda K. Kishore

Front Endocrinol (Lausanne) 2020; 11: 341. Published online 2020 Jun 3. doi: 10.3389/fendo.2020.00341

PMCID:: PMC7283874

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Select item 698340017.

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten A. Wagner, Markus Schwaninger

Proc Natl Acad Sci U S A. 2020 Jan 21; 117(3): 1753–1761. Published online 2020 Jan 2. doi: 10.1073/pnas.1907467117

PMCID:: PMC6983400

Article PDF–3.6M

Select item 664405318.

P2Y₂R deletion ameliorates sialadenitis in IL-14α-transgenic mice

LT Woods, JM Camden, MG Khalafalla, MJ Petris, L Erb, JL Ambrus, Jr, GA Weisman

Oral Dis. Author manuscript; available in PMC 2019 Jul 22.

Published in final edited form as: Oral Dis. 2018 Jul; 24(5): 761–771. Published online 2018 Mar 13. doi: 10.1111/odi.12823

PMCID:: PMC6644053

Article PDF–1.4M

Select item 630435419.

Genetic Deletion of P2Y₂ Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation

Yue Zhang, Anne Riquier-Brison, Tao Liu, Yufeng Huang, Noel G. Carlson, János Peti-Peterdi, Bellamkonda K. Kishore

Front Physiol. 2018; 9: 1765. Published online 2018 Dec 17. doi: 10.3389/fphys.2018.01765

PMCID:: PMC6304354

Article PDF–3.7M

Select item 584215020.

Myeloid P2Y2 receptor promotes acute inflammation but is dispensable for chronic high-fat diet-induced metabolic dysfunction

Samantha E. Adamson, Garren Montgomery, Scott A. Seaman, Shayn M. Peirce-Cottler, Norbert Leitinger

Purinergic Signal. 2018 Mar; 14(1): 19–26. Published online 2017 Oct 30. doi: 10.1007/s11302-017-9589-9

PMCID:: PMC5842150

Article PDF–1.1M

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