Variation Analysis


Genetic variation or polymorphism

- the regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (Single Nucleotide Polymorphism) to large nucleotide sequences visible at a chromosomal level.

Basic classes of DNA variation

  • Insertion-Deletion Length Polymorphism (INDEL)
  • Single Nucleotide Polymorphism (SNP)
  • Simple Sequence Repeat (SSR) Length Polymorphism (Mini- and Micro- Satellites)

Single Nucleotide Polymorphism

single nucleotide polymorphism

Importance of genetic variation analysis

  • Early diagnosis, prevention and treatment of human diseases;
  • Systematics and taxonomy
  • Population, quantitative, and evolutionary genetics;
  • Plant and animal breeding;
  • Identifying individuals and populations (paternity and forensic analysis).


» dbSNP: the NCBI database of genetic variation

» About genetic variation in PubMed

Illumina bead array Affymetrix SSO

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Last updated: 2017-11-13T10:57:24Z