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Select item 110059181.

Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis

Hiroki Ohzono, Yiwen Hu, Keita Nagira, Haruhisa Kanaya, Naoki Okubo, Merissa Olmer, Masafumi Gotoh, Ichiro Kurakazu, Yukio Akasaki, Manabu Kawata, Emily Chen, Alan C. Chu, Kristen A. Johnson, Martin K. Lotz

Ann Rheum Dis. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Ann Rheum Dis. 2023 Feb; 82(2): 262–271. Published online 2022 Sep 15. doi: 10.1136/ard-2021-221269

PMCID:: PMC11005918

Article PDF–1.9M

Select item 109039482.

Histone deacetylases maintain expression of the pluripotent gene network via recruitment of RNA polymerase II to coding and noncoding loci

Richard D.W. Kelly, Kristy R. Stengel, Aditya Chandru, Lyndsey C. Johnson, Scott W. Hiebert, Shaun M. Cowley

Genome Res. 2024 Jan; 34(1): 34–46. doi: 10.1101/gr.278050.123

PMCID:: PMC10903948

Article PDF–7.4M

Select item 109036303.

Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a

Marie Armani-Tourret, Ce Gao, Ciputra Adijaya Hartana, WeiWei Sun, Leah Carrere, Liliana Vela, Alexander Hochroth, Maxime Bellefroid, Amy Sbrolla, Katrina Shea, Theresa Flynn, Isabelle Roseto, Yelizaveta Rassadkina, Carole Lee, Francoise Giguel, Rajeev Malhotra, Frederic D. Bushman, Rajesh T. Gandhi, Xu G. Yu, Daniel R. Kuritzkes, Mathias Lichterfeld

Cell. 2024 Feb 29; 187(5): 1238–1254.e14. doi: 10.1016/j.cell.2024.01.037

PMCID:: PMC10903630

Article PDF–7.9M

Select item 108480814.

Comprehensive analysis of PSMD family members and validation of PSMD9 as a potential therapeutic target in human glioblastoma

Yaquan Li, Xuemeng Liu, Feihu Zhao, Zhimin Zhao, Xingang Li, Jian Wang, Bin Huang, Anjing Chen

CNS Neurosci Ther. 2024 Feb; 30(2): e14366. Published online 2023 Jul 23. doi: 10.1111/cns.14366

PMCID:: PMC10848081

Article PDF–24M

Select item 108161535.

EphA2- and HDAC-Targeted Combination Therapy in Endometrial Cancer

Robiya Joseph, Santosh K. Dasari, Sujanitha Umamaheswaran, Lingegowda S. Mangala, Emine Bayraktar, Cristian Rodriguez-Aguayo, Yutuan Wu, Nghi Nguyen, Reid T. Powell, Mary Sobieski, Yuan Liu, Mark Seungwook Kim, Sara Corvigno, Katherine Foster, Pahul Hanjra, Thanh Chung Vu, Mamur A. Chowdhury, Paola Amero, Clifford Stephan, Gabriel Lopez-Berestein, Shannon N. Westin, Anil K. Sood

Int J Mol Sci. 2024 Jan; 25(2): 1278. Published online 2024 Jan 20. doi: 10.3390/ijms25021278

PMCID:: PMC10816153

Article PDF–3.4M

Select item 107281056.

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove

Nat Commun. 2023; 14: 8397. Published online 2023 Dec 18. doi: 10.1038/s41467-023-44020-5

PMCID:: PMC10728105

Article PDF–2.4M

Select item 105174947.

Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway

Bo Sheng, Wenwen Wang, Dongyue Xia, Xiangdong Qu

BMC Pharmacol Toxicol. 2023; 24: 45. Published online 2023 Sep 22. doi: 10.1186/s40360-023-00686-7

PMCID:: PMC10517494

Article PDF–4.9M

Select item 104836158.

Targeting mitochondrial energetics reverses panobinostat‐ and marizomib‐induced resistance in pediatric and adult high‐grade gliomas

Esther P. Jane, Matthew C. Reslink, Taylor A. Gatesman, Matthew E. Halbert, Tracy A. Miller, Brian J. Golbourn, Stephanie M. Casillo, Steven J. Mullett, Stacy G. Wendell, Udochukwu Obodo, Dinesh Mohanakrishnan, Riya Dange, Antony Michealraj, Charles Brenner, Sameer Agnihotri, Daniel R. Premkumar, Ian F. Pollack

Mol Oncol. 2023 Sep; 17(9): 1821–1843. Published online 2023 May 12. doi: 10.1002/1878-0261.13427

PMCID:: PMC10483615

Article PDF–2.0M

Select item 103978159.

Estimating the Economic Impact of Adding Panobinostat to a U.S. Formulary for Relapsed and/or Refractory Multiple Myeloma: A Budget Impact and Cost-Benefit Model

Lisa Bloudek, Anuja Roy, Jonathan K. Kish, David S. Siegel, Sundar Jagannath, Denise Globe, Laurie Orloski, Emil T. Kuriakose

J Manag Care Spec Pharm. 2016 Aug; 22(8): 10.18553/jmcp.2016.22.8.991. doi: 10.18553/jmcp.2016.22.8.991

PMCID:: PMC10397815

Article PDF–343K

Select item 1039403510.

HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

Matthew C. Garrett, Rebecca Albano, Troy Carnwath, Lubayna Elahi, Catherine A. Behrmann, Merissa Pemberton, Daniel Woo, Eric O’Brien, Brett VanCauwenbergh, John Perentesis, Sanjit Shah, Matthew Hagan, Ady Kendler, Chuntao Zhao, Aditi Paranjpe, Krishna Roskin, Harley Kornblum, David R. Plas, Q. Richard Lu

Sci Rep. 2023; 13: 12433. Published online 2023 Aug 1. doi: 10.1038/s41598-023-33889-3

PMCID:: PMC10394035

Article PDF–1.6M

Select item 1036612811.

A performance evaluation of drug response prediction models for individual drugs

Aron Park, Yeeun Lee, Seungyoon Nam

Sci Rep. 2023; 13: 11911. Published online 2023 Jul 24. doi: 10.1038/s41598-023-39179-2

PMCID:: PMC10366128

Article PDF–2.2M

Select item 1035593112.

Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6

Hirofumi Ando, Tsutomu Miyamoto, Hiroyasu Kashima, Shotaro Higuchi, Koichi Ida, David Hamisi Mvunta, Tanri Shiozawa

Horm Cancer. 2017 Aug; 8(4): 257–267. Published online 2017 May 17. doi: 10.1007/s12672-017-0295-4

PMCID:: PMC10355931

Article PDF–3.9M

Select item 1028434413.

Combinatorial treatment for spinal muscular atrophy

Angelo Poletti, Kenneth H. Fischbeck

J Neurochem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: J Neurochem. 2020 Apr; 153(2): 146–149. Published online 2020 Feb 14. doi: 10.1111/jnc.14974

PMCID:: PMC10284344

Article PDF–625K

Select item 1024417314.

Causal linkage of presence of mutant NPM1 to efficacy of novel therapeutic agents against AML cells with mutant NPM1

Christopher P. Mill, Warren Fiskus, Kaberi Das, John A. Davis, Christine E. Birdwell, Tapan M. Kadia, Courtney D. DiNardo, Naval Daver, Koichi Takahashi, Koji Sasaki, Gerard M. McGeehan, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Hagop Kantarjian, Kapil N. Bhalla

Leukemia. 2023; 37(6): 1336–1348. Published online 2023 Mar 28. doi: 10.1038/s41375-023-01882-4

PMCID:: PMC10244173

Article PDF–3.2M

Select item 1013339415.

Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling

Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin, Jyun-Yu Chen, Jia-Hua Li, Yeong-Shiau Pu, Ann-Lii Cheng, Jason Chia-Hsien Cheng, Sheng-Fang Su

Br J Cancer. 2023 May 18; 128(9): 1753–1764. Published online 2023 Feb 21. doi: 10.1038/s41416-023-02195-0

PMCID:: PMC10133394

Article PDF–5.3M

Select item 985640716.

Panobinostat Induced Spatial In Situ Biomarkers Predictive of Anti-PD-1 Efficacy in Mouse Mammary Carcinoma

Zuzana Tatarova, Dylan C. Blumberg, AeSoon Bensen, Gordon B. Mills, Oliver Jonas

Cells. 2023 Jan; 12(2): 308. Published online 2023 Jan 13. doi: 10.3390/cells12020308

PMCID:: PMC9856407

Article PDF–3.3M

Select item 978154717.

Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD-1/PD-L1 Blocking in Glioma and Squamous Cell Carcinoma Models

Yinglin Wu, Xiaoqing Chen, Lei Wang, Xusha Zhou, Yonghong Liu, Dongmei Ji, Peigen Ren, Grace Guoying Zhou, Jing Zhao

Viruses. 2022 Dec; 14(12): 2796. Published online 2022 Dec 15. doi: 10.3390/v14122796

PMCID:: PMC9781547

Article PDF–2.1M

Select item 977872818.

The Combination of Panobinostat and Melphalan for the Treatment of Patients with Multiple Myeloma

Maria Gkotzamanidou, Evangelos Terpos, Meletios A. Dimopoulos, Vassilis L. Souliotis

Int J Mol Sci. 2022 Dec; 23(24): 15671. Published online 2022 Dec 10. doi: 10.3390/ijms232415671

PMCID:: PMC9778728

Article PDF–3.7M

Select item 977847519.

Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells

Giorgio Milazzo, Giovanni Perini, Federico M. Giorgi

Genes (Basel) 2022 Dec; 13(12): 2240. Published online 2022 Nov 29. doi: 10.3390/genes13122240

PMCID:: PMC9778475

Article PDF–4.7M

Select item 975087420.

A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs

Zuzana Tatarova, Dylan C. Blumberg, James E. Korkola, Laura M. Heiser, John L. Muschler, Pepper J. Schedin, Sebastian W. Ahn, Gordon B. Mills, Lisa M. Coussens, Oliver Jonas, Joe W. Gray

Nat Biotechnol. 2022; 40(12): 1823–1833. Published online 2022 Jul 4. doi: 10.1038/s41587-022-01379-y