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Select item 102660161.

Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis

Bryce Z. Stewart, Tatyana Mamonova, W. Bruce Sneddon, Airah Javorsky, Yanmei Yang, Bin Wang, Thomas D. Nolin, Patrick O. Humbert, Peter A. Friedman, Marc Kvansakul

Proc Natl Acad Sci U S A. 2023 Jun 6; 120(23): e2220851120. Published online 2023 May 30. doi: 10.1073/pnas.2220851120

PMCID:: PMC10266016

Article PDF–8.4M

Select item 101032622.

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment

Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak

J Am Soc Nephrol. 2023 Apr; 34(4): 572–589. Published online 2022 Dec 15. doi: 10.1681/ASN.2022040460

PMCID:: PMC10103262

Article

Select item 97007973.

Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse

Gabriel Khelifi, Theresa Chow, Jennifer Whiteley, Victoire Fort, Benjamin D. Humphreys, Samer M.I. Hussein, Ian M. Rogers

Sci Rep. 2022; 12: 20340. Published online 2022 Nov 25. doi: 10.1038/s41598-022-24581-z

PMCID:: PMC9700797

Article PDF–3.6M

Select item 93426414.

Targeted Disruption of a Proximal Tubule–Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification

Shinobu Miyazaki-Anzai, Audrey L. Keenan, Judith Blaine, Makoto Miyazaki

J Am Soc Nephrol. 2022 Aug; 33(8): 1477–1486. Published online 2022 Aug. doi: 10.1681/ASN.2021121578

PMCID:: PMC9342641

Article

Select item 92329755.

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency

Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase

Kidney Int. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Kidney Int. 2022 Jul; 102(1): 108–120. Published online 2022 Mar 24. doi: 10.1016/j.kint.2022.02.030

PMCID:: PMC9232975

Article PDF–1.7M

Select item 90127876.

Tmem174, a regulator of phosphate transporter prevents hyperphosphatemia

Sumire Sasaki, Yuji Shiozaki, Ai Hanazaki, Megumi Koike, Kazuya Tanifuji, Minori Uga, Kota Kawahara, Ichiro Kaneko, Yasuharu Kawamoto, Pattama Wiriyasermkul, Tomoka Hasegawa, Norio Amizuka, Ken-ichi Miyamoto, Shushi Nagamori, Yoshikatsu Kanai, Hiroko Segawa

Sci Rep. 2022; 12: 6353. Published online 2022 Apr 15. doi: 10.1038/s41598-022-10409-3

PMCID:: PMC9012787

Article PDF–2.7M

Select item 90056007.

The human pathogenic 91del7 mutation in SLC34A1 has no effect in mineral homeostasis in mice

Cornelia Bieri, Arezoo Daryadel, Carla Bettoni, Eva-Maria Pastor-Arroyo, Udo Schnitzbauer, Nati Hernando, Carsten A. Wagner

Sci Rep. 2022; 12: 6102. Published online 2022 Apr 12. doi: 10.1038/s41598-022-10046-w

PMCID:: PMC9005600

Article PDF–2.0M

Select item 87757588.

The Therapeutic Potential of Zinc-Alpha2-Glycoprotein (AZGP1) in Fibrotic Kidney Disease

Inga Sörensen-Zender, Song Rong, Hermann Haller, Roland Schmitt

Int J Mol Sci. 2022 Jan; 23(2): 646. Published online 2022 Jan 7. doi: 10.3390/ijms23020646

PMCID:: PMC8775758

Article PDF–2.0M

Select item 85367349.

Cumulative DNA damage by repeated low-dose cisplatin injection promotes the transition of acute to chronic kidney injury in mice

Noriyuki Yamashita, Kunihiro Nakai, Tomohiro Nakata, Itaru Nakamura, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki, Tetsuro Kusaba

Sci Rep. 2021; 11: 20920. Published online 2021 Oct 22. doi: 10.1038/s41598-021-00392-6

PMCID:: PMC8536734

Article PDF–14M

Select item 820530710.

Cre/loxP approach-mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells

Ting Liu, Jialing Yuan, Caihong Dai, Jinxian Xu, Shude Li, Benjamin D. Humphreys, Daniel T. Kleven, Jian-Kang Chen

J Cell Physiol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: J Cell Physiol. 2020 Dec; 235(12): 9958–9973. Published online 2020 May 31. doi: 10.1002/jcp.29811

PMCID:: PMC8205307

Article PDF–3.4M

Select item 815893011.

