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Select item 109455671.

Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function

Chao Chang, Sara L Banerjee, Sung Soon Park, Xiao Lei Zhang, David Cotnoir-White, Karla J Opperman, Muriel Desbois, Brock Grill, Artur Kania

eLife. 2024; 12: RP89176. Published online 2024 Jan 30. doi: 10.7554/eLife.89176

PMCID:: PMC10945567

Abstract Article PDF–3.7M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100807263.

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity

Daniel C. Scott, Moeko T. King, Kheewoong Baek, Clifford T. Gee, Ravi Kalathur, Jerry Li, Nicholas Purser, Amanda Nourse, Sergio C. Chai, Sivaraja Vaithiyalingam, Taosheng Chen, Richard E. Lee, Stephen J. Elledge, Gary Kleiger, Brenda A. Schulman

Mol Cell. Author manuscript; available in PMC 2024 Mar 2.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 770–786.e9. Published online 2023 Feb 16. doi: 10.1016/j.molcel.2023.01.019

PMCID:: PMC10080726

Abstract Article PDF–3.0M

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 95537915.

RNF186/EPHB2 Axis Is Essential in Regulating TNF Signaling for Colorectal Tumorigenesis in Colorectal Epithelial Cells

Huazhi Zhang, Zhihui Cui, Ting Pan, Huijun Hu, Ruirui He, Ming Yi, Wanwei Sun, Ru Gao, Heping Wang, Xiaojian Ma, Qianwen Peng, Xiong Feng, Shuyan Liang, Yanyun Du, Chenhui Wang

J Immunol. 2022 Nov 1; 209(9): 1796–1805. Published online 2022 Nov 1. doi: 10.4049/jimmunol.2200229

PMCID:: PMC9553791

Abstract Article PDF–1.7M

Select item 95521186.

Claudin-4 localization in epithelial ovarian cancer

Margaret C. Neville, Patricia G. Webb, Heidi K. Baumgartner, Benjamin G. Bitler

Heliyon. 2022 Oct; 8(10): e10862. Published online 2022 Oct 4. doi: 10.1016/j.heliyon.2022.e10862

PMCID:: PMC9552118

Abstract Article PDF–4.5M

Select item 92316237.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 91714118.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 85259249.

RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis

Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang

Autophagy. 2021; 17(10): 3030–3047. Published online 2020 Dec 17. doi: 10.1080/15548627.2020.1851496

PMCID:: PMC8525924

Abstract Article PDF–18M

Select item 829886810.

Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion

Tae Ho Lee, Jin Hyung Heo, Ju-Yeon Jeong, Gee Hoon Lee, Dong Soo Park, Tae Hoen Kim

Yonsei Med J. 2021 Aug 1; 62(8): 679–690. Published online 2021 Jul 19. doi: 10.3349/ymj.2021.62.8.679

PMCID:: PMC8298868

Abstract Article PDF–2.7M

Select item 821708811.

Loss of Ephrin B2 Receptor (EPHB2) Sets Lipid Rheostat by Regulating Proteins DGAT1 and ATGL Inducing Lipid Droplet Storage in Prostate Cancer Cells

Alejandro Morales, Max Greenberg, Francesca Nardi, Victoria Gil, Simon W. Hayward, Susan E. Crawford, Omar E. Franco

Lab Invest. Author manuscript; available in PMC 2021 Oct 6.

Published in final edited form as: Lab Invest. 2021 Jul; 101(7): 921–934. Published online 2021 Apr 6. doi: 10.1038/s41374-021-00583-9

PMCID:: PMC8217088

Abstract Article PDF–1.8M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 784472113.

miR-204 Regulates Cell Proliferation and Invasion by Targeting EphB2 in Human Cervical Cancer

Shanhong Duan, Ali Wu, Zhengyu Chen, Yarong Yang, Liying Liu, Qi Shu

Oncol Res. 2018; 26(5): 713–723. Published online 2018 Jun 11. doi: 10.3727/096504017X15016337254641

PMCID:: PMC7844721

Abstract Article PDF–7.2M

Select item 756688114.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 749636515.

EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands

Dianne Vreeken, Caroline Suzanne Bruikman, Stefan Martinus Leonardus Cox, Huayu Zhang, Reshma Lalai, Angela Koudijs, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Janine Maria van Gils

J Leukoc Biol. 2020 Sep; 108(3): 999–1011. Published online 2020 Apr 26. doi: 10.1002/JLB.2A0320-283RR

PMCID:: PMC7496365

Abstract Article PDF–6.4M

Select item 742732716.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 739233417.

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells

Seung W. Ryu, Rose Stewart, D. Chase Pectol, Nicolette A. Ender, Oshadi Wimalarathne, Ji-Hoon Lee, Carlos P. Zanini, Antony Harvey, Jon M. Huibregtse, Peter Mueller, Tanya T. Paull

PLoS Biol. 2020 Jul; 18(7): e3000606. Published online 2020 Jul 20. doi: 10.1371/journal.pbio.3000606

PMCID:: PMC7392334

Abstract Article PDF–2.7M

Select item 725603418.

Synergistic antifibrotic effects of miR-451 with miR-185 partly by co-targeting EphB2 on hepatic stellate cells

Xiaogang Chen, Dan Zhang, Yi Wang, Ke Chen, Limeng Zhao, Yating Xu, Hulin Jiang, Shuzhen Wang

Cell Death Dis. 2020 May; 11(5): 402. Published online 2020 May 28. doi: 10.1038/s41419-020-2613-y

PMCID:: PMC7256034

Abstract Article PDF–1.9M

Select item 721096619.

Dysregulation of the EphrinB2−EphB4 ratio in pediatric cerebral arteriovenous malformations is associated with endothelial cell dysfunction in vitro and functions as a novel noninvasive biomarker in patients

Katie Pricola Fehnel, David L. Penn, Micah Duggins-Warf, Maxwell Gruber, Steven Pineda, Julie Sesen, Alexander Moses-Gardner, Nishali Shah, Jessica Driscoll, David Zurakowski, Darren B. Orbach, Edward R. Smith

Exp Mol Med. 2020 Apr; 52(4): 658–671. Published online 2020 Apr 14. doi: 10.1038/s12276-020-0414-0

PMCID:: PMC7210966

Abstract Article PDF–2.0M

Select item 708603920.

The Shb scaffold binds the Nck adaptor protein, p120 RasGAP, and Chimaerins and thereby facilitates heterotypic cell segregation by the receptor EphB2

Melany J. Wagner, Marilyn S. Hsiung, Gerald D. Gish, Rick D. Bagshaw, Sasha A. Doodnauth, Mohamed A. Soliman, Claus Jørgensen, Monika Tucholska, Robert Rottapel

J Biol Chem. 2020 Mar 20; 295(12): 3932–3944. Published online 2020 Feb 14. doi: 10.1074/jbc.RA119.009276

PMCID:: PMC7086039

Abstract Article PDF–5.0M

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