Name: rs1805414
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1805414

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr1:226385663 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: A>G / A>T
Variation Type: SNV Single Nucleotide Variation
Frequency: G=0.438725 (116126/264690, TOPMED)
G=0.426227 (107127/251338, GnomAD_exome)
G=0.423236 (59264/140026, GnomAD) (+ 23 more)
G=0.422802 (51280/121286, ExAC)
G=0.36121 (32229/89226, ALFA)
A=0.22027 (6224/28256, 14KJPN)
A=0.21975 (3683/16760, 8.3KJPN)
G=0.40773 (5303/13006, GO-ESP)
A=0.4797 (3072/6404, 1000G_30x)
A=0.4834 (2421/5008, 1000G)
G=0.3377 (1513/4480, Estonian)
G=0.3243 (1250/3854, ALSPAC)
G=0.3104 (1151/3708, TWINSUK)
A=0.2290 (671/2930, KOREAN)
A=0.4709 (891/1892, HapMap)
A=0.2172 (398/1832, Korea1K)
G=0.363 (362/998, GoNL)
A=0.220 (174/790, PRJEB37584)
A=0.165 (101/612, Vietnamese)
G=0.398 (239/600, NorthernSweden)
G=0.283 (151/534, MGP)
A=0.295 (125/424, SGDP_PRJ)
G=0.395 (120/304, FINRISK)
G=0.361 (78/216, Qatari)
A=0.30 (14/46, Siberian)
G=0.38 (15/40, GENOME_DK)

Clinical Significance: Not Reported in ClinVar
Gene : Consequence: PARP1 : Synonymous Variant
Publications: 9 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	89226	A=0.63879	G=0.36121
European	Sub	66044	A=0.67017	G=0.32983
African	Sub	5786	A=0.4597	G=0.5403
African Others	Sub	198	A=0.359	G=0.641
African American	Sub	5588	A=0.4633	G=0.5367
Asian	Sub	510	A=0.212	G=0.788
East Asian	Sub	412	A=0.204	G=0.796
Other Asian	Sub	98	A=0.24	G=0.76
Latin American 1	Sub	944	A=0.604	G=0.396
Latin American 2	Sub	4982	A=0.4851	G=0.5149
South Asian	Sub	178	A=0.657	G=0.343
Other	Sub	10782	A=0.63662	G=0.36338

