PMC Links for Nucleotide (Select 387912533) - PMC

Select item 67426461.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 59949182.

Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia

Jill S. Butler, Yi Hua Qiu, Nianxiang Zhang, Suk-Young Yoo, Kevin R. Coombes, Sharon Y.R. Dent, Steven M. Kornblau

Leuk Lymphoma. Author manuscript; available in PMC 2018 Jun 11.

Published in final edited form as: Leuk Lymphoma. 2017 May; 58(5): 1207–1218. Published online 2016 Oct 13. doi: 10.1080/10428194.2016.1235272

PMCID:: PMC5994918

Abstract Article PDF–3.7M

Select item 55274793.

Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex

Sara Weirich, Srikanth Kudithipudi, Albert Jeltsch

Mol Oncol. 2017 Apr; 11(4): 373–387. Published online 2017 Mar 10. doi: 10.1002/1878-0261.12041

PMCID:: PMC5527479

Abstract Article PDF–1.1M

Select item 1960264.

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1

Joanna Wysocka, Michael P. Myers, Carol D. Laherty, Robert N. Eisenman, Winship Herr

Genes Dev. 2003 Apr 1; 17(7): 896–911. doi: 10.1101/gad.252103

PMCID:: PMC196026

Abstract Article PDF–850K

Select item 1406705.

Activating Signal Cointegrator 2 Belongs to a Novel Steady-State Complex That Contains a Subset of Trithorax Group Proteins

Young-Hwa Goo, Young Chang Sohn, Dae-Hwan Kim, Seung-Whan Kim, Min-Jung Kang, Dong-Ju Jung, Eunyee Kwak, Nickolai A. Barlev, Shelley L. Berger, Vincent T. Chow, Robert G. Roeder, David O. Azorsa, Paul S. Meltzer, Pan-Gil Suh, Eun Joo Song, Kong-Joo Lee, Young Chul Lee, Jae Woon Lee

Mol Cell Biol. 2003 Jan; 23(1): 140–149. doi: 10.1128/MCB.23.1.140-149.2003

PMCID:: PMC140670

Abstract Article PDF–934K

Select item 69865596.

Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Jianhua Tian, Kevin B. Teuscher, Erin R. Aho, Joseph R. Alvarado, Jonathan J. Mills, Kenneth M. Meyers, Rocco D. Gogliotti, Changho Han, Jonathan D. Macdonald, Jiqing Sai, J. Grace Shaw, John L. Sensintaffar, Bin Zhao, Tyson A. Rietz, Lance R. Thomas, William G. Payne, William J. Moore, Gordon M. Stott, Jumpei Kondo, Masahiro Inoue, Robert J. Coffey, William P. Tansey, Shaun R. Stauffer, Taekyu Lee, Stephen W. Fesik

J Med Chem. Author manuscript; available in PMC 2020 Jan 28.

Published in final edited form as: J Med Chem. 2020 Jan 23; 63(2): 656–675. Published online 2020 Jan 7. doi: 10.1021/acs.jmedchem.9b01608

PMCID:: PMC6986559

Abstract Article PDF–2.1M

Select item 68423057.

Discovery of Potent 2-Aryl-6,7-Dihydro-5H-Pyrrolo[1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Feng Wang, Kyu Ok Jeon, James M. Salovich, Jonathan D. Macdonald, Joseph Alvarado, Rocco D. Gogliotti, Jason Phan, Edward T. Olejniczak, Qi Sun, Shidong Wang, DeMarco Camper, Joannes P. Yuh, J. Grace Shaw, Jiqing Sai, Olivia W. Rossanese, William P. Tansey, Shaun R. Stauffer, Stephen W. Fesik

J Med Chem. Author manuscript; available in PMC 2019 Nov 9.

Published in final edited form as: J Med Chem. 2018 Jul 12; 61(13): 5623–5642. Published online 2018 Jun 29. doi: 10.1021/acs.jmedchem.8b00375

PMCID:: PMC6842305

Abstract Article PDF–2.3M

Select item 61202168.

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

Nathan P. Coussens, Stephen C. Kales, Mark J. Henderson, Olivia W. Lee, Kurumi Y. Horiuchi, Yuren Wang, Qing Chen, Ekaterina Kuznetsova, Jianghong Wu, Sirisha Chakka, Dorian M. Cheff, Ken Chih-Chien Cheng, Paul Shinn, Kyle R. Brimacombe, Min Shen, Anton Simeonov, Madhu Lal-Nag, Haiching Ma, Ajit Jadhav, Matthew D. Hall

J Biol Chem. 2018 Aug 31; 293(35): 13750–13765. Published online 2018 Jun 26. doi: 10.1074/jbc.RA118.004274

PMCID:: PMC6120216

Abstract Article PDF–3.9M

Select item 48240129.

Genes that affect brain structure and function identified by rare variant analyses of Mendelian neurologic disease

Ender Karaca, Tamar Harel, Davut Pehlivan, Shalini N. Jhangiani, Tomasz Gambin, Zeynep Coban Akdemir, Claudia Gonzaga-Jauregui, Serkan Erdin, Yavuz Bayram, Ian M. Campbell, Jill V. Hunter, Mehmed M. Atik, Hilde Van Esch, Bo Yuan, Wojciech Wiszniewski, Sedat Isikay, Gozde Yesil, Ozge O. Yuregir, Sevcan Tug Bozdogan, Huseyin Aslan, Hatip Aydin, Tulay Tos, Ayse Aksoy, Darryl C. De Vivo, Preti Jain, B. Bilge Geckinli, Ozlem Sezer, Davut Gul, Burak Durmaz, Ozgur Cogulu, Ferda Ozkinay, Vehap Topcu, Sukru Candan, Alper Han Cebi, Mevlit Ikbal, Elif Yilmaz Gulec, Alper Gezdirici, Erkan Koparir, Fatma Ekici, Salih Coskun, Salih Cicek, Kadri Karaer, Asuman Koparir, Mehmet Bugrahan Duz, Emre Kirat, Elif Fenercioglu, Hakan Ulucan, Mehmet Seven, Tulay Guran, Nursel Elcioglu, Mahmut Selman Yildirim, Dilek Aktas, Mehmet Alikaşifoğlu, Mehmet Ture, Tahsin Yakut, John D. Overton, Adnan Yuksel, Mustafa Ozen, Donna M. Muzny, David R. Adams, Eric Boerwinkle, Wendy K. Chung, Richard A. Gibbs, James R Lupski

Neuron. Author manuscript; available in PMC 2016 Nov 4.

Published in final edited form as: Neuron. 2015 Nov 4; 88(3): 499–513. doi: 10.1016/j.neuron.2015.09.048

PMCID:: PMC4824012

Abstract Article PDF–3.2M

Select item 449070710.

Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases

Joseph J. Ferry, Robert F. Smith, Natalie Denney, Colin P. Walsh, Lauren McCauley, Jie Qian, Haiching Ma, Kurumi Y. Horiuchi, Konrad T. Howitz

Assay Drug Dev Technol. 2015 May 1; 13(4): 221–234. doi: 10.1089/adt.2015.646

PMCID:: PMC4490707

Abstract Article PDF–761K

Select item 365662711.

Assay Development for Histone Methyltransferases

Kurumi Y. Horiuchi, Mia M. Eason, Joseph J. Ferry, Jamie L. Planck, Colin P. Walsh, Robert F. Smith, Konrad T. Howitz, Haiching Ma

Assay Drug Dev Technol. 2013 May; 11(4): 227–236. doi: 10.1089/adt.2012.480

PMCID:: PMC3656627

Abstract Article PDF–510K

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