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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Article PDF–4.8M

Select item 108346162.

METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke

Wenjie Su, Xiang Yu, Shan Wang, Xu Wang, Zheng Dai, Yi Li

Cell Biol Toxicol. 2024; 40(1): 8. Published online 2024 Feb 2. doi: 10.1007/s10565-024-09844-x

PMCID:: PMC10834616

Article PDF–7.0M

Select item 106892033.

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

Bekir Altas, Hong-Jun Rhee, Anes Ju, Hugo Cruces Solís, Samir Karaca, Jan Winchenbach, Oykum Kaplan-Arabaci, Manuela Schwark, Mateusz C. Ambrozkiewicz, ChungKu Lee, Lena Spieth, Georg L. Wieser, Viduth K. Chaugule, Irina Majoul, Mohamed A. Hassan, Rashi Goel, Sonja M. Wojcik, Noriko Koganezawa, Kenji Hanamura, Daniela Rotin, Andrea Pichler, Miso Mitkovski, Livia de Hoz, Alexandros Poulopoulos, Henning Urlaub, Olaf Jahn, Gesine Saher, Nils Brose, JeongSeop Rhee, Hiroshi Kawabe

J Cell Biol. 2024 Jan 1; 223(1): e201902050. Published online 2023 Nov 30. doi: 10.1083/jcb.201902050

PMCID:: PMC10689203

Article PDF–6.2M

Select item 104787514.

Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension

Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A Mendiola Plá, Dawn E Bowles, Andreas M Beyer, Xinping Yue, Eric Lazartigues, Catalin M Filipeanu

Cardiovasc Res. 2023 Aug; 119(11): 2130–2141. Published online 2023 May 10. doi: 10.1093/cvr/cvad070

PMCID:: PMC10478751

Article PDF–1.4M

Select item 102852695.

Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

Xin Gu, Haoyu Meng, Chengyi Peng, Shiyu Lin, Baihong Li, Lin Zhao, Xue Yang, Guangyan Wang, Wenyuan Cai, Jiawen Zhou, Shuiyuan Liu, Peng Wu, Yingqiang Du, Jianliang Jin, Xiaoyan Wang

Clin Transl Med. 2023 Jun; 13(6): e1308. Published online 2023 Jun 21. doi: 10.1002/ctm2.1308

PMCID:: PMC10285269

Article PDF–20M

Select item 101577406.

A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis

Qian Guo, Mingyang Xin, Qingchun Lu, Dechun Feng, Vicky Yang, Lee F. Peng, Kelly A. Whelan, Wenhui Hu, Sheng Wu, Xiaofeng Yang, Hong Wang, Brad S. Rothberg, Ana M. Gamero, Glenn S. Gerhard, Bin Gao, Ling Yang

Theranostics. 2023; 13(7): 2210–2225. Published online 2023 Apr 9. doi: 10.7150/thno.81192

PMCID:: PMC10157740

Article PDF–10M

Select item 98368127.

Molecular Mechanism of Long Noncoding RNA SNHG14 in Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells through the NEDD4L/FOXA2/PCP4 Axis

Han Wang, Mingxing Fan, Yan An, Da He

Stem Cells Int. 2023; 2023: 7545635. Published online 2023 Jan 5. doi: 10.1155/2023/7545635

PMCID:: PMC9836812

Article PDF–3.3M

Select item 96388568.

E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2

Hui Li, Ning Wang, Yu Jiang, Haofei Wang, Zengfeng Xin, Huazhang An, Hao Pan, Wangqian Ma, Ting Zhang, Xiaojian Wang, Wenlong Lin

EMBO Rep. 2022 Nov; 23(11): e54603. Published online 2022 Sep 26. doi: 10.15252/embr.202254603

PMCID:: PMC9638856

Article PDF–4.2M

Select item 92719139.

Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures

Xiaoliang Liu, Lu Zhang, Hebo Zhang, Xiaoyan Liang, Bijun Zhang, Jianqiao Tu, Yanyan Zhao

Front Mol Neurosci. 2022; 15: 919718. Published online 2022 Jun 27. doi: 10.3389/fnmol.2022.919718

PMCID:: PMC9271913

Article PDF–5.6M

Select item 893044310.

