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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 85710812.

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Jacqueline Georgy, Yvonne Arlt, Jens M. Moll, Meryem Ouzin, Hendrik T. Weitz, Lothar Gremer, Dieter Willbold, Joachim Grötzinger, Felix Thives-Kurenbach, Jürgen Scheller, Doreen M. Floss

J Biol Chem. 2021 Nov; 297(5): 101295. Published online 2021 Oct 9. doi: 10.1016/j.jbc.2021.101295

PMCID:: PMC8571081

Abstract Article PDF–3.2M

Select item 56802413.

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling

D. M. Floss, M. Schönberg, M. Franke, F. C. Horstmeier, E. Engelowski, A. Schneider, E. M. Rosenfeldt, J. Scheller

Sci Rep. 2017; 7: 15172. Published online 2017 Nov 9. doi: 10.1038/s41598-017-15173-3

PMCID:: PMC5680241

Abstract Article PDF–2.0M

Select item 52958214.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 42942305.

IL12Rβ1ΔTM Is a Secreted Product of il12rb1 That Promotes Control of Extrapulmonary Tuberculosis

Aurelie A. Ray, Jeffrey J. Fountain, Halli E. Miller, Andrea M. Cooper, Richard T. Robinson

Infect Immun. 2015 Feb; 83(2): 560–571. Prepublished online 2014 Nov 17. Published online 2015 Jan 14. doi: 10.1128/IAI.01230-13

PMCID:: PMC4294230

Abstract Article PDF–2.9M

Select item 40557796.

Toxoplasma gondii Profilin Promotes Recruitment of Ly6C^hi CCR2⁺ Inflammatory Monocytes That Can Confer Resistance to Bacterial Infection

Lori M. Neal, Laura J. Knoll

PLoS Pathog. 2014 Jun; 10(6): e1004203. Published online 2014 Jun 12. doi: 10.1371/journal.ppat.1004203

PMCID:: PMC4055779

Abstract Article PDF–976K

Select item 39649557.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 39564298.

Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis

Malabendu Jana, Susanta Mondal, Arundhati Jana, Kalipada Pahan

Immunology. 2014 Apr; 141(4): 549–563. Published online 2014 Mar 11. doi: 10.1111/imm.12214

PMCID:: PMC3956429

Abstract Article PDF–887K

Select item 39481109.

Distinct Pathways of Humoral and Cellular Immunity Induced with the Mucosal Administration of a Nanoemulsion Adjuvant

Anna U. Bielinska, Paul E. Makidon, Katarzyna W. Janczak, Luz P. Blanco, Benjamin Swanson, Douglas M. Smith, Tiffany Pham, Zsuzsanna Szabo, Jolanta F. Kukowska-Latallo, James R. Baker, Jr.

J Immunol. 2014 Mar 15; 192(6): 2722–2733. Published online 2014 Feb 14. doi: 10.4049/jimmunol.1301424

PMCID:: PMC3948110

Abstract Article PDF–1.2M

Select item 393165910.

The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation

Gaëlle Chognard, Lisa Bellemare, Adam-Nicolas Pelletier, Maria C. Dominguez-Punaro, Claudine Beauchamp, Marie-Josée Guyon, Guy Charron, Nicolas Morin, Durga Sivanesan, Vijay Kuchroo, Ramnik Xavier, Stephen W. Michnick, Sylvain Chemtob, John D. Rioux, Sylvie Lesage

PLoS One. 2014; 9(2): e89092. Published online 2014 Feb 21. doi: 10.1371/journal.pone.0089092

PMCID:: PMC3931659

Abstract Article PDF–2.3M

Select item 387205811.

Lung airway-surveilling CXCR3^hi memory CD8⁺ T cells are critical for protection against Influenza A virus

Bram Slütter, Lecia L. Pewe, Susan M. Kaech, John T. Harty

Immunity. Author manuscript; available in PMC 2014 Nov 14.

Published in final edited form as: Immunity. 2013 Nov 14; 39(5): 10.1016/j.immuni.2013.09.013. doi: 10.1016/j.immuni.2013.09.013

PMCID:: PMC3872058

Abstract Article PDF–2.9M

Select item 370764312.

Identification of Canonical Tyrosine-dependent and Non-canonical Tyrosine-independent STAT3 Activation Sites in the Intracellular Domain of the Interleukin 23 Receptor

Doreen M. Floss, Simone Mrotzek, Tobias Klöcker, Jutta Schröder, Joachim Grötzinger, Stefan Rose-John, Jürgen Scheller

J Biol Chem. 2013 Jul 5; 288(27): 19386–19400. Published online 2013 May 14. doi: 10.1074/jbc.M112.432153

PMCID:: PMC3707643

Abstract Article PDF–4.9M

Select item 363786413.

Dynamic regulatory network controlling Th17 cell differentiation

Nir Yosef, Alex K. Shalek, Jellert T. Gaublomme, Hulin Jin, Youjin Lee, Amit Awasthi, Chuan Wu, Katarzyna Karwacz, Sheng Xiao, Marsela Jorgolli, David Gennert, Rahul Satija, Arvind Shakya, Diana Y. Lu, John J. Trombetta, Meenu R. Pillai, Peter J. Ratcliffe, Mathew L. Coleman, Mark Bix, Dean Tantin, Hongkun Park, Vijay K. Kuchroo, Aviv Regev

Nature. Author manuscript; available in PMC 2013 Oct 25.

Published in final edited form as: Nature. 2013 Apr 25; 496(7446): 461–468. Published online 2013 Mar 6. doi: 10.1038/nature11981

PMCID:: PMC3637864

Abstract Article PDF–1.5M

Select item 357241014.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 355757415.

Pathogen-specific inflammatory milieux tune the antigen sensitivity of CD8⁺ T cells by enhancing T cell receptor signaling

Martin J. Richer, Jeffrey C. Nolz, John T. Harty

Immunity. Author manuscript; available in PMC 2014 Jan 24.

Published in final edited form as: Immunity. 2013 Jan 24; 38(1): 140–152. Published online 2012 Dec 20. doi: 10.1016/j.immuni.2012.09.017

PMCID:: PMC3557574

Abstract Article PDF–2.2M

Select item 352915116.

The composition and signaling of the IL-35 receptor are unconventional

Lauren W. Collison, Greg M. Delgoffe, Clifford S. Guy, Kate M. Vignali, Vandana Chaturvedi, DeLisa Fairweather, Abhay R. Satoskar, K. Christopher Garcia, Christopher A. Hunter, Charles G. Drake, Peter J. Murray, Dario A. A. Vignali

Nat Immunol. Author manuscript; available in PMC 2013 Mar 1.

Published in final edited form as: Nat Immunol. 2012 Feb 5; 13(3): 290–299. Published online 2012 Feb 5. doi: 10.1038/ni.2227