PMC Articles for MedGen (Select 442699) - PMC

Result Filters

Links from MedGen

Items: 1 to 20 of 500

<< First< Prev

Page of 25

Select item 108466101.

The Small Interactor of PKD2 protein promotes the assembly and ciliary entry of the Chlamydomonas PKD2–mastigoneme complexes

Poulomi Das, Betlehem Mekonnen, Rama Alkhofash, Abha V. Ingle, E. Blair Workman, Alec Feather, Gui Zhang, Nathan Chasen, Peiwei Liu, Karl F. Lechtreck

J Cell Sci. 2024 Jan 1; 137(1): jcs261497. Published online 2024 Jan 12. doi: 10.1242/jcs.261497

PMCID:: PMC10846610

Article

Select item 108271232.

The mechanosensitive Pkd2 channel modulates the recruitment of myosin II and actin to the cytokinetic contractile ring

Pritha Chowdhury, Debatrayee Sinha, Abhishek Poddar, Madhurya Chetluru, Qian Chen

Version 2. bioRxiv. Preprint. 2024 Jan 16 [revised 2024 Apr 6]. doi: 10.1101/2024.01.15.575753

PMCID:: PMC10827123

Article

Select item 106857723.

Targeted Next Generation Sequencing Revealed Novel Variants in the PKD1 and PKD2 Genes of Iranian Patients with Autosomal Dominant Polycystic Kidney Disease

Maryam Hosseinpour, Fariba Ardalani, Marzieh Mohseni, Maryam Beheshtian, Sanaz Arzhangi, Shahrzad Ossareh, Hossein Najmabadi, Ali Nobakht, Kimia Kahrizi, Behrooz Broumand

Arch Iran Med. 2022 Sep; 25(9): 600–608. Published online 2022 Sep 1. doi: 10.34172/aim.2022.95

PMCID:: PMC10685772

Article PDF–1.3M

Select item 104546524.

Co-Inheritance of Pathogenic Variants in PKD1 and PKD2 Genes Determined by Parental Segregation and De Novo Origin: A Case Report

Ludovico Graziani, Stefania Zampatti, Miriam Lucia Carriero, Chiara Minotti, Cristina Peconi, Mario Bengala, Emiliano Giardina, Giuseppe Novelli

Genes (Basel) 2023 Aug; 14(8): 1589. Published online 2023 Aug 6. doi: 10.3390/genes14081589

PMCID:: PMC10454652

Article PDF–534K

Select item 103549975.

Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay

Xuyan Liu, Xiaomeng Shi, Qing Xin, Zhiying Liu, Fengjiao Pan, Dan Qiao, Mengke Chen, Yiyin Zhang, Wencong Guo, Changying Li, Yan Zhang, Leping Shao, Ruixiao Zhang

BMC Genomics. 2023; 24: 407. Published online 2023 Jul 19. doi: 10.1186/s12864-023-09444-9

PMCID:: PMC10354997

Article PDF–2.0M

Select item 103127286.

Small Interactor of PKD2 (SIP), a novel PKD2-related single-pass transmembrane protein, is required for proteolytic processing and ciliary import of Chlamydomonas PKD2

Poulomi Das, Betlehem Mekonnen, Rama Alkhofash, Abha Ingle, E. Blair Workman, Alec Feather, Peiwei Liu, Karl F. Lechtreck

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.13.544839

Published in:: J Cell Sci. 2024 Jan 1; 137(1): jcs261497.

PMCID:: PMC10312728

Article PDF–2.8M

Select item 102017797.

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Elizabeth J. Wilk, Timothy C. Howton, Jennifer L. Fisher, Vishal H. Oza, Ryan T. Brownlee, Kasi C. McPherson, Hannah L. Cleary, Bradley K. Yoder, James F. George, Michal Mrug, Brittany N. Lasseigne

Mol Med. 2023; 29: 67. Published online 2023 May 22. doi: 10.1186/s10020-023-00664-z

PMCID:: PMC10201779

Article PDF–4.7M

Select item 101937828.

PKD2/polycystin-2 inhibits LPS-induced acute lung injury in vitro and in vivo by activating autophagy

Fan Pan, Lina Bu, Kaixuan Wu, Aizhong Wang, Xiaotao Xu

BMC Pulm Med. 2023; 23: 171. Published online 2023 May 18. doi: 10.1186/s12890-023-02449-w

PMCID:: PMC10193782

Article PDF–4.0M

Select item 100178219.

Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine

Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai

Sci Rep. 2023; 13: 4271. Published online 2023 Mar 15. doi: 10.1038/s41598-023-31322-3

PMCID:: PMC10017821

Article PDF–4.1M

Select item 972780610.

Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis

Abhishek Poddar, Yen-Yu Hsu, Faith Zhang, Abeda Shamma, Zachary Kreais, Clare Muller, Mamata Malla, Aniruddha Ray, Allen P. Liu, Qian Chen

Mol Biol Cell. 2022 Dec 1; 33(14): ar134. Published online 2022 Nov 18. doi: 10.1091/mbc.E22-07-0248

PMCID:: PMC9727806

Article PDF–4.1M

Select item 970235611.

