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Items: 1 to 20 of 27

1.
Baseline Toxicity Model to Identify the Specific and Nonspecific Effects of Per- and Polyfluoroalkyl Substances in Cell-Based Bioassays
Weiping Qin, Luise Henneberger, Juliane Glüge, Maria König, Beate I. Escher
Environ Sci Technol. 2024 Apr 2; 58(13): 5727–5738. Published online 2024 Feb 23. doi: 10.1021/acs.est.3c09950
PMCID:
PMC10993398
AbstractArticlePDF–3.9M
2.
Verification of in vivo estrogenic activity for four per- and polyfluoroalkyl substances (PFAS) identified as estrogen receptor agonists via new approach methodologies
Daniel L. Villeneuve, Brett R. Blackwell, Jenna E. Cavallin, Jacob Collins, John X. Hoang, Rachel N. Hofer, Keith A. Houck, Kathleen M. Jensen, Michael D. Kahl, Robin N. Kutsi, Anne S. Opseth, Kelvin J. Santana Rodriguez, Christopher M. Schaupp, Emma H. Stacy, Gerald T. Ankley
Environ Sci Technol. Author manuscript; available in PMC 2024 Mar 7.
Published in final edited form as: Environ Sci Technol. 2023 Mar 7; 57(9): 3794–3803. Published online 2023 Feb 17. doi: 10.1021/acs.est.2c09315
PMCID:
PMC10898820
AbstractArticlePDF–791K
3.
Oxidation of Per- and Polyfluoroalkyl Ether Acids and Other Per- and Polyfluoroalkyl Substances by Sulfate and Hydroxyl Radicals: Kinetic Insights from Experiments and Models
Chuhui Zhang, Tiffany Tang, Detlef R.U. Knappe
Environ Sci Technol. Author manuscript; available in PMC 2024 Feb 23.
Published in final edited form as: Environ Sci Technol. 2023 Nov 28; 57(47): 18970–18980. Published online 2023 May 24. doi: 10.1021/acs.est.3c00947
PMCID:
PMC10667564
AbstractArticlePDF–1.1M
4.
PFAS soil concentrations surrounding a hazardous waste incinerator in East Liverpool, Ohio, an environmental justice community
Kaitlin Vollet Martin, Timothy J. Hilbert, Michael Reilly, W. Jay Christian, Anna Hoover, Kelly G. Pennell, Qunxing Ding, Erin N. Haynes
Environ Sci Pollut Res Int. Author manuscript; available in PMC 2023 Sep 20.
Published in final edited form as: Environ Sci Pollut Res Int. 2023 Jul; 30(33): 80643–80654. Published online 2023 Jun 10. doi: 10.1007/s11356-023-27880-8
PMCID:
PMC10510938
AbstractArticlePDF–748K
5.
Exposure to a mixture of Per-and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines.
Zhao Yang, Katherine Roth, Jiahui Ding, Christopher D. Kassotis, Gil Mor, Michael C. Petriello
Toxicol Appl Pharmacol. Author manuscript; available in PMC 2023 Dec 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2022 Dec 1; 456: 116284. Published online 2022 Oct 18. doi: 10.1016/j.taap.2022.116284
PMCID:
PMC10325118
AbstractArticlePDF–738K
6.
Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death
Chad M. Thompson, Melissa M. Heintz, Jeffrey C. Wolf, Roza Cheru, Laurie C. Haws, John M. Cullen
Toxicol Pathol. 2023 Jan; 51(1-2): 4–14. Published online 2023 Mar 29. doi: 10.1177/01926233231159078
PMCID:
PMC10278389
AbstractArticlePDF–1.9M
7.
Environmental Exposure to Emerging Alternatives of Per- and Polyfluoroalkyl Substances and Polycystic Ovarian Syndrome in Women Diagnosed with Infertility: A Mixture Analysis
Wenqiang Zhan, Wei Qiu, Yan Ao, Wei Zhou, Yun Sun, Han Zhao, Jun Zhang
Environ Health Perspect. 2023 May; 131(5): 057001. Published online 2023 May 3. doi: 10.1289/EHP11814
PMCID:
PMC10156134
AbstractArticlePDF–882K
8.
Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans
Melissa M Heintz, Laurie C Haws, James E Klaunig, John M Cullen, Chad M Thompson
Toxicol Sci. 2023 Mar; 192(1): 15–29. Published online 2023 Jan 11. doi: 10.1093/toxsci/kfad004
PMCID:
PMC10025879
AbstractArticlePDF–600K
9.
Toxicity assessment of hexafluoropropylene oxide-dimer acid on morphology, heart physiology, and gene expression during zebrafish (Danio rerio) development
Sylvia Gong, Flannery McLamb, Damian Shea, Jeanne P. Vu, Miguel F. Vasquez, Zuying Feng, Kesten Bozinovic, Ken K. Hirata, Richard M. Gersberg, Goran Bozinovic
Environ Sci Pollut Res Int. 2023; 30(12): 32320–32336. Published online 2022 Dec 3. doi: 10.1007/s11356-022-24542-z
PMCID:
PMC10017623
AbstractArticlePDF–1.8M
10.