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	A=0.561275	G=0.438725
gnomAD - Exomes	Global	Study-wide	251338	A=0.573773	G=0.426227
gnomAD - Exomes	European	Sub	135286	A=0.651080	G=0.348920
gnomAD - Exomes	Asian	Sub	49004	A=0.46696	G=0.53304
gnomAD - Exomes	American	Sub	34586	A=0.44619	G=0.55381
gnomAD - Exomes	African	Sub	16246	A=0.44749	G=0.55251
gnomAD - Exomes	Ashkenazi Jewish	Sub	10078	A=0.66610	G=0.33390
gnomAD - Exomes	Other	Sub	6138	A=0.6241	G=0.3759
gnomAD - Genomes	Global	Study-wide	140026	A=0.576764	G=0.423236
gnomAD - Genomes	European	Sub	75844	A=0.65999	G=0.34001
gnomAD - Genomes	African	Sub	41950	A=0.45800	G=0.54200
gnomAD - Genomes	American	Sub	13632	A=0.54673	G=0.45327
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	A=0.6728	G=0.3272
gnomAD - Genomes	East Asian	Sub	3130	A=0.1827	G=0.8173
gnomAD - Genomes	Other	Sub	2148	A=0.5740	G=0.4260
ExAC	Global	Study-wide	121286	A=0.577198	G=0.422802
ExAC	Europe	Sub	73274	A=0.65014	G=0.34986
ExAC	Asian	Sub	25148	A=0.48521	G=0.51479
ExAC	American	Sub	11564	A=0.42243	G=0.57757
ExAC	African	Sub	10392	A=0.45256	G=0.54744
ExAC	Other	Sub	908	A=0.637	G=0.363
Allele Frequency Aggregator	Total	Global	89226	A=0.63879	G=0.36121
Allele Frequency Aggregator	European	Sub	66044	A=0.67017	G=0.32983
Allele Frequency Aggregator	Other	Sub	10782	A=0.63662	G=0.36338
Allele Frequency Aggregator	African	Sub	5786	A=0.4597	G=0.5403
Allele Frequency Aggregator	Latin American 2	Sub	4982	A=0.4851	G=0.5149
Allele Frequency Aggregator	Latin American 1	Sub	944	A=0.604	G=0.396
Allele Frequency Aggregator	Asian	Sub	510	A=0.212	G=0.788
Allele Frequency Aggregator	South Asian	Sub	178	A=0.657	G=0.343
14KJPN	JAPANESE	Study-wide	28256	A=0.22027	G=0.77973
8.3KJPN	JAPANESE	Study-wide	16760	A=0.21975	G=0.78025
GO Exome Sequencing Project	Global	Study-wide	13006	A=0.59227	G=0.40773
GO Exome Sequencing Project	European American	Sub	8600	A=0.6585	G=0.3415
GO Exome Sequencing Project	African American	Sub	4406	A=0.4630	G=0.5370
1000Genomes_30x	Global	Study-wide	6404	A=0.4797	G=0.5203
1000Genomes_30x	African	Sub	1786	A=0.4334	G=0.5666
1000Genomes_30x	Europe	Sub	1266	A=0.6611	G=0.3389
1000Genomes_30x	South Asian	Sub	1202	A=0.6190	G=0.3810
1000Genomes_30x	East Asian	Sub	1170	A=0.2077	G=0.7923
1000Genomes_30x	American	Sub	980	A=0.484	G=0.516
1000Genomes	Global	Study-wide	5008	A=0.4834	G=0.5166
1000Genomes	African	Sub	1322	A=0.4418	G=0.5582
1000Genomes	East Asian	Sub	1008	A=0.2054	G=0.7946
1000Genomes	Europe	Sub	1006	A=0.6710	G=0.3290
1000Genomes	South Asian	Sub	978	A=0.624	G=0.376
1000Genomes	American	Sub	694	A=0.497	G=0.503
Genetic variation in the Estonian population	Estonian	Study-wide	4480	A=0.6623	G=0.3377
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.6757	G=0.3243
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.6896	G=0.3104
KOREAN population from KRGDB	KOREAN	Study-wide	2930	A=0.2290	G=0.7710, T=0.0000
HapMap	Global	Study-wide	1892	A=0.4709	G=0.5291
HapMap	American	Sub	770	A=0.483	G=0.517
HapMap	African	Sub	692	A=0.486	G=0.514
HapMap	Asian	Sub	254	A=0.220	G=0.780
HapMap	Europe	Sub	176	A=0.722	G=0.278
Korean Genome Project	KOREAN	Study-wide	1832	A=0.2172	G=0.7828
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	A=0.637	G=0.363
CNV burdens in cranial meningiomas	Global	Study-wide	790	A=0.220	G=0.780
CNV burdens in cranial meningiomas	CRM	Sub	790	A=0.220	G=0.780
A Vietnamese Genetic Variation Database	Global	Study-wide	612	A=0.165	G=0.835
Northern Sweden	ACPOP	Study-wide	600	A=0.602	G=0.398
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	A=0.717	G=0.283
SGDP_PRJ	Global	Study-wide	424	A=0.295	G=0.705
FINRISK	Finnish from FINRISK project	Study-wide	304	A=0.605	G=0.395
Qatari	Global	Study-wide	216	A=0.639	G=0.361
Siberian	Global	Study-wide	46	A=0.30	G=0.70
The Danish reference pan genome	Danish	Study-wide	40	A=0.62	G=0.38

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 1	NC_000001.11:g.226385663A>G
GRCh38.p14 chr 1	NC_000001.11:g.226385663A>T
GRCh37.p13 chr 1	NC_000001.10:g.226573364A>G
GRCh37.p13 chr 1	NC_000001.10:g.226573364A>T

Gene: PARP1, poly(ADP-ribose) polymerase 1 (minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
PARP1 transcript	NM_001618.4:c.852T>C	A [GCT] > A [GCC]	Coding Sequence Variant
poly [ADP-ribose] polymerase 1	NP_001609.2:p.Ala284=	A (Ala) > A (Ala)	Synonymous Variant
PARP1 transcript	NM_001618.4:c.852T>A	A [GCT] > A [GCA]	Coding Sequence Variant
poly [ADP-ribose] polymerase 1	NP_001609.2:p.Ala284=	A (Ala) > A (Ala)	Synonymous Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	A=	G	T
GRCh38.p14 chr 1	NC_000001.11:g.226385663=	NC_000001.11:g.226385663A>G	NC_000001.11:g.226385663A>T
GRCh37.p13 chr 1	NC_000001.10:g.226573364=	NC_000001.10:g.226573364A>G	NC_000001.10:g.226573364A>T
PARP1 transcript	NM_001618.4:c.852=	NM_001618.4:c.852T>C	NM_001618.4:c.852T>A
PARP1 transcript	NM_001618.3:c.852=	NM_001618.3:c.852T>C	NM_001618.3:c.852T>A
poly [ADP-ribose] polymerase 1	NP_001609.2:p.Ala284=	NP_001609.2:p.Ala284=	NP_001609.2:p.Ala284=

