Sequence of a family of Ser/Thr kinases containing a Cdc42-binding domain and other functional domains. (A) Deduced amino acid sequences of rat MRCKα and MRCKβ. Regions in boldface represent, in order, kinase, cysteine-rich (CR), PH, and p21 GTPase-binding (GBD) domains. In MRCKα, the region underlined is identical, apart from an initial L→V, to the human sequence shown in Fig. A. Domain organization of MRCKs, myotonic dystrophy kinase (DMK), and ROKα, along with percent identities of related domains, is also shown. (B) Kinase domains of MRCKα, MRCKβ, myotonic dystrophy kinase (DMK), and ROKα. (C) PH domains in MRCKα, MRCKβ, ROKα, and pleckstrin N terminus (Pleck N). Amino acids identical to the most commonly occurring consensus sequence in PH domains (in boldface and uppercase) are marked with asterisks. (D) Cysteine-rich domains of MRCKs, PKCα, and n-chimaerin (n-CHIM). Conserved residues () are indicated by asterisks.