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Select item 102935061.

A Subset of Salivary Intercalated Duct Lesions Harbors Recurrent CTNNB1 and HRAS Mutations: A Molecular Link to Basal Cell Adenoma and Epithelial-Myoepithelial Carcinoma?

Anne C. McLean, Lisa M. Rooper, Jeffrey Gagan, Lester D. R. Thompson, Justin A. Bishop

Head Neck Pathol. 2023 Jun; 17(2): 393–400. Published online 2022 Dec 8. doi: 10.1007/s12105-022-01513-x

PMCID:: PMC10293506

Abstract Article PDF–2.0M

Select item 101879302.

Cytosolic EpCAM cooperates with H-Ras to regulate epithelial to mesenchymal transition through ZEB1

Fatma A. Omar, Taylor C. Brown, William E. Gillanders, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal

PLoS One. 2023; 18(5): e0285707. Published online 2023 May 16. doi: 10.1371/journal.pone.0285707

PMCID:: PMC10187930

Abstract Article PDF–4.1M

Select item 100733433.

Mutated HRAS activates YAP1-AXL signaling to drive metastasis of head and neck cancer

Sankar Jagadeeshan, Manu Prasad, Mai Badarni, Talal Ben Lulu, Vijayasteltar Belsamma Liju, Sooraj Mathukkada, Claire Saunders, Avital Beeri Shnerb, Jonathan Zorea, Ksenia M Yegodayev, Monica Wainer, Liza Vtorov, Irit Allon, Ofir Cohen, Gro Gausdal, Dinorah Friedmann-Morvinski, Sok Ching Cheong, Alan L Ho, Ari J Rosenberg, Linda Kessler, Francis Burrows, Dexin Kong, Jennifer R Grandis, J Silvio Gutkind, Moshe Elkabets

Cancer Res. Author manuscript; available in PMC 2023 Oct 4.

Published in final edited form as: Cancer Res. 2023 Apr 4; 83(7): 1031–1047. doi: 10.1158/0008-5472.CAN-22-2586

PMCID:: PMC10073343

Abstract Article PDF–2.6M

Select item 98953714.

HRAS overexpression predicts response to Lenvatinib treatment in gastroenteropancreatic neuroendocrine tumors

Chiara Liverani, Chiara Spadazzi, Toni Ibrahim, Federica Pieri, Flavia Foca, Chiara Calabrese, Alessandro De Vita, Giacomo Miserocchi, Claudia Cocchi, Silvia Vanni, Giorgio Ercolani, Davide Cavaliere, Nicoletta Ranallo, Elisa Chiadini, Giovanna Prisinzano, Stefano Severi, Maddalena Sansovini, Giovanni Martinelli, Alberto Bongiovanni, Laura Mercatali

Front Endocrinol (Lausanne) 2022; 13: 1045038. Published online 2023 Jan 20. doi: 10.3389/fendo.2022.1045038

PMCID:: PMC9895371

Abstract Article PDF–4.0M

Select item 98051345.

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang

Cell Biosci. 2022; 12: 211. Published online 2022 Dec 30. doi: 10.1186/s13578-022-00950-z

PMCID:: PMC9805134

Abstract Article PDF–9.4M

Select item 94370316.

A novel HRAS c.466C>T p.(Phe156Leu) variant in two patients with attenuated features of Costello syndrome

Suzanna Lindsey-Temple, Matt Edwards, Verena Rickassel, Theresa Nauth, Georg Rosenberger

Eur J Hum Genet. 2022 Sep; 30(9): 1088–1093. Published online 2022 Jun 29. doi: 10.1038/s41431-022-01139-1

PMCID:: PMC9437031

Abstract Article PDF–1.1M

Select item 91393727.

HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature

Laurent Mathiot, Guillaume Herbreteau, Siméon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Denis, Elvire Pons-Tostivint

Curr Oncol. 2022 May; 29(5): 3748–3758. Published online 2022 May 20. doi: 10.3390/curroncol29050300

PMCID:: PMC9139372

Abstract Article PDF–976K

Select item 90405568.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 90122939.

HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models

Laetitia Dard, Christophe Hubert, Pauline Esteves, Wendy Blanchard, Ghina Bou About, Lyla Baldasseroni, Elodie Dumon, Chloe Angelini, Mégane Delourme, Véronique Guyonnet-Dupérat, Stéphane Claverol, Laura Fontenille, Karima Kissa, Pierre-Emmanuel Séguéla, Jean-Benoît Thambo, Lévy Nicolas, Yann Herault, Nadège Bellance, Nivea Dias Amoedo, Frédérique Magdinier, Tania Sorg, Didier Lacombe, Rodrigue Rossignol

J Clin Invest. 2022 Apr 15; 132(8): e131053. Published online 2022 Apr 15. doi: 10.1172/JCI131053

PMCID:: PMC9012293

Abstract Article PDF–14M

Select item 900533210.

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

Danielle L. Swaney, Dana J. Ramms, Zhiyong Wang, Jisoo Park, Yusuke Goto, Margaret Soucheray, Neil Bhola, Kyumin Kim, Fan Zheng, Yan Zeng, Michael McGregor, Kari A. Herrington, Rachel O’Keefe, Nan Jin, Nathan K. VanLandingham, Helene Foussard, John Von Dollen, Mehdi Bouhaddou, David Jimenez-Morales, Kirsten Obernier, Jason F. Kreisberg, Minkyu Kim, Daniel E. Johnson, Natalia Jura, Jennifer R. Grandis, J. Silvio Gutkind, Trey Ideker, Nevan J. Krogan

Science. Author manuscript; available in PMC 2022 Apr 13.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf2911. Published online 2021 Oct 1. doi: 10.1126/science.abf2911

PMCID:: PMC9005332

Abstract Article PDF–2.0M

Select item 870904811.

Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members

Panagiotis G. Adamopoulos, Panagiotis Tsiakanikas, Michaela A. Boti, Andreas Scorilas

Int J Mol Sci. 2021 Dec; 22(24): 13298. Published online 2021 Dec 10. doi: 10.3390/ijms222413298

PMCID:: PMC8709048

Abstract Article PDF–2.2M

Select item 853376812.

Higher RET Gene Expression Levels Do Not Represent anAlternative RET Activation Mechanism in Medullary Thyroid Carcinoma

Chiara Mulè, Raffaele Ciampi, Teresa Ramone, Alessandro Prete, Antonio Matrone, Virginia Cappagli, Liborio Torregrossa, Fulvio Basolo, Rossella Elisei, Cristina Romei

Biomolecules. 2021 Oct; 11(10): 1542. Published online 2021 Oct 19. doi: 10.3390/biom11101542

PMCID:: PMC8533768

Abstract Article PDF–1.4M

Select item 842493513.

HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast

Ivan Bièche, Florence Coussy, Rania El-Botty, Sophie Vacher, Sophie Château-Joubert, Ahmed Dahmani, Elodie Montaudon, Cécile Reyes, David Gentien, Fabien Reyal, Francesco Ricci, André Nicolas, Caterina Marchio, Anne Vincent-Salomon, Marick Laé, Elisabetta Marangoni

J Hematol Oncol. 2021; 14: 143. Published online 2021 Sep 8. doi: 10.1186/s13045-021-01158-3

PMCID:: PMC8424935

Abstract Article PDF–1.0M

Select item 836363214.

Expression of oncogenic HRAS in human Rh28 and RMS-YM rhabdomyosarcoma cells leads to oncogene-induced senescence

Jenny J. Li, Alexander R. Kovach, Margaret DeMonia, Katherine K. Slemmons, Kristianne M. Oristian, Candy Chen, Corinne M. Linardic

Sci Rep. 2021; 11: 16505. Published online 2021 Aug 13. doi: 10.1038/s41598-021-95355-2

PMCID:: PMC8363632

Abstract Article PDF–2.0M

Select item 830191315.

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation

Trinity Cookis, Carla Mattos

Biomolecules. 2021 Jul; 11(7): 996. Published online 2021 Jul 7. doi: 10.3390/biom11070996

PMCID:: PMC8301913

Abstract Article PDF–5.6M

Select item 826641716.

Tipifarnib in Recurrent, Metastatic HRAS-Mutant Salivary Gland Cancer

Glenn J. Hanna, Jeffrey P. Guenette, Nicole G. Chau, Cyrus M. Sayehli, Christian Wilhelm, Robert Metcalf, Deborah J. Wong, Marcia Brose, Mohammad Razaq, Elisabeth Pérez-Ruiz, Ezra E. W. Cohen, Rahul Aggarwal, Catherine Scholz, Antonio Gualberto, Alan L. Ho

Cancer. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Cancer. 2020 Sep 1; 126(17): 3972–3981. Published online 2020 Jun 18. doi: 10.1002/cncr.33036

PMCID:: PMC8266417

Abstract Article PDF–1.0M

Select item 823801517.

Costello syndrome: Clinical phenotype, genotype, and management guidelines

Karen W. Gripp, Lindsey A. Morse, Marni Axelrad, Kathryn C. Chatfield, Aaron Chidekel, William Dobyns, Daniel Doyle, Bronwyn Kerr, Angela E. Lin, David D. Schwartz, Barbara J. Sibbles, Dawn Siegel, Suma P. Shankar, David A. Stevenson, Mihir M. Thacker, K. Nicole Weaver, Sue M. White, Katherine A. Rauen

Am J Med Genet A. Author manuscript; available in PMC 2021 Jun 28.

Published in final edited form as: Am J Med Genet A. 2019 Sep; 179(9): 1725–1744. Published online 2019 Jun 20. doi: 10.1002/ajmg.a.61270

PMCID:: PMC8238015

Abstract Article PDF–953K

Select item 818962718.

Tipifarnib in Head and Neck Squamous Cell Carcinoma With HRAS Mutations

Alan L. Ho, Irene Brana, Robert Haddad, Jessica Bauman, Keith Bible, Sjoukje Oosting, Deborah J. Wong, Myung-Ju Ahn, Valentina Boni, Caroline Even, Jerome Fayette, Maria José Flor, Kevin Harrington, David S. Hong, Sung-Bae Kim, Lisa Licitra, Ioanna Nixon, Nabil F. Saba, Stephan Hackenberg, Pol Specenier, Francis Worden, Binaifer Balsara, Mollie Leoni, Bridget Martell, Catherine Scholz, Antonio Gualberto

J Clin Oncol. 2021 Jun 10; 39(17): 1856–1864. Published online 2021 May 14. doi: 10.1200/JCO.20.02903

PMCID:: PMC8189627

Abstract Article PDF–427K

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 805862020.

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

M. Steklov, S. Pandolfi, M. F. Baietti, A. Batiuk, P. Carai, P. Najm, M. Zhang, H. Jang, F. Renzi, Y. Cai, L. Abbasi Asbagh, T. Pastor, M. De Troyer, M. Simicek, E. Radaelli, H. Brems, E. Legius, J. Tavernier, K. Gevaert, F. Impens, L. Messiaen, R. Nussinov, S. Heymans, S. Eyckerman, A. A. Sabina

Science. Author manuscript; available in PMC 2021 Apr 21.

Published in final edited form as: Science. 2018 Dec 7; 362(6419): 1177–1182. Published online 2018 Nov 15. doi: 10.1126/science.aap7607

PMCID:: PMC8058620

Abstract Article PDF–1.1M

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