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Select item 110567001.

Benefits and risks of clofarabine in adult acute lymphoblastic leukemia investigated in depth by multi‐state modeling

Sjoerd J. F. Hermans, Yvette van Norden, Jurjen Versluis, Anita W. Rijneveld, Bronno van der Holt, Okke de Weerdt, Bart J. Biemond, Arjan A. van de Loosdrecht, Lotte E. van der Wagen, Mar Bellido, Michel van Gelder, Walter J. F. M. van der Velden, Dominik Selleslag, Daniëlle van Lammeren‐Venema, Vincent H. J. van der Velden, Liesbeth C. de Wreede, Douwe Postmus, Francesco Pignatti, Jan J. Cornelissen

Cancer Med. 2024 May; 13(9): e6756. Published online 2024 Apr 29. doi: 10.1002/cam4.6756

PMCID:: PMC11056700

Abstract Article PDF–1019K

Select item 108158442.

Clofarabine Preconditioning followed by Allogeneic Transplant Using TBI and Post-Transplant Cyclophosphamide for Relapsed Refractory Leukemia

Seema Naik, Kevin Rakszawski, Hong Zheng, David Claxton, Kentaro Minagawa, Shin Mineishi

Int J Mol Sci. 2024 Jan; 25(2): 957. Published online 2024 Jan 12. doi: 10.3390/ijms25020957

PMCID:: PMC10815844

Abstract Article PDF–828K

Select item 106118553.

Patient-Level Meta-analysis of Clofarabine in Acute Lymphoblastic Leukemia

Sima Jeha, Hiroaki Goto, André Baruchel, Emmanuelle Boëlle-Le Corfec, Christine Geffriaud-Ricouard, Rob Pieters, Hee Young Shin

Adv Ther. 2023; 40(12): 5447–5463. Published online 2023 Oct 11. doi: 10.1007/s12325-023-02696-7

PMCID:: PMC10611855

Abstract Article PDF–508K

Select item 102917044.

POPULATION PHARMACOKINETICS OF CLOFARABINE AS PART OF PRE-TRANSPLANT CONDITIONING IN PEDIATRIC SUBJECTS PRIOR TO HEMATOPOIETIC CELL TRANSPLANTATION (HCT)

Hechuan Wang, Aksana K. Jones, Christopher C Dvorak, Liusheng Huang, Paul Orchard, Vijay Ivaturi, Janel Long-Boyle

Biol Blood Marrow Transplant. Author manuscript; available in PMC 2023 Jun 26.

Published in final edited form as: Biol Blood Marrow Transplant. 2019 Aug; 25(8): 1603–1610. Published online 2019 Apr 17. doi: 10.1016/j.bbmt.2019.04.017

PMCID:: PMC10291704

Abstract Article PDF–2.4M

Select item 100659445.

Design, Synthesis and Biological Evaluation of Nucleosidic CD99 Inhibitors that Selectively Reduce Ewing Sarcoma Viability

Kaluvu Balaraman, Emre Deniz, Eryn Nelson, Samantha L. Pilicer, Sezen Atasoy, Anna Molotkova, Handan Sevim, Purushottam B. Tiwari, Aykut Üren, Christian Wolf

Eur J Med Chem. Author manuscript; available in PMC 2024 May 5.

Published in final edited form as: Eur J Med Chem. 2023 Mar 2; 251: 115244. Published online 2023 Mar 2. doi: 10.1016/j.ejmech.2023.115244

PMCID:: PMC10065944

Abstract Article PDF–2.8M

Select item 99369216.

Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99

Haydar Çelik, Marika Sciandra, Bess Flashner, Elif Gelmez, Neslihan Kayraklıoğlu, David V. Allegakoen, Jeff R. Petro, Erin J. Conn, Sarah Hour, Jenny Han, Lalehan Oktay, Purushottam B. Tiwari, Mutlu Hayran, Brent T. Harris, Maria Cristina Manara, Jeffrey A. Toretsky, Katia Scotlandi, Aykut Üren

Oncogene. Author manuscript; available in PMC 2023 Feb 17.

Published in final edited form as: Oncogene. 2018 Apr; 37(16): 2181–2196. Published online 2018 Jan 31. doi: 10.1038/s41388-017-0080-4

PMCID:: PMC9936921

Abstract Article PDF–1.8M

Select item 97682377.

Clofarabine treatment of KMT2Ar infantile patients with acute lymphoblastic leukemia in St. Jude Total Therapy Study 16

Tanja A. Gruber, Deqing Pei, John Choi, Cheng Cheng, Elaine Coustan-Smith, Dario Campana, Hope D. Swanson, Jennifer L. Pauley, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Susana C. Raimondi, Ching-Hon Pui, Sima Jeha

Blood Adv. 2022 Dec 27; 6(24): 6131–6134. Published online 2022 Oct 20. doi: 10.1182/bloodadvances.2022008557

PMCID:: PMC9768237

Article PDF–239K

Select item 93525708.

