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Items: 1 to 20 of 229

1.
The E3 ligase SMURF1 stabilizes p27 via UbcH7 catalyzed K29-linked ubiquitin chains to promote cell migration SMURF1-UbcH7 K29 ubiquitination of p27 and cell migration
Jasper Weinberg, Elizabeth Whitcomb, Andrew Bohm, Uday Kumar Chekkilla, Allen Taylor
J Biol Chem. 2024 Mar; 300(3): 105693. Published online 2024 Feb 1. doi: 10.1016/j.jbc.2024.105693
PMCID:
PMC10897894
AbstractArticlePDF–3.0M
2.
The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer
Mohamed I. Khalil, Canchai Yang, Lexi Vu, Smriti Chadha, Harrison Nabors, Claire D. James, Iain M. Morgan, Dohun Pyeon
J Virol. 2024 Feb; 98(2): e01726-23. Published online 2024 Jan 16. doi: 10.1128/jvi.01726-23
PMCID:
PMC10878100
AbstractArticlePDF–3.0M
3.
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett
Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4
PMCID:
PMC10869800
AbstractArticlePDF–9.3M
4.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
5.
A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma
Xianli Du, Jing Pang, Bin Gu, Tian Si, Yan Chang, Tianqi Li, Min Wu, Zicheng Wang, Yuxia Wang, Jiannan Feng, Ning Wu, Jianghong Man, Huiyan Li, Ailing Li, Tong Zhang, Bo Wang, Xiaotao Duan
Nucleic Acids Res. 2023 Feb 22; 51(3): 1050–1066. Published online 2023 Jan 20. doi: 10.1093/nar/gkad002
PMCID:
PMC9943648
AbstractArticlePDF–5.3M
6.
Recognition of the CCT5 di‐Glu degron by CRL4DCAF12 is dependent on TRiC assembly
Carlos Pla‐Prats, Simone Cavadini, Georg Kempf, Nicolas H Thomä
EMBO J. 2023 Feb; 42(4): e112253. Published online 2023 Jan 30. doi: 10.15252/embj.2022112253
PMCID:
PMC9929631
AbstractArticlePDF–4.3M
7.
Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor
Seung Un Seo, Seon Min Woo, Min Wook Kim, Eun-Woo Lee, Kyoung-jin Min, Taeg Kyu Kwon
Cell Death Differ. 2023 Jan; 30(1): 82–93. Published online 2022 Aug 4. doi: 10.1038/s41418-022-01047-3
PMCID:
PMC9883261
AbstractArticlePDF–4.6M
8.
Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
Ryota Hayashida, Reika Kikuchi, Kenichiro Imai, Waka Kojima, Tatsuya Yamada, Miho Iijima, Hiromi Sesaki, Keiji Tanaka, Noriyuki Matsuda, Koji Yamano
J Biol Chem. 2023 Feb; 299(2): 102822. Published online 2022 Dec 21. doi: 10.1016/j.jbc.2022.102822
PMCID:
PMC9860496
AbstractArticlePDF–6.6M
9.
Structural basis for ubiquitylation by HOIL-1
Qilong Wu, Marios G. Koliopoulos, Katrin Rittinger, Benjamin Stieglitz
Front Mol Biosci. 2022; 9: 1098144. Published online 2023 Jan 6. doi: 10.3389/fmolb.2022.1098144
PMCID:
PMC9853177
AbstractArticlePDF–2.0M
10.
Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies
Shady I. Tantawy, Aloke Sarkar, Stefan Hubner, Zhi Tan, William G. Wierda, Abdelraouf Eldeib, Shuxing Zhang, Steven Kornblau, Varsha Gandhi
Clin Cancer Res. Author manuscript; available in PMC 2023 Jul 17.
Published in final edited form as: Clin Cancer Res. 2023 Jan 17; 29(2): 446–457. doi: 10.1158/1078-0432.CCR-22-2088
PMCID:
PMC9852224
AbstractArticlePDF–2.1M
11.
