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Select item 110308891.

Characterization of human CD4 helper T cell responses against Aurora kinase A

Hiroya Kobayashi, Makoto Azumi, Satoshi Hayashi, Keisuke Sato, Naoko Aoki, Shoji Kimura, Hidehiro Kakizaki, Toshihiro Nagato, Yasuaki Harabuchi, Masatoshi Tateno, Esteban Celis

Cancer Immunol Immunother. 2010 Jul; 59(7): 1029–1039. Published online 2010 Feb 25. doi: 10.1007/s00262-010-0826-0

PMCID:: PMC11030889

Abstract Article PDF–571K

Select item 110229382.

Biotransformation Pathways and Metabolite Profiles of Oral [¹⁴C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors

Sandeepraj Pusalkar, Xiaofei Zhou, Yuexian Li, Lawrence Cohen, Jun Johnny Yang, Suresh K. Balani, Cindy Xia, Wen Chyi Shyu, Chuang Lu, Karthik Venkatakrishnan, Swapan K. Chowdhury

Drug Metab Dispos. 2020 Mar; 48(3): 217–229. Published online 2020 Mar. doi: 10.1124/dmd.119.087338

PMCID:: PMC11022938

Abstract Article PDF–802K

Select item 109608343.

AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis

Bing Deng, Fang Liu, Nana Chen, Xinhao Li, Jie Lei, Ning Chen, Jingjing Wu, Xuan Wang, Jie Lu, Mouxiang Fang, Ailin Chen, Zijian Zhang, Bin He, Min Yan, Yuchen Zhang, Zifeng Wang, Quentin Liu

Cell Death Dis. 2024 Mar; 15(3): 233. Published online 2024 Mar 23. doi: 10.1038/s41419-024-06577-x

PMCID:: PMC10960834

Abstract Article PDF–6.4M

Select item 108698004.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

Christopher B. Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J. Atkinson, Alexander P. Sobinoff, Christopher G. Tomlinson, Anton Hsu, Robert Lu, Eloise Dray, Michelle Haber, Jamie I. Fletcher, Anthony J. Cesare, Rashmi S. Hegde, Hilda A. Pickett

Nat Commun. 2024; 15: 1385. Published online 2024 Feb 15. doi: 10.1038/s41467-024-45683-4

PMCID:: PMC10869800

Abstract Article PDF–9.3M

Select item 108252075.

AURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis

Huimou Chen, Jing Hu, Xilin Xiong, Hongling Chen, Biaojun Lin, Yusong Chen, Yang Li, Di Cheng, Zhihua Li

Cell Death Dis. 2024 Jan; 15(1): 99. Published online 2024 Jan 29. doi: 10.1038/s41419-024-06485-0

PMCID:: PMC10825207

Abstract Article PDF–6.1M

Select item 106030486.

Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex

Pinar Altiner, Süleyman Selim Çınaroğlu, Ahmet Can Timucin, Emel Timucin

Sci Rep. 2023; 13: 18399. Published online 2023 Oct 26. doi: 10.1038/s41598-023-45272-3

PMCID:: PMC10603048

Abstract Article PDF–6.3M

Select item 104742977.

CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly

Susana Eibes, Girish Rajendraprasad, Claudia Guasch-Boldu, Mirela Kubat, Yulia Steblyanko, Marin Barisic

Nat Commun. 2023; 14: 5317. Published online 2023 Sep 1. doi: 10.1038/s41467-023-41091-2

PMCID:: PMC10474297

Abstract Article PDF–6.3M

Select item 103579868.

Functional Significance of Aurora Kinase A Regulatory Interactions with p53–ERα Complex in Human Breast Cancer Cells

Hiroshi Katayama, Subrata Sen

Horm Cancer. 2011 Apr; 2(2): 117–124. Published online 2011 Mar 4. doi: 10.1007/s12672-011-0070-x

PMCID:: PMC10357986

Abstract Article PDF–371K

Select item 103539409.