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

132 SubSNP, 26 Frequency submissions

No	Submitter	Submission ID	Date (Build)
1	UWGC	ss2667859	Jan 12, 2001 (92)
2	WICVAR	ss3177617	Aug 15, 2001 (102)
3	HGBASE	ss3188749	Aug 15, 2001 (98)
4	SC_JCM	ss3955326	Sep 28, 2001 (100)
5	EGP_SNPS	ss4480442	Jul 03, 2002 (106)
6	YUSUKE	ss4924712	Aug 28, 2002 (108)
7	SNP500CANCER	ss5586202	Mar 31, 2003 (113)
8	SC_SNP	ss13004606	Dec 05, 2003 (119)
9	SC_SNP	ss15382304	Feb 27, 2004 (120)
10	CGAP-GAI	ss16230519	Feb 28, 2004 (126)
11	IMCJ-GDT	ss22886570	Apr 05, 2004 (123)
12	PERLEGEN	ss23186308	Sep 20, 2004 (123)
13	MGC_GENOME_DIFF	ss28498595	Sep 24, 2004 (126)
14	MGC_GENOME_DIFF	ss28513528	Sep 24, 2004 (126)
15	ABI	ss43891203	Mar 10, 2006 (126)
16	ILLUMINA	ss65741016	Oct 16, 2006 (127)
17	ILLUMINA	ss74902009	Dec 07, 2007 (129)
18	CGM_KYOTO	ss76877468	Dec 07, 2007 (129)
19	HGSV	ss79028231	Dec 07, 2007 (129)
20	HGSV	ss83546974	Dec 16, 2007 (130)
21	CORNELL	ss86237649	Mar 23, 2008 (129)
22	CANCER-GENOME	ss86342308	Mar 23, 2008 (129)
23	CNG	ss95212966	Mar 25, 2008 (129)
24	BGI	ss106636540	Feb 06, 2009 (130)
25	1000GENOMES	ss108999493	Jan 23, 2009 (130)
26	1000GENOMES	ss111868141	Jan 25, 2009 (130)
27	ILLUMINA-UK	ss119229508	Feb 15, 2009 (130)
28	KRIBB_YJKIM	ss119404164	Dec 01, 2009 (131)
29	GMI	ss156364899	Dec 01, 2009 (131)
30	SEATTLESEQ	ss159700721	Dec 01, 2009 (131)
31	ILLUMINA	ss160463337	Dec 01, 2009 (131)
32	COMPLETE_GENOMICS	ss165300486	Jul 04, 2010 (132)
33	COMPLETE_GENOMICS	ss165860156	Jul 04, 2010 (132)
34	COMPLETE_GENOMICS	ss167543484	Jul 04, 2010 (132)
35	BUSHMAN	ss199689238	Jul 04, 2010 (132)
36	1000GENOMES	ss218916087	Jul 14, 2010 (132)
37	1000GENOMES	ss230928887	Jul 14, 2010 (132)
38	1000GENOMES	ss238536660	Jul 15, 2010 (132)
39	GMI	ss276244174	May 04, 2012 (137)
40	PJP	ss290747267	May 09, 2011 (134)
41	NHLBI-ESP	ss342033466	May 09, 2011 (134)
42	ILLUMINA	ss481069138	Sep 08, 2015 (146)
43	ILLUMINA	ss482246929	May 04, 2012 (137)
44	ILLUMINA	ss483846963	May 04, 2012 (137)
45	1000GENOMES	ss489794790	May 04, 2012 (137)
46	CLINSEQ_SNP	ss491616380	May 04, 2012 (137)
47	ILLUMINA	ss536042797	Sep 08, 2015 (146)
48	TISHKOFF	ss555178900	Apr 25, 2013 (138)
49	SSMP	ss648750584	Apr 25, 2013 (138)
50	ILLUMINA	ss779518404	Sep 08, 2015 (146)
51	ILLUMINA	ss782367050	Sep 08, 2015 (146)
52	ILLUMINA	ss834988856	Sep 08, 2015 (146)
53	JMKIDD_LAB	ss974439990	Aug 21, 2014 (142)
54	EVA-GONL	ss976213739	Aug 21, 2014 (142)
55	JMKIDD_LAB	ss1067432553	Aug 21, 2014 (142)
56	JMKIDD_LAB	ss1068653989	Aug 21, 2014 (142)
57	1000GENOMES	ss1294911987	Aug 21, 2014 (142)
58	EVA_GENOME_DK	ss1574721912	Apr 01, 2015 (144)
59	EVA_FINRISK	ss1584015460	Apr 01, 2015 (144)
60	EVA_UK10K_ALSPAC	ss1602279379	Apr 01, 2015 (144)
61	EVA_UK10K_TWINSUK	ss1645273412	Apr 01, 2015 (144)
62	EVA_EXAC	ss1686082357	Apr 01, 2015 (144)
63	EVA_MGP	ss1710945838	Apr 01, 2015 (144)
64	EVA_SVP	ss1712410437	Apr 01, 2015 (144)
65	HAMMER_LAB	ss1795818602	Sep 08, 2015 (146)
