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1.
Figure 3

Figure 3. Meta-analysis of the odds of CKD per each additional copy of the minor T allele at UMOD rs12917707 across strata of major kidney disease risk factors. From: Multiple Novel Loci are Associated with Indices of Renal Function and Chronic Kidney Disease.

Error bars correspond to 95% confidence intervals. Meta-analysis values obtained from the discovery samples.

Anna Köttgen, et al. Nat Genet. ;41(6):712-717.

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2.
Figure 1

Figure 1. Meta-analysis -log10(P-value) vs. genomic position plots for CKD (A), eGFRcrea (B), and eGFRcys (C) in the discovery samples. From: Multiple Novel Loci are Associated with Indices of Renal Function and Chronic Kidney Disease.

Genomic loci with evidence of suggestive association (p<4*10−7) are plotted in orange and with significant association (p<5*10−8) in red, with the exception of the SNP at the JAG1 locus on chromosome 20 (panel B, grey) which did not replicate.

Anna Köttgen, et al. Nat Genet. ;41(6):712-717.

CitationFull text

3.
Figure 2

Figure 2. Genetic architecture of the genome-wide significant susceptibility loci for renal disease in the discovery samples: (A): UMOD gene region, (B): SHROOM3 gene region, (C): GATM/SPATA5L1 gene region, (D) CST genes region, (E) STC1 gene region. From: Multiple Novel Loci are Associated with Indices of Renal Function and Chronic Kidney Disease.

−log10 P-values are plotted versus genomic position (Build 36). The most significant SNP in each region is plotted in blue. LD based on the HapMap CEU sample is color-coded: red (r2 to top SNP 0.8–.0), orange (0.5–.8), yellow (0.2–.5), and white (<0.2). Gene annotations are based on Build 36 and arrows present direction of transcription. P-values are obtained from the discovery traits: CKD (UMOD), eGFRcrea (SHROOM3, GATM), eGFRcys (CST, STC1).

Anna Köttgen, et al. Nat Genet. ;41(6):712-717.

CitationFull text

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