Impaired 1,25 dihydroxyvitamin D₃ action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH

Ye Yuan, Supriya Jagga, Janaina S. Martins, Rakshya Rana, Paola Divieti Pajevic, Eva S. Liu

PLoS One. 2021; 16(5): e0252348. Published online 2021 May 27. doi: 10.1371/journal.pone.0252348

PMCID:: PMC8158930

Article PDF–3.5M

Select item 768573712.

Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion

Valerie Clerin, Hiroshi Saito, Kevin J. Filipski, An Hai Nguyen, Jeonifer Garren, Janka Kisucka, Monica Reyes, Harald Jüppner

J Clin Invest. 2020 Dec 1; 130(12): 6510–6522. Published online 2020 Nov 9. doi: 10.1172/JCI135665

PMCID:: PMC7685737

Article PDF–2.7M

Select item 706451413.

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice

Masahiro Uehara, Tetsuro Kusaba, Tomoharu Ida, Kunihiro Nakai, Tomohiro Nakata, Aya Tomita, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Noriyuki Yamashita, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki

Sci Rep. 2020; 10: 4441. Published online 2020 Mar 10. doi: 10.1038/s41598-020-61456-7

PMCID:: PMC7064514

Article PDF–12M

Select item 700253414.

Role of sodium‐dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages

Ai Hanazaki, Kayo Ikuta, Shohei Sasaki, Sumire Sasaki, Megumi Koike, Kazuya Tanifuji, Yuki Arima, Ichiro Kaneko, Yuji Shiozaki, Sawako Tatsumi, Tomoka Hasegawa, Norio Amizuka, Ken‐ichi Miyamoto, Hiroko Segawa

Physiol Rep. 2020 Feb; 8(3): e14324. Published online 2020 Feb 5. doi: 10.14814/phy2.14324

PMCID:: PMC7002534

Article PDF–2.3M

Select item 691649515.

Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content

Xiaofeng Zuo, Sang-Ho Kwon, Michael G. Janech, Yujing Dang, Steven D. Lauzon, Ben Fogelgren, Noemi Polgar, Joshua H. Lipschutz

J Biol Chem. 2019 Dec 13; 294(50): 19099–19110. Published online 2019 Nov 6. doi: 10.1074/jbc.RA119.009297

PMCID:: PMC6916495

Article PDF–2.3M

Select item 690080016.

Proximal Tubule–Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis

Eirini Kefaloyianni, Manikanda Raja Keerthi Raja, Julian Schumacher, Muthu Lakshmi Muthu, Vaishali Krishnadoss, Sushrut S. Waikar, Andreas Herrlich

J Am Soc Nephrol. 2019 Dec; 30(12): 2370–2383. Published online 2019 Oct 31. doi: 10.1681/ASN.2019030321

PMCID:: PMC6900800

Article

Select item 681910417.

Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses

Seiji Kishi, Craig R. Brooks, Kensei Taguchi, Takaharu Ichimura, Yutaro Mori, Akinwande Akinfolarin, Navin Gupta, Pierre Galichon, Bertha C. Elias, Tomohisa Suzuki, Qian Wang, Leslie Gewin, Ryuji Morizane, Joseph V. Bonventre

J Clin Invest. 2019 Nov 1; 129(11): 4797–4816. Published online 2019 Oct 7. doi: 10.1172/JCI122313

PMCID:: PMC6819104

Article PDF–41M

Select item 671851918.

Cell-specific image-guided transcriptomics identifies complex injuries caused by ischemic acute kidney injury in mice

Tomoaki Miyazaki, Sina A. Gharib, Yun-Wei A. Hsu, Katherine Xu, Pavlo Khodakivskyi, Akio Kobayashi, Jason Paragas, Alexander D. Klose, Kevin P. Francis, Elena Dubikovskaya, Patrick S. Page-McCaw, Jonathan Barasch, Neal Paragas

Commun Biol. 2019; 2: 326. Published online 2019 Sep 2. doi: 10.1038/s42003-019-0571-7

PMCID:: PMC6718519

Article PDF–3.0M

Select item 652711719.

Cyclin G1 and TASCC regulate kidney epithelial cell G₂-M arrest and fibrotic maladaptive repair

Guillaume Canaud, Craig R. Brooks, Seiji Kishi, Kensei Taguchi, Kenji Nishimura, Sato Magassa, Adam Scott, Li-Li Hsiao, Takaharu Ichimura, Fabiola Terzi, Li Yang, Joseph V. Bonventre

Sci Transl Med. Author manuscript; available in PMC 2020 Jan 23.

Published in final edited form as: Sci Transl Med. 2019 Jan 23; 11(476): eaav4754. doi: 10.1126/scitranslmed.aav4754