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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 99279332.

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells

Shizhen Zhang, Xiahong You, Yawen Zheng, Yanwen Shen, Xiufang Xiong, Yi Sun

J Clin Invest. 2023 Feb 15; 133(4): e162434. Published online 2023 Feb 15. doi: 10.1172/JCI162434

PMCID:: PMC9927933

Abstract Article PDF–11M

Select item 98270613.

DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice

Charles Colas, Mathilde Mouchiroud, Manal Al Dow, Alona Kolnohuz, Yves Gélinas, Alexandre Caron, Mathieu Laplante

Mol Metab. 2023 Jan; 67: 101660. Published online 2022 Dec 16. doi: 10.1016/j.molmet.2022.101660

PMCID:: PMC9827061

Abstract Article PDF–2.6M

Select item 82805154.

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Marina Serrano-Maciá, Jorge Simón, Maria J. González-Rellan, Mikel Azkargorta, Naroa Goikoetxea-Usandizaga, Fernando Lopitz-Otsoa, Diego Saenz De Urturi, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, Maria Mercado-Gomez, Virginia Gutiérrez de Juan, Maider Bizkarguenaga, David Fernández-Ramos, Xabier Buque, Guido A. Baselli, Luca V.C. Valenti, Paula Iruzubieta, Javier Crespo, Erica Villa, Jesus M. Banales, Matias A. Avila, Jose J.G. Marin, Patricia Aspichueta, James Sutherland, Rosa Barrio, Ugo Mayor, Félix Elortza, Dimitris P. Xirodimas, Rubén Nogueiras, Teresa C. Delgado, María Luz Martínez-Chantar

Mol Metab. 2021 Nov; 53: 101275. Published online 2021 Jun 18. doi: 10.1016/j.molmet.2021.101275

PMCID:: PMC8280515

Abstract Article PDF–4.0M

Select item 78176955.

Accelerating functional gene discovery in osteoarthritis

Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett

Nat Commun. 2021; 12: 467. Published online 2021 Jan 20. doi: 10.1038/s41467-020-20761-5

Correction in:: Nat Commun. 2021; 12: 3302.

PMCID:: PMC7817695

Abstract Article PDF–8.0M

Select item 73514916.

A trans-eQTL network regulates osteoclast multinucleation and bone mass

Marie Pereira, Jeong-Hun Ko, John Logan, Hayley Protheroe, Kee-Beom Kim, Amelia Li Min Tan, Peter I Croucher, Kwon-Sik Park, Maxime Rotival, Enrico Petretto, JH Duncan Bassett, Graham R Williams, Jacques Behmoaras

eLife. 2020; 9: e55549. Published online 2020 Jun 19. doi: 10.7554/eLife.55549

PMCID:: PMC7351491

Abstract Article PDF–5.1M

Select item 73481877.

miRNA‐182/Deptor/mTOR axis regulates autophagy to reduce intestinal ischaemia/reperfusion injury

Yunsheng Li, Yanhua Luo, Baochuan Li, Lijun Niu, Jiaxin Liu, Xiaoyun Duan

J Cell Mol Med. 2020 Jul; 24(14): 7873–7883. Published online 2020 Jun 8. doi: 10.1111/jcmm.15420

PMCID:: PMC7348187

Abstract Article PDF–2.0M

Select item 70186638.

DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals

Xiaoyu Chen, Xiufang Xiong, Danrui Cui, Fei Yang, Dongping Wei, Haomin Li, Jianfeng Shu, Yanli Bi, Xiaoqing Dai, Longyuan Gong, Yi Sun, Yongchao Zhao

Oncogene. 2020; 39(7): 1557–1571. Published online 2019 Nov 4. doi: 10.1038/s41388-019-1085-y

PMCID:: PMC7018663

Abstract Article PDF–4.3M

Select item 63811439.

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

Ningning Li, Roya Babaei-Jadidi, Federica Lorenzi, Bradley Spencer-Dene, Philip Clarke, Enric Domingo, Eugene Tulchinsky, Robert G. J. Vries, David Kerr, Yihang Pan, Yulong He, David O. Bates, Ian Tomlinson, Hans Clevers, Abdolrahman S. Nateri

Oncogenesis. 2019 Mar; 8(3): 13. Published online 2019 Feb 19. doi: 10.1038/s41389-019-0125-3

PMCID:: PMC6381143

Abstract Article PDF–10M

Select item 631063410.

