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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 80017602.

Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages

Asami Watahiki, Seira Hoshikawa, Mitsuki Chiba, Hiroshi Egusa, Satoshi Fukumoto, Hiroyuki Inuzuka

Int J Mol Sci. 2021 Mar; 22(6): 2893. Published online 2021 Mar 12. doi: 10.3390/ijms22062893

PMCID:: PMC8001760

Abstract Article PDF–16M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 63079604.

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

Peixiang Zhang, Lauren S. Csaki, Emilio Ronquillo, Lynn J. Baufeld, Jason Y. Lin, Alexis Gutierrez, Jennifer R. Dwyer, David N. Brindley, Loren G. Fong, Peter Tontonoz, Stephen G. Young, Karen Reue

J Clin Invest. 2019 Jan 2; 129(1): 281–295. Published online 2018 Dec 3. doi: 10.1172/JCI122595

PMCID:: PMC6307960

Abstract Article PDF–17M

Select item 59355635.

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

Andrew J. Lutkewitte, George G. Schweitzer, Stefanie Kennon-McGill, Melissa M. Clemens, Laura P. James, Hartmut Jaeschke, Brian N. Finck, Mitchell R. McGill

Food Chem Toxicol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Food Chem Toxicol. 2018 May; 115: 273–283. Published online 2018 Mar 11. doi: 10.1016/j.fct.2018.03.014

PMCID:: PMC5935563

Article PDF–3.2M

Select item 54571416.

Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia

Xin Heng, Qiuxia Guo, Alan W Leung, James YH Li

eLife. 2017; 6: e23253. Published online 2017 May 10. doi: 10.7554/eLife.23253

PMCID:: PMC5457141

Abstract Article PDF–11M

Select item 52958217.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 52948608.

Lipin-2 regulates NLRP3 inflammasome by affecting P2X₇ receptor activation

Gema Lordén, Itziar Sanjuán-García, Nagore de Pablo, Clara Meana, Inés Alvarez-Miguel, M. Teresa Pérez-García, Pablo Pelegrín, Jesús Balsinde, María A. Balboa

J Exp Med. 2017 Feb; 214(2): 511–528. doi: 10.1084/jem.20161452

PMCID:: PMC5294860

Abstract Article PDF–3.0M

Select item 41403009.

Lipin 2 Binds Phosphatidic Acid by the Electrostatic Hydrogen Bond Switch Mechanism Independent of Phosphorylation

James M. Eaton, Sankeerth Takkellapati, Robert T. Lawrence, Kelley E. McQueeney, Salome Boroda, Garrett R. Mullins, Samantha G. Sherwood, Brian N. Finck, Judit Villén, Thurl E. Harris

J Biol Chem. 2014 Jun 27; 289(26): 18055–18066. Published online 2014 May 8. doi: 10.1074/jbc.M114.547604

PMCID:: PMC4140300

Abstract Article PDF–2.1M

Select item 395370110.

Lipin-1 and lipin-3 together determine adiposity in vivo

Lauren S. Csaki, Jennifer R. Dwyer, Xia Li, Michael H.K. Nguyen, Jay Dewald, David N. Brindley, Aldons J. Lusis, Yuko Yoshinaga, Pieter de Jong, Loren Fong, Stephen G. Young, Karen Reue

Mol Metab. 2014 Apr; 3(2): 145–154. Published online 2013 Nov 28. doi: 10.1016/j.molmet.2013.11.008

PMCID:: PMC3953701

Abstract Article PDF–2.0M

Select item 384306511.

Distinct Roles of the Phosphatidate Phosphatases Lipin 1 and 2 during Adipogenesis and Lipid Droplet Biogenesis in 3T3-L1 Cells

Hiroshi Sembongi, Merce Miranda, Gil-Soo Han, Stylianos Fakas, Neil Grimsey, Joan Vendrell, George M. Carman, Symeon Siniossoglou

J Biol Chem. 2013 Nov 29; 288(48): 34502–34513. Published online 2013 Oct 16. doi: 10.1074/jbc.M113.488445

PMCID:: PMC3843065

Abstract Article PDF–2.5M

Select item 369479612.

Regulation of lipid droplet and membrane biogenesis by the acidic tail of the phosphatidate phosphatase Pah1p

Eleftherios Karanasios, Antonio Daniel Barbosa, Hiroshi Sembongi, Muriel Mari, Gil-Soo Han, Fulvio Reggiori, George M. Carman, Symeon Siniossoglou

Mol Biol Cell. 2013 Jul 1; 24(13): 2124–2133. doi: 10.1091/mbc.E13-01-0021

PMCID:: PMC3694796

Abstract Article PDF–2.0M

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 344314514.

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

Jennifer R. Dwyer, Jimmy Donkor, Peixiang Zhang, Lauren S. Csaki, Laurent Vergnes, Jessica M. Lee, Jay Dewald, David N. Brindley, Elisa Atti, Sotirios Tetradis, Yuko Yoshinaga, Pieter J. De Jong, Loren G. Fong, Stephen G. Young, Karen Reue

Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37): E2486–E2495. Published online 2012 Aug 20. doi: 10.1073/pnas.1205221109

PMCID:: PMC3443145

Abstract Article PDF–1.6M

Select item 343226415.

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Dyna I. Shirasaki, Erin R. Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, X. William Yang

Neuron. Author manuscript; available in PMC 2013 Jul 12.

Published in final edited form as: Neuron. 2012 Jul 12; 75(1): 41–57. doi: 10.1016/j.neuron.2012.05.024

PMCID:: PMC3432264

Abstract Article PDF–4.9M

Select item 332285816.

Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages

Martín Valdearcos, Esperanza Esquinas, Clara Meana, Lucía Peña, Luis Gil-de-Gómez, Jesús Balsinde, María A. Balboa

J Biol Chem. 2012 Mar 30; 287(14): 10894–10904. Published online 2012 Feb 8. doi: 10.1074/jbc.M112.342915

PMCID:: PMC3322858

Abstract Article PDF–3.1M

Select item 317805917.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 315346118.

Dietary Cholesterol Reduces Plasma Triacylglycerol in Apolipoprotein E-Null Mice: Suppression of Lipin-1 and -2 in the Glycerol-3-Phosphate Pathway

Takashi Obama, Sayaka Nagaoka, Kazuki Akagi, Rina Kato, Naomi Horiuchi, Yasushi Horai, Toshihiro Aiuchi, Satoru Arata, Tomohiro Yamaguchi, Mitsuhiro Watanabe, Hiroyuki Itabe

PLoS One. 2011; 6(8): e22917. Published online 2011 Aug 9. doi: 10.1371/journal.pone.0022917

PMCID:: PMC3153461

Abstract Article PDF–668K

Select item 306408119.

Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance

Dongryeol Ryu, Woo-Young Seo, Young-Sil Yoon, Yo-Na Kim, Su Sung Kim, Hye-Jin Kim, Tae-Sik Park, Cheol Soo Choi, Seung-Hoi Koo

Diabetes. 2011 Apr; 60(4): 1072–1081. Published online 2011 Mar 22. doi: 10.2337/db10-1046

PMCID:: PMC3064081

Abstract Article PDF–1.5M

Select item 278562520.

A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2

Jimmy Donkor, Peixiang Zhang, Samantha Wong, Lauren O'Loughlin, Jay Dewald, Bernard P.C. Kok, David N. Brindley, Karen Reue

J Biol Chem. 2009 Oct 23; 284(43): 29968–29978. Published online 2009 Aug 28. doi: 10.1074/jbc.M109.023663

PMCID:: PMC2785625

Abstract Article PDF–3.7M

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