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Select item 110079371.

Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus

Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller

BMC Genomics. 2024; 25: 360. Published online 2024 Apr 11. doi: 10.1186/s12864-024-10282-6

PMCID:: PMC11007937

Abstract Article PDF–8.6M

Select item 109502822.

CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells

Shufeng Liu, Xiaoguang Chen, Liqi Zhang, Bo Lu

Cancer Biol Ther. 2024; 25(1): 2329372. Published online 2024 Mar 17. doi: 10.1080/15384047.2024.2329372

PMCID:: PMC10950282

Abstract Article PDF–18M

Select item 103959143.

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

Dong Han, Wei Wang, Julie Heejin Jeon, Tao Shen, Xiangsheng Huang, Ping Yi, Bingning Dong, Feng Yang

PLoS Biol. 2023 Aug; 21(8): e3002227. Published online 2023 Aug 2. doi: 10.1371/journal.pbio.3002227

PMCID:: PMC10395914

Abstract Article PDF–4.5M

Select item 103675554.

SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1

Li You, Yi Dou, Yu Zhang, Hongwei Xiao, Hong Lv, Gong-Hong Wei, Dazhi Xu

Int J Biol Sci. 2023; 19(11): 3483–3498. Published online 2023 Jul 9. doi: 10.7150/ijbs.84331

PMCID:: PMC10367555

Abstract Article PDF–10M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 92792857.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91620218.

Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression

Fei Jiang, Xueju Hu, Hongyong Cao, Xiaobing Shen

Bioengineered. 2022; 13(4): 8277–8290. Published online 2022 Mar 18. doi: 10.1080/21655979.2022.2053796

PMCID:: PMC9162021

Abstract Article PDF–2.0M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 878241710.

A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee

PLoS One. 2022; 17(1): e0261696. Published online 2022 Jan 21. doi: 10.1371/journal.pone.0261696

Correction in:: PLoS One. 2024; 19(5): e0304731.

PMCID:: PMC8782417

Abstract Article PDF–2.0M

Select item 859986411.

TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway

Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing

Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1

PMCID:: PMC8599864

Abstract Article PDF–5.8M

Select item 849670612.

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3

Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou

Autophagy. 2021; 17(9): 2166–2183. Published online 2020 Sep 10. doi: 10.1080/15548627.2020.1817279

PMCID:: PMC8496706

Abstract Article PDF–10M

Select item 845620113.

Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei

Adv Sci (Weinh) 2021 Sep; 8(18): 2004303. Published online 2021 Jul 18. doi: 10.1002/advs.202004303

PMCID:: PMC8456201

Abstract Article PDF–3.1M

Select item 842541214.

SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells

Yujie Ren, An Wang, Yuan Fang, Ting Shu, Di Wu, Chong Wang, Muhan Huang, Juan Min, Liang Jin, Wei Zhou, Yang Qiu, Xi Zhou

Front Cell Infect Microbiol. 2021; 11: 706252. Published online 2021 Aug 25. doi: 10.3389/fcimb.2021.706252

PMCID:: PMC8425412

Abstract Article PDF–3.4M

Select item 838661515.

Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway

Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou

Autophagy. 2020; 16(9): 1697–1710. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704118

PMCID:: PMC8386615

Abstract Article PDF–3.6M

Select item 835296416.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 834046117.

SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions

Qiwei Jiang, Nana Zheng, Lang Bu, Xiaomei Zhang, Xiaoling Zhang, Yuanzhong Wu, Yaqing Su, Lei Wang, Xiaomin Zhang, Shancheng Ren, Xiangpeng Dai, Depei Wu, Wei Xie, Wenyi Wei, Yasheng Zhu, Jianping Guo

Mol Cancer. 2021; 20: 100. Published online 2021 Aug 5. doi: 10.1186/s12943-021-01397-5

PMCID:: PMC8340461

Abstract Article PDF–3.2M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808779819.

POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway

Rui Yang, Mei Wang, Guanghui Zhang, Yanping Li, Lulin Wang, Hongjuan Cui

Cell Death Dis. 2021 May; 12(5): 433. Published online 2021 Apr 30. doi: 10.1038/s41419-021-03719-3

PMCID:: PMC8087798

Abstract Article PDF–3.5M

Select item 787119620.

Impact of WIN site inhibitor on the WDR5 interactome

Alissa D. Guarnaccia, Kristie L. Rose, Jing Wang, Bin Zhao, Tessa M. Popay, Christina E. Wang, Kiana Guerrazzi, Salisha Hill, Chase M. Woodley, Tyler J. Hansen, Shelly L. Lorey, J. Grace Shaw, William G. Payne, April M. Weissmiller, Edward T. Olejniczak, Stephen W. Fesik, Qi Liu, William P. Tansey

Cell Rep. Author manuscript; available in PMC 2021 Feb 9.

Published in final edited form as: Cell Rep. 2021 Jan 19; 34(3): 108636. doi: 10.1016/j.celrep.2020.108636

PMCID:: PMC7871196

Abstract Article PDF–3.3M

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