Theoretical Study on the Origin of Abnormal Regioselectivity in Ring-Opening Reaction of Hexafluoropropylene Oxide
Cui Yu, Yueqian Sang, Yao Li, Xiaosong Xue
Molecules. 2023 Feb; 28(4): 1669. Published online 2023 Feb 9. doi: 10.3390/molecules28041669
PMCID:
PMC9962681
AbstractArticlePDF–2.4M
11.
Transcriptional pathways linked to fetal and maternal hepatic dysfunction caused by gestational exposure to perfluorooctanoic acid (PFOA) or hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) in CD-1 mice
Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton
Ecotoxicol Environ Saf. Author manuscript; available in PMC 2022 Dec 15.
Published in final edited form as: Ecotoxicol Environ Saf. 2022 Dec 15; 248: 114314. Published online 2022 Nov 24. doi: 10.1016/j.ecoenv.2022.114314
PMCID:
PMC9742811
AbstractArticlePDF–2.0M
12.
Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice
Brecht Attema, Aafke W.F. Janssen, Deborah Rijkers, Evert M. van Schothorst, Guido J.E.J. Hooiveld, Sander Kersten
Mol Metab. 2022 Dec; 66: 101602. Published online 2022 Sep 14. doi: 10.1016/j.molmet.2022.101602
PMCID:
PMC9526138
AbstractArticlePDF–5.2M
13.
In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays
Nicola Evans, Justin M. Conley, Mary Cardon, Phillip Hartig, Elizabeth Medlock-Kakaley, L. Earl Gray, Jr.
Toxicol Appl Pharmacol. Author manuscript; available in PMC 2023 Aug 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2022 Aug 15; 449: 116136. Published online 2022 Jun 22. doi: 10.1016/j.taap.2022.116136
PMCID:
PMC9341220
AbstractArticlePDF–1.7M
14.
Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA
Melissa M. Heintz, Grace A. Chappell, Chad M. Thompson, Laurie C. Haws
Front Toxicol. 2022; 4: 937168. Published online 2022 Jun 27. doi: 10.3389/ftox.2022.937168
PMCID:
PMC9271854
AbstractArticlePDF–1.5M
15.
Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway
L. Earl Gray, Jr., Christy S. Lambright, Justin M. Conley, Nicola Evans, Johnathan R. Fur, Bethany R. Hannas, Vickie S. Wilson, Hunter Sampson, Paul M. D. Foster
Toxicol Sci. Author manuscript; available in PMC 2022 Aug 3.
Published in final edited form as: Toxicol Sci. 2021 Aug 3; 182(2): 195–214. doi: 10.1093/toxsci/kfab053
PMCID:
PMC9139873
AbstractArticlePDF–5.1M
16.
A High-Throughput Toxicity Screen of 42 Per- and Polyfluoroalkyl Substances (PFAS) and Functional Assessment of Migration and Gene Expression in Human Placental Trophoblast Cells
Bevin E. Blake, Brittany P. Rickard, Suzanne E. Fenton
Front Toxicol. 2022; 4: 881347. Published online 2022 Apr 25. doi: 10.3389/ftox.2022.881347
PMCID:
PMC9081605
AbstractArticlePDF–2.9M
17.
Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes
Emily Marques, Marisa Pfohl, Wei Wei, Giuseppe Tarantola, Lucie Ford, Ogochukwu Amaeze, Jessica Alesio, Sangwoo Ryu, Xuelian Jia, Hao Zhu, Geoffrey D. Bothun, Angela Slitt
Toxicol Appl Pharmacol. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2022 May 1; 442: 115991. Published online 2022 Mar 23. doi: 10.1016/j.taap.2022.115991
PMCID:
PMC9036616
AbstractArticlePDF–1.6M
18.
Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS)
Justin M. Conley, Christy S. Lambright, Nicola Evans, Elizabeth Medlock-Kakaley, Donna Hill, James McCord, Mark J. Strynar, Leah C. Wehmas, Susan Hester, Denise K. MacMillan, L. Earl Gray, Jr.
Environ Int. Author manuscript; available in PMC 2023 Feb 1.
Published in final edited form as: Environ Int. 2022 Feb; 160: 107056. Published online 2021 Dec 22. doi: 10.1016/j.envint.2021.107056
PMCID:
PMC8821375
AbstractArticlePDF–1.1M
19.
Hexafluoropropylene oxide dimer acid (GenX) exposure induces apoptosis in HepG2 cells
Hee Joon Yoo, Min Cheol Pyo, Yoonjin Park, Bo Yong Kim, Kwang-Won Lee
Heliyon. 2021 Nov; 7(11): e08272. Published online 2021 Oct 28. doi: 10.1016/j.heliyon.2021.e08272
PMCID:
PMC8571496
AbstractArticlePDF–1.4M
20.
Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat
Justin M. Conley, Christy S. Lambright, Nicola Evans, James McCord, Mark J. Strynar, Donna Hill, Elizabeth Medlock-Kakaley, Vickie S. Wilson, L. Earl Gray, Jr.
Environ Int. Author manuscript; available in PMC 2022 Jan 1.
Published in final edited form as: Environ Int. 2021 Jan; 146: 106204. Published online 2020 Oct 27. doi: 10.1016/j.envint.2020.106204
PMCID:
PMC7775906
AbstractArticlePDF–2.8M

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