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Select item 99382161.

Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub

Marc P. Forrest, Marc Dos Santos, Nicolas H. Piguel, Yi-Zhi Wang, Nicole A. Hawkins, Vikram A. Bagchi, Leonardo E. Dionisio, Sehyoun Yoon, Dina Simkin, Maria Dolores Martin-de-Saavedra, Ruoqi Gao, Katherine E. Horan, Alfred L. George, Jr., Mark S. LeDoux, Jennifer A. Kearney, Jeffrey N. Savas, Peter Penzes

Nat Commun. 2023; 14: 825. Published online 2023 Feb 17. doi: 10.1038/s41467-023-36087-x

PMCID:: PMC9938216

Article PDF–5.3M

Select item 97007812.

mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity

Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang

Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y

PMCID:: PMC9700781

Article PDF–11M

Select item 91161523.

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero

Cell Metab. 2022 May 3; 34(5): 731–746.e9. doi: 10.1016/j.cmet.2022.03.013

PMCID:: PMC9116152

Article

Select item 79387704.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 79331165.

The Pyruvate-Lactate Axis Modulates Cardiac Hypertrophy and Heart Failure

Ahmad A. Cluntun, Rachit Badolia, Sandra Lettlova, K. Mark Parnell, Thirupura S. Shankar, Nikolaos A. Diakos, Kristofor A. Olson, Iosif Taleb, Sean M. Tatum, Jordan A. Berg, Corey N. Cunningham, Tyler Van Ry, Alex J. Bott, Aspasia Thodou Krokidi, Sarah Fogarty, Sophia Skedros, Wojciech I. Swiatek, Xuejing Yu, Bai Luo, Shannon Merx, Sutip Navankasattusas, James E. Cox, Gregory S. Ducker, William L. Holland, Stephen H. McKellar, Jared Rutter, Stavros G. Drakos

Cell Metab. Author manuscript; available in PMC 2022 Mar 2.

Published in final edited form as: Cell Metab. 2021 Mar 2; 33(3): 629–648.e10. Published online 2020 Dec 16. doi: 10.1016/j.cmet.2020.12.003

PMCID:: PMC7933116

Article PDF–3.1M

Select item 76108766.

Metabolic Reprogramming of Terminally Exhausted CD8⁺ T cells by IL-10 Enhances Anti-Tumor Immunity

Yugang Guo, Yu-Qing Xie, Min Gao, Yang Zhao, Fabien Franco, Mathias Wenes, Imran Siddiqui, Alessio Bevilacqua, Haiping Wang, Hanshuo Yang, Bing Feng, Xin Xie, Catherine M. Sabatel, Benjamin Tschumi, Amphun Chaiboonchoe, Yuxi Wang, Weimin Li, Weihua Xiao, Werner Held, Pedro Romero, Ping-Chih Ho, Li Tang

Nat Immunol. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Nat Immunol. 2021 Jun 1; 22(6): 746–756. Published online 2021 May 24. doi: 10.1038/s41590-021-00940-2

PMCID:: PMC7610876

Article PDF–5.7M

Select item 76104047.

Mitochondrial pyruvate carrier abundance mediates pathological cardiac hypertrophy

Mariana Fernandez-Caggiano, Alisa Kamynina, Asvi A. Francois, Oleksandra Prysyazhna, Thomas R. Eykyn, Susanne Krasemann, Maria G. Crespo-Leiro, Maria Garcia Vieites, Katiuscia Bianchi, Valle Morales, Nieves Domenech, Philip Eaton

Nat Metab. Author manuscript; available in PMC 2021 Mar 23.

Published in final edited form as: Nat Metab. 2020 Nov 1; 2(11): 1223–1231. Published online 2020 Oct 26. doi: 10.1038/s42255-020-00276-5

PMCID:: PMC7610404

Article PDF–3.5M

Select item 73256018.

T cell-expressed microRNA-155 reduces lifespan in a mouse model of age-related chronic inflammation

H. Atakan Ekiz, Andrew G. Ramstead, Soh-Hyun Lee, Morgan C. Nelson, Kaylyn M. Bauer, Jared A. Wallace, Ruozhen Hu, June L. Round, Jared Rutter, Micah J. Drummond, Dinesh S. Rao, Ryan M. O’Connell

J Immunol. Author manuscript; available in PMC 2021 Apr 15.

Published in final edited form as: J Immunol. 2020 Apr 15; 204(8): 2064–2075. Published online 2020 Mar 11. doi: 10.4049/jimmunol.1901484

PMCID:: PMC7325601

Article PDF–2.3M

Select item 72950339.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Article PDF–2.7M

Select item 722702810.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Article PDF–5.4M

Select item 717021711.

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development

Andrew G. Ramstead, Jared A. Wallace, Soh-Hyun Lee, Kaylyn M. Bauer, William W. Tang, H. Atakan Ekiz, Thomas E. Lane, Ahmad A. Cluntun, Matthew L. Bettini, June L. Round, Jared Rutter, Ryan M. O’Connell

Cell Rep. Author manuscript; available in PMC 2020 Apr 20.

Published in final edited form as: Cell Rep. 2020 Mar 3; 30(9): 2889–2899.e6. doi: 10.1016/j.celrep.2020.02.042

PMCID:: PMC7170217

Article PDF–2.1M

Select item 700487812.

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Claire L. Bensard, Dona R. Wisidagama, Kristofor A. Olson, Jordan A. Berg, Nathan M. Krah, John C. Schell, Sara M. Nowinski, Sarah Fogarty, Alex J. Bott, Peng Wei, Katja K. Dove, Jason M. Tanner, Vanja Panic, Ahmad Cluntun, Sandra Lettlova, Christian S. Earl, David F. Namnath, Karina Vázquez-Arregun, Claudio J. Villanueva, Dean Tantin, L. Charles Murtaugh, Kimberley J. Evason, Gregory S. Ducker, Carl S. Thummel, Jared Rutter

Cell Metab. Author manuscript; available in PMC 2021 Feb 4.

