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Select item 107998621.

DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1

Siyu Chen, Wenxiang Zhang, Xiao Li, Zhengyu Cao, Chang Liu

Cell Death Dis. 2024 Jan; 15(1): 78. Published online 2024 Jan 20. doi: 10.1038/s41419-024-06462-7

PMCID:: PMC10799862

Abstract Article PDF–4.4M

Select item 102536262.

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates

Artemiy S. Bakman, Stanislav S. Boichenko, Aleksandra A. Kuznetsova, Alexander A. Ishchenko, Murat Saparbaev, Nikita A. Kuznetsov

Int J Mol Sci. 2023 Jun; 24(11): 9594. Published online 2023 May 31. doi: 10.3390/ijms24119594

PMCID:: PMC10253626

Abstract Article PDF–2.4M

Select item 101770363.

The Activity of Natural Polymorphic Variants of Human DNA Polymerase β Having an Amino Acid Substitution in the Transferase Domain

Olga A. Kladova, Timofey E. Tyugashev, Elena S. Mikushina, Nikita A. Kuznetsov, Daria S. Novopashina, Aleksandra A. Kuznetsova

Cells. 2023 May; 12(9): 1300. Published online 2023 May 2. doi: 10.3390/cells12091300

PMCID:: PMC10177036

Abstract Article PDF–5.9M

Select item 100512654.

Human Polβ Natural Polymorphic Variants G118V and R149I Affects Substate Binding and Catalysis

Olga A. Kladova, Timofey E. Tyugashev, Elena S. Mikushina, Nikita O. Soloviev, Nikita A. Kuznetsov, Daria S. Novopashina, Aleksandra A. Kuznetsova

Int J Mol Sci. 2023 Mar; 24(6): 5892. Published online 2023 Mar 20. doi: 10.3390/ijms24065892

PMCID:: PMC10051265

Abstract Article PDF–4.5M

Select item 99786355.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 98841446.

Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair

Pawlos S. Tsegay, Daniela Hernandez, Christopher Brache, Chryssostomos Chatgilialoglu, Marios G. Krokidis, Prem Chapagain, Yuan Liu

DNA Repair (Amst) Author manuscript; available in PMC 2023 Jan 28.

Published in final edited form as: DNA Repair (Amst). 2022 Jan; 109: 103258. Published online 2021 Nov 24. doi: 10.1016/j.dnarep.2021.103258

PMCID:: PMC9884144

Abstract Article PDF–2.5M

Select item 98239257.

Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response

Shengyuan Zhao, Julia A. Goewey Ruiz, Manu Sebastian, Dawit Kidane

Front Immunol. 2022; 13: 1039009. Published online 2022 Dec 23. doi: 10.3389/fimmu.2022.1039009

PMCID:: PMC9823925

Abstract Article PDF–12M

Select item 94917138.

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li

Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831

PMCID:: PMC9491713

Abstract Article PDF–12M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 893049111.

Polymorphic mutations in the polb gene promoter and their impact on transcriptional activity

Qingjun Wu, Yuying Qi, Shuanghu Wang, Jian Liu, Peiwu Geng, Quan Zhou, Wenqian Zhang, Jianping Cai, Bin Hu, Dapeng Dai, Hui Li

Thorac Cancer. 2022 Mar; 13(6): 853–857. Published online 2022 Feb 6. doi: 10.1111/1759-7714.14337

PMCID:: PMC8930491

Abstract Article PDF–913K

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 795771413.

Silencing DNA Polymerase β Induces Aneuploidy as a Biomarker of Poor Prognosis in Oral Squamous Cell Cancer

Hui-Ching Wang, Leong-Perng Chan, Chun-Chieh Wu, Shu-Jyuan Chang, Sin-Hua Moi, Chi-Wen Luo, Mei-Ren Pan

Int J Mol Sci. 2021 Mar; 22(5): 2402. Published online 2021 Feb 27. doi: 10.3390/ijms22052402

PMCID:: PMC7957714

Abstract Article PDF–1.4M

Select item 791916214.

Two polymorphic mutations in promoter region of DNA polymerase β in relatively higher percentage of thymic hyperplasia patients

Qingjun Wu, Shan Zhou, Jian Liu, Hongfeng Tong, Yaoguang Sun, Wenxin Tian, Hanbo Yu, Chuan Huang, Donghang Li, Peng Jiao, Chao Ma, Jianping Cai, Dapeng Dai

Thorac Cancer. 2021 Mar; 12(5): 588–592. Published online 2020 Dec 13. doi: 10.1111/1759-7714.13773

PMCID:: PMC7919162

Abstract Article PDF–384K

Select item 778255315.

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia

Hu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu, Zhi-Xiao Fang, Jin Jin, Bo Jing, Xin-Hua Xiao, Shen-Meng Gao, Feng-Hou Gao, Li Xia, Li Yang, Li-Gen Liu, Wei-Wei Wang, Chuan-Xu Liu, Yin Tong, Yun-Zhao Wu, Jun-Ke Zheng, Guo-Qiang Chen, Li Zhou, Ying-Li Wu

Nat Commun. 2021; 12: 51. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20259-0

PMCID:: PMC7782553

Abstract Article PDF–5.4M

Select item 766963916.

Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications

Melike Çağlayan

DNA Repair (Amst) Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: DNA Repair (Amst). 2020 Nov; 95: 102945. Published online 2020 Aug 14. doi: 10.1016/j.dnarep.2020.102945

PMCID:: PMC7669639

Abstract Article PDF–2.2M

Select item 764381117.

DNA Polymerase β: Closing the Gap between Structure and Function

William A. Beard

DNA Repair (Amst) Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102910. doi: 10.1016/j.dnarep.2020.102910

PMCID:: PMC7643811

Abstract Article PDF–1.2M

Select item 758673718.

History of DNA polymerase β X-ray crystallography

Amy M. Whitaker, Bret D. Freudenthal

DNA Repair (Amst) Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: DNA Repair (Amst). 2020 Sep; 93: 102928. doi: 10.1016/j.dnarep.2020.102928

PMCID:: PMC7586737

Abstract Article PDF–1.7M

Select item 752655119.

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna

JCI Insight. 2020 Sep 17; 5(18): e138117. Published online 2020 Sep 17. doi: 10.1172/jci.insight.138117

PMCID:: PMC7526551

Abstract Article PDF–9.1M

Select item 744349820.

Lysines in the lyase active site of DNA polymerase β destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition

Michael J. Howard, Julie K. Horton, Ming-Lang Zhao, Samuel H. Wilson

J Biol Chem. 2020 Aug 21; 295(34): 12181–12187. Published online 2020 Jul 9. doi: 10.1074/jbc.RA120.013547

PMCID:: PMC7443498

Abstract Article PDF–1.7M

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