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Select item 62231291.

Cryo-EM structure of substrate-bound human telomerase holoenzyme

Thi Hoang Duong Nguyen, Jane Tam, Robert A. Wu, Basil J. Greber, Daniel Toso, Eva Nogales, Kathleen Collins

Nature. Author manuscript; available in PMC 2018 Nov 8.

Published in final edited form as: Nature. 2018 May; 557(7704): 190–195. Published online 2018 Apr 25. doi: 10.1038/s41586-018-0062-x

PMCID:: PMC6223129

Abstract Article PDF–5.0M

Select item 43493912.

Telomerase modulates Wnt signalling by association with target gene chromatin

Jae-Il Park, Andrew S. Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji, Margaret McLaughlin, Timothy D. Veenstra, Roel Nusse, Pierre D. McCrea, Steven E. Artandi

Nature. Author manuscript; available in PMC 2015 Mar 4.

Published in final edited form as: Nature. 2009 Jul 2; 460(7251): 66–72. doi: 10.1038/nature08137

PMCID:: PMC4349391

Abstract Article PDF–949K

Select item 36687093.

HIV-1 Vpr Protein Inhibits Telomerase Activity via the EDD-DDB1-VPRBP E3 Ligase Complex

Xin Wang, Shailbala Singh, Hae-Yun Jung, Guojun Yang, Sohee Jun, K. Jagannadha Sastry, Jae-Il Park

J Biol Chem. 2013 May 31; 288(22): 15474–15480. Published online 2013 Apr 23. doi: 10.1074/jbc.M112.416735

PMCID:: PMC3668709

Abstract Article PDF–961K

Select item 35916334.

Dyrk2-associated EDD-DDB1-VprBP E3 Ligase Inhibits Telomerase by TERT Degradation

Hae-Yun Jung, Xin Wang, Sohee Jun, Jae-Il Park

J Biol Chem. 2013 Mar 8; 288(10): 7252–7262. Published online 2013 Jan 28. doi: 10.1074/jbc.M112.416792

PMCID:: PMC3591633

Abstract Article PDF–2.6M

Select item 32416505.

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme

Simon Lattmann, Michael B. Stadler, James P. Vaughn, Steven A. Akman, Yoshikuni Nagamine

Nucleic Acids Res. 2011 Nov; 39(21): 9390–9404. Published online 2011 Aug 16. doi: 10.1093/nar/gkr630

PMCID:: PMC3241650

Abstract Article PDF–2.8M

Select item 31558066.

Telomere shortening and loss of self-renewal in dyskeratosis congenita iPS cells

Luis F.Z. Batista, Matthew F. Pech, Franklin L. Zhong, Ha Nam Nguyen, Kathleen T. Xie, Arthur J. Zaug, Sharon M. Crary, Jinkuk Choi, Vittorio Sebastiano, Athena Cherry, Neelam Giri, Marius Wernig, Blanche P. Alter, Thomas R. Cech, Sharon A. Savage, Renee A. Reijo Pera, Steven E. Artandi

Nature. Author manuscript; available in PMC 2011 Dec 16.

Published in final edited form as: Nature. 2011 Jun 16; 474(7351): 399–402. Published online 2011 May 22. doi: 10.1038/nature10084

PMCID:: PMC3155806

Abstract Article PDF–1.1M

Select item 31100227.

Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase

Erin M. Parry, Jonathan K. Alder, Xiaodong Qi, Julian J.-L. Chen, Mary Armanios

Blood. 2011 May 26; 117(21): 5607–5611. Prepublished online 2011 Mar 24. doi: 10.1182/blood-2010-11-322149

Correction in:: Blood. 2016 Apr 7; 127(14): 1837.

PMCID:: PMC3110022

Abstract Article

Select item 30691108.

Ancestral Mutation in Telomerase Causes Defects in Repeat Addition Processivity and Manifests As Familial Pulmonary Fibrosis

Jonathan K. Alder, Joy D. Cogan, Andrew F. Brown, Collin J. Anderson, William E. Lawson, Peter M. Lansdorp, John A. Phillips, III, James E. Loyd, Julian J.-L. Chen, Mary Armanios

PLoS Genet. 2011 Mar; 7(3): e1001352. Published online 2011 Mar 31. doi: 10.1371/journal.pgen.1001352

PMCID:: PMC3069110

Abstract Article PDF–1.5M

Select item 29175959.

Purification of Human Telomerase Complexes Identifies Factors Involved in Telomerase Biogenesis and Telomere Length Regulation

Dragony Fu, Kathleen Collins

Mol Cell. Author manuscript; available in PMC 2010 Aug 7.

