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Items: 1 to 20 of 53

1.
Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
Irene Bodega-Mayor, Pablo Delgado-Wicke, Alejandro Arrabal, Estíbaliz Alegría-Carrasco, Ana Nicolao-Gómez, Marta Jaén-Castaño, Cristina Espadas, Ana Dopazo, Enrique Martín-Gayo, María Luisa Gaspar, Belén de Andrés, Elena Fernández-Ruiz
Cell Mol Life Sci. 2024 Dec; 81(1): 199. Published online 2024 Apr 29. doi: 10.1007/s00018-024-05234-y
PMCID:
PMC11058799
AbstractArticlePDF–9.3M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Tyk2 is a tumor suppressor in colorectal cancer
Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl, Robert Eferl
Oncoimmunology. 2022; 11(1): 2127271. Published online 2022 Sep 26. doi: 10.1080/2162402X.2022.2127271
PMCID:
PMC9519006
AbstractArticlePDF–26M
4.
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis
Hong-Guang Zhang, Bin Wang, Yong Yang, Xuan Liu, Junjie Wang, Ning Xin, Shifeng Li, Ying Miao, Qiuyu Wu, Tingting Guo, Yukang Yuan, Yibo Zuo, Xiangjie Chen, Tengfei Ren, Chunsheng Dong, Jun Wang, Hang Ruan, Miao Sun, Xingshun Xu, Hui Zheng
Cell Res. 2022 Oct; 32(10): 897–913. Published online 2022 Jul 12. doi: 10.1038/s41422-022-00689-9
PMCID:
PMC9274186
AbstractArticlePDF–6.7M
5.
Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma
Nicole Prutsch, Elisabeth Gurnhofer, Tobias Suske, Huan Chang Liang, Michaela Schlederer, Simone Roos, Lawren C. Wu, Ingrid Simonitsch-Klupp, Andrea Alvarez-Hernandez, Christoph Kornauth, Dario A. Leone, Jasmin Svinka, Robert Eferl, Tanja Limberger, Astrid Aufinger, Nitesh Shirsath, Peter Wolf, Thomas Hielscher, Christina Sternberg, Fritz Aberger, Johannes Schmoellerl, Dagmar Stoiber, Birgit Strobl, Ulrich Jäger, Philipp B. Staber, Florian Grebien, Richard Moriggl, Mathias Müller, Giorgio G. Inghirami, Takaomi Sanda, A. Thomas Look, Suzanne D. Turner, Lukas Kenner, Olaf Merkel
Leukemia. 2019; 33(3): 696–709. Published online 2018 Aug 21. doi: 10.1038/s41375-018-0239-1
Correction in:
Leukemia. 2020; 34(11): 3105.
PMCID:
PMC8076043
AbstractArticlePDF–3.0M
6.
TYK2 licenses non-canonical inflammasome activation during endotoxemia
Andrea Poelzl, Caroline Lassnig, Simone Tangermann, Dominika Hromadová, Ursula Reichart, Riem Gawish, Kristina Mueller, Richard Moriggl, Andreas Linkermann, Martin Glösmann, Lukas Kenner, Mathias Mueller, Birgit Strobl
Cell Death Differ. 2021 Feb; 28(2): 748–763. Published online 2020 Sep 14. doi: 10.1038/s41418-020-00621-x
PMCID:
PMC7862449
AbstractArticlePDF–4.0M
7.
Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion
Michael Riedelberger, Philipp Penninger, Michael Tscherner, Bernhard Hadriga, Carina Brunnhofer, Sabrina Jenull, Anton Stoiber, Christelle Bourgeois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Michael A. Lynes, Gernot Schabbauer, Guenter Weiss, Karl Kuchler
iScience. 2020 May 22; 23(5): 101121. Published online 2020 May 4. doi: 10.1016/j.isci.2020.101121
PMCID:
PMC7232100
AbstractArticlePDF–34M
8.
TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis
Eric Gracey, Dominika Hromadová, Melissa Lim, Zoya Qaiyum, Michael Zeng, Yuchen Yao, Archita Srinath, Yuriy Baglaenko, Natalia Yeremenko, William Westlin, Craig Masse, Mathias Müller, Birgit Strobl, Wenyan Miao, Robert D. Inman
J Clin Invest. 2020 Apr 1; 130(4): 1863–1878. Published online 2020 Mar 9. doi: 10.1172/JCI126567
PMCID:
PMC7108927
AbstractArticlePDF–11M
9.
Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation
Kartiga Natarajan, Velmurugan Meganathan, Courtney Mitchell, Vijay Boggaram
Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317(1): L127–L140. Published online 2019 May 1. doi: 10.1152/ajplung.00448.2018
Correction in:
Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1; 317(2): L303.
PMCID:
PMC6689743
AbstractArticle
10.
NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
Natalija Simonović, Agnieszka Witalisz-Siepracka, Katrin Meissl, Caroline Lassnig, Ursula Reichart, Thomas Kolbe, Matthias Farlik, Christoph Bock, Veronika Sexl, Mathias Müller, Birgit Strobl
J Immunol. 2019 Mar 15; 202(6): 1724–1734. Published online 2019 Feb 4. doi: 10.4049/jimmunol.1701649
PMCID:
PMC6398083
AbstractArticlePDF–1.5M
11.
