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Items: 16

1.
Mechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency
Benni Vargas, James Boslett, Nathan Yates, Nicolas Sluis-Cremer
Biomolecules. 2023 Jan; 13(1): 100. Published online 2023 Jan 4. doi: 10.3390/biom13010100
PMCID:
PMC9855626
ArticlePDF–1.6M
2.
Targeting PAK4 inhibits Ras-mediated signaling and multiple oncogenic pathways in high-risk Rhabdomyosarcoma
Atreyi Dasgupta, Laura Sierra, Susan V. Tsang, Lyazat Kurenbekova, Tajhal Patel, Kimal Rajapakse, Ryan L. Shuck, Nino Rainusso, Yosef Landesman, Thaddeus Unger, Cristian Coarfa, Jason T. Yustein
Cancer Res. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Cancer Res. 2021 Jan 1; 81(1): 199–212. Published online 2020 Nov 9. doi: 10.1158/0008-5472.CAN-20-0854
PMCID:
PMC7878415
ArticlePDF–1.9M
3.
PAK4 Regulates Actin and Microtubule Dynamics during Meiotic Maturation in Mouse Oocyte
Ya-Ting He, Lei-Lei Yang, Shi-Ming Luo, Wei Shen, Shen Yin, Qing-Yuan Sun
Int J Biol Sci. 2019; 15(11): 2408–2418. Published online 2019 Sep 7. doi: 10.7150/ijbs.34718
PMCID:
PMC6775323
ArticlePDF–1.7M
4.
The target landscape of clinical kinase drugs
Susan Klaeger, Stephanie Heinzlmeir, Mathias Wilhelm, Harald Polzer, Binje Vick, Paul-Albert Koenig, Maria Reinecke, Benjamin Ruprecht, Svenja Petzoldt, Chen Meng, Jana Zecha, Katrin Reiter, Huichao Qiao, Dominic Helm, Heiner Koch, Melanie Schoof, Giulia Canevari, Elena Casale, Stefania Re Depaolini, Annette Feuchtinger, Zhixiang Wu, Tobias Schmidt, Lars Rueckert, Wilhelm Becker, Jan Huenges, Anne-Kathrin Garz, Bjoern-Oliver Gohlke, Daniel Paul Zolg, Gian Kayser, Tonu Vooder, Robert Preissner, Hannes Hahne, Neeme Tonisson, Karl Kramer, Katharina Goetze, Florian Bassermann, Judith Schlegl, Hans-Christian Ehrlich, Stephan Aiche, Axel Walch, Philipp A. Greif, Sabine Schneider, Eduard Rudolf Felder, Juergen Ruland, Guillaume Medard, Irmela Jeremias, Karsten Spiekermann, Bernhard Kuster
Science. Author manuscript; available in PMC 2019 May 30.
Published in final edited form as: Science. 2017 Dec 1; 358(6367): eaan4368. doi: 10.1126/science.aan4368
PMCID:
PMC6542668
ArticlePDF–2.5M
5.
Cyclic AMP-dependent protein kinase A and EPAC mediate VIP and secretin stimulation of PAK4 and activation of Na+,K+-ATPase in pancreatic acinar cells
Irene Ramos-Alvarez, Lingaku Lee, R. T. Jensen
Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1; 316(2): G263–G277. Published online 2018 Dec 6. doi: 10.1152/ajpgi.00275.2018
PMCID:
PMC6397337
Article
6.
Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency
Benni Vargas, Nicholas S. Giacobbi, Anwesha Sanyal, Narasimhan J. Venkatachari, Feng Han, Phalguni Gupta, Nicolas Sluis-Cremer
Antimicrob Agents Chemother. 2019 Feb; 63(2): e01744-18. Prepublished online 2018 Nov 19. Published online 2019 Jan 29. doi: 10.1128/AAC.01744-18
PMCID:
PMC6355603
ArticlePDF–1.0M
7.
Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4
Zhiheng Li, Xiaolu Li, Lixiao Xu, Yanfang Tao, Chun Yang, Xiaolan Chen, Fang Fang, Yi Wu, Xin Ding, He Zhao, Mei Li, Guanghui Qian, Yunyun Xu, Junli Ren, Weiwei Du, Jian Wang, Jun Lu, Shaoyan Hu, Jian Pan
Oncol Rep. 2017 Nov; 38(5): 2705–2716. Published online 2017 Sep 22. doi: 10.3892/or.2017.5989
PMCID:
PMC5780023
ArticlePDF–1.7M
8.
Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis
Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam, Hong He
BMC Cancer. 2017; 17: 431. Published online 2017 Jun 19. doi: 10.1186/s12885-017-3432-0
PMCID:
PMC5477105
ArticlePDF–1.2M
9.
P21-Activated Kinase 1 Regulates Resistance to BRAF Inhibition in Human Cancer Cells
Mahamat Babagana, Sydney Johnson, Hannah Slabodkin, Wiam Bshara, Carl Morrison, Eugene S. Kandel
Mol Carcinog. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Mol Carcinog. 2017 May; 56(5): 1515–1525. Published online 2017 Feb 23. doi: 10.1002/mc.22611
PMCID:
PMC5392142
ArticlePDF–1.1M
10.
Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells
Remya Raja, Nandini A. Sahasrabuddhe, Aneesha Radhakrishnan, Nazia Syed, Hitendra S. Solanki, Vinuth N. Puttamallesh, Sai A. Balaji, Vishalakshi Nanjappa, Keshava K. Datta, Niraj Babu, Santosh Renuse, Arun H. Patil, Evgeny Izumchenko, T.S. Keshava Prasad, Xiaofei Chang, Annapoorni Rangarajan, David Sidransky, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee
Oncotarget. 2016 Sep 20; 7(38): 61229–61245. Published online 2016 Aug 16. doi: 10.18632/oncotarget.11310
PMCID:
PMC5308647
ArticlePDF–6.1M
11.
Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, Marie-Helene Bellance, Werner Breitenstein, Dylan Daniel, Regis Denay, Doriano Fabbro, Cesar Fernandez, Inga Galuba, Stephanie Guerro-Lagasse, Sascha Gutmann, Linda Hinh, Wolfgang Jahnke, Julia Klopp, Albert Lai, Mika K. Lindvall, Sylvia Ma, Henrik Möbitz, Sabina Pecchi, Gabriele Rummel, Kevin Shoemaker, Joerg Trappe, Charles Voliva, Sandra W. Cowan-Jacob, Andreas L. Marzinzik
ACS Med Chem Lett. 2015 Jul 9; 6(7): 776–781. Published online 2015 May 22. doi: 10.1021/acsmedchemlett.5b00102
PMCID:
PMC4499825
ArticlePDF–2.9M
12.
The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity
Widyawilis Selamat, Pei-Ling Felicia Tay, Yohendran Baskaran, Ed Manser
PLoS One. 2015; 10(6): e0129634. Published online 2015 Jun 11. doi: 10.1371/journal.pone.0129634
PMCID:
PMC4466050
ArticlePDF–5.0M
13.
PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/ERK-dependent pathways
Xueqiong Fu, Jiarui Feng, Duan Zeng, Yu Ding, Changshou Yu, Bing Yang
Biosci Rep. 2014; 34(2): e00094. Prepublished online 2014 Jan 29. Published online 2014 Mar 4. doi: 10.1042/BSR20130102
PMCID:
PMC3941610
ArticlePDF–926K
14.
Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6
Jia Gao, Byung Hak Ha, Hua Jane Lou, Elizabeth M. Morse, Rong Zhang, David A. Calderwood, Benjamin E. Turk, Titus J. Boggon
PLoS One. 2013; 8(10): e77818. Published online 2013 Oct 28. doi: 10.1371/journal.pone.0077818
PMCID:
PMC3810134
ArticlePDF–2.1M
15.
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells
Luis E. Arias-Romero, Olga Villamar-Cruz, Min Huang, Klaus P. Hoeflich, Jonathan Chernoff
Cancer Res. Author manuscript; available in PMC 2014 Jun 15.
Published in final edited form as: Cancer Res. 2013 Jun 15; 73(12): 3671–3682. Published online 2013 Apr 10. doi: 10.1158/0008-5472.CAN-12-4453
PMCID:
PMC3687032
ArticlePDF–1.7M
16.
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth
Brion W. Murray, Chuangxing Guo, Joseph Piraino, John K. Westwick, Cathy Zhang, Jane Lamerdin, Eleanor Dagostino, Daniel Knighton, Cho-Ming Loi, Michael Zager, Eugenia Kraynov, Ian Popoff, James G. Christensen, Ricardo Martinez, Susan E. Kephart, Joseph Marakovits, Shannon Karlicek, Simon Bergqvist, Tod Smeal
Proc Natl Acad Sci U S A. 2010 May 18; 107(20): 9446–9451. Published online 2010 May 3. doi: 10.1073/pnas.0911863107
PMCID:
PMC2889050
ArticlePDF–926K

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