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Select item 107900971.

Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex

Lutgarde Serneels, Leen Bammens, An Zwijsen, Alexandra Tolia, Lucía Chávez-Gutiérrez, Bart De Strooper

J Biol Chem. 2024 Jan; 300(1): 105533. Published online 2023 Dec 10. doi: 10.1016/j.jbc.2023.105533

PMCID:: PMC10790097

Article PDF–2.9M

Select item 93974722.

Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system

Marcel Klein, Abuzar Kaleem, Sandra Oetjen, Daniela Wünkhaus, Lars Binkle, Sandra Schilling, Milena Gjorgjieva, Ralf Scholz, Doris Gruber-Schoffnegger, Stephan Storch, Stefan Kins, Gerard Drewes, Sabine Hoffmeister-Ullerich, Dietmar Kuhl, Guido Hermey

Autophagy. 2022; 18(9): 2068–2085. Published online 2021 Dec 29. doi: 10.1080/15548627.2021.2016232

PMCID:: PMC9397472

Article PDF–4.5M

Select item 88849113.

JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency

Jui M. Dave, Raja Chakraborty, Aglaia Ntokou, Junichi Saito, Fatima Z. Saddouk, Zhonghui Feng, Ashish Misra, George Tellides, Robert K. Riemer, Zsolt Urban, Caroline Kinnear, James Ellis, Seema Mital, Robert Mecham, Kathleen A. Martin, Daniel M. Greif

J Clin Invest. 2022 Mar 1; 132(5): e142338. Published online 2022 Mar 1. doi: 10.1172/JCI142338

PMCID:: PMC8884911

Article PDF–3.3M

Select item 84828624.

Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1

He Wang, Mengjia Liu, Zhuoyang Ye, Cuihua Zhou, Huiru Bi, Long Wang, Chen Zhang, Hui Fu, Ying Shen, Jian-Jun Yang, Yimin Hu, Guiquan Chen

J Neurosci. 2021 Sep 29; 41(39): 8163–8180. doi: 10.1523/JNEUROSCI.2432-20.2021

PMCID:: PMC8482862

Article PDF–10M

Select item 83024505.

Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum

Rosanne Wouters, Christine Michiels, Ragna Sannerud, Bertrand Kleizen, Katleen Dillen, Wendy Vermeire, Abril Escamilla Ayala, David Demedts, Randy Schekman, Wim Annaert

J Cell Biol. 2021 Sep 6; 220(9): e201911104. Published online 2021 Jul 22. doi: 10.1083/jcb.201911104

PMCID:: PMC8302450

Article PDF–7.0M

Select item 81976336.

Pen-2 Negatively Regulates the Differentiation of Oligodendrocyte Precursor Cells into Astrocytes in the Central Nervous System

Jinxing Hou, Huiru Bi, Zhuoyang Ye, Wenhui Huang, Gang Zou, Xiaochuan Zou, Yun Stone Shi, Ying Shen, Quanhong Ma, Frank Kirchhoff, Yimin Hu, Guiquan Chen

J Neurosci. 2021 Jun 9; 41(23): 4976–4990. doi: 10.1523/JNEUROSCI.2455-19.2021

PMCID:: PMC8197633

Article PDF–8.0M

Select item 78162087.

Neuron‐specific deletion of presenilin enhancer2 causes progressive astrogliosis and age‐related neurodegeneration in the cortex independent of the Notch signaling

Hui‐Ru Bi, Cui‐Hua Zhou, Yi‐Zhi Zhang, Xu‐Dong Cai, Mu‐Huo Ji, Jian‐Jun Yang, Gui‐Quan Chen, Yi‐Min Hu

CNS Neurosci Ther. 2021 Feb; 27(2): 174–185. Published online 2020 Sep 22. doi: 10.1111/cns.13454

PMCID:: PMC7816208

Article PDF–3.9M

Select item 73404978.