66	WEILL_CORNELL_DGM	ss1919435796	Feb 12, 2016 (147)
67	GENOMED	ss1966989382	Jul 19, 2016 (147)
68	JJLAB	ss2020242361	Sep 14, 2016 (149)
69	USC_VALOUEV	ss2148276678	Dec 20, 2016 (150)
70	HUMAN_LONGEVITY	ss2170628856	Dec 20, 2016 (150)
71	SYSTEMSBIOZJU	ss2624632465	Nov 08, 2017 (151)
72	ILLUMINA	ss2632637651	Nov 08, 2017 (151)
73	GRF	ss2698274869	Nov 08, 2017 (151)
74	GNOMAD	ss2732318943	Nov 08, 2017 (151)
75	GNOMAD	ss2746575252	Nov 08, 2017 (151)
76	GNOMAD	ss2766965374	Nov 08, 2017 (151)
77	SWEGEN	ss2988559557	Nov 08, 2017 (151)
78	EVA_SAMSUNG_MC	ss3023057643	Nov 08, 2017 (151)
79	BIOINF_KMB_FNS_UNIBA	ss3023881582	Nov 08, 2017 (151)
80	CSHL	ss3343943019	Nov 08, 2017 (151)
81	ILLUMINA	ss3626323413	Oct 11, 2018 (152)
82	ILLUMINA	ss3630667052	Oct 11, 2018 (152)
83	ILLUMINA	ss3636055062	Oct 11, 2018 (152)
84	ILLUMINA	ss3642824010	Oct 11, 2018 (152)
85	OMUKHERJEE_ADBS	ss3646254271	Oct 11, 2018 (152)
86	EGCUT_WGS	ss3656518493	Jul 12, 2019 (153)
87	EVA_DECODE	ss3688758527	Jul 12, 2019 (153)
88	ACPOP	ss3727920070	Jul 12, 2019 (153)
89	EVA	ss3747417414	Jul 12, 2019 (153)
90	KHV_HUMAN_GENOMES	ss3800420258	Jul 12, 2019 (153)
91	EVA	ss3823721672	Apr 25, 2020 (154)
92	EVA	ss3825518981	Apr 25, 2020 (154)
93	EVA	ss3825535934	Apr 25, 2020 (154)
94	EVA	ss3825589459	Apr 25, 2020 (154)
95	EVA	ss3826678103	Apr 25, 2020 (154)
96	EVA	ss3836741105	Apr 25, 2020 (154)
97	EVA	ss3842153368	Apr 25, 2020 (154)
98	SGDP_PRJ	ss3851034773	Apr 25, 2020 (154)
99	KRGDB	ss3896371483	Apr 25, 2020 (154)
100	KOGIC	ss3946626735	Apr 25, 2020 (154)
101	FSA-LAB	ss3983965153	Apr 25, 2021 (155)
102	FSA-LAB	ss3983965154	Apr 25, 2021 (155)
103	EVA	ss3984473079	Apr 25, 2021 (155)
104	EVA	ss3986015759	Apr 25, 2021 (155)
105	EVA	ss3986161476	Apr 25, 2021 (155)
106	TOPMED	ss4485896017	Apr 25, 2021 (155)
107	TOMMO_GENOMICS	ss5148735135	Apr 25, 2021 (155)
108	EVA	ss5236879293	Apr 25, 2021 (155)
109	EVA	ss5237634412	Oct 12, 2022 (156)
110	1000G_HIGH_COVERAGE	ss5246025923	Oct 12, 2022 (156)
111	TRAN_CS_UWATERLOO	ss5314399346	Oct 12, 2022 (156)
112	EVA	ss5314687437	Oct 12, 2022 (156)
113	EVA	ss5325209365	Oct 12, 2022 (156)
114	HUGCELL_USP	ss5446438024	Oct 12, 2022 (156)
115	EVA	ss5506212453	Oct 12, 2022 (156)
116	1000G_HIGH_COVERAGE	ss5520239871	Oct 12, 2022 (156)
117	EVA	ss5623918624	Oct 12, 2022 (156)
118	EVA	ss5624003758	Oct 12, 2022 (156)
119	SANFORD_IMAGENETICS	ss5627577256	Oct 12, 2022 (156)
120	TOMMO_GENOMICS	ss5676581754	Oct 12, 2022 (156)
121	EVA	ss5799412575	Oct 12, 2022 (156)
122	EVA	ss5800090533	Oct 12, 2022 (156)
123	YY_MCH	ss5801697572	Oct 12, 2022 (156)
124	EVA	ss5833355036	Oct 12, 2022 (156)
125	EVA	ss5846863372	Oct 12, 2022 (156)
126	EVA	ss5848287298	Oct 12, 2022 (156)
127	EVA	ss5849314810	Oct 12, 2022 (156)
128	EVA	ss5912236342	Oct 12, 2022 (156)
129	EVA	ss5936514156	Oct 12, 2022 (156)
130	EVA	ss5939421261	Oct 12, 2022 (156)
131	EVA	ss5980018947	Oct 12, 2022 (156)
132	EVA	ss5981201324	Oct 12, 2022 (156)
133	1000Genomes	NC_000001.10 - 226573364	Oct 11, 2018 (152)