Establishment of transgenic pigs overexpressing human PKD2-D511V mutant

Yuan Zhang, Saifei Xu, Qiao Jin, Jianing Luo, Ce Gao, Sakthidasan Jayaprakash, Huanan Wang, Lenan Zhuang, Jin He

Front Genet. 2022; 13: 1059682. Published online 2022 Nov 14. doi: 10.3389/fgene.2022.1059682

PMCID:: PMC9702356

Article PDF–3.1M

Select item 939964912.

Role of PKD2 in the endoplasmic reticulum calcium homeostasis

Xiong Liu, Jingfeng Tang, Xing-Zhen Chen

Front Physiol. 2022; 13: 962571. Published online 2022 Aug 10. doi: 10.3389/fphys.2022.962571

PMCID:: PMC9399649

Article PDF–757K

Select item 937245413.

Lnc-PKD2-2-3/miR-328/GPAM ceRNA Network Induces Cholangiocarcinoma Proliferation, Invasion and 5-FU Chemoresistance

Lei Zhang, Donglai Ma, Fujun Li, Gongcai Qiu, Dongsheng Sun, Zhaolin Zeng

Front Oncol. 2022; 12: 871281. Published online 2022 Jul 29. doi: 10.3389/fonc.2022.871281

PMCID:: PMC9372454

Article PDF–16M

Select item 924987414.

PKD2 founder mutation is the most common mutation of polycystic kidney disease in Taiwan

Chih-Chuan Yu, An-Fu Lee, Stefen Kohl, Ming-Yen Lin, Siao Muk Cheng, Chi-Chih Hung, Jer-Ming Chang, Yi-Wen Chiu, Shang-Jyh Hwang, Edgar A. Otto, Friedhelm Hildebrandt, Taiwan PKD Consortium, Daw-Yang Hwang

NPJ Genom Med. 2022; 7: 40. Published online 2022 Jul 1. doi: 10.1038/s41525-022-00309-w

PMCID:: PMC9249874

Article PDF–1.4M

Select item 903180315.

Novel PKD2 Missense Mutation p.Ile424Ser in an Individual with Multiple Hepatic Cysts: A Case Report

Seiko Miura, Yo Niida, Chieko Hashizume, Ai Fujii, Yuta Takagaki, Kahoru Kusama, Sumiyo Akazawa, Tetsuya Minami, Tsuyoshi Mukai, Kengo Furuichi, Mutsumi Tsuchishima, Nobuhiko Ueda, Hiroyuki Takamura, Daisuke Koya, Tohru Ito

Medicines (Basel) 2022 Apr; 9(4): 25. Published online 2022 Mar 29. doi: 10.3390/medicines9040025

PMCID:: PMC9031803

Article PDF–1.7M

Select item 888217016.

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas

Ling Gao, Qian Zhang, Shaoming Li, Jingjing Zheng, Wenhao Ren, Keqian Zhi

Cell Death Dis. 2022 Feb; 13(2): 192. Published online 2022 Feb 26. doi: 10.1038/s41419-021-04497-8

PMCID:: PMC8882170

Article PDF–4.1M

Select item 866101417.

Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions

Farideh Amirrad, Rajasekharreddy Pala, Kiumars Shamloo, Brian S. Muntean, Surya M. Nauli

Front Cardiovasc Med. 2021; 8: 772961. Published online 2021 Nov 26. doi: 10.3389/fcvm.2021.772961

PMCID:: PMC8661014

Article PDF–5.9M

Select item 863838618.

Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing

Zhengmao Zhang, Hanwen Bai, Jon Blumenfeld, Andrew B. Ramnauth, Irina Barash, Martin Prince, Adrian Y. Tan, Alber Michaeel, Genyan Liu, Ines Chicos, Lior Rennert, Stavros Giannakopoulos, Karen Larbi, Stuart Hughes, Steven P. Salvatore, Brian D. Robinson, Sandip Kapur, Hanna Rennert

J Am Soc Nephrol. 2021 Dec; 32(12): 3114–3129. Published online 2021 Dec. doi: 10.1681/ASN.2021050690

PMCID:: PMC8638386

Article

Select item 850291219.

LPA₁-mediated PKD2 activation promotes LPA-induced tissue factor expression via the p38α and JNK2 MAPK pathways in smooth muscle cells

Feng Hao, Qiwei Liu, Fuqiang Zhang, Jiaxin Du, Amanda Dumire, Xuemin Xu, Mei-Zhen Cui

J Biol Chem. 2021 Oct; 297(4): 101152. Published online 2021 Aug 31. doi: 10.1016/j.jbc.2021.101152

PMCID:: PMC8502912

Article PDF–2.3M

Select item 835459420.

PKD2/polycystin-2 induces autophagy by forming a complex with BECN1

Daniel Peña-Oyarzun, Marcelo Rodriguez-Peña, Francesca Burgos-Bravo, Angelo Vergara, Catalina Kretschmar, Cristian Sotomayor-Flores, Cesar A. Ramirez-Sarmiento, Humbert De Smedt, Montserrat Reyes, William Perez, Vicente A. Torres, Eugenia Morselli, Francisco Altamirano, Christian A. M. Wilson, Joseph A. Hill, Sergio Lavandero, Alfredo Criollo

Autophagy. 2021; 17(7): 1714–1728. Published online 2020 Jun 30. doi: 10.1080/15548627.2020.1782035