A randomized phase III study of pretransplant conditioning for AML/MDS with fludarabine and once daily IV busulfan ± clofarabine in allogeneic stem cell transplantation

Borje S. Andersson, Peter F. Thall, Junsheng Ma, Benigno C. Valdez, Roland Bassett, Jr., Julianne Chen, Sairah Ahmed, Amin Alousi, Qaiser Bashir, Stefan Ciurea, Alison Gulbis, Rita Cool, Jitesh Kawedia, Chitra Hosing, Partow Kebriaei, Steve Kornblau, Alan Myers, Betul Oran, Katayoun Rezvani, Nina Shah, Elizabeth Shpall, Simrit Parmar, Uday R. Popat, Yago Nieto, Richard E. Champlin

Bone Marrow Transplant. 2022; 57(8): 1295–1303. Published online 2022 May 24. doi: 10.1038/s41409-022-01705-7

PMCID:: PMC9352570

Abstract Article PDF–1.3M

Select item 93516659.

Clofarabine monotherapy in two patients with refractory Langerhans cell histiocytosis

Masahiro Irie, Tomohiro Nakano, Saori Katayama, Tasuku Suzuki, Kunihiko Moriya, Yuko Watanabe, Nobu Suzuki, Yuka Saitoh‐Nanjyo, Masaei Onuma, Takeshi Rikiishi, Hidetaka Niizuma, Yoji Sasahara, Shigeo Kure

Cancer Rep (Hoboken) 2022 Aug; 5(8): e1579. Published online 2021 Nov 1. doi: 10.1002/cnr2.1579

PMCID:: PMC9351665

Abstract Article PDF–1.8M

Select item 915152010.

Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation

Masato Ooka, Jinghua Zhao, Pranav Shah, Jameson Travers, Carleen Klumpp-Thomas, Xin Xu, Ruili Huang, Stephen Ferguson, Kristine L. Witt, Stephanie L. Smith-Roe, Anton Simeonov, Menghang Xia

Arch Toxicol. 2022; 96(7): 1975–1987. Published online 2022 Apr 18. doi: 10.1007/s00204-022-03291-5

PMCID:: PMC9151520

Abstract Article PDF–1.6M

Select item 905290111.

Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group.

Gabriele Escherich, Udo zur Stadt, Arndt Borkhardt, Dagmar Dilloo, Jörg Faber, Tobias Feuchtinger, Thomas Imschweiler, Norbert Jorch, Arnulf Pekrun, Irene Schmid, Franziska Schramm, Michael Spohn, Martin Zimmermann, Martin A Horstmann

Haematologica. 2022 May 1; 107(5): 1026–1033. Published online 2021 Aug 5. doi: 10.3324/haematol.2021.279357

PMCID:: PMC9052901

Abstract Article PDF–3.2M

Select item 904392612.

Clofarabine with topotecan, vinorelbine, and thiotepa reinduction regimen for children and young adults with relapsed AML

Kavitha Ramaswamy, Peter G. Steinherz, Anurag K. Agrawal, Christopher J. Forlenza, Audrey Mauguen, Mikhail Roshal, Tanya Trippett, Nancy A. Kernan, Maria Luisa Sulis, Neerav Shukla

Blood Adv. 2022 Apr 26; 6(8): 2688–2694. Published online 2022 Apr 25. doi: 10.1182/bloodadvances.2021005753

PMCID:: PMC9043926

Abstract Article PDF–874K

Select item 894145513.

Clofarabine-fludarabine-busulfan in HCT for pediatric leukemia: an effective, low toxicity, TBI-free conditioning regimen

A. Birgitta Versluijs, Coco C. H. de Koning, Arjan C. Lankester, Stefan Nierkens, Wouter J. Kollen, Dorine Bresters, Caroline A. Lindemans, Jaap Jan Boelens, Marc Bierings

Blood Adv. 2022 Mar 22; 6(6): 1719–1730. Published online 2022 Mar 14. doi: 10.1182/bloodadvances.2021005224

PMCID:: PMC8941455

Abstract Article PDF–1.2M

Select item 891524714.

Phase 1 study of the histone deacetylase inhibitor entinostat plus clofarabine for poor-risk Philadelphia chromosome-negative (newly diagnosed older adults or adults with relapsed refractory disease) acute lymphoblastic leukemia or biphenotypic leukemia

Hetty E. Carraway, Yazeed Sawalha, Ivana Gojo, Min-Jung Lee, Sunmin Lee, Yusuke Tomita, Akira Yuno, Jackie Greer, B. Douglas Smith, Keith W Pratz, Mark J. Levis, Steven D. Gore, Nilanjan Ghosh, Amy Dezern, Amanda L. Blackford, Maria R. Baer, Lia Gore, Richard Piekarz, Jane B. Trepel, Judith E. Karp

Leuk Res. Author manuscript; available in PMC 2022 Mar 11.

Published in final edited form as: Leuk Res. 2021 Nov; 110: 106707. Published online 2021 Sep 10. doi: 10.1016/j.leukres.2021.106707

PMCID:: PMC8915247

Abstract Article PDF–1.0M

Select item 886464015.