134	1000Genomes_30x	NC_000001.11 - 226385663	Oct 12, 2022 (156)
135	The Avon Longitudinal Study of Parents and Children	NC_000001.10 - 226573364	Oct 11, 2018 (152)
136	Genetic variation in the Estonian population	NC_000001.10 - 226573364	Oct 11, 2018 (152)
137	ExAC	NC_000001.10 - 226573364	Oct 11, 2018 (152)
138	FINRISK	NC_000001.10 - 226573364	Apr 25, 2020 (154)
139	The Danish reference pan genome	NC_000001.10 - 226573364	Apr 25, 2020 (154)
140	gnomAD - Genomes	NC_000001.11 - 226385663	Apr 25, 2021 (155)
141	gnomAD - Exomes	NC_000001.10 - 226573364	Jul 12, 2019 (153)
142	GO Exome Sequencing Project	NC_000001.10 - 226573364	Oct 11, 2018 (152)
143	Genome of the Netherlands Release 5	NC_000001.10 - 226573364	Apr 25, 2020 (154)
144	HapMap	NC_000001.11 - 226385663	Apr 25, 2020 (154)
145	KOREAN population from KRGDB	NC_000001.10 - 226573364	Apr 25, 2020 (154)
146	Korean Genome Project	NC_000001.11 - 226385663	Apr 25, 2020 (154)
147	Medical Genome Project healthy controls from Spanish population	NC_000001.10 - 226573364	Apr 25, 2020 (154)
148	Northern Sweden	NC_000001.10 - 226573364	Jul 12, 2019 (153)
149	CNV burdens in cranial meningiomas	NC_000001.10 - 226573364	Apr 25, 2021 (155)
150	Qatari	NC_000001.10 - 226573364	Apr 25, 2020 (154)
151	SGDP_PRJ	NC_000001.10 - 226573364	Apr 25, 2020 (154)
152	Siberian	NC_000001.10 - 226573364	Apr 25, 2020 (154)
153	8.3KJPN	NC_000001.10 - 226573364	Apr 25, 2021 (155)
154	14KJPN	NC_000001.11 - 226385663	Oct 12, 2022 (156)
155	TopMed	NC_000001.11 - 226385663	Apr 25, 2021 (155)
156	UK 10K study - Twins	NC_000001.10 - 226573364	Oct 11, 2018 (152)
157	A Vietnamese Genetic Variation Database	NC_000001.10 - 226573364	Jul 12, 2019 (153)
158	ALFA	NC_000001.11 - 226385663	Apr 25, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs2230482	Jan 04, 2002 (102)
rs3738712	Oct 09, 2002 (108)
rs11541663	Mar 10, 2006 (126)
rs13306132	Sep 24, 2004 (123)
rs16845837	Oct 07, 2004 (123)
rs17846210	Mar 10, 2006 (126)
rs17859226	Mar 10, 2006 (126)
rs61304985	May 26, 2008 (130)
rs117404261	Aug 16, 2010 (132)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss79028231, ss83546974	NC_000001.8:222880098:A:G	NC_000001.11:226385662:A:G	(self)
ss108999493, ss111868141, ss119229508, ss165300486, ss165860156, ss167543484, ss199689238, ss276244174, ss290747267, ss482246929, ss491616380, ss1712410437, ss3642824010	NC_000001.9:224639986:A:G	NC_000001.11:226385662:A:G	(self)
5776075, 3192290, 2256741, 5321107, 11921, 1913173, 1355944, 180181, 1395057, 3548877, 62590, 1204935, 22400, 1477726, 3051753, 793032, 6704442, 3192290, 