The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets
Jacquelyn A. Gorman, Christian Hundhausen, Mackenzie Kinsman, Tanvi Arkatkar, Eric J. Allenspach, Courtnee Clough, Samuel E. West, Kerri Thomas, Ahmet Eken, Socheath Khim, Malika Hale, Mohamed Oukka, Shaun W. Jackson, Karen Cerosaletti, Jane H. Buckner, David J. Rawlings
Front Immunol. 2019; 10: 44. Published online 2019 Jan 25. doi: 10.3389/fimmu.2019.00044
PMCID:
PMC6355696
AbstractArticlePDF–2.9M
12.
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Calliope A. Dendrou, Adrian Cortes, Lydia Shipman, Hayley G. Evans, Kathrine E. Attfield, Luke Jostins, Thomas Barber, Gurman Kaur, Subita Balaram Kuttikkatte, Oliver A. Leach, Christiane Desel, Soren L. Faergeman, Jane Cheeseman, Matt J. Neville, Stephen Sawcer, Alastair Compston, Adam R. Johnson, Christine Everett, John I. Bell, Fredrik Karpe, Mark Ultsch, Charles Eigenbrot, Gil McVean, Lars Fugger
Sci Transl Med. Author manuscript; available in PMC 2017 Dec 20.
Published in final edited form as: Sci Transl Med. 2016 Nov 2; 8(363): 363ra149. doi: 10.1126/scitranslmed.aag1974
PMCID:
PMC5737835
AbstractArticlePDF–2.4M
13.
Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain
Ruud H. P. Wilbers, Debbie R. van Raaij, Lotte B. Westerhof, Jaap Bakker, Geert Smant, Arjen Schots
PLoS One. 2017; 12(10): e0186317. Published online 2017 Oct 10. doi: 10.1371/journal.pone.0186317
PMCID:
PMC5634637
AbstractArticlePDF–5.5M
14.
Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells
Vidisha Raje, Marta Derecka, Marc Cantwell, Jeremy Meier, Karol Szczepanek, Jennifer D. Sisler, Birgit Strobl, Ana Gamero, Thurl E. Harris, Andrew C. Larner
Endocrinology. 2017 Jan 1; 158(1): 148–157. Published online 2016 Nov 1. doi: 10.1210/en.2015-2048
PMCID:
PMC5412977
AbstractArticle
15.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
16.
Parsing the interferon transcriptional network and its disease associations
Sara Mostafavi, Hideyuki Yoshida, Devapregasan Moodley, Hugo LeBoité, Katherine Rothamel, Towfique Raj, Chun Jimmie Ye, Nicolas Chevrier, Shen-Ying Zhang, Ting Feng, Mark Lee, Jean-Laurent Casanova, James D. Clark, Martin Hegen, Jean-Baptiste Telliez, Nir Hacohen, Philip L. De Jager, Aviv Regev, Diane Mathis, Christophe Benoist, the Immunological Genome Project Consortium
Cell. Author manuscript; available in PMC 2017 Jan 28.
Published in final edited form as: Cell. 2016 Jan 28; 164(3): 564–578. doi: 10.1016/j.cell.2015.12.032
PMCID:
PMC4743492
AbstractArticlePDF–2.1M
17.
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
Eva Hainzl, Silvia Stockinger, Isabella Rauch, Susanne Heider, David Berry, Caroline Lassnig, Clarissa Schwab, Felix Rosebrock, Gabriel Milinovich, Michaela Schlederer, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Lukas Kenner, Xiaonan Han, Thomas Decker, Birgit Strobl, Mathias Müller
J Immunol. 2015 Nov 15; 195(10): 5011–5024. Published online 2015 Oct 2. doi: 10.4049/jimmunol.1402565
PMCID:
PMC4635564
AbstractArticlePDF–2.4M
18.
Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes
Kenichi Izumi, Keiichiro Mine, Yoshitaka Inoue, Miho Teshima, Shuichiro Ogawa, Yuji Kai, Toshinobu Kurafuji, Kanako Hirakawa, Daiki Miyakawa, Haruka Ikeda, Akari Inada, Manami Hara, Hisakata Yamada, Koichi Akashi, Yoshiyuki Niho, Keisuke Ina, Takashi Kobayashi, Yasunobu Yoshikai, Keizo Anzai, Teruo Yamashita, Hiroko Minagawa, Shuji Fujimoto, Hironori Kurisaki, Kazuya Shimoda, Hitoshi Katsuta, Seiho Nagafuchi
Nat Commun. 2015 Apr 7; 6: 6748. Published online 2015 Apr 7. doi: 10.1038/ncomms7748
PMCID:
PMC4396380
AbstractArticlePDF–1.6M
19.
Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 axis
Melissa G. Works, Fangfang Yin, Catherine C. Yin, Ying Yiu, Kenneth Shew, Thanh-Thuy Tran, Nahoko Dunlap, Jennifer Lam, Tim Mitchell, John Reader, Paul L. Stein, Annalisa D’Andrea
J Immunol. Author manuscript; available in PMC 2015 Oct 1.
Published in final edited form as: J Immunol. 2014 Oct 1; 193(7): 3278–3287. Published online 2014 Aug 25. doi: 10.4049/jimmunol.1400205
PMCID:
PMC4170002
AbstractArticlePDF–2.4M
20.
Role of Tyk-2 in Th9 and Th17 cells in allergic asthma
Caroline Übel, Anna Graser, Sonja Koch, Ralf J. Rieker, Hans A. Lehr, Mathias Müller, Susetta Finotto
Sci Rep. 2014; 4: 5865. Published online 2014 Aug 11. doi: 10.1038/srep05865
PMCID:
PMC4127519
AbstractArticlePDF–995K

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