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Select item 109327801.

Association between copy number variations in parkin (PRKN) and schizophrenia and autism spectrum disorder: A case–control study

Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki

Neuropsychopharmacol Rep. 2024 Mar; 44(1): 42–50. Published online 2023 Nov 1. doi: 10.1002/npr2.12370

PMCID:: PMC10932780

Abstract Article PDF–801K

Select item 109047552.

Parkin inhibits proliferation and migration of bladder cancer via ubiquitinating Catalase

Renjie Zhang, Wenyu Jiang, Gang Wang, Yi Zhang, Wei Liu, Mingxing Li, Jingtian Yu, Xin Yan, Fenfang Zhou, Wenzhi Du, Kaiyu Qian, Yu Xiao, Tongzu Liu, Lingao Ju, Xinghuan Wang

Commun Biol. 2024; 7: 245. Published online 2024 Feb 29. doi: 10.1038/s42003-024-05935-x

PMCID:: PMC10904755

Abstract Article PDF–3.0M

Select item 107917113.

Pregnancy, fertile life factors, and associated clinical course in PRKN early-onset Parkinson’s disease

Roberta Bovenzi, Matteo Conti, Giulia Rebecca Degoli, Rocco Cerroni, Carlo Alberto Artusi, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Tommaso Schirinzi

Neurol Sci. 2024; 45(2): 591–599. Published online 2023 Sep 2. doi: 10.1007/s10072-023-07029-8

PMCID:: PMC10791711

Abstract Article PDF–553K

Select item 107065644.

History of Parkinson’s Disease-Associated Gene, Parkin: Research over a Quarter Century in Quest of Finding the Physiological Substrate

Tohru Kitada, Mustafa T. Ardah, M. Emdadul Haque

Int J Mol Sci. 2023 Dec; 24(23): 16734. Published online 2023 Nov 24. doi: 10.3390/ijms242316734

PMCID:: PMC10706564

Abstract Article PDF–871K

Select item 106187375.

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

Renzo Perales-Linares, Nektaria Maria Leli, Hesham Mohei, Silvia Beghi, Osvaldo D. Rivera, Nektarios Kostopoulos, Andrea Giglio, Subin S. George, Mireia Uribe-Herranz, Francesca Costabile, Stefano Pierini, Sergei Pustylnikov, Giorgos Skoufos, Yoseph Barash, Artemis G. Hatzigeorgiou, Constantinos Koumenis, Amit Maity, Michael T. Lotze, Andrea Facciabene

Cancer Res. 2023 Nov 1; 83(21): 3562–3576. Published online 2023 Aug 14. doi: 10.1158/0008-5472.CAN-22-2499

PMCID:: PMC10618737

Abstract Article PDF–7.9M

Select item 106180766.

Tumor suppressor Parkin induces p53-mediated cell cycle arrest in human lung and colorectal cancer cells

Byung Chul Jung, Sung Hoon Kim, Yoonjung Cho, Yoon Suk Kim

BMB Rep. 2023 Oct 31; 56(10): 557–562. Published online 2023 Sep 6. doi: 10.5483/BMBRep.2023-0134

PMCID:: PMC10618076

Abstract Article PDF–6.7M

Select item 105992787.

Parkin regulates IGF2BP3 through ubiquitination in the tumourigenesis of cervical cancer

Xin Sun, Guiqin Ye, Jiuzhou Li, Huafeng Shou, Gongxun Bai, Jianbin Zhang

Clin Transl Med. 2023 Oct; 13(10): e1457. Published online 2023 Oct 25. doi: 10.1002/ctm2.1457

PMCID:: PMC10599278

Abstract Article PDF–8.2M

Select item 105732408.

Parkin-Mediated Mitophagy by TGF-β Is Connected with Hepatic Stellate Cell Activation

Ji Hyun Lee, Kyu Min Kim, Eun Hee Jung, Hye Rim Lee, Ji Hye Yang, Sam Seok Cho, Sung Hwan Ki

Int J Mol Sci. 2023 Oct; 24(19): 14826. Published online 2023 Oct 2. doi: 10.3390/ijms241914826

PMCID:: PMC10573240

Abstract Article PDF–2.9M

Select item 104670419.

Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent

Xu Hou, Taylor Hsuan‐Yu Chen, Shunsuke Koga, Jenny M. Bredenberg, Ayman H. Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K. Wszolek, Jonathan A. Carr, Owen A. Ross, Pamela J. McLean, Melissa E. Murray, Dennis W. Dickson, Fabienne C. Fiesel, Wolfdieter Springer

Brain Pathol. 2023 Sep; 33(5): e13175. Published online 2023 May 31. doi: 10.1111/bpa.13175

PMCID:: PMC10467041

Abstract Article PDF–2.9M

Select item 1039273210.

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1

Ying Liu, Hanwen Zhang, Yiwei Liu, Siyue Zhang, Peng Su, Lijuan Wang, Yaming Li, Yiran Liang, Xiaolong Wang, Weijing Zhao, Bing Chen, Dan Luo, Ning Zhang, Qifeng Yang

Autophagy. 2023; 19(9): 2443–2463. Published online 2023 Mar 1. doi: 10.1080/15548627.2023.2182482

PMCID:: PMC10392732

Abstract Article PDF–10M

Select item 1035582411.

Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease

Wesley Peng, Leonie F. Schröder, Pingping Song, Yvette C. Wong, Dimitri Krainc

Sci Adv. 2023 Jul; 9(29): eadh3347. Published online 2023 Jul 19. doi: 10.1126/sciadv.adh3347

PMCID:: PMC10355824

Abstract Article PDF–1.9M

Select item 1024098312.

PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models

Rui Han, Yanting Liu, Shihua Li, Xiao-Jiang Li, Weili Yang

Autophagy. 2023; 19(5): 1396–1405. Published online 2022 Nov 3. doi: 10.1080/15548627.2022.2139080

PMCID:: PMC10240983

Abstract Article PDF–619K

Select item 1023645613.

Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression

Minjeong Yeon, Irene Bertolini, Ekta Agarwal, Jagadish C. Ghosh, Hsin-Yao Tang, David W. Speicher, Frederick Keeney, Khalid Sossey-Alaoui, Elzbieta Pluskota, Katarzyna Bialkowska, Edward F. Plow, Lucia R. Languino, Emmanuel Skordalakes, M. Cecilia Caino, Dario C. Altieri

J Biol Chem. 2023 Jun; 299(6): 104774. Published online 2023 May 2. doi: 10.1016/j.jbc.2023.104774

PMCID:: PMC10236456

Abstract Article PDF–3.1M

Select item 1011716514.

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway—implications for Parkinson’s disease

Willcyn Tang, John Thundyil, Grace Gui Yin Lim, Teddy J W Tng, Sean Qing Zhang Yeow, Aditya Nair, Chou Chai, Tso-Pang Yao, Kah-Leong Lim

Hum Mol Genet. 2023 May 1; 32(9): 1466–1482. Published online 2022 Nov 26. doi: 10.1093/hmg/ddac297

Correction in:: Hum Mol Genet. 2023 Jun 1; 32(11): 1943.

PMCID:: PMC10117165

Abstract Article PDF–2.3M

Select item 1008412415.

Praja1 RING‐finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease‐associated protein aggregation

Kazuhiko Watabe, Motoko Niida‐Kawaguchi, Mari Tada, Yoichiro Kato, Makiko Murata, Kunikazu Tanji, Koichi Wakabayashi, Mitsunori Yamada, Akiyoshi Kakita, Noriyuki Shibata

Neuropathology. 2022 Dec; 42(6): 488–504. Published online 2022 Jun 14. doi: 10.1111/neup.12840

PMCID:: PMC10084124

Abstract Article PDF–4.8M

Select item 1004748816.

Interaction of a Novel Alternatively Spliced Variant of HSD11B1L with Parkin Enhances the Carcinogenesis Potential of Glioblastoma: Peiminine Interferes with This Interaction

Ru-Huei Fu, Syuan-Yu Hong, Chia-Wen Tsai, Shih-Ping Liu, Shao-Chih Chiu, Meng-Zhen Wu, Woei-Cherng Shyu, Shinn-Zong Lin

Cells. 2023 Mar; 12(6): 894. Published online 2023 Mar 14. doi: 10.3390/cells12060894

PMCID:: PMC10047488

Abstract Article PDF–20M

Select item 1004715417.

Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma

Jian Wu, Shengjun Fan, Daniel Feinberg, Xiaobei Wang, Shaima Jabbar, Yubin Kang

Curr Oncol. 2023 Mar; 30(3): 3047–3063. Published online 2023 Mar 4. doi: 10.3390/curroncol30030231

PMCID:: PMC10047154

Abstract Article PDF–5.1M

Select item 1002790118.

Structure-based design and characterization of Parkin-activating mutations

Michael U Stevens, Nathalie Croteau, Mohamed A Eldeeb, Odetta Antico, Zhi Wei Zeng, Rachel Toth, Thomas M Durcan, Wolfdieter Springer, Edward A Fon, Miratul MK Muqit, Jean-François Trempe

Life Sci Alliance. 2023 Jun; 6(6): e202201419. Published online 2023 Mar 20. doi: 10.26508/lsa.202201419

PMCID:: PMC10027901

Abstract Article PDF–2.8M

Select item 992702719.

Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter

Samuel A. Hasson, Adam I. Fogel, Chunxin Wang, Ryan MacArthur, Rajarshi Guha, Sabrina Heman-Ackah, Scott Martin, Richard J. Youle, James Inglese

ACS Chem Biol. Author manuscript; available in PMC 2023 Feb 14.

Published in final edited form as: ACS Chem Biol. 2015 May 15; 10(5): 1188–1197. Published online 2015 Feb 26. doi: 10.1021/cb5010417

PMCID:: PMC9927027

Abstract Article PDF–2.1M

Select item 991714520.

Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress

Tsung-Lang Chiu, Hsin-Yi Huang, Hui-Fen Chang, Hsin-Rong Wu, Mei-Jen Wang

Int J Mol Sci. 2023 Feb; 24(3): 2017. Published online 2023 Jan 19. doi: 10.3390/ijms24032017

PMCID:: PMC9917145

Abstract Article PDF–2.7M

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