693325, ss218916087, ss230928887, ss238536660, ss342033466, ss481069138, ss483846963, ss489794790, ss536042797, ss555178900, ss648750584, ss779518404, ss782367050, ss834988856, ss974439990, ss976213739, ss1067432553, ss1068653989, ss1294911987, ss1574721912, ss1584015460, ss1602279379, ss1645273412, ss1686082357, ss1710945838, ss1795818602, ss1919435796, ss1966989382, ss2020242361, ss2148276678, ss2624632465, ss2632637651, ss2698274869, ss2732318943, ss2746575252, ss2766965374, ss2988559557, ss3023057643, ss3343943019, ss3626323413, ss3630667052, ss3636055062, ss3646254271, ss3656518493, ss3727920070, ss3747417414, ss3823721672, ss3825518981, ss3825535934, ss3825589459, ss3826678103, ss3836741105, ss3851034773, ss3896371483, ss3983965153, ss3983965154, ss3984473079, ss3986015759, ss3986161476, ss5148735135, ss5314687437, ss5325209365, ss5506212453, ss5623918624, ss5624003758, ss5627577256, ss5799412575, ss5800090533, ss5833355036, ss5848287298, ss5936514156, ss5939421261, ss5980018947, ss5981201324	NC_000001.10:226573363:A:G	NC_000001.11:226385662:A:G	(self)
7765806, 41486064, 282175, 3004736, 10418858, 49502352, 5369728705, ss2170628856, ss3023881582, ss3688758527, ss3800420258, ss3842153368, ss3946626735, ss4485896017, ss5236879293, ss5237634412, ss5246025923, ss5314399346, ss5446438024, ss5520239871, ss5676581754, ss5801697572, ss5846863372, ss5849314810, ss5912236342	NC_000001.11:226385662:A:G	NC_000001.11:226385662:A:G	(self)
ss13004606	NT_004559.10:86681:A:G	NC_000001.11:226385662:A:G	(self)
ss15382304	NT_004559.11:2749557:A:G	NC_000001.11:226385662:A:G	(self)
ss2667859, ss3177617, ss3188749, ss3955326, ss4480442, ss4924712, ss5586202, ss16230519, ss22886570, ss23186308, ss28498595, ss28513528, ss43891203, ss65741016, ss74902009, ss76877468, ss86237649, ss86342308, ss95212966, ss106636540, ss119404164, ss156364899, ss159700721, ss160463337	NT_167186.1:20091142:A:G	NC_000001.11:226385662:A:G	(self)
3548877, ss3896371483	NC_000001.10:226573363:A:T	NC_000001.11:226385662:A:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

9 citations for rs1805414

PMID	Title	Author	Year	Journal
18805967	Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping.	Johnson DC et al.	2008	Blood
19604089	Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.	Hoskins JM et al.	2009	Pharmacogenomics
21695249	Identification of novel SNPs in glioblastoma using targeted resequencing.	Keller A et al.	2011	PloS one
21767974	Association analysis of PARP1 polymorphisms with Parkinson's disease.	Brighina L et al.	2011	Parkinsonism & related disorders
27746584	The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3'Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort.	Alhadheq AM et al.	2016	Disease markers
29662639	Polymorphisms in BER genes and risk of breast cancer: evidences from 69 studies with 33760 cases and 33252 controls.	Qiao L et al.	2018	Oncotarget
30183716	Interaction among susceptibility genotypes of PARP1 SNPs in thyroid carcinoma.	Bashir K et al.	2018	PloS one
31609976	Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study.	Khan AU et al.	2019	PloS one
33284833	Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.	Jin J et al.	2020	PloS one

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

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Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs1805414