Published in final edited form as: Cell Metab. 2020 Feb 4; 31(2): 284–300.e7. Published online 2019 Dec 5. doi: 10.1016/j.cmet.2019.11.002

PMCID:: PMC7004878

Article PDF–3.7M

Select item 674633413.

Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis

Sean C. Tompkins, Ryan D. Sheldon, Adam J. Rauckhorst, Maria F. Noterman, Shane R. Solst, Jane L. Buchanan, Kranti A. Mapuskar, Alvin D. Pewa, Lawrence R. Gray, Lalita Oonthonpan, Arpit Sharma, Diego A. Scerbo, Adam J. Dupuy, Douglas R. Spitz, Eric B. Taylor

Cell Rep. Author manuscript; available in PMC 2019 Sep 16.

Published in final edited form as: Cell Rep. 2019 Sep 3; 28(10): 2608–2619.e6. doi: 10.1016/j.celrep.2019.07.098

PMCID:: PMC6746334

Article PDF–2.3M

Select item 639759314.

Loss of MPC1 reprograms retinal metabolism to impair visual function

Allison Grenell, Yekai Wang, Michelle Yam, Aditi Swarup, Tanya L. Dilan, Allison Hauer, Jonathan D. Linton, Nancy J. Philp, Elizabeth Gregor, Siyan Zhu, Quan Shi, Joseph Murphy, Tongju Guan, Daniel Lohner, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Andrew F. X. Goldberg, James B. Hurley, Jianhai Du

Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3530–3535. Published online 2019 Feb 11. doi: 10.1073/pnas.1812941116

PMCID:: PMC6397593

Article PDF–1.4M

Select item 634941815.

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Katharina Timper, Lars Paeger, Carmen Sánchez-Lasheras, Luis Varela, Alexander Jais, Hendrik Nolte, Merly C. Vogt, A. Christine Hausen, Christian Heilinger, Nadine Evers, J. Andrew Pospisilik, Josef M. Penninger, Eric B. Taylor, Tamas L. Horvath, Peter Kloppenburg, Jens Claus Brüning

Cell Rep. Author manuscript; available in PMC 2019 Jan 28.

Published in final edited form as: Cell Rep. 2018 Oct 9; 25(2): 383–397.e10. doi: 10.1016/j.celrep.2018.09.034

PMCID:: PMC6349418

Article PDF–3.3M

Select item 631414416.

Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II–driven respiration

Brian D. Fink, Fan Bai, Liping Yu, Ryan D. Sheldon, Arpit Sharma, Eric B. Taylor, William I. Sivitz

J Biol Chem. 2018 Dec 21; 293(51): 19932–19941. Published online 2018 Nov 1. doi: 10.1074/jbc.RA118.005144

PMCID:: PMC6314144

Article PDF–1.6M

Select item 613733417.

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

John C. Schell, Dona R. Wisidagama, Claire Bensard, Helong Zhao, Peng Wei, Jason Tanner, Aimee Flores, Jeffrey Mohlman, Lise K. Sorensen, Christian S. Earl, Kristofor A. Olson, Ren Miao, T. Cameron Waller, Don Delker, Priyanka Kanth, Lei Jiang, Ralph J. DeBerardinis, Mary P. Bronner, Dean Y. Li, James E. Cox, Heather R. Christofk, William E. Lowry, Carl S. Thummel, Jared Rutter

Nat Cell Biol. Author manuscript; available in PMC 2018 Sep 14.

Published in final edited form as: Nat Cell Biol. 2017 Sep; 19(9): 1027–1036. Published online 2017 Aug 14. doi: 10.1038/ncb3593

PMCID:: PMC6137334

Article PDF–4.7M

Select item 568128118.

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

Adam J. Rauckhorst, Lawrence R. Gray, Ryan D. Sheldon, Xiaorong Fu, Alvin D. Pewa, Charlotte R. Feddersen, Adam J. Dupuy, Katherine N. Gibson-Corley, James E. Cox, Shawn C. Burgess, Eric B. Taylor

Mol Metab. 2017 Nov; 6(11): 1468–1479. Published online 2017 Sep 18. doi: 10.1016/j.molmet.2017.09.002

PMCID:: PMC5681281

Article PDF–4.0M

Select item 554227319.

Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells

Xiaoli Li, Gaoyang Han, Xiaoran Li, Quancheng Kan, Zhirui Fan, Yaqing Li, Yasai Ji, Jing Zhao, Mingzhi Zhang, Mantas Grigalavicius, Viktor Berge, Mariusz Adam Goscinski, Jahn M. Nesland, Zhenhe Suo

Oncotarget. 2017 Jul 11; 8(28): 46363–46380. Published online 2017 May 25. doi: 10.18632/oncotarget.18199

PMCID:: PMC5542273

Article PDF–13M

Select item 534676520.

Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses

Xiaoli Li, Yaqing Li, Gaoyang Han, Xiaoran Li, Yasai Ji, Zhirui Fan, Yali Zhong, Jing Cao, Jing Zhao, Goscinski Mariusz, Mingzhi Zhang, Jianguo Wen, Jahn M. Nesland, Zhenhe Suo

Oncotarget. 2016 Nov 29; 7(48): 79981–79994. Published online 2016 Nov 8. doi: 10.18632/oncotarget.13210

PMCID:: PMC5346765

Article PDF–8.5M

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