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Select item 28758061.

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

Junyu Ning, David R. Clemmons

Mol Endocrinol. 2010 Jun; 24(6): 1218–1229. Published online 2010 Apr 2. doi: 10.1210/me.2009-0474

PMCID:: PMC2875806

Article

Select item 18511702.

Polycystic Kidney Disease as a Result of Loss of the Tuberous Sclerosis 2 Tumor Suppressor Gene During Development

Shengli Cai, Jeffrey I. Everitt, Hiroyuki Kugo, Jennifer Cook, Elena Kleymenova, Cheryl Lyn Walker

Am J Pathol. 2003 Feb; 162(2): 457–468. doi: 10.1016/S0002-9440(10)63840-0

PMCID:: PMC1851170

Article PDF–1.2M

Select item 452413.

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

R S Yeung, G H Xiao, F Jin, W C Lee, J R Testa, A G Knudson

Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24): 11413–11416. doi: 10.1073/pnas.91.24.11413

PMCID:: PMC45241

Summary Page Browse PDF–1.0M

Select item 280954.

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

Gabriela Rennebeck, Elena V. Kleymenova, Rebecca Anderson, Raymond S. Yeung, Karen Artzt, Cheryl L. Walker

Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26): 15629–15634. doi: 10.1073/pnas.95.26.15629

PMCID:: PMC28095

Article PDF–653K

Select item 110044695.

Case report: Response to everolimus in a patient with platinum resistant, high grade serous ovarian carcinoma with biallelic TSC2 inactivation

Mariko Peterson, David L. Kolin, Panagiotis A. Konstantinopoulos

Front Oncol. 2024; 14: 1357980. Published online 2024 Mar 27. doi: 10.3389/fonc.2024.1357980

PMCID:: PMC11004469

Article PDF–2.2M

Select item 110029906.

Tuberous sclerosis complex associated lymphangioleiomyomatosis caused by de novo mutation of TSC2 gene in Vietnam: A case report

Dinh Van Luong, Le Ngoc Huy, Nguyen Xuan Giang, Nguyen Huu Hong Thu, Nguyen Hai Ha, Nguyen Huy Binh

Respirol Case Rep. 2024 Apr; 12(4): e01346. Published online 2024 Apr 9. doi: 10.1002/rcr2.1346

PMCID:: PMC11002990

Article PDF–37M

Select item 109995377.

TSC2 nonsense mutation in angiomyolipoma with epithelial cysts: a case report and literature review

Hong Song, Guoliang Mao, Nanlin Jiao, Jiajia Li, Wanwan Gao, Yinhua Liu, Linming Lu

Front Oncol. 2024; 14: 1274953. Published online 2024 Mar 25. doi: 10.3389/fonc.2024.1274953

PMCID:: PMC10999537

Article PDF–3.3M

Select item 109447438.

HOXA5-induced lncRNA DNM3OS promotes human embryo lung fibroblast fibrosis via recruiting EZH2 to epigenetically suppress TSC2 expression

Hong Lv, Xingjia Qian, Zhengzheng Tao, Jun Shu, Dongfang Shi, Jing Yu, Guiqin Fan, Qiuhong Qian, Luhong Shen, Bing Lu

J Thorac Dis. 2024 Feb 29; 16(2): 1234–1246. Published online 2024 Feb 21. doi: 10.21037/jtd-23-1145

PMCID:: PMC10944743

Article PDF–2.5M

Select item 108760839.

An overview of actionable and potentially actionable TSC1 and TSC2 germline variants in an online Database

Arthur Bandeira de Mello Garcia, Guilherme Danielski Viola, Bruno da Silveira Corrêa, Taís da Silveira Fischer, Maria Clara de Freitas Pinho, Grazielle Motta Rodrigues, Patricia Ashton-Prolla, Clévia Rosset

Genet Mol Biol. 2023; 46(3 Suppl 1): e20230132. Published online 2024 Feb 19. doi: 10.1590/1678-4685-GMB-2023-0132

PMCID:: PMC10876083

Article PDF–3.6M

Select item 1081367410.

Early Post-Natal Immune Activation Leads to Object Memory Deficits in Female Tsc2^+/− Mice: The Importance of Including Both Sexes in Neuroscience Research

Manuel F. López-Aranda, Karen Bach, Raymond Bui, Miranda Phan, Odilia Lu, Chirag Thadani, Alessandro Luchetti, Rochelle Mandanas, Isaiah Herrera, María Dolores López-Ávalos, Alcino J. Silva

Biomedicines. 2024 Jan; 12(1): 203. Published online 2024 Jan 17. doi: 10.3390/biomedicines12010203

PMCID:: PMC10813674

Article PDF–2.6M

Select item 1079078311.

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose starvation

Matthew H. Raymonda, Irene Rodríguez-Sánchez, Xenia L. Schafer, Leonid Smorodintsev-Schiller, Isaac S. Harris, Joshua Munger

mBio. 2024 Jan; 15(1): e03031-23. Published online 2023 Dec 20. doi: 10.1128/mbio.03031-23

PMCID:: PMC10790783

Article PDF–3.4M

Select item 1072469312.