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

Abril Angélica Escamilla-Ayala, Ragna Sannerud, Magali Mondin, Karin Poersch, Wendy Vermeire, Laura Paparelli, Caroline Berlage, Marcelle Koenig, Lucia Chavez-Gutierrez, Maximilian H Ulbrich, Sebastian Munck, Hideaki Mizuno, Wim Annaert

eLife. 2020; 9: e56679. Published online 2020 Jul 7. doi: 10.7554/eLife.56679

PMCID:: PMC7340497

Article PDF–3.7M

Select item 64337629.

Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors

Shanshan Cheng, Tingting Liu, Yimin Hu, Yingqian Xia, Jinxing Hou, Chaoli Huang, Xiaochuan Zou, Juan Liang, Yun Stone Shi, Yuanlin Zheng, Jun Lu, Guiquan Chen

J Neurosci. 2019 Mar 20; 39(12): 2195–2207. doi: 10.1523/JNEUROSCI.2523-18.2019

PMCID:: PMC6433762

Article PDF–9.1M

Select item 564499210.

Pen-2 and presenilin are sufficient to catalyze Notch processing

Chen Hu, Junjie Xu, Linlin Zeng, Ting Li, Mei-Zhen Cui, Xuemin Xu

J Alzheimers Dis. Author manuscript; available in PMC 2017 Oct 17.

Published in final edited form as: J Alzheimers Dis. 2017; 56(4): 1263–1269. doi: 10.3233/JAD-161094

PMCID:: PMC5644992

Article PDF–475K

Select item 435881211.

Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease

Dan Xia, Hirotaka Watanabe, Bei Wu, Sang Hun Lee, Yan Li, Evgeny Tsvetkov, Vadim Y. Bolshakov, Jie Shen, Raymond J. Kelleher, III

Neuron. Author manuscript; available in PMC 2016 Mar 4.

Published in final edited form as: Neuron. 2015 Mar 4; 85(5): 967–981. doi: 10.1016/j.neuron.2015.02.010

PMCID:: PMC4358812

Article PDF–2.5M

Select item 431955912.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Article PDF–3.0M

Select item 421618813.

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis

Oliver Holmes, Swetha Paturi, Dennis J. Selkoe, Michael S. Wolfe

Biochemistry. 2014 Jul 15; 53(27): 4393–4406. Published online 2014 Jun 18. doi: 10.1021/bi500489j

PMCID:: PMC4216188

Article PDF–7.5M

Select item 357241014.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Article PDF–1.1M

Select item 350948515.

Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment

Guozhang Mao, Mei-Zhen Cui, Tong Li, Yipeng Jin, Xuemin Xu

J Neurochem. Author manuscript; available in PMC 2013 Dec 1.

Published in final edited form as: J Neurochem. 2012 Dec; 123(5): 837–844. Published online 2012 Oct 11. doi: 10.1111/jnc.12016

PMCID:: PMC3509485

Article PDF–1.2M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Article PDF–1.0M

Select item 315769417.

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

Gael Barthet, Junichi Shioi, Zhiping Shao, Yimin Ren, Anastasios Georgakopoulos, Nikolaos K. Robakis

FASEB J. 2011 Sep; 25(9): 2937–2946. doi: 10.1096/fj.11-183806

PMCID:: PMC3157694

Article

Select item 285394218.

γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin

Guojun Zhao, Zhenyi Liu, Ma. Xenia G. Ilagan, Raphael Kopan

J Neurosci. 2010 Feb 3; 30(5): 1648–1656. doi: 10.1523/JNEUROSCI.3826-09.2010

PMCID:: PMC2853942

Article PDF–2.6M

Select item 120153319.

Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

Yun-wu Zhang, Wen-jie Luo, Hong Wang, Ping Lin, Kulandaivelu S. Vetrivel, Fang Liao, Feng Li, Philip C. Wong, Marilyn G. Farquhar, Gopal Thinakaran, Huaxi Xu

J Biol Chem. Author manuscript; available in PMC 2005 Sep 13.

Published in final edited form as: J Biol Chem. 2005 Apr 29; 280(17): 17020–17026. Published online 2005 Feb 11. doi: 10.1074/jbc.M409467200

PMCID:: PMC1201533

Article PDF–276K

Select item 52892820.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Article PDF–140K

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