Published in final edited form as: Mol Cell. 2007 Dec 14; 28(5): 773–785. doi: 10.1016/j.molcel.2007.09.023

PMCID:: PMC2917595

Abstract Article PDF–2.1M

Select item 288223010.

Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome

Anna Marrone, Amanda Walne, Hannah Tamary, Yuka Masunari, Michael Kirwan, Richard Beswick, Tom Vulliamy, Inderjeet Dokal

Blood. Author manuscript; available in PMC 2010 Jun 8.

Published in final edited form as: Blood. 2007 Dec 15; 110(13): 4198–4205. Published online 2007 Sep 4. doi: 10.1182/blood-2006-12-062851

PMCID:: PMC2882230

Abstract Article PDF–1.3M

Select item 287652111.

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled In Vivo

Emily D. Egan, Kathleen Collins

Mol Cell Biol. 2010 Jun; 30(11): 2775–2786. Published online 2010 Mar 29. doi: 10.1128/MCB.00151-10

PMCID:: PMC2876521

Abstract Article PDF–2.0M

Select item 274456512.

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo

Haley D. M. Wyatt, Allison R. Tsang, Deirdre A. Lobb, Tara L. Beattie

PLoS One. 2009; 4(9): e7176. Published online 2009 Sep 24. doi: 10.1371/journal.pone.0007176

PMCID:: PMC2744565

Abstract Article PDF–909K

Select item 272807113.

A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

Andrew S. Venteicher, Eladio B. Abreu, Zhaojing Meng, Kelly E. McCann, Rebecca M. Terns, Timothy D. Veenstra, Michael P. Terns, Steven E. Artandi

Science. Author manuscript; available in PMC 2009 Aug 17.

Published in final edited form as: Science. 2009 Jan 30; 323(5914): 644–648. doi: 10.1126/science.1165357

PMCID:: PMC2728071

Abstract Article PDF–2.9M

Select item 266225014.

Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase

Sascha Jakob, Peter Schroeder, Margarete Lukosz, Nicole Büchner, Ioakim Spyridopoulos, Joachim Altschmied, Judith Haendeler

J Biol Chem. 2008 Nov 28; 283(48): 33155–33161. doi: 10.1074/jbc.M805138200

PMCID:: PMC2662250

Abstract Article PDF–437K

Select item 262780615.

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia

Rodrigo T. Calado, Joshua A. Regal, Mark Hills, William T. Yewdell, Leandro F. Dalmazzo, Marco A. Zago, Peter M. Lansdorp, Donna Hogge, Stephen J. Chanock, Elihu H. Estey, Roberto P. Falcão, Neal S. Young

Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4): 1187–1192. Published online 2009 Jan 15. doi: 10.1073/pnas.0807057106

PMCID:: PMC2627806

Abstract Article PDF–397K

Select item 221474916.

Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene

Hong-Yan Du, Elena Pumbo, Peter Manley, Joshua J. Field, Susan J. Bayliss, David B. Wilson, Philip J. Mason, Monica Bessler

Blood. 2008 Feb 1; 111(3): 1128–1130. Prepublished online 2007 Nov 27. doi: 10.1182/blood-2007-10-120907

PMCID:: PMC2214749

Abstract Article

Select item 219261117.

Regulated expression of telomerase activity in human T lymphocyte development and activation

J Exp Med. 1996 Jun 1; 183(6): 2471–2479. doi: 10.1084/jem.183.6.2471

PMCID:: PMC2192611

Summary PDF–1.4M

Select item 189991318.

Characterization of Physical and Functional Anchor Site Interactions in Human Telomerase

Haley D. M. Wyatt, Deirdre A. Lobb, Tara L. Beattie

Mol Cell Biol. 2007 Apr; 27(8): 3226–3240. Published online 2007 Feb 12. doi: 10.1128/MCB.02368-06

PMCID:: PMC1899913

Abstract Article PDF–531K

Select item 185591719.

Adult-onset pulmonary fibrosis caused by mutations in telomerase

Kalliopi D. Tsakiri, Jennifer T. Cronkhite, Phillip J. Kuan, Chao Xing, Ganesh Raghu, Jonathan C. Weissler, Randall L. Rosenblatt, Jerry W. Shay, Christine Kim Garcia

Proc Natl Acad Sci U S A. 2007 May 1; 104(18): 7552–7557. Published online 2007 Apr 25. doi: 10.1073/pnas.0701009104