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Select item 106763141.

KAT6A mutations in Arboleda-Tham syndrome drive epigenetic regulation of posterior HOXC cluster

Meghna Singh, Sarah J. Spendlove, Angela Wei, Leroy M. Bondhus, Aileen A. Nava, Francisca N. de L. Vitorino, Seth Amano, Jacob Lee, Gesenia Echeverria, Dianne Gomez, Benjamin A. Garcia, Valerie A. Arboleda

Hum Genet. 2023; 142(12): 1705–1720. Published online 2023 Oct 20. doi: 10.1007/s00439-023-02608-3

PMCID:: PMC10676314

Abstract Article PDF–4.2M

Select item 99088892.

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain

Dustin C. Becht, Brianna J. Klein, Akinori Kanai, Suk Min Jang, Khan L. Cox, Bing-Rui Zhou, Sabrina K. Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C. Ebmeier, Catherine Lachance, Maxime Galloy, Amelie Fradet-Turcotte, Martha L. Bulyk, Yawen Bai, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze

Nat Commun. 2023; 14: 697. Published online 2023 Feb 8. doi: 10.1038/s41467-023-36368-5

PMCID:: PMC9908889

Abstract Article PDF–12M

Select item 98811363.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 95403454.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 92966765.

Matrix stiffness-induced upregulation of histone acetyltransferase KAT6A promotes hepatocellular carcinoma progression through regulating SOX2 expression

Wei Zhao, Huanye Mo, Runkun Liu, Tianxiang Chen, Nan Yang, Zhikui Liu

Br J Cancer. 2022 Jul 20; 127(2): 202–210. Published online 2022 Mar 24. doi: 10.1038/s41416-022-01784-9

PMCID:: PMC9296676

Abstract Article PDF–2.9M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91197367.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 89160378.

KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs

Fangxue Yan, Jinyang Li, Jelena Milosevic, Ricardo Petroni, Suying Liu, Zhennan Shi, Salina Yuan, Janice M. Reynaga, Yuwei Qi, Joshua Rico, Sixiang Yu, Yiman Liu, Susumu Rokudai, Neil Palmisiano, Sara E. Meyer, Pamela J Sung, Liling Wan, Fei Lan, Benjamin A. Garcia, Ben Z. Stanger, David B. Sykes, M. Andrés Blanco

Cancer Discov. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Cancer Discov. 2022 Mar 1; 12(3): 792–811. doi: 10.1158/2159-8290.CD-20-1459

PMCID:: PMC8916037

Abstract Article PDF–2.6M

Select item 85294949.

KAT6A Acetylation of SMAD3 Regulates Myeloid‐Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple‐Negative Breast Cancer

Bo Yu, Fei Luo, Bowen Sun, Wenxue Liu, Qiqi Shi, Shi‐Yuan Cheng, Ceshi Chen, Guoqiang Chen, Yanxin Li, Haizhong Feng

Adv Sci (Weinh) 2021 Oct; 8(20): 2100014. Published online 2021 Aug 13. doi: 10.1002/advs.202100014

Correction in:: Adv Sci (Weinh). 2022 Jan; 9(3): 2105793.

PMCID:: PMC8529494

Abstract Article PDF–4.5M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812022711.

KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1

Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng

Theranostics. 2021; 11(13): 6278–6292. Published online 2021 Apr 15. doi: 10.7150/thno.57455

PMCID:: PMC8120227

Abstract Article PDF–2.7M

Select item 770266212.

Acute Monoblastic Leukemia with Erythrophagocytosis and Absence of KAT6A Rearrangement

Carlos De Miguel Sánchez, Diego Robles de Castro, Ana Vega González de Viñaspre, Ariane Unamunzaga Zilaurren, Arantza Mendizábal Abad, José María Guinea de Castro

Turk J Haematol. 2020 Dec; 37(4): 282–283. Published online 2020 Nov 19. doi: 10.4274/tjh.galenos.2020.2020.0237

PMCID:: PMC7702662

Article PDF–243K

Select item 746727713.

KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma

Ozlen Saglam, Zhenya Tang, Guilin Tang, L. Jeffrey Medeiros, Gokce A. Toruner

PLoS One. 2020; 15(9): e0238477. Published online 2020 Sep 2. doi: 10.1371/journal.pone.0238477

PMCID:: PMC7467277

Abstract Article PDF–2.8M

Select item 701127414.

Five new cases of syndromic intellectual disability due to KAT6A mutations: widening the molecular and clinical spectrum

Roser Urreizti, Estrella Lopez-Martin, Antonio Martinez-Monseny, Montse Pujadas, Laura Castilla-Vallmanya, Luis Alberto Pérez-Jurado, Mercedes Serrano, Daniel Natera-de Benito, Beatriz Martínez-Delgado, Manuel Posada-de-la-Paz, Javier Alonso, Purificación Marin-Reina, Mar O’Callaghan, Daniel Grinberg, Eva Bermejo-Sánchez, Susanna Balcells

Orphanet J Rare Dis. 2020; 15: 44. Published online 2020 Feb 10. doi: 10.1186/s13023-020-1317-9

PMCID:: PMC7011274

Abstract Article PDF–1.9M

Select item 694204415.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 663431016.

KAT6A Syndrome: Genotype-phenotype correlation in 76 patients with pathogenic KAT6A variants

Joanna Kennedy, David Goudie, Edward Blair, Kate Chandler, Shelagh Joss, Victoria McKay, Andrew Green, Ruth Armstrong, Melissa Lees, Benjamin Kamien, Bruce Hopper, Tiong Yang Tan, Patrick Yap, Zornitza Stark, Nobuhiko Okamoto, Noriko Miyake, Naomichi Matsumoto, Ellen Macnamara, Jennifer L. Murphy, Elizabeth McCormick, Hakon Hakonarson, Marni J. Falk, Dong Li, Patrick Blackburn, Eric Klee, Dusica Babovic-Vuksanovic, Susan Schelley, Louanne Hudgins, Sarina Kant, Bertrand Isidor, Benjamin Cogne, Kimberley Bradbury, Mark Williams, Chirag Patel, Helen Heussler, Celia Duff-Farrier, Phillis Lakeman, Ingrid Scurr, Usha Kini, Mariet Elting, Margot Reijnders, Janneke Schuurs-Hoeijmakers, Mohamed Wafik, Anne Blomhoff, Claudia A.L. Ruivenkamp, Esther Nibbeling, Alexander J.M. Dingemans, Emilie D. Douine, Stanley F. Nelson, The DDD Study, Valerie A. Arboleda, Ruth Newbury-Ecob

Genet Med. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Genet Med. 2019 Apr; 21(4): 850–860. Published online 2018 Sep 24. doi: 10.1038/s41436-018-0259-2

Correction in:: Genet Med. 2020 Aug 19

PMCID:: PMC6634310

Abstract Article PDF–801K

Select item 648643517.

NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma

Jianming Pei, Harry Cooper, Douglas B. Flieder, Jacqueline N. Talarchek, Tahseen Al-Saleem, Robert G. Uzzo, Essel Dulaimi, Arthur S. Patchefsky, Joseph R. Testa, Shuanzeng Wei

Mod Pathol. Author manuscript; available in PMC 2019 Jul 8.

Published in final edited form as: Mod Pathol. 2019 May; 32(5): 710–716. Published online 2019 Jan 8. doi: 10.1038/s41379-018-0191-7

PMCID:: PMC6486435

Abstract Article PDF–860K

Select item 616668218.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 582692619.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 569080920.

Histone acetyltransferase KAT6A upregulates PI3K/AKT signaling through TRIM24 binding

Deguan Lv, Feng Jia, Yanli Hou, Youzhou Sang, Angel A. Alvarez, Weiwei Zhang, Wei-Qiang Gao, Bo Hu, Shi-Yuan Cheng, Jianwei Ge, Yanxin Li, Haizhong Feng

Cancer Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Cancer Res. 2017 Nov 15; 77(22): 6190–6201. Published online 2017 Oct 11. doi: 10.1158/0008-5472.CAN-17-1388

PMCID:: PMC5690809

Abstract Article PDF–4.3M

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