The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
Nat Commun. 2023; 14: 168. Published online 2023 Jan 11. doi: 10.1038/s41467-023-35871-z
PMCID:
PMC9834252
AbstractArticlePDF–4.2M
12.
LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF‐κB to the nucleus
Zhixiao Wu, Lena A Berlemann, Verian Bader, Dominik A Sehr, Eva Dawin, Alberto Covallero, Jens Meschede, Lena Angersbach, Cathrin Showkat, Jonas B Michaelis, Christian Münch, Bettina Rieger, Dmitry Namgaladze, Maria Georgina Herrera, Fabienne C Fiesel, Wolfdieter Springer, Marta Mendes, Jennifer Stepien, Katalin Barkovits, Katrin Marcus, Albert Sickmann, Gunnar Dittmar, Karin B Busch, Dietmar Riedel, Marisa Brini, Jörg Tatzelt, Tito Cali, Konstanze F Winklhofer
EMBO J. 2022 Dec; 41(24): e112006. Published online 2022 Nov 18. doi: 10.15252/embj.2022112006
PMCID:
PMC9753471
AbstractArticlePDF–4.3M
13.
HOIP modulates the stability of GPx4 by linear ubiquitination
Kangyun Dong, Ran Wei, Taijie Jin, Mengmeng Zhang, Jiali Shen, Huaijiang Xiang, Bing Shan, Junying Yuan, Ying Li
Proc Natl Acad Sci U S A. 2022 Nov 1; 119(44): e2214227119. Published online 2022 Oct 24. doi: 10.1073/pnas.2214227119
PMCID:
PMC9636971
AbstractArticlePDF–2.3M
14.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
15.
Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function
Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner
Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1
PMCID:
PMC9481602
AbstractArticlePDF–3.7M
16.
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain
Katherine H Reiter, Alex Zelter, Maria K Janowska, Michael Riffle, Nicholas Shulman, Brendan X. MacLean, Kaipo Tamura, Matthew C Chambers, Michael J MacCoss, Trisha N Davis, Miklos Guttman, Peter S Brzovic, Rachel E Klevit
Structure. Author manuscript; available in PMC 2023 Sep 1.
Published in final edited form as: Structure. 2022 Sep 1; 30(9): 1269–1284.e6. Published online 2022 Jun 17. doi: 10.1016/j.str.2022.05.017
PMCID:
PMC9444911
AbstractArticlePDF–3.2M
17.
Elevated intracellular Na+ and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2
Avinash Persaud, Chong Jiang, Zetao Liu, George Kefalas, Wael L. Demian, Daniela Rotin
Proc Natl Acad Sci U S A. 2022 Jul 26; 119(30): e2122495119. Published online 2022 Jul 18. doi: 10.1073/pnas.2122495119
PMCID:
PMC9335340
AbstractArticlePDF–2.1M
18.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
19.
Structural basis for feedforward control in the PINK1/Parkin pathway
Véronique Sauvé, George Sung, Emma J MacDougall, Guennadi Kozlov, Anshu Saran, Rayan Fakih, Edward A Fon, Kalle Gehring
EMBO J. 2022 Jun; 41(12): e109460. Published online 2022 May 2. doi: 10.15252/embj.2021109460
PMCID:
PMC9194792
AbstractArticlePDF–1.8M
20.
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration
Mila Daoud, Pia Nora Broxtermann, Fabian Schorn, J Paul Werthenbach, Jens Michael Seeger, Lars M Schiffmann, Kerstin Brinkmann, Domagoj Vucic, Thomas Tüting, Cornelia Mauch, Dagmar Kulms, Paola Zigrino, Hamid Kashkar
EMBO Rep. 2022 Jun; 23(6): e53608. Published online 2022 Apr 19. doi: 10.15252/embr.202153608
PMCID:
PMC9171690
AbstractArticlePDF–2.1M

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