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Select item 108940041.

Developmental expression of the Sturge–Weber syndrome-associated genetic mutation in Gnaq: a formal test of Happle's paradominant inheritance hypothesis

Sarah E Wetzel-Strong, Francesca Galeffi, Christian Benavides, Mary Patrucco, Jessica L Bullock, Carol J Gallione, Han Kyu Lee, Douglas A Marchuk

Genetics. 2023 Aug; 224(4): iyad077. Published online 2023 Apr 25. doi: 10.1093/genetics/iyad077

PMCID:: PMC10894004

Abstract Article PDF–6.8M

Select item 105072892.

Gαq Signaling Activates β-Catenin-Dependent Gene Transcription

Sara Ansari, Sedighe Kolivand, Sara Salmanian, Marie Saghaeian Jazi, S Mahmoud A Najafi

Iran Biomed J. 2023 Jul; 27(4): 183–190. Published online 2023 May 31. doi: 10.61186/ibj.3890

PMCID:: PMC10507289

Abstract Article PDF–692K

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100879264.

Early‐onset hypertension associated with extensive cutaneous capillary malformations harboring postzygotic variants in GNAQ and GNA11

Olivia M. T. Davies, Ashley T. Ng, Jennifer Tran, Shoshana Blumenthal, Lisa M. Arkin, Amy J. Nopper, Catherine E. Cottrell, Maria Garzon, Dawn H. Siegel, Ilona J. Frieden, Beth A. Drolet

Pediatr Dermatol. 2022 Nov-Dec; 39(6): 914–919. Published online 2022 Aug 10. doi: 10.1111/pde.15103

PMCID:: PMC10087926

Abstract Article PDF–1.0M

Select item 95297925.

A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis

F. Galeffi, D. A. Snellings, S. E. Wetzel-Strong, N. Kastelic, J. Bullock, C. J. Gallione, P. E. North, D. A. Marchuk

Angiogenesis. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Angiogenesis. 2022 Nov; 25(4): 493–502. Published online 2022 May 30. doi: 10.1007/s10456-022-09841-w

PMCID:: PMC9529792

Abstract Article PDF–905K

Select item 92344086.

Somatic GNAQ R183Q mutation is located within the sclera and episclera in patients with Sturge-Weber syndrome

Yue Wu, Cheng Peng, Lulu Huang, Li Xu, Xuming Ding, Yixin Liu, Changjuan Zeng, Hao Sun, Wenyi Guo

Br J Ophthalmol. 2022 Jul; 106(7): 1006–1011. Published online 2021 Mar 11. doi: 10.1136/bjophthalmol-2020-317287

PMCID:: PMC9234408

Abstract Article PDF–1.0M

Select item 91754827.

LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression

Xuexue Xu, Pengsheng Ding, Lan Shi, Gang Wu, Xiaoling Ma

BMC Cancer. 2022; 22: 630. Published online 2022 Jun 8. doi: 10.1186/s12885-022-09680-4

PMCID:: PMC9175482

Abstract Article PDF–15M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88956279.

Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma

Justine S. Paradis, Monica Acosta, Robert Saddawi-Konefka, Ayush Kishore, Frederico Gomes, Nadia Arang, Manoela Tiago, Silvia Coma, Simone Lubrano, Xingyu Wu, Kyle Ford, Chi-Ping Day, Glenn Merlino, Prashant Mali, Jonathan A. Pachter, Takami Sato, Andrew E. Aplin, J. Silvio Gutkind

Clin Cancer Res. Author manuscript; available in PMC 2022 Mar 4.

Published in final edited form as: Clin Cancer Res. 2021 Jun 1; 27(11): 3190–3200. Published online 2021 Feb 10. doi: 10.1158/1078-0432.CCR-20-3363

PMCID:: PMC8895627

Abstract Article PDF–2.6M

Select item 884218510.

Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids

Caroline Cvetkovic, Rajan Patel, Arya Shetty, Matthew K. Hogan, Morgan Anderson, Nupur Basu, Samira Aghlara-Fotovat, Srivathsan Ramesh, Debosmita Sardar, Omid Veiseh, Michael E. Ward, Benjamin Deneen, Philip J. Horner, Robert Krencik

J Cell Biol. 2022 Apr 4; 221(4): e202107135. Published online 2022 Feb 9. doi: 10.1083/jcb.202107135

PMCID:: PMC8842185

Abstract Article PDF–5.6M

Select item 882155811.