E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress

Daphne E Lodes, Jiuhe Zhu, Nien-Pei Tsai

J Neurochem. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: J Neurochem. 2022 Mar; 160(6): 613–624. Published online 2021 Dec 29. doi: 10.1111/jnc.15567

PMCID:: PMC8930443

Article PDF–1.9M

Select item 890678311.

The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na_V1.7 via the Ubiquitin-Ligase NEDD4-2

Alexandru-Florian Deftu, Paul Chu Sin Chung, Cédric J. Laedermann, Ludovic Gillet, Marie Pertin, Guylène Kirschmann, Isabelle Decosterd

eNeuro. 2022 Mar-Apr; 9(2): ENEURO.0409-21.2022. Prepublished online 2022 Feb 7. Published online 2022 Mar 3. doi: 10.1523/ENEURO.0409-21.2022

PMCID:: PMC8906783

Article PDF–2.1M

Select item 871425412.

ROMK channels are inhibited in the aldosterone-sensitive distal nephron of renal tubule Nedd4-2-deficient mice

Dan-Dan Zhang, Jun-Ya Zheng, Xin-Peng Duan, Dao-Hong Lin, Wen-Hui Wang

Am J Physiol Renal Physiol. 2022 Jan 1; 322(1): F55–F67. Published online 2021 Nov 29. doi: 10.1152/ajprenal.00306.2021

PMCID:: PMC8714254

Article

Select item 849098813.

Infantile spasms‐linked Nedd4‐2 mediates hippocampal plasticity and learning via cofilin signaling

Kwan Young Lee, Jiuhe Zhu, Cathryn A Cutia, Catherine A Christian‐Hinman, Justin S Rhodes, Nien‐Pei Tsai

EMBO Rep. 2021 Oct 5; 22(10): e52645. Published online 2021 Aug 3. doi: 10.15252/embr.202152645

PMCID:: PMC8490988

Article PDF–2.3M

Select item 832180014.

Deletion of renal Nedd4-2 abolishes the effect of high K⁺ intake on Kir4.1/Kir5.1 and NCC activity in the distal convoluted tubule

Yu Xiao, Xin-Peng Duan, Dan-Dan Zhang, Wen-Hui Wang, Dao-Hong Lin

Am J Physiol Renal Physiol. 2021 Jul 1; 321(1): F1–F11. Published online 2021 May 24. doi: 10.1152/ajprenal.00072.2021

PMCID:: PMC8321800

Article

Select item 831323915.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Article PDF–1.6M

Select item 830611216.

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2

Theresa A. Engelmann, Lars Knudsen, Dominik H. W. Leitz, Julia Duerr, Michael F. Beers, Marcus A. Mall, Matthias Ochs

Int J Mol Sci. 2021 Jul; 22(14): 7607. Published online 2021 Jul 16. doi: 10.3390/ijms22147607

PMCID:: PMC8306112

Article PDF–4.3M

Select item 829860217.

14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil, Veronika Obsilova

Commun Biol. 2021; 4: 899. Published online 2021 Jul 22. doi: 10.1038/s42003-021-02419-0

PMCID:: PMC8298602

Article PDF–3.3M

Select item 820115518.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice

Dominik H. W. Leitz, Julia Duerr, Surafel Mulugeta, Ayça Seyhan Agircan, Stefan Zimmermann, Hiroshi Kawabe, Alexander H. Dalpke, Michael F. Beers, Marcus A. Mall

Int J Mol Sci. 2021 Jun; 22(11): 6146. Published online 2021 Jun 7. doi: 10.3390/ijms22116146

PMCID:: PMC8201155

Article PDF–2.3M

Select item 809735119.

E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation

Huan Liu, Wenlong Lin, Zhiyong Liu, Yinjing Song, Hao Cheng, Huazhang An, Xiaojian Wang

EMBO Rep. 2021 May 5; 22(5): e52063. Published online 2021 Mar 26. doi: 10.15252/embr.202052063

PMCID:: PMC8097351

Article PDF–3.1M

Select item 805472220.

Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage

TaeHee Kim, Anil K Chokkalla, Raghu Vemuganti

J Cereb Blood Flow Metab. 2021 May; 41(5): 1058–1066. Published online 2020 Jul 23. doi: 10.1177/0271678X20943804

PMCID:: PMC8054722

Article PDF–1.3M

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