Clofarabine added to intensive treatment in adult patients with newly diagnosed ALL: the HOVON-100 trial

Anita W. Rijneveld, Bronno van der Holt, Okke de Weerdt, Bart J. Biemond, Arjen A. van de Loosdrecht, Lotte E. van der Wagen, Mar Bellido, Michel van Gelder, Walter J. F. M. van der Velden, Dominik Selleslag, Daniëlle van Lammeren-Venema, Constantijn J. M. Halkes, Rob Fijnheer, Violaine Havelange, Geerte L. van Sluis, Marie-Cecile Legdeur, Dries Deeren, Alain Gadisseur, Harm A. M. Sinnige, Dimitri A. Breems, Aurélie Jaspers, Ollivier Legrand, Wim E. Terpstra, Rinske S. Boersma, Dominiek Mazure, Agnes Triffet, Lidwine W. Tick, Karolien Beel, Johan A. Maertens, H. Berna Beverloo, Marleen Bakkus, Christa H. E. Homburg, Valerie de Haas, Vincent H. J. van der Velden, Jan J. Cornelissen, the Dutch-Belgian HOVON Cooperative group

Blood Adv. 2022 Feb 22; 6(4): 1115–1125. Published online 2022 Feb 11. doi: 10.1182/bloodadvances.2021005624

PMCID:: PMC8864640

Abstract Article PDF–1.1M

Select item 885703316.

Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma

Caitlin M. O’Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla

Cancer Res. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Cancer Res. 2022 Feb 15; 82(4): 721–733. doi: 10.1158/0008-5472.CAN-21-1987

PMCID:: PMC8857033

Abstract Article PDF–2.3M

Select item 881707517.

The added value of multi‐state modelling in a randomized controlled trial: The HOVON 102 study re‐analyzed

Katerina Bakunina, Hein Putter, Jurjen Versluis, Eva A. S. Koster, Bronno van der Holt, Markus G. Manz, Dimitri A. Breems, Bjorn T. Gjertsen, Jacqueline Cloos, Peter J. M. Valk, Jakob Passweg, Thomas Pabst, Gert J. Ossenkoppele, Bob Löwenberg, Jan J. Cornelissen, Liesbeth C. de Wreede

Cancer Med. 2022 Feb; 11(3): 630–640. Published online 2021 Dec 24. doi: 10.1002/cam4.4392

PMCID:: PMC8817075

Abstract Article PDF–1.0M

Select item 871008318.

PHASE I STUDY OF BENDAMUSTINE IN COMBINATION WITH CLOFARABINE, ETOPOSIDE, AND DEXAMETHASONE IN PEDIATRIC PATIENTS WITH RELAPSED OR REFRACTORY HEMATOLOGIC MALIGNANCIES

Sima Jeha, Kristine R Crews, Deqing Pei, Melissa Peyton, John C Panetta, Raul C Ribeiro, Xujie Zhao, Patrick Campbell, Monika L. Metzger, Jun J. Yang, Cheng Cheng, Ching-Hon Pui, Deepa Bhojwani

Cancer. Author manuscript; available in PMC 2022 Jun 15.

Published in final edited form as: Cancer. 2021 Jun 15; 127(12): 2074–2082. Published online 2021 Feb 17. doi: 10.1002/cncr.33465

PMCID:: PMC8710083

Abstract Article PDF–226K

Select item 852403019.

Effectiveness and Safety of Clofarabine Monotherapy or Combination Treatment in Relapsed/Refractory Childhood Acute Lymphoblastic Leukemia: A Pragmatic, Non-interventional Study in Korea

Jung Yoon Choi, Che Ry Hong, Kyung Taek Hong, Hyoung Jin Kang, Seongkoo Kim, Jae Wook Lee, Pil Sang Jang, Nack-Gyun Chung, Bin Cho, Hyery Kim, Kyung-Nam Koh, Ho Joon Im, Jong Jin Seo, Seung Min Hahn, Jung Woo Han, Chuhl Joo Lyu, Eu Jeen Yang, Young Tak Lim, Keon Hee Yoo, Hong Hoe Koo, Hoon Kook, In Sang Jeon, Hana Cho, Hee Young Shin

Cancer Res Treat. 2021 Oct; 53(4): 1184–1194. Published online 2021 Jan 4. doi: 10.4143/crt.2020.289

PMCID:: PMC8524030

Abstract Article PDF–2.2M

Select item 835927920.

Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients

A. Laura Nijstad, Stefan Nierkens, Caroline A. Lindemans, Jaap Jan Boelens, Marc Bierings, A. Birgitta Versluys, Kim C.M. van der Elst, Alwin D.R. Huitema

Br J Clin Pharmacol. 2021 Aug; 87(8): 3218–3226. Published online 2021 Feb 1. doi: 10.1111/bcp.14738

PMCID:: PMC8359279

Abstract Article PDF–1.8M

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