Cryo-EM structures of human bradykinin receptor-G_q proteins complexes

Jinkang Shen, Dongqi Zhang, Yao Fu, Anqi Chen, Xiaoli Yang, Haitao Zhang

Nat Commun. 2022; 13: 714. Published online 2022 Feb 7. doi: 10.1038/s41467-022-28399-1

PMCID:: PMC8821558

Abstract Article PDF–5.6M

Select item 870248712.

Endothelial GNAQ p.R183Q increases angiopoietin-2 and drives formation of enlarged blood vessels

Lan Huang, Colette Bichsel, Alexis Norris, Jeremy Thorpe, Jonathan Pevsner, Sanda Alexandrescu, Anna Pinto, David Zurakowski, Robin J. Kleiman, Mustafa Sahin, Arin K. Greene, Joyce Bischoff

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Jan; 42(1): e27–e43. Published online 2021 Oct 21. doi: 10.1161/ATVBAHA.121.316651

PMCID:: PMC8702487

Abstract Article PDF–2.0M

Select item 864180413.

Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Pawan Sharma, Santosh K. Yadav, Sushrut D. Shah, Elham Javed, John M. Lim, Shi Pan, Ajay P. Nayak, Reynold A. Panettieri, Jr., Raymond B. Penn, Taku Kambayashi, Deepak A. Deshpande

Am J Respir Cell Mol Biol. 2021 Dec; 65(6): 658–671. Published online 2021 Mar 30. doi: 10.1165/rcmb.2021-0106OC

PMCID:: PMC8641804

Abstract Article PDF–1.5M

Select item 855290714.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 842550115.

GNAQ Mutations in Diffuse and Solitary Choroidal Hemangiomas

JH Francis, T Milman, H Grossniklaus, DM Albert, R Folberg, GM Levitin, SE Coupland, F Catalanotti, D Rabady, C Kandoth, KJ Busam, DH Abramson

Ophthalmology. Author manuscript; available in PMC 2021 Sep 8.

Published in final edited form as: Ophthalmology. 2019 May; 126(5): 759–763. Published online 2018 Dec 8. doi: 10.1016/j.ophtha.2018.12.011

Correction in:: Ophthalmology. 2021 Aug; 128(8): 1245.

PMCID:: PMC8425501

Abstract Article PDF–310K

Select item 821874616.

A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer

Noor Mazin Abdulkareem, Raksha Bhat, Lanfang Qin, Suhas Vasaikar, Ambily Gopinathan, Tamika Mitchell, Martin J. Shea, Sarmistha Nanda, Hariprasad Thangavel, Bing Zhang, Carmine De Angelis, Rachel Schiff, Meghana V. Trivedi

FASEB J. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: FASEB J. 2021 Jul; 35(7): e21719. doi: 10.1096/fj.202100070R

PMCID:: PMC8218746

Abstract Article PDF–2.5M

Select item 820856917.

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Jesse I. Mobbs, Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah J. Piper, Xiaomeng Xu, Sebastian G. B. Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M. Thal, Laurence J. Miller, Patrick M. Sexton

PLoS Biol. 2021 Jun; 19(6): e3001295. Published online 2021 Jun 4. doi: 10.1371/journal.pbio.3001295

PMCID:: PMC8208569

Abstract Article PDF–4.0M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 814290019.

A somatic missense mutation in GNAQ causes capillary malformation

Colette Bichsel, Joyce Bischoff

Curr Opin Hematol. Author manuscript; available in PMC 2021 May 24.

Published in final edited form as: Curr Opin Hematol. 2019 May; 26(3): 179–184. doi: 10.1097/MOH.0000000000000500

PMCID:: PMC8142900

Abstract Article PDF–462K

Select item 802471020.

An experimental strategy to probe Gq contribution to signal transduction in living cells

Julian Patt, Judith Alenfelder, Eva Marie Pfeil, Jan Hendrik Voss, Nicole Merten, Funda Eryilmaz, Nina Heycke, Uli Rick, Asuka Inoue, Stefan Kehraus, Xavier Deupi, Christa E. Müller, Gabriele M. König, Max Crüsemann, Evi Kostenis

J Biol Chem. 2021 Jan-Jun; 296: 100472. Published online 2021 Feb 25. doi: 10.1016/j.jbc.2021.100472

PMCID:: PMC8024710

Abstract Article PDF–3.4M

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