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Select item 109594201.

Childhood cancer mutagenesis caused by transposase-derived PGBD5

Makiko Yamada, Ross R. Keller, Rodrigo Lopez Gutierrez, Daniel Cameron, Hiromichi Suzuki, Reeti Sanghrajka, Jake Vaynshteyn, Jeffrey Gerwin, Francesco Maura, William Hooper, Minita Shah, Nicolas Robine, Phillip Demarest, N. Sumru Bayin, Luz Jubierre Zapater, Casie Reed, Steven Hébert, Ignas Masilionis, Ronan Chaligne, Nicholas D. Socci, Michael D. Taylor, Claudia L. Kleinman, Alexandra L. Joyner, G. Praveen Raju, Alex Kentsis

Sci Adv. 2024 Mar 22; 10(12): eadn4649. Published online 2024 Mar 22. doi: 10.1126/sciadv.adn4649

PMCID:: PMC10959420

Article PDF–4.7M

Select item 108500992.

SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma

Ludovica Lospinoso Severini, Elena Loricchio, Shirin Navacci, Irene Basili, Romina Alfonsi, Flavia Bernardi, Marta Moretti, Marilisa Conenna, Antonino Cucinotta, Sonia Coni, Marialaura Petroni, Enrico De Smaele, Giuseppe Giannini, Marella Maroder, Gianluca Canettieri, Angela Mastronuzzi, Daniele Guardavaccaro, Olivier Ayrault, Paola Infante, Francesca Bufalieri, Lucia Di Marcotullio

Cell Death Differ. 2024 Feb; 31(2): 170–187. Published online 2023 Dec 7. doi: 10.1038/s41418-023-01246-6

PMCID:: PMC10850099

Article PDF–7.7M

Select item 107351893.

Autonomous and non-cell autonomous role of cilia in structural birth defects in mice

Richard J. B. Francis, Jovenal T. San Agustin, Heather L. Szabo Rogers, Cheng Cui, Julie A. Jonassen, Thibaut Eguether, John A. Follit, Cecilia W. Lo, Gregory J. Pazour

PLoS Biol. 2023 Dec; 21(12): e3002425. Published online 2023 Dec 11. doi: 10.1371/journal.pbio.3002425

PMCID:: PMC10735189

Article PDF–9.1M

Select item 106948644.

Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development

Sung-Eun Kim, Pooja J. Chothani, Rehana Shaik, Westley Pollard, Richard H. Finnell

Dis Model Mech. 2023 Nov 1; 16(11): dmm050277. Published online 2023 Nov 28. doi: 10.1242/dmm.050277

PMCID:: PMC10694864

Article

Select item 106564275.

GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter

Jennifer Kurz, Anna-Carina Weiss, Timo H.-W. Lüdtke, Lena Deuper, Mark-Oliver Trowe, Hauke Thiesler, Herbert Hildebrandt, Joerg Heineke, Stephen A. Duncan, Andreas Kispert

Development. 2022 Aug 1; 149(15): dev200522. Published online 2022 Jul 29. doi: 10.1242/dev.200522

PMCID:: PMC10656427

Article

Select item 105891226.

Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid

Marija Dubaic, Lucie Peskova, Marek Hampl, Kamila Weissova, Canan Celiker, Natalia A Shylo, Eva Hruba, Michaela Kavkova, Tomas Zikmund, Scott D Weatherbee, Jozef Kaiser, Tomas Barta, Marcela Buchtova

Life Sci Alliance. 2023 Dec; 6(12): e202302073. Published online 2023 Oct 20. doi: 10.26508/lsa.202302073

PMCID:: PMC10589122

Article PDF–5.2M

Select item 104505917.

Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality

Mai T. Dang, Michael V. Gonzalez, Krutika S. Gaonkar, Komal S. Rathi, Patricia Young, Sherjeel Arif, Li Zhai, Zahidul Alam, Samir Devalaraja, Tsun Ki Jerrick To, Ian W. Folkert, Pichai Raman, Jo Lynne Rokita, Daniel Martinez, Jaclyn N. Taroni, Joshua A. Shapiro, Casey S. Greene, Candace Savonen, Fernanda Mafra, Hakon Hakonarson, Tom Curran, Malay Haldar

Cell Rep. Author manuscript; available in PMC 2023 Aug 25.

Published in final edited form as: Cell Rep. 2021 Mar 30; 34(13): 108917. doi: 10.1016/j.celrep.2021.108917

Correction in:: Cell Rep. 2023 Jun 27; 42(6): 112600.

PMCID:: PMC10450591

Article PDF–3.2M

Select item 104068648.

ISL1 regulates lung branching morphogenesis via Shh signaling pathway

Ruiqi Huang, Chujing Zhang, Yuting Zheng, Wei Zhang, Huarong Huang, Mengsheng Qiu, Jianying Li, Feixue Li

J Biol Chem. 2023 Aug; 299(8): 105034. Published online 2023 Jul 11. doi: 10.1016/j.jbc.2023.105034

PMCID:: PMC10406864

Article PDF–3.6M

Select item 103871109.

Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development

Jiyoung Lee, Yeonjoo Kim, Paris Ataliotis, Hyung-Goo Kim, Dae-Won Kim, Dorothy C. Bennett, Nigel A. Brown, Lawrence C. Layman, Soo-Hyun Kim

Sci Rep. 2023; 13: 12309. Published online 2023 Jul 29. doi: 10.1038/s41598-023-38017-9

PMCID:: PMC10387110

Article PDF–11M

Select item 1029068610.

Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration

Alessandra M. Norris, Ambili Bai Appu, Connor D. Johnson, Lylybell Y. Zhou, David W. McKellar, Marie-Ange Renault, David Hammers, Benjamin D. Cosgrove, Daniel Kopinke

Nat Commun. 2023; 14: 3766. Published online 2023 Jun 24. doi: 10.1038/s41467-023-39506-1

PMCID:: PMC10290686

Article PDF–5.5M

Select item 1026673611.

Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression

Caiqi Cheng, Qian Cong, Yuchen Liu, Yizhong Hu, Guoyan Liang, Kevin Marc Manquiquis Dioneda, Yingzi Yang

Sci Adv. 2023 Jun; 9(24): eadf6927. Published online 2023 Jun 14. doi: 10.1126/sciadv.adf6927

PMCID:: PMC10266736

Article PDF–2.4M

Select item 1024421712.

Ranbp1 modulates morphogenesis of the craniofacial midline in mouse models of 22q11.2 deletion syndrome

Elizabeth M Paronett, Corey A Bryan, Megan E Maynard, Julia A Goroff, Daniel W Meechan, Anthony-Samuel LaMantia, Thomas M Maynard

Hum Mol Genet. 2023 Jun 15; 32(12): 1959–1974. Published online 2023 Feb 15. doi: 10.1093/hmg/ddad030

PMCID:: PMC10244217

Article PDF–2.6M

Select item 1020371013.

Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos

Lu Yan, Hailing Yin, Yiwei Mi, Yu Wu, Yufang Zheng

Front Cell Dev Biol. 2023; 11: 1084245. Published online 2023 May 9. doi: 10.3389/fcell.2023.1084245

PMCID:: PMC10203710

Article PDF–4.6M

Select item 1007300914.

Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse

Sarah Escuin, Saba Rose Raza-Knight, Dawn Savery, Carles Gaston-Massuet, Gabriel L. Galea, Nicholas D. E. Greene, Andrew J. Copp

Dis Model Mech. 2023 Mar 1; 16(3): dmm049858. Published online 2023 Mar 14. doi: 10.1242/dmm.049858

PMCID:: PMC10073009

Article

Select item 1001765715.

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli

Cell Mol Life Sci. 2023; 80(4): 89. Published online 2023 Mar 15. doi: 10.1007/s00018-023-04735-6

PMCID:: PMC10017657

Article PDF–5.2M

Select item 991059416.

Hypomorphic and dominant-negative impact of truncated SOX9 dysregulates Hedgehog–Wnt signaling, causing campomelia

Tiffany Y. K. Au, Raymond K. H. Yip, Sarah L. Wynn, Tiong Y. Tan, Alex Fu, Yu Hong Geng, Irene Y. Y. Szeto, Ben Niu, Kevin Y. Yip, Martin C. H. Cheung, Robin Lovell-Badge, Kathryn S. E. Cheah

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2208623119. Published online 2022 Dec 30. doi: 10.1073/pnas.2208623119

PMCID:: PMC9910594

Article PDF–4.0M

Select item 991045817.

Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals

Hei Yeun Koo, Min-A Kim, Hyehyun Min, Jae Yeon Hwang, Meenakshi Prajapati-DiNubila, Kwan Soo Kim, Martin M. Matzuk, Juw Won Park, Angelika Doetzlhofer, Un-Kyung Kim, Jinwoong Bok

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2213099120. Published online 2022 Dec 28. doi: 10.1073/pnas.2213099120

PMCID:: PMC9910458

Article PDF–11M

Select item 971853218.

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

Xiaodong Li, Patrick J Gordon, John A Gaynes, Alexandra W Fuller, Randy Ringuette, Clayton P Santiago, Valerie Wallace, Seth Blackshaw, Pulin Li, Edward M Levine

eLife. 2022; 11: e78342. Published online 2022 Dec 2. doi: 10.7554/eLife.78342

PMCID:: PMC9718532

Article PDF–14M

Select item 971852619.

Hedgehog regulation of epithelial cell state and morphogenesis in the larynx

Janani Ramachandran, Weiqiang Zhou, Anna E Bardenhagen, Talia Nasr, Ellen R Yates, Aaron M Zorn, Hongkai Ji, Steven A Vokes

eLife. 2022; 11: e77055. Published online 2022 Nov 18. doi: 10.7554/eLife.77055

PMCID:: PMC9718526

Article PDF–14M

Select item 970969320.

Sonic Hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice

Jianjian Zhu, Rashmi Patel, Anna Trofka, Brian D. Harfe, Susan Mackem

Dev Cell. Author manuscript; available in PMC 2023 Sep 12.

Published in final edited form as: Dev Cell. 2022 Sep 12; 57(17): 2048–2062.e4. Published online 2022 Aug 16. doi: 10.1016/j.devcel.2022.07.016

PMCID:: PMC9709693

Article PDF–2.6M

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