Tsc2 coordinates neuroprogenitor differentiation

Victoria A. Riley, Vijay Shankar, Jennie C. Holmberg, Aidan M. Sokolov, Victoria N. Neckles, Kaitlyn Williams, Rachel Lyman, Trudy F.C. Mackay, David M. Feliciano

iScience. 2023 Dec 15; 26(12): 108442. Published online 2023 Nov 14. doi: 10.1016/j.isci.2023.108442

PMCID:: PMC10724693

Article PDF–6.0M

Select item 1072125813.

TSC2 S1365A mutation potently regulates CD8⁺ T cell function and differentiation and improves adoptive cellular cancer therapy

Chirag H. Patel, Yi Dong, Navid Koleini, Xiaoxu Wang, Brittany L. Dunkerly-Eyring, Jiayu Wen, Mark J. Ranek, Laura M. Bartle, Daniel B. Henderson, Jason Sagert, David A. Kass, Jonathan D. Powell

JCI Insight. 2023 Nov 8; 8(21): e167829. Published online 2023 Nov 8. doi: 10.1172/jci.insight.167829

PMCID:: PMC10721258

Article PDF–7.8M

Select item 1060510314.

Uncommon Large and Bilateral Fibrous Cephalic Plaques in a Patient with TSC2-Related Tuberous Sclerosis Complex

Ariadna González-del Angel, Adriana Ruiz-Herrera, Nancy Leticia Hernández-Martínez, Carlos G. Todd-Quiñones, Carola Durán-McKinster, Patricia Herrera-Mora, Miguel Angel Alcántara-Ortigoza

Children (Basel) 2023 Oct; 10(10): 1614. Published online 2023 Sep 28. doi: 10.3390/children10101614

PMCID:: PMC10605103

Article PDF–2.1M

Select item 1055012415.

Non-canonical functions of a mutant TSC2 protein in mitotic division

Mary-Bronwen L. Chalkley, Rachel B. Mersfelder, Maria Sundberg, Laura C. Armstrong, Mustafa Sahin, Rebecca A. Ihrie, Kevin C. Ess

PLoS One. 2023; 18(10): e0292086. Published online 2023 Oct 4. doi: 10.1371/journal.pone.0292086

PMCID:: PMC10550124

Article PDF–1.3M

Select item 1038269916.

Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene

Manuel F. López-Aranda, Gayle M. Boxx, Miranda Phan, Karen Bach, Rochelle Mandanas, Isaiah Herrera, Sunrae Taloma, Chirag Thadani, Odilia Lu, Raymond Bui, Shuhan Liu, Nan Li, Yu Zhou, Genhong Cheng, Alcino J. Silva

Biol Psychiatry Glob Open Sci. 2023 Jul; 3(3): 451–459. Published online 2022 Apr 14. doi: 10.1016/j.bpsgos.2022.03.015

PMCID:: PMC10382699

Article PDF–1.5M

Select item 1031705417.

TSC2-mutant uterine sarcomas with JAZF1-SUZ12 fusions demonstrate hybrid features of endometrial stromal sarcoma and PEComa and are responsive to mTOR inhibition

Sarah Chiang, Varshini Vasudevaraja, Jonathan Serrano, Colin J.R. Stewart, Esther Oliva, Amir Momeni-Boroujeni, Achim A. Jungbluth, Arnaud Da Cruz Paula, Edaise M da Silva, Britta Weigelt, Kay J. Park, Robert A. Soslow, Rajmohan Murali, Lora H. Ellenson, Ryma Benayed, Marc Ladanyi, Nadeem R. Abu-Rustum, Mark A. Dickson, Seth Cohen, Carol Aghajanian, Martee L. Hensley, Cheng-Han Lee, Matija Snuderl, Jason A. Konner

Mod Pathol. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Mod Pathol. 2022 Jan; 35(1): 117–127. Published online 2021 Sep 24. doi: 10.1038/s41379-021-00922-7

PMCID:: PMC10317054

Article PDF–1.2M

Select item 1024570518.

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

Matthew H. Raymonda, Irene Rodríguez-Sánchez, Xenia L. Schafer, Leonid Smorodintsev-Schiller, Isaac S. Harris, Joshua Munger

Version 1. bioRxiv. Preprint. 2023 May 17. doi: 10.1101/2023.05.17.541212

Published in:: mBio. 2024 Jan; 15(1): e03031-23.

PMCID:: PMC10245705

Article PDF–1.7M

Select item 1024449819.

Reversal of memory and autism-related phenotypes in Tsc2^+/− mice via inhibition of Nlgn1

Kleanthi Chalkiadaki, Elpida Statoulla, Maria Zafeiri, Nabila Haji, Jean-Claude Lacaille, Craig M. Powell, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas

Front Cell Dev Biol. 2023; 11: 1205112. Published online 2023 May 24. doi: 10.3389/fcell.2023.1205112

PMCID:: PMC10244498

Article PDF–2.3M

Select item 1023605020.

Induction by rapamycin and proliferation‑promoting activity of Hspb1 in a Tsc2‑deficient cell line

Takayuki Kitano, Keiko Nishikawa, Tetsuya Takagaki, Yoshinobu Sugitani, Okio Hino, Toshiyuki Kobayashi

Exp Ther Med. 2023 Jul; 26(1): 315. Published online 2023 May 12. doi: 10.3892/etm.2023.12014

PMCID:: PMC10236050

Article PDF–588K

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