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Select item 105559501.

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis

Yaping An, Zihan Zhai, Xin Wang, Yiyun Ding, Linlin He, Lingfeng Li, Qi Mo, Chenlu Mu, Runxiang Xie, Tianyu Liu, Weilong Zhong, Bangmao Wang, Hailong Cao

J Adv Res. 2023 Oct; 52: 219–232. Published online 2023 Aug 15. doi: 10.1016/j.jare.2023.08.008

PMCID:: PMC10555950

Abstract Article PDF–6.3M

Select item 102374472.

Pan-cancer analysis of the intervertebral-disc-degeneration-related innate immunity gene NAIP

Wen-Bin Xu, Vit Kotheeranurak, Ding-Qiang Chen, Nai-Kun Sun, Di-Xin Cai, Chien-Min Chen, Guang-Xun Lin, Gang Rui

PLoS One. 2023; 18(6): e0286647. Published online 2023 Jun 2. doi: 10.1371/journal.pone.0286647

PMCID:: PMC10237447

Abstract Article PDF–4.6M

Select item 93021793.

Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells

Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin

Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21

PMCID:: PMC9302179

Abstract Article PDF–2.0M

Select item 80722244.

Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

Pilar Samperio Ventayol, Petra Geiser, Maria Letizia Di Martino, Alexandra Florbrant, Stefan A. Fattinger, Naemi Walder, Eduardo Sima, Feng Shao, Nelson O. Gekara, Magnus Sundbom, Wolf-Dietrich Hardt, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

Proc Natl Acad Sci U S A. 2021 Apr 20; 118(16): e2013963118. Published online 2021 Apr 12. doi: 10.1073/pnas.2013963118

PMCID:: PMC8072224

Abstract Article PDF–4.7M

Select item 72202275.

The analysis of the association between the copy numbers of survival motor neuron gene 2 and neuronal apoptosis inhibitory protein genes and the clinical phenotypes in 40 patients with spinal muscular atrophy: Observational study

Yinhong Zhang, Jing He, Yunqian Zhang, Li Li, Xinhua Tang, Lei Wang, Jingjing Guo, Chanchan Jin, Sean Tighe, Yuan Zhang, Yingting Zhu, Baosheng Zhu

Medicine (Baltimore) 2020 Jan; 99(3): e18809. Published online 2020 Jan 17. doi: 10.1097/MD.0000000000018809

PMCID:: PMC7220227

Abstract Article PDF–211K

Select item 67582456.

The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7

Johannes K. X. Maier, Zahia Lahoua, Nathalie H. Gendron, Raouf Fetni, Anne Johnston, Jamshid Davoodi, Dita Rasper, Sophie Roy, Ruth S. Slack, Donald W. Nicholson, Alex E. MacKenzie

J Neurosci. 2002 Mar 15; 22(6): 2035–2043. doi: 10.1523/JNEUROSCI.22-06-02035.2002

PMCID:: PMC6758245

Abstract Article PDF–541K

Select item 58432217.

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization

Virginia Morón-Calvente, Salvador Romero-Pinedo, Sofía Toribio-Castelló, Julio Plaza-Díaz, Ana C. Abadía-Molina, Domingo I. Rojas-Barros, Shawn T. Beug, Eric C. LaCasse, Alex MacKenzie, Robert Korneluk, Francisco Abadía-Molina

PLoS One. 2018; 13(3): e0193643. Published online 2018 Mar 8. doi: 10.1371/journal.pone.0193643

PMCID:: PMC5843221

Abstract Article PDF–8.4M

Select item 57587778.

Neuronal apoptosis inhibitory protein is implicated in amyotrophic lateral sclerosis symptoms

Osamu Kano, Kazunori Tanaka, Takuya Kanno, Yasuo Iwasaki, Joh-E Ikeda

Sci Rep. 2018; 8: 6. Published online 2018 Jan 8. doi: 10.1038/s41598-017-18627-w

PMCID:: PMC5758777

Abstract Article PDF–1.2M

Select item 54952259.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

Select item 521639610.

Neuronal apoptosis inhibitory protein (NAIP) localizes to the cytokinetic machinery during cell division

Francisco Abadía-Molina, Virginia Morón-Calvente, Stephen D. Baird, Fahad Shamim, Francisco Martín, Alex MacKenzie

Sci Rep. 2017; 7: 39981. Published online 2017 Jan 6. doi: 10.1038/srep39981

PMCID:: PMC5216396

Abstract Article PDF–1.7M

Select item 453942511.

Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele

Letteria Minutoli, Salvatore Arena, Pietro Antonuccio, Carmelo Romeo, Alessandra Bitto, Carlo Magno, Mariagrazia Rinaldi, Antonio Micali, Natasha Irrera, Gabriele Pizzino, Federica Galfo, Francesco Squadrito, Domenica Altavilla, Herbert Marini

Biomed Res Int. 2015; 2015: 248976. Published online 2015 Aug 4. doi: 10.1155/2015/248976

PMCID:: PMC4539425

Abstract Article PDF–3.4M

Select item 451903512.

Inflammasomes: Mechanism of Action, Role in Disease, and Therapeutics

Haitao Guo, Justin B. Callaway, Jenny P.-Y. Ting

Nat Med. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Nat Med. 2015 Jul; 21(7): 677–687. Published online 2015 Jun 29. doi: 10.1038/nm.3893

PMCID:: PMC4519035

Abstract Article PDF–1.2M

Select item 450595513.

Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin

Jens Kortmann, Sky W. Brubaker, Denise M. Monack

J Immunol. 2015 Aug 1; 195(3): 815–819. Published online 2015 Jun 24. doi: 10.4049/jimmunol.1403100

PMCID:: PMC4505955

Abstract Article PDF–810K

Select item 432824614.

Molecular characterization and copy number of SMN1, SMN2 and NAIP in Chinese patients with spinal muscular atrophy and unrelated healthy controls

Ping Fang, Liang Li, Jian Zeng, Wan-Jun Zhou, Wei-Qing Wu, Ze-Yan Zhong, Ti-Zhen Yan, Jian-Sheng Xie, Jing Huang, Li Lin, Ying Zhao, Xiang-Min Xu

BMC Musculoskelet Disord. 2015; 16(1): 11. Published online 2015 Feb 7. doi: 10.1186/s12891-015-0457-x

PMCID:: PMC4328246

Abstract Article PDF–566K

Select item 403419515.

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

Si Ming Man, Lee J. Hopkins, Eileen Nugent, Susan Cox, Ivo M. Glück, Panagiotis Tourlomousis, John A. Wright, Pietro Cicuta, Tom P. Monie, Clare E. Bryant

Proc Natl Acad Sci U S A. 2014 May 20; 111(20): 7403–7408. Published online 2014 May 6. doi: 10.1073/pnas.1402911111

PMCID:: PMC4034195

Abstract Article PDF–1.1M

Select item 386161616.

The HECT Type Ubiquitin Ligase NEDL2 Is Degraded by Anaphase-promoting Complex/Cyclosome (APC/C)-Cdh1, and Its Tight Regulation Maintains the Metaphase to Anaphase Transition

Li Lu, Shaohua Hu, Rongfei Wei, Xiao Qiu, Kefeng Lu, Yesheng Fu, Hongchang Li, Guichun Xing, Dong Li, Ruiyun Peng, Fuchu He, Lingqiang Zhang

J Biol Chem. 2013 Dec 13; 288(50): 35637–35650. Published online 2013 Oct 25. doi: 10.1074/jbc.M113.472076

PMCID:: PMC3861616

Abstract Article PDF–4.4M

Select item 376159717.

Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation

Jieling Yang, Yue Zhao, Jianjin Shi, Feng Shao

Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35): 14408–14413. Published online 2013 Aug 12. doi: 10.1073/pnas.1306376110

PMCID:: PMC3761597

Abstract Article PDF–1.2M

Select item 349389118.

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

Els F. Halff, Christoph A. Diebolder, Marian Versteeg, Arie Schouten, T. Harma C. Brondijk, Eric G. Huizinga

J Biol Chem. 2012 Nov 9; 287(46): 38460–38472. Published online 2012 Sep 25. doi: 10.1074/jbc.M112.393512

PMCID:: PMC3493891

Abstract Article PDF–3.7M

Select item 346548319.

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

Jakob von Moltke, Norver J. Trinidad, Mahtab Moayeri, Alexander F. Kintzer, Samantha B. Wang, Nico van Rooijen, Charles R. Brown, Bryan A. Krantz, Stephen H. Leppla, Karsten Gronert, Russell E. Vance

Nature. Author manuscript; available in PMC 2013 Apr 4.

Published in final edited form as: Nature. 2012 Oct 4; 490(7418): 107–111. Published online 2012 Aug 19. doi: 10.1038/nature11351