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Items: 1 to 20 of 88

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
MK2 drives progression of pancreas and colon cancers by suppressing CD8+ T cell cytotoxic function and is a potential immunotherapy target
Damian Jacenik, Eric J. Lebish, Ellen J. Beswick
Front Immunol. 2023; 14: 1212100. Published online 2023 Jun 21. doi: 10.3389/fimmu.2023.1212100
PMCID:
PMC10321668
AbstractArticlePDF–3.9M
3.
The MK2 cascade mediates transient alteration in mGluR‐LTD and spatial learning in a murine model of Alzheimer's disease
Lucia Privitera, Ellen L. Hogg, Marcia Lopes, Luana B. Domingos, Matthias Gaestel, Jürgen Müller, Mark J. Wall, Sonia A. L. Corrêa
Aging Cell. 2022 Oct; 21(10): e13717. Published online 2022 Sep 22. doi: 10.1111/acel.13717
PMCID:
PMC9577942
AbstractArticlePDF–1.4M
4.
Gene Therapy with Pellino-1 Improves Perfusion and Decreases Tissue Loss in Flk-1 Heterozygous Mice but Fails in MAPKAP KINASE-2 Knockout Murine Hind Limb Ischemia Model
Mahesh Thirunavukkarasu, Seetur R. Pradeep, Gopi Ukani, Salim Abunnaja, Mark Youssef, Diego Accorsi, Santosh Swaminathan, Sue Ting Lim, Virginia Parker, Jacob Campbell, Muhammad Tipu Rishi, J. Alexander Palesty, Nilanjana Maulik
Microvasc Res. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Microvasc Res. 2022 May; 141: 104311. Published online 2022 Jan 7. doi: 10.1016/j.mvr.2022.104311
PMCID:
PMC9250804
AbstractArticlePDF–4.8M
5.
Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
I‐Ting Chen, Hsiao‐Chi Chen, Yu‐Hsun Lo, Peng‐Yeh Lai, Fu‐Yi Hsieh, Yung‐Hsuan Wu, Hsiu‐Ming Shih, Ming‐Zong Lai
EMBO Rep. 2021 Dec 6; 22(12): e52254. Published online 2021 Oct 11. doi: 10.15252/embr.202052254
PMCID:
PMC8647022
AbstractArticlePDF–3.1M
6.
IL‐3 is essential for ICOS‐L stabilization on mast cells, and sustains the IL‐33‐induced RORγt+ Treg generation via enhanced IL‐6 induction
Sebastian Drube, Sylvia Müller, Franziska Weber, Philine Wegner, Romy Böttcher‐Loschinski, Matthias Gaestel, Andreas Hutloff, Thomas Kamradt, Nico Andreas
Immunology. 2021 May; 163(1): 86–97. Published online 2021 Jan 27. doi: 10.1111/imm.13305
PMCID:
PMC8044339
AbstractArticlePDF–901K
7.
MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer
Lucia Suarez-Lopez, Yi Wen Kong, Ganapathy Sriram, Jesse C. Patterson, Samantha Rosenberg, Sandra Morandell, Kevin M. Haigis, Michael B. Yaffe
Front Immunol. 2020; 11: 607891. Published online 2021 Feb 23. doi: 10.3389/fimmu.2020.607891
PMCID:
PMC7940202
AbstractArticlePDF–1.8M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells
Christiane Helbig, Franziska Weber, Nico Andreas, Thomas Herdegen, Matthias Gaestel, Thomas Kamradt, Sebastian Drube
Sci Rep. 2020; 10: 8152. Published online 2020 May 18. doi: 10.1038/s41598-020-65072-3
PMCID:
PMC7235212
AbstractArticlePDF–1.9M
10.
Substrate-based kinase activity inference identifies MK2 as driver of colitis
Samantha Dale Strasser, Phaedra C. Ghazi, Alina Starchenko, Myriam Boukhali, Amanda Edwards, Lucia Suarez-Lopez, Jesse Lyons, Paul S. Changelian, Joseph B. Monahan, Jon Jacobsen, Douglas K. Brubaker, Brian A. Joughin, Michael B. Yaffe, Wilhelm Haas, Douglas A. Lauffenburger, Kevin M. Haigis
Integr Biol (Camb) Author manuscript; available in PMC 2020 May 8.
Published in final edited form as: Integr Biol (Camb). 2019 Nov 26; 11(7): 301–314. doi: 10.1093/intbio/zyz025
PMCID:
PMC7208439
AbstractArticlePDF–1.9M
11.
Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages
Ardeshir Ariana, Norah A. Alturki, Stephanie Hajjar, Deborah J. Stumpo, Christopher Tiedje, Emad S. Alnemri, Matthias Gaestel, Perry J. Blackshear, Subash Sad
J Biol Chem. 2020 Apr 3; 295(14): 4661–4672. Published online 2020 Feb 24. doi: 10.1074/jbc.RA119.011633
PMCID:
PMC7135981
AbstractArticlePDF–3.4M
12.
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2) Contributes to Secondary Damage after Spinal Cord Injury
Nader Ghasemlou, Ruben Lopez-Vales, Claude Lachance, Thusanth Thuraisingam, Matthias Gaestel, Danuta Radzioch, Samuel David
J Neurosci. 2010 Oct 13; 30(41): 13750–13759. doi: 10.1523/JNEUROSCI.2998-10.2010
PMCID:
PMC6633726
AbstractArticlePDF–1.4M
13.
Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration
Wei Fan, Xiu Kui Gao, Xi Sheng Rao, Yin Pu Shi, Xiao Ceng Liu, Fei Ya Wang, Yu Fen Liu, Xiao Xia Cong, Min Yi He, Shui Bo Xu, Wei Liang Shen, Yue Shen, Shi Gui Yan, Yan Luo, Boon Chuan Low, Hongwei Ouyang, Zhang Bao, Li Ling Zheng, Yi Ting Zhou
Mol Cell Biol. 2018 Dec 15; 38(24): e00211-18. Prepublished online 2018 Oct 1. Published online 2018 Nov 28. doi: 10.1128/MCB.00211-18
PMCID:
PMC6275188
AbstractArticlePDF–6.7M
14.
A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver Ischemia/Reperfusion Injury
Lei Sun, Qiong Wu, Yunjuan Nie, Ni Cheng, Rui Wang, Gang Wang, Dan Zhang, Huiqiong He, Richard D. Ye, Feng Qian
Front Immunol. 2018; 9: 2610. Published online 2018 Nov 13. doi: 10.3389/fimmu.2018.02610
PMCID:
PMC6243022
AbstractArticlePDF–3.4M
15.
MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection
Katharina Köther, Carolin Nordhoff, Dörthe Masemann, Georg Varga, Jay H. Bream, Matthias Gaestel, Viktor Wixler, Stephan Ludwig
FASEB J. 2014 Oct; 28(10): 4235–4246. doi: 10.1096/fj.14-249599
PMCID:
PMC6188229
AbstractArticle
16.
MK2 Regulates Macrophage Chemokine Activity and Recruitment to Promote Colon Tumor Growth
Brandon B. Phinney, Anita L. Ray, Amanda S. Peretti, Stephanie J. Jerman, Carl Grim, Irina V. Pinchuk, Ellen J. Beswick
Front Immunol. 2018; 9: 1857. Published online 2018 Sep 21. doi: 10.3389/fimmu.2018.01857
PMCID:
PMC6160543
AbstractArticlePDF–5.2M
17.
T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K
Gautham K. Rao, Albert Wong, Mark Collinge, Joseph Sarhan, Timur O. Yarovinsky, Vinod S. Ramgolam, Matthias Gaestel, Ruggero Pardi, Jeffrey R. Bender
PLoS One. 2018; 13(7): e0201103. Published online 2018 Jul 26. doi: 10.1371/journal.pone.0201103
PMCID:
PMC6065199
AbstractArticlePDF–7.4M
18.
Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis
Ana Henriques, Vasiliki Koliaraki, George Kollias
Proc Natl Acad Sci U S A. 2018 Jun 12; 115(24): E5546–E5555. Published online 2018 May 29. doi: 10.1073/pnas.1805683115
PMCID:
PMC6004446
AbstractArticlePDF–2.8M
19.
Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome
Xiaojing Nie, Melinda A. Chanley, Ruma Pengal, David B. Thomas, Shipra Agrawal, William E. Smoyer
Am J Physiol Renal Physiol. 2018 Apr 1; 314(4): F602–F613. Published online 2017 Nov 29. doi: 10.1152/ajprenal.00207.2017
Correction in:
Am J Physiol Renal Physiol. 2022 May 1; 322(5): F573–F574.
PMCID:
PMC5966757
AbstractArticle
20.
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis
Lucia Suarez-Lopez, Ganapathy Sriram, Yi Wen Kong, Sandra Morandell, Karl A. Merrick, Yuliana Hernandez, Kevin M. Haigis, Michael B. Yaffe
Proc Natl Acad Sci U S A. 2018 May 1; 115(18): E4236–E4244. Published online 2018 Apr 16. doi: 10.1073/pnas.1722020115
PMCID:
PMC5939099
AbstractArticlePDF–1.5M

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