PMC Links for GEO Profiles (Select 21224748) - PMC

Tadahisa Takahashi, Yuqing Li, Weijian Chen, Mazvita R. Nyasha, Kazumi Ogawa, Kazuaki Suzuki, Masashi Koide, Yoshihiro Hagiwara, Eiji Itoi, Toshimi Aizawa, Masahiro Tsuchiya, Naoki Suzuki, Masashi Aoki, Makoto Kanzaki

Sci Rep. 2022; 12: 14291. Published online 2022 Aug 22. doi: 10.1038/s41598-022-18190-z

PMCID:: PMC9395423

Abstract Article PDF–1.3M

Select item 83637474.

RSPO3 is important for trabecular bone and fracture risk in mice and humans

Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engström Ruud, Terho Lehtimäki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Movérare-Skrtic, Claes Ohlsson

Nat Commun. 2021; 12: 4923. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25124-2

PMCID:: PMC8363747

Abstract Article PDF–2.5M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78214296.

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers

Caitlin B. Conboy, Germán L. Vélez-Reyes, Susan K. Rathe, Juan E. Abrahante, Nuri A. Temiz, Michael B. Burns, Reuben S. Harris, Timothy K. Starr, David A. Largaespada

DNA Cell Biol. January 2021; 40(1): 70–79. Published online 2021 Jan 19. doi: 10.1089/dna.2020.5585

PMCID:: PMC7821429

Abstract Article PDF–612K

Select item 72712107.

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia El-Sayed Moustafa, John P. Kemp, Celia L. Gregson, David M. Evans, Matt J. Neville, Kerrin S. Small, Mark I. McCarthy, Anubha Mahajan, John F. Rawls, Fredrik Karpe, Constantinos Christodoulides

Nat Commun. 2020; 11: 2797. Published online 2020 Jun 3. doi: 10.1038/s41467-020-16592-z

PMCID:: PMC7271210

Abstract Article PDF–2.3M

Select item 72396548.

R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi

eLife. 2020; 9: e54469. Published online 2020 May 20. doi: 10.7554/eLife.54469

PMCID:: PMC7239654

Abstract Article PDF–2.7M

Select item 70658099.

Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs

Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M. Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D. Nathan, Jorg Distler, David A. Brenner, Kandasamy Hariharan, Ho Cho, Weilin Xie

PLoS One. 2020; 15(3): e0229445. Published online 2020 Mar 11. doi: 10.1371/journal.pone.0229445

PMCID:: PMC7065809

Abstract Article PDF–7.5M

Select item 646673910.

RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer

Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong, Stanley K. Liu

J Transl Med. 2019; 17: 125. Published online 2019 Apr 15. doi: 10.1186/s12967-019-1878-3

PMCID:: PMC6466739

Abstract Article PDF–1.4M

Select item 633688911.

WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation

Woo-Jeong Jeong, Jong-Chan Park, Woo-Shin Kim, Eun Ji Ro, Soung Hoo Jeon, Sang-Kyu Lee, Young Nyun Park, Do Sik Min, Kang-Yell Choi

Nat Commun. 2019; 10: 295. Published online 2019 Jan 17. doi: 10.1038/s41467-018-08230-6

PMCID:: PMC6336889

Abstract Article PDF–2.9M

Select item 616668212.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 611636713.

RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1

Tom Skaria, Esther Bachli, Gabriele Schoedon

Mol Med. 2018; 24: 45. Published online 2018 Aug 29. doi: 10.1186/s10020-018-0048-z

PMCID:: PMC6116367

Abstract Article PDF–1.8M

Select item 601645914.

Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling

Soohyun Park, Jie Cui, Wangsheng Yu, Ling Wu, Kendra S. Carmon, Qingyun J. Liu

J Biol Chem. 2018 Jun 22; 293(25): 9759–9769. Published online 2018 May 11. doi: 10.1074/jbc.RA118.002743

PMCID:: PMC6016459

Abstract Article PDF–2.2M

Select item 579749815.

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Rudi Alberts, Elisabeth M G de Vries, Elizabeth C Goode, Xiaojun Jiang, Fotis Sampaziotis, Krista Rombouts, Katrin Böttcher, Trine Folseraas, Tobias J Weismüller, Andrew L Mason, Weiwei Wang, Graeme Alexander, Domenico Alvaro, Annika Bergquist, Niklas K Björkström, Ulrich Beuers, Einar Björnsson, Kirsten Muri Boberg, Christopher L Bowlus, Maria C Bragazzi, Marco Carbone, Olivier Chazouillères, Angela Cheung, Georgios Dalekos, John Eaton, Bertus Eksteen, David Ellinghaus, Martti Färkkilä, Eleonora A M Festen, Annarosa Floreani, Irene Franceschet, Daniel Nils Gotthardt, Gideon M Hirschfield, Bart van Hoek, Kristian Holm, Simon Hohenester, Johannes Roksund Hov, Floris Imhann, Pietro Invernizzi, Brian D Juran, Henrike Lenzen, Wolfgang Lieb, Jimmy Z Liu, Hanns-Ulrich Marschall, Marco Marzioni, Espen Melum, Piotr Milkiewicz, Tobias Müller, Albert Pares, Christian Rupp, Christian Rust, Richard N Sandford, Christoph Schramm, Stefan Schreiber, Erik Schrumpf, Mark S Silverberg, Brijesh Srivastava, Martina Sterneck, Andreas Teufel, Ludovic Vallier, Joanne Verheij, Arnau Vich Vila, Boudewijn de Vries, Kalliopi Zachou, The International PSC Study Group, The UK PSC Consortium, Roger W Chapman, Michael P Manns, Massimo Pinzani, Simon M Rushbrook, Konstantinos N Lazaridis, Andre Franke, Carl A Anderson, Tom H Karlsen, Cyriel Y Ponsioen, Rinse K Weersma

Gut. Author manuscript; available in PMC 2018 Aug 1.

Published in final edited form as: Gut. 2018 Aug; 67(8): 1517–1524. Published online 2017 Aug 4. doi: 10.1136/gutjnl-2016-313598

PMCID:: PMC5797498

Abstract Article PDF–1.0M

Select item 568166616.

RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations

Marcus M. Fischer, V. Pete Yeung, Fiore Cattaruzza, Rajaa Hussein, Wan-Ching Yen, Christopher Murriel, James W. Evans, Gilbert O’Young, Alayne L. Brunner, Min Wang, Jennifer Cain, Belinda Cancilla, Ann Kapoun, Timothy Hoey

Sci Rep. 2017; 7: 15270. Published online 2017 Nov 10. doi: 10.1038/s41598-017-15704-y

PMCID:: PMC5681666

Abstract Article PDF–6.6M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 533121018.

Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

Gabriele Picco, Consalvo Petti, Alessia Centonze, Erica Torchiaro, Giovanni Crisafulli, Luca Novara, Andrea Acquaviva, Alberto Bardelli, Enzo Medico

EMBO Mol Med. 2017 Mar; 9(3): 293–303. Published online 2017 Jan 18. doi: 10.15252/emmm.201606773

PMCID:: PMC5331210

Abstract Article PDF–1.0M

Select item 532540219.

RSPOs facilitated HSC activation and promoted hepatic fibrogenesis

Xinguang Yin, Huixing Yi, Linlin Wang, Wanxin Wu, Xiaojun Wu, Linghua Yu

Oncotarget. 2016 Sep 27; 7(39): 63767–63778. Published online 2016 Aug 27. doi: 10.18632/oncotarget.11654

PMCID:: PMC5325402

Abstract Article PDF–7.2M

Select item 531887120.

RSPO3-LGR4 Regulates Osteogenic Differentiation Of Human Adipose-Derived Stem Cells Via ERK/FGF Signalling

Min Zhang, Ping Zhang, Yunsong Liu, Longwei Lv, Xiao Zhang, Hao Liu, Yongsheng Zhou

Sci Rep. 2017; 7: 42841. Published online 2017 Feb 21. doi: 10.1038/srep42841

PMCID:: PMC5318871

Abstract Article PDF–3.5M

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