DEPTOR MODULATES ACTIVATION RESPONSES IN CD4⁺ T CELLS AND ENHANCES IMMUNOREGULATION FOLLOWING TRANSPLANTATION

Johannes Wedel, Sarah Bruneau, Kaifeng Liu, Sek Won Kong, Peter T. Sage, David M. Sabatini, Mathieu Laplante, David M. Briscoe

Am J Transplant. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: Am J Transplant. 2019 Jan; 19(1): 77–88. Published online 2018 Aug 17. doi: 10.1111/ajt.14995

Correction in:: Am J Transplant. 2020 Mar; 20(3): 908.

PMCID:: PMC6310634

Abstract Article PDF–1.0M

Select item 609791211.

DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease

Hanqing Chen, Feng Shen, Alex Sherban, Allison Nocon, Yu Li, Hua Wang, Ming-Jiang Xu, Xianliang Rui, Jinyan Han, Bingbing Jiang, Donghwan Lee, Na Li, Farnaz Keyhani-Nejad, Jian-gao Fan, Feng Liu, Amrita Kamat, Nicolas Musi, Leonard Guarente, Pal Pacher, Bin Gao, Mengwei Zang

Hepatology. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Hepatology. 2018 Aug; 68(2): 496–514. Published online 2018 May 21. doi: 10.1002/hep.29849

PMCID:: PMC6097912

Abstract Article PDF–2.1M

Select item 603320312.

DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis

Si Chen, Lingfei Jia, Shan Zhang, Yunfei Zheng, Yongsheng Zhou

Stem Cell Res Ther. 2018; 9: 185. Published online 2018 Jul 4. doi: 10.1186/s13287-018-0935-9

PMCID:: PMC6033203

Abstract Article PDF–4.0M

Select item 600425513.

Deptor is a novel target of Wnt/β-catenin/c-Myc and contributes to colorectal cancer cell growth

Qingding Wang, Yuning Zhou, Piotr Rychahou, Jennifer W. Harris, Yekaterina Y. Zaytseva, Jinpeng Liu, Chi Wang, Heidi L. Weiss, Chunming Liu, Eun Y. Lee, B. Mark Evers

Cancer Res. Author manuscript; available in PMC 2019 Jun 15.

Published in final edited form as: Cancer Res. 2018 Jun 15; 78(12): 3163–3175. Published online 2018 Apr 17. doi: 10.1158/0008-5472.CAN-17-3107

PMCID:: PMC6004255

Abstract Article PDF–1.2M

Select item 590665914.

Loss of DEPTOR in renal tubules protects against cisplatin-induced acute kidney injury

Caixia Wang, Huaiqian Dai, Zhi Xiong, Qiancheng Song, Zhipeng Zou, Mangmang Li, Jing Nie, Xiaochun Bai, Zhenguo Chen

Cell Death Dis. 2018 May; 9(5): 441. Published online 2018 Apr 18. doi: 10.1038/s41419-018-0483-3

PMCID:: PMC5906659

Abstract Article PDF–2.3M

Select item 547682815.

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

Bárbara González-Terán, Juan Antonio López, Elena Rodríguez, Luis Leiva, Sara Martínez-Martínez, Juan Antonio Bernal, Luis Jesús Jiménez-Borreguero, Juan Miguel Redondo, Jesús Vazquez, Guadalupe Sabio

Nat Commun. 2016; 7: 10477. Published online 2016 Jan 22. doi: 10.1038/ncomms10477

PMCID:: PMC5476828

Abstract Article PDF–4.1M

Select item 540410216.

Loss of hepatic DEPTOR alters the metabolic transition to fasting

Alexandre Caron, Mathilde Mouchiroud, Nicolas Gautier, Sébastien M. Labbé, Romain Villot, Laurie Turcotte, Blandine Secco, Guillaume Lamoureux, Michael Shum, Yves Gélinas, André Marette, Denis Richard, David M. Sabatini, Mathieu Laplante

Mol Metab. 2017 May; 6(5): 447–458. Published online 2017 Feb 17. doi: 10.1016/j.molmet.2017.02.005

PMCID:: PMC5404102

Abstract Article PDF–1.3M

Select item 509495117.

Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation

Mengmeng Cheng, Shurong Hu, Zhengting Wang, Yaofei Pei, Rong Fan, Xiqiang Liu, Lei Wang, Jie Zhou, Sichang Zheng, Tianyu Zhang, Yun Lin, Maochen Zhang, Ran Tao, Jie Zhong

Oncotarget. 2016 Jun 14; 7(24): 35643–35654. Published online 2016 May 21. doi: 10.18632/oncotarget.9543