E2F1-mediated KDM4A-AS1 up-regulation promotes EMT of hepatocellular carcinoma cells by recruiting ILF3 to stabilize AURKA mRNA

Hao-Ming Shen, Di Zhang, Ping Xiao, Bin Qu, Yi-Fan Sun

Cancer Gene Ther. 2023; 30(7): 1007–1017. Published online 2023 Mar 27. doi: 10.1038/s41417-023-00607-0

PMCID:: PMC10353940

Abstract Article PDF–5.9M

Select item 1032852210.

Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

Roberta Cacioppo, Hesna Begum Akman, Taner Tuncer, Ayse Elif Erson-Bensan, Catherine Lindon

eLife. 2023; 12: RP87253. Published online 2023 Jun 29. doi: 10.7554/eLife.87253

PMCID:: PMC10328522

Abstract Article PDF–5.1M

Select item 1023742211.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1014593312.

Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression

Xiaobo Wang, Jing Huang, Fenglin Liu, Qian Yu, Ruina Wang, Jiaqi Wang, Zewen Zhu, Juan Yu, Jun Hou, Joong Sup Shim, Wei Jiang, Zengxia Li, Yuanyuan Zhang, Yongjun Dang

J Clin Invest. 2023 May 1; 133(9): e161929. Published online 2023 May 1. doi: 10.1172/JCI161929

PMCID:: PMC10145933

Abstract Article PDF–1.6M

Select item 1013137213.

STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer

Jingxian Li, Yuanjiong Qi, Bo Li, Yan Liu, Kuo Yang, Zhihong Zhang, Jianqiang Zhu, E. Du

J Transl Med. 2023; 21: 281. Published online 2023 Apr 26. doi: 10.1186/s12967-023-04118-2

PMCID:: PMC10131372

Abstract Article PDF–4.9M

Select item 1007290614.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1005368715.

The promotion action of AURKA on post-ischemic angiogenesis in diabetes-related limb ischemia

Tao Bai, Mingxing Li, Yuanfeng Liu, Zhentao Qiao, Xusheng Zhang, Yafeng Wang, Zhiwei Wang

Mol Med. 2023; 29: 39. Published online 2023 Mar 28. doi: 10.1186/s10020-023-00635-4

PMCID:: PMC10053687

Abstract Article PDF–16M

Select item 995044716.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 993616217.

AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation

Italia Anna Asteriti, Federica Polverino, Venturina Stagni, Valentina Sterbini, Camilla Ascanelli, Francesco Davide Naso, Anna Mastrangelo, Alessandro Rosa, Alessandro Paiardini, Catherine Lindon, Giulia Guarguaglini

Life Sci Alliance. 2023 May; 6(5): e202201726. Published online 2023 Feb 16. doi: 10.26508/lsa.202201726

PMCID:: PMC9936162

Abstract Article PDF–2.6M

Select item 992372618.

Protein Kinase D2 Modulates Cell Cycle by Stabilizing Aurora A Kinase at Centrosomes

Adhiraj Roy, Maria Victoria Veroli, Sahdeo Prasad, Qiming Jane Wang

Mol Cancer Res. Author manuscript; available in PMC 2023 Feb 13.

Published in final edited form as: Mol Cancer Res. 2018 Nov; 16(11): 1785–1797. Published online 2018 Jul 17. doi: 10.1158/1541-7786.MCR-18-0641

PMCID:: PMC9923726

Abstract Article PDF–4.2M

Select item 981664719.

Aurora A phosphorylates Ndel1 to reduce the levels of Mad1 and NuMA at spindle poles

Paweł Ł. Janczyk, Eliza Żyłkiewicz, Henry De Hoyos, Thomas West, Daniel R. Matson, Won-Chan Choi, Heather M. Raimer Young, Zygmunt S. Derewenda, P. Todd Stukenberg

Mol Biol Cell. 2023 Jan 1; 34(1): br1. Published online 2022 Dec 15. doi: 10.1091/mbc.E21-09-0438