PMC

Box plots (median, interquartile ranges) of serum levels of MIF in the 5 time-point after PTB treatment (N = 47). MIF = Macrophage migration inhibitory factor; PTB=Pulmonary Tuberculosis

Receiver operator characteristic curve demonstrating sensitivity as a function of 1-specificity for predicting the mortality based on the different biomarkers. Combined model included MIF/CRP/IL-6. CRP=C-reactive protein; IL-6 = Interleukin 6; MIF = Macrophage migration inhibitory factor

Kaplan-Meier curves analysis for serum MIF concentrations according to quartiles to predict the end point of mortality in PTB patients. Patients in the lowest and second quartiles had a minimal risk for death, in contrast with patients with FABP concentrations in the 3rd and 4th quartiles (P < 0.0001). MIF = Macrophage migration inhibitory factor; PTB=Pulmonary Tuberculosis

Serum levels of MIF in different groups. a serum levels of MIF in advanced disease and mild-to-moderate clinical severity; (b) serum levels of MIF in disseminated and non-disseminated PTB; (c) serum levels of MIF in drug-resistant and drug-sensitive PTB; (d) serum levels of MIF in survivors and non- survivors. All data are medians and in-terquartile ranges (IQR); P values refer to Mann-Whitney U tests for differences between groups(P < 0.0001). MIF = Macrophage migration inhibitory factor; PTB=